Predicted complex interactions
CCL16_HUMAN + CXCR4
SUMMARY
- Chemokine
- CCL16_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR4 View partner entry
- Partner description
- UniProt: P61073; Gene: cxcr4_human; Family: Chemokine
- Interactions detected
- 138
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| PRO 2 | NTc.Cm35 | PHE 189 | - | Hydrophobic |
| PRO 2 | NTc.Cm35 | PHE 189 | - | VdWContact |
| PRO 2 | NTc.Cm35 | TYR 190 | - | VdWContact |
| LYS 3 | NTc.Cm34 | ASP 193 | 5.32x33 | Cationic |
| LYS 3 | NTc.Cm34 | ASP 193 | 5.32x33 | HBDonor |
| LYS 3 | NTc.Cm34 | ASP 193 | 5.32x33 | VdWContact |
| LYS 3 | NTc.Cm34 | VAL 196 | 5.35x36 | Hydrophobic |
| LYS 3 | NTc.Cm34 | VAL 196 | 5.35x36 | VdWContact |
| LYS 3 | NTc.Cm34 | LEU 266 | 6.62x62 | Hydrophobic |
| LYS 3 | NTc.Cm34 | LEU 266 | 6.62x62 | VdWContact |
| VAL 4 | NTc.Cm33 | ILE 185 | - | Hydrophobic |
| VAL 4 | NTc.Cm33 | ASP 187 | 45.51x51 | Hydrophobic |
| VAL 4 | NTc.Cm33 | ASP 187 | 45.51x51 | VdWContact |
| VAL 4 | NTc.Cm33 | PHE 189 | - | Hydrophobic |
| PRO 5 | NTc.Cm32 | ASP 187 | 45.51x51 | VdWContact |
| PRO 5 | NTc.Cm32 | ARG 188 | 45.52x52 | Hydrophobic |
| PRO 5 | NTc.Cm32 | TYR 190 | - | Hydrophobic |
| GLU 6 | NTc.Cm31 | ILE 259 | 6.55x55 | VdWContact |
| GLU 6 | NTc.Cm31 | HIS 281 | 7.32x31 | HBAcceptor |
| GLU 6 | NTc.Cm31 | HIS 281 | 7.32x31 | Hydrophobic |
| GLU 6 | NTc.Cm31 | HIS 281 | 7.32x31 | VdWContact |
| GLU 6 | NTc.Cm31 | ILE 284 | 7.35x34 | Hydrophobic |
| GLU 6 | NTc.Cm31 | ILE 284 | 7.35x34 | VdWContact |
| TRP 7 | NTc.Cm30 | TRP 94 | 2.60x60 | Hydrophobic |
| TRP 7 | NTc.Cm30 | TRP 94 | 2.60x60 | VdWContact |
| TRP 7 | NTc.Cm30 | HIS 113 | 3.29x29 | Hydrophobic |
| TRP 7 | NTc.Cm30 | HIS 113 | 3.29x29 | VdWContact |
| TRP 7 | NTc.Cm30 | CYS 186 | 45.50x50 | VdWContact |
| TRP 7 | NTc.Cm30 | ASP 187 | 45.51x51 | VdWContact |
| TRP 7 | NTc.Cm30 | GLU 288 | 7.39x38 | VdWContact |
| VAL 8 | NTc.Cm29 | ILE 185 | - | Hydrophobic |
| VAL 8 | NTc.Cm29 | ASP 187 | 45.51x51 | Hydrophobic |
| VAL 8 | NTc.Cm29 | ASP 187 | 45.51x51 | VdWContact |
| ASN 9 | NTc.Cm28 | ASP 97 | 2.63x63 | HBDonor |
| ASN 9 | NTc.Cm28 | ASP 97 | 2.63x63 | VdWContact |
| ASN 9 | NTc.Cm28 | ILE 185 | - | Hydrophobic |
| THR 10 | NTc.Cm27 | ARG 30 | 1.24x24 | HBAcceptor |
| THR 10 | NTc.Cm27 | ARG 30 | 1.24x24 | VdWContact |
| SER 12 | NTc.Cm25 | CYS 28 | - | VdWContact |
| SER 12 | NTc.Cm25 | PHE 29 | - | VdWContact |
| SER 12 | NTc.Cm25 | ARG 30 | 1.24x24 | HBAcceptor |
| SER 12 | NTc.Cm25 | ARG 30 | 1.24x24 | VdWContact |
| SER 12 | NTc.Cm25 | GLU 31 | 1.25x25 | VdWContact |
| THR 13 | NTc.Cm24 | PRO 27 | - | Hydrophobic |
| THR 13 | NTc.Cm24 | PHE 29 | - | Hydrophobic |
| THR 13 | NTc.Cm24 | PHE 29 | - | VdWContact |
| CYS 14 | NTc.Cm23 | CYS 28 | - | HBAcceptor |
| CYS 14 | NTc.Cm23 | CYS 28 | - | HBDonor |
| CYS 14 | NTc.Cm23 | CYS 28 | - | VdWContact |
| CYS 15 | NTc.Cm22 | PRO 27 | - | VdWContact |
| LEU 16 | NTc.Cm21 | CYS 28 | - | Hydrophobic |
| LEU 16 | NTc.Cm21 | GLU 277 | 7.28x27 | VdWContact |
| LYS 17 | NTc.Cm20 | LYS 25 | - | Hydrophobic |
| LYS 17 | NTc.Cm20 | LYS 25 | - | VdWContact |
| LYS 17 | NTc.Cm20 | GLU 268 | 6.64x64 | Cationic |
| LYS 17 | NTc.Cm20 | GLU 268 | 6.64x64 | HBDonor |
| LYS 17 | NTc.Cm20 | GLU 268 | 6.64x64 | VdWContact |
| TYR 18 | NTc.Cm19 | LYS 25 | - | HBAcceptor |
| TYR 18 | NTc.Cm19 | LYS 25 | - | VdWContact |
| TYR 19 | NTc.Cm18 | MET 16 | - | Hydrophobic |
| TYR 19 | NTc.Cm18 | SER 23 | - | VdWContact |
| TYR 19 | NTc.Cm18 | MET 24 | - | Hydrophobic |
| TYR 19 | NTc.Cm18 | MET 24 | - | VdWContact |
| GLU 20 | NTc.Cm17 | LYS 25 | - | Anionic |
| GLU 20 | NTc.Cm17 | LYS 25 | - | HBAcceptor |
| GLU 20 | NTc.Cm17 | LYS 25 | - | VdWContact |
| LYS 21 | NTc.Cm16 | ASP 20 | - | Cationic |
| LYS 21 | NTc.Cm16 | ASP 20 | - | HBDonor |
| LYS 21 | NTc.Cm16 | ASP 20 | - | VdWContact |
| LEU 23 | NTc.Cm14 | MET 24 | - | Hydrophobic |
| PRO 24 | NTc.Cm13 | MET 16 | - | Hydrophobic |
| PRO 24 | NTc.Cm13 | MET 16 | - | VdWContact |
| ARG 26 | NTc.Cm11 | TYR 12 | - | HBDonor |
| ARG 26 | NTc.Cm11 | TYR 12 | - | VdWContact |
| ARG 26 | NTc.Cm11 | GLU 14 | - | Cationic |
| ARG 26 | NTc.Cm11 | GLU 14 | - | HBDonor |
| ARG 26 | NTc.Cm11 | GLU 14 | - | VdWContact |
| LEU 27 | NTc.Cm10 | MET 16 | - | Hydrophobic |
| LEU 27 | NTc.Cm10 | MET 16 | - | VdWContact |
| LEU 27 | NTc.Cm10 | TYR 21 | - | Hydrophobic |
| LEU 27 | NTc.Cm10 | TYR 21 | - | VdWContact |
| ASN 36 | NTc.Cm1 | GLU 179 | - | HBDonor |
| ASN 36 | NTc.Cm1 | ALA 180 | - | Hydrophobic |
| HIS 38 | CX.5 | ASN 192 | - | Hydrophobic |
| HIS 38 | CX.5 | ASP 193 | 5.32x33 | Hydrophobic |
| HIS 38 | CX.5 | ASP 193 | 5.32x33 | VdWContact |
| ILE 43 | cxb1.7 | PRO 27 | - | Hydrophobic |
| ARG 48 | cxb1.15 | TYR 21 | - | CationPi |
| ARG 50 | B1.1 | TYR 21 | - | VdWContact |
| ARG 50 | B1.1 | ASP 22 | - | Cationic |
| ARG 50 | B1.1 | ASP 22 | - | HBDonor |
| ARG 50 | B1.1 | ASP 22 | - | VdWContact |
| ARG 50 | B1.1 | GLU 26 | - | Cationic |
| ARG 50 | B1.1 | GLU 26 | - | VdWContact |
| GLU 51 | B1.2 | GLU 26 | - | VdWContact |
| GLU 51 | B1.2 | PRO 27 | - | Hydrophobic |
| GLU 51 | B1.2 | PRO 27 | - | VdWContact |
| GLU 51 | B1.2 | PHE 29 | - | Hydrophobic |
| GLU 51 | B1.2 | PHE 29 | - | VdWContact |
| VAL 52 | B1.3 | MET 24 | - | Hydrophobic |
| CYS 53 | B1.4 | LYS 25 | - | HBDonor |
| CYS 53 | B1.4 | LYS 25 | - | VdWContact |
| CYS 53 | B1.4 | PRO 27 | - | VdWContact |
| THR 75 | B3.2 | ASP 181 | - | HBDonor |
| THR 75 | B3.2 | ASP 181 | - | VdWContact |
| ARG 76 | B3.3 | PHE 29 | - | CationPi |
| ARG 76 | B3.3 | PHE 29 | - | Hydrophobic |
| ARG 76 | B3.3 | PHE 29 | - | VdWContact |
| ARG 76 | B3.3 | GLU 31 | 1.25x25 | Cationic |
| ARG 76 | B3.3 | GLU 31 | 1.25x25 | VdWContact |
| ASN 77 | B3.4 | ASP 181 | - | HBDonor |
| ASN 77 | B3.4 | ASP 181 | - | Hydrophobic |
| ASN 77 | B3.4 | ASP 181 | - | VdWContact |
| LEU 78 | b3h.1 | LYS 38 | 1.32x32 | VdWContact |
| LEU 78 | b3h.1 | ARG 183 | - | VdWContact |
| SER 79 | b3h.2 | ASP 181 | - | HBDonor |
| SER 79 | b3h.2 | ASP 181 | - | VdWContact |
| SER 79 | b3h.2 | ASP 182 | - | VdWContact |
| SER 79 | b3h.2 | ARG 183 | - | VdWContact |
| THR 80 | b3h.3 | ASP 181 | - | VdWContact |
| THR 80 | b3h.3 | ASP 182 | - | HBAcceptor |
| THR 80 | b3h.3 | ASP 182 | - | HBDonor |
| THR 80 | b3h.3 | ASP 182 | - | VdWContact |
| VAL 81 | b3h.4 | GLU 179 | - | Hydrophobic |
| VAL 81 | b3h.4 | GLU 179 | - | VdWContact |
| VAL 81 | b3h.4 | ALA 180 | - | VdWContact |
| VAL 81 | b3h.4 | ASP 181 | - | VdWContact |
| VAL 81 | b3h.4 | ASP 182 | - | HBAcceptor |
| VAL 81 | b3h.4 | ASP 182 | - | HBDonor |
| VAL 81 | b3h.4 | ASP 182 | - | Hydrophobic |
| VAL 81 | b3h.4 | ASP 182 | - | VdWContact |
| LYS 82 | H.1 | GLU 179 | - | HBDonor |
| LYS 82 | H.1 | GLU 179 | - | VdWContact |
| ILE 83 | H.2 | GLU 179 | - | HBDonor |
| ILE 83 | H.2 | GLU 179 | - | Hydrophobic |
| ILE 83 | H.2 | GLU 179 | - | VdWContact |
| ILE 84 | H.3 | GLU 179 | - | HBDonor |
| ILE 84 | H.3 | GLU 179 | - | VdWContact |
