Predicted complex interactions
CCL18_HUMAN + CXCR4
SUMMARY
- Chemokine
- CCL18_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR4 View partner entry
- Partner description
- UniProt: P61073; Gene: cxcr4_human; Family: Chemokine
- Interactions detected
- 76
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| LYS 7 | NTc.Cm23 | ILE 4 | - | Hydrophobic |
| LYS 7 | NTc.Cm23 | SER 5 | - | HBDonor |
| LYS 7 | NTc.Cm23 | SER 5 | - | VdWContact |
| LYS 7 | NTc.Cm23 | ILE 6 | - | Hydrophobic |
| LYS 7 | NTc.Cm23 | ILE 6 | - | VdWContact |
| LEU 9 | NTc.Cm21 | ILE 6 | - | Hydrophobic |
| VAL 13 | NTc.Cm17 | PHE 29 | - | Hydrophobic |
| VAL 13 | NTc.Cm17 | PHE 29 | - | VdWContact |
| VAL 13 | NTc.Cm17 | GLU 31 | 1.25x25 | Hydrophobic |
| VAL 13 | NTc.Cm17 | GLU 31 | 1.25x25 | VdWContact |
| TYR 14 | NTc.Cm16 | PHE 29 | - | VdWContact |
| THR 15 | NTc.Cm15 | PHE 29 | - | VdWContact |
| THR 15 | NTc.Cm15 | ASP 181 | - | VdWContact |
| SER 16 | NTc.Cm14 | ALA 180 | - | VdWContact |
| SER 16 | NTc.Cm14 | ASP 181 | - | VdWContact |
| TRP 17 | NTc.Cm13 | ARG 30 | 1.24x24 | VdWContact |
| TRP 17 | NTc.Cm13 | ALA 180 | - | Hydrophobic |
| TRP 17 | NTc.Cm13 | ALA 180 | - | VdWContact |
| TRP 17 | NTc.Cm13 | ILE 185 | - | Hydrophobic |
| ILE 19 | NTc.Cm11 | PRO 27 | - | Hydrophobic |
| ILE 19 | NTc.Cm11 | PRO 27 | - | VdWContact |
| LYS 22 | NTc.Cm8 | MET 24 | - | Hydrophobic |
| LYS 22 | NTc.Cm8 | MET 24 | - | VdWContact |
| LYS 22 | NTc.Cm8 | PRO 191 | - | HBDonor |
| LYS 22 | NTc.Cm8 | PRO 191 | - | VdWContact |
| PHE 23 | NTc.Cm7 | MET 24 | - | Hydrophobic |
| PHE 23 | NTc.Cm7 | MET 24 | - | VdWContact |
| LEU 42 | cxb1.16 | GLU 26 | - | VdWContact |
| THR 43 | B1.1 | MET 24 | - | VdWContact |
| THR 43 | B1.1 | GLU 26 | - | HBDonor |
| THR 43 | B1.1 | GLU 26 | - | Hydrophobic |
| THR 43 | B1.1 | GLU 26 | - | VdWContact |
| THR 43 | B1.1 | PRO 27 | - | VdWContact |
| LYS 44 | B1.2 | ASP 22 | - | Cationic |
| LYS 44 | B1.2 | ASP 22 | - | HBDonor |
| LYS 44 | B1.2 | ASP 22 | - | Hydrophobic |
| LYS 44 | B1.2 | ASP 22 | - | VdWContact |
| LYS 44 | B1.2 | MET 24 | - | Hydrophobic |
| ARG 45 | B1.3 | SER 23 | - | HBDonor |
| ARG 45 | B1.3 | SER 23 | - | VdWContact |
| ARG 45 | B1.3 | MET 24 | - | VdWContact |
| ARG 45 | B1.3 | LYS 25 | - | Hydrophobic |
| ARG 45 | B1.3 | LYS 25 | - | VdWContact |
| ARG 45 | B1.3 | GLU 26 | - | Hydrophobic |
| ARG 45 | B1.3 | GLU 26 | - | VdWContact |
| ARG 45 | B1.3 | ASP 193 | 5.32x33 | Cationic |
| ARG 45 | B1.3 | ASP 193 | 5.32x33 | HBDonor |
| ARG 45 | B1.3 | ASP 193 | 5.32x33 | VdWContact |
| ARG 45 | B1.3 | LEU 266 | 6.62x62 | HBDonor |
| ARG 45 | B1.3 | LEU 266 | 6.62x62 | VdWContact |
| ARG 45 | B1.3 | GLU 268 | 6.64x64 | Cationic |
| ARG 45 | B1.3 | GLU 268 | 6.64x64 | HBDonor |
| ARG 45 | B1.3 | GLU 268 | 6.64x64 | VdWContact |
| GLY 46 | B1.4 | GLU 26 | - | VdWContact |
| ARG 47 | B1.5 | LYS 25 | - | VdWContact |
| ARG 47 | B1.5 | GLU 26 | - | HBDonor |
| ARG 47 | B1.5 | GLU 26 | - | Hydrophobic |
| ARG 47 | B1.5 | GLU 26 | - | VdWContact |
| ARG 47 | B1.5 | PRO 27 | - | VdWContact |
| ARG 47 | B1.5 | CYS 28 | - | Cationic |
| ARG 47 | B1.5 | CYS 28 | - | VdWContact |
| ARG 47 | B1.5 | CYS 274 | 7.25x24 | Cationic |
| ARG 47 | B1.5 | CYS 274 | 7.25x24 | VdWContact |
| ARG 47 | B1.5 | GLU 277 | 7.28x27 | Cationic |
| ARG 47 | B1.5 | GLU 277 | 7.28x27 | HBDonor |
| ARG 47 | B1.5 | GLU 277 | 7.28x27 | VdWContact |
| GLN 48 | B1.6 | GLU 26 | - | VdWContact |
| ILE 49 | B1.7 | PRO 27 | - | Hydrophobic |
| ILE 49 | B1.7 | PRO 27 | - | VdWContact |
| ILE 49 | B1.7 | PHE 29 | - | Hydrophobic |
| CYS 50 | b1b2.4 | PHE 29 | - | Hydrophobic |
| CYS 50 | b1b2.4 | PHE 29 | - | VdWContact |
| LYS 55 | b1b2.13 | ASP 181 | - | Cationic |
| LYS 55 | b1b2.13 | ASP 181 | - | VdWContact |
| LYS 55 | b1b2.13 | ASP 182 | - | Cationic |
| LYS 55 | b1b2.13 | ASP 182 | - | VdWContact |
