Predicted complex interactions
CCL2_HUMAN + CXCR4
SUMMARY
- Chemokine
- CCL2_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR4 View partner entry
- Partner description
- UniProt: P61073; Gene: cxcr4_human; Family: Chemokine
- Interactions detected
- 79
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| GLN 1 | NTc.Cm33 | TRP 94 | 2.60x60 | Hydrophobic |
| GLN 1 | NTc.Cm33 | TRP 94 | 2.60x60 | VdWContact |
| GLN 1 | NTc.Cm33 | HIS 113 | 3.29x29 | HBDonor |
| GLN 1 | NTc.Cm33 | HIS 113 | 3.29x29 | Hydrophobic |
| GLN 1 | NTc.Cm33 | HIS 113 | 3.29x29 | VdWContact |
| GLN 1 | NTc.Cm33 | ASP 187 | 45.51x51 | HBDonor |
| GLN 1 | NTc.Cm33 | ASP 187 | 45.51x51 | VdWContact |
| GLN 1 | NTc.Cm33 | ARG 188 | 45.52x52 | HBAcceptor |
| GLN 1 | NTc.Cm33 | ARG 188 | 45.52x52 | VdWContact |
| PRO 2 | NTc.Cm32 | TYR 45 | 1.39x39 | Hydrophobic |
| PRO 2 | NTc.Cm32 | TRP 94 | 2.60x60 | Hydrophobic |
| PRO 2 | NTc.Cm32 | GLU 288 | 7.39x38 | VdWContact |
| PRO 2 | NTc.Cm32 | PHE 292 | 7.43x42 | Hydrophobic |
| ASP 3 | NTc.Cm31 | TYR 255 | 6.51x51 | HBAcceptor |
| ASP 3 | NTc.Cm31 | TYR 255 | 6.51x51 | VdWContact |
| ASP 3 | NTc.Cm31 | ILE 259 | 6.55x55 | Hydrophobic |
| ASP 3 | NTc.Cm31 | ILE 284 | 7.35x34 | Hydrophobic |
| ASP 3 | NTc.Cm31 | GLU 288 | 7.39x38 | HBDonor |
| ASP 3 | NTc.Cm31 | GLU 288 | 7.39x38 | VdWContact |
| ALA 4 | NTc.Cm30 | ASN 37 | 1.31x31 | VdWContact |
| ALA 4 | NTc.Cm30 | LEU 41 | 1.35x35 | Hydrophobic |
| ALA 4 | NTc.Cm30 | SER 285 | 7.36x35 | VdWContact |
| ALA 4 | NTc.Cm30 | GLU 288 | 7.39x38 | HBDonor |
| ALA 4 | NTc.Cm30 | GLU 288 | 7.39x38 | VdWContact |
| ILE 5 | NTc.Cm29 | LEU 41 | 1.35x35 | Hydrophobic |
| ILE 5 | NTc.Cm29 | TYR 45 | 1.39x39 | Hydrophobic |
| ILE 5 | NTc.Cm29 | TYR 45 | 1.39x39 | VdWContact |
| ILE 5 | NTc.Cm29 | TRP 94 | 2.60x60 | Hydrophobic |
| ILE 5 | NTc.Cm29 | TRP 94 | 2.60x60 | VdWContact |
| ILE 5 | NTc.Cm29 | ASP 97 | 2.63x63 | Hydrophobic |
| ILE 5 | NTc.Cm29 | ALA 98 | 2.64x64 | Hydrophobic |
| ALA 7 | NTc.Cm27 | ILE 185 | - | Hydrophobic |
| ALA 7 | NTc.Cm27 | ILE 185 | - | VdWContact |
| PRO 8 | NTc.Cm26 | ARG 30 | 1.24x24 | Hydrophobic |
| PRO 8 | NTc.Cm26 | ALA 34 | 1.28x28 | Hydrophobic |
| VAL 9 | NTc.Cm25 | ARG 30 | 1.24x24 | VdWContact |
| THR 10 | NTc.Cm24 | PRO 27 | - | Hydrophobic |
| THR 10 | NTc.Cm24 | PRO 27 | - | VdWContact |
| THR 10 | NTc.Cm24 | CYS 28 | - | VdWContact |
| THR 10 | NTc.Cm24 | PHE 29 | - | Hydrophobic |
| CYS 11 | NTc.Cm23 | CYS 28 | - | HBAcceptor |
| CYS 11 | NTc.Cm23 | CYS 28 | - | HBDonor |
| CYS 11 | NTc.Cm23 | CYS 28 | - | VdWContact |
| CYS 11 | NTc.Cm23 | ARG 30 | 1.24x24 | Anionic |
| TYR 13 | NTc.Cm21 | CYS 28 | - | Hydrophobic |
| TYR 13 | NTc.Cm21 | CYS 28 | - | VdWContact |
| TYR 13 | NTc.Cm21 | ARG 30 | 1.24x24 | HBAcceptor |
| TYR 13 | NTc.Cm21 | ARG 30 | 1.24x24 | VdWContact |
| TYR 13 | NTc.Cm21 | CYS 274 | 7.25x24 | Hydrophobic |
| TYR 13 | NTc.Cm21 | GLU 277 | 7.28x27 | VdWContact |
| ASN 14 | NTc.Cm20 | LYS 25 | - | Hydrophobic |
| ASN 14 | NTc.Cm20 | LYS 25 | - | VdWContact |
| ARG 18 | NTc.Cm16 | ASP 20 | - | Cationic |
| ARG 18 | NTc.Cm16 | ASP 20 | - | HBDonor |
| ARG 18 | NTc.Cm16 | ASP 20 | - | VdWContact |
| ARG 24 | NTc.Cm10 | GLU 14 | - | Cationic |
| ARG 24 | NTc.Cm10 | MET 16 | - | VdWContact |
| SER 34 | CX.1 | ASN 192 | - | VdWContact |
| SER 34 | CX.1 | ASP 193 | 5.32x33 | VdWContact |
| SER 34 | CX.1 | VAL 196 | 5.35x36 | VdWContact |
| LYS 35 | CX.5 | ASP 187 | 45.51x51 | Cationic |
| LYS 35 | CX.5 | ASP 187 | 45.51x51 | HBDonor |
| LYS 35 | CX.5 | ASP 187 | 45.51x51 | VdWContact |
| PRO 37 | cxb1.2 | LEU 266 | 6.62x62 | VdWContact |
| PRO 37 | cxb1.2 | GLU 268 | 6.64x64 | Hydrophobic |
| LYS 38 | cxb1.5 | GLU 268 | 6.64x64 | Cationic |
| LYS 38 | cxb1.5 | GLU 268 | 6.64x64 | VdWContact |
| ILE 42 | cxb1.10 | PRO 27 | - | Hydrophobic |
| LYS 49 | B1.3 | TYR 21 | - | Hydrophobic |
| LYS 49 | B1.3 | TYR 21 | - | VdWContact |
| GLU 50 | B1.4 | PRO 27 | - | Hydrophobic |
| GLU 50 | B1.4 | PRO 27 | - | VdWContact |
| GLU 50 | B1.4 | PHE 29 | - | Hydrophobic |
| ILE 51 | B1.5 | MET 24 | - | Hydrophobic |
| ILE 51 | B1.5 | MET 24 | - | VdWContact |
| CYS 52 | B1.6 | LYS 25 | - | HBDonor |
| CYS 52 | B1.6 | LYS 25 | - | Hydrophobic |
| CYS 52 | B1.6 | LYS 25 | - | VdWContact |
| CYS 52 | B1.6 | PRO 27 | - | VdWContact |
