Predicted complex interactions
CCL22_HUMAN + CXCR4
SUMMARY
- Chemokine
- CCL22_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR4 View partner entry
- Partner description
- UniProt: P61073; Gene: cxcr4_human; Family: Chemokine
- Interactions detected
- 80
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| GLY 1 | NTc.Cm35 | TRP 94 | 2.60x60 | VdWContact |
| GLY 1 | NTc.Cm35 | HIS 113 | 3.29x29 | HBDonor |
| GLY 1 | NTc.Cm35 | HIS 113 | 3.29x29 | VdWContact |
| GLY 1 | NTc.Cm35 | ASP 187 | 45.51x51 | Cationic |
| GLY 1 | NTc.Cm35 | ASP 187 | 45.51x51 | VdWContact |
| GLY 1 | NTc.Cm35 | ARG 188 | 45.52x52 | HBAcceptor |
| GLY 1 | NTc.Cm35 | ARG 188 | 45.52x52 | VdWContact |
| PRO 2 | NTc.Cm34 | TRP 94 | 2.60x60 | Hydrophobic |
| PRO 2 | NTc.Cm34 | TRP 94 | 2.60x60 | VdWContact |
| PRO 2 | NTc.Cm34 | TYR 116 | 3.32x32 | Hydrophobic |
| PRO 2 | NTc.Cm34 | GLU 288 | 7.39x38 | VdWContact |
| PRO 2 | NTc.Cm34 | PHE 292 | 7.43x42 | Hydrophobic |
| TYR 3 | NTc.Cm33 | ILE 259 | 6.55x55 | Hydrophobic |
| TYR 3 | NTc.Cm33 | ASP 262 | 6.58x58 | HBDonor |
| TYR 3 | NTc.Cm33 | ASP 262 | 6.58x58 | VdWContact |
| TYR 3 | NTc.Cm33 | HIS 281 | 7.32x31 | Hydrophobic |
| TYR 3 | NTc.Cm33 | HIS 281 | 7.32x31 | VdWContact |
| TYR 3 | NTc.Cm33 | ILE 284 | 7.35x34 | Hydrophobic |
| TYR 3 | NTc.Cm33 | ILE 284 | 7.35x34 | VdWContact |
| TYR 3 | NTc.Cm33 | GLU 288 | 7.39x38 | HBDonor |
| TYR 3 | NTc.Cm33 | GLU 288 | 7.39x38 | VdWContact |
| GLY 4 | NTc.Cm32 | ASN 37 | 1.31x31 | VdWContact |
| GLY 4 | NTc.Cm32 | LEU 41 | 1.35x35 | VdWContact |
| GLY 4 | NTc.Cm32 | GLU 288 | 7.39x38 | HBDonor |
| GLY 4 | NTc.Cm32 | GLU 288 | 7.39x38 | VdWContact |
| ALA 5 | NTc.Cm31 | TRP 94 | 2.60x60 | Hydrophobic |
| ASN 6 | NTc.Cm30 | ASP 97 | 2.63x63 | HBDonor |
| ASN 6 | NTc.Cm30 | ASP 97 | 2.63x63 | VdWContact |
| ASN 6 | NTc.Cm30 | CYS 186 | 45.50x50 | VdWContact |
| ASN 6 | NTc.Cm30 | ASP 187 | 45.51x51 | Hydrophobic |
| MET 7 | NTc.Cm29 | ASN 33 | 1.27x27 | Hydrophobic |
| MET 7 | NTc.Cm29 | ASN 37 | 1.31x31 | VdWContact |
| MET 7 | NTc.Cm29 | HIS 281 | 7.32x31 | Hydrophobic |
| MET 7 | NTc.Cm29 | HIS 281 | 7.32x31 | VdWContact |
| MET 7 | NTc.Cm29 | SER 285 | 7.36x35 | VdWContact |
| GLU 8 | NTc.Cm28 | ARG 30 | 1.24x24 | VdWContact |
| ASP 9 | NTc.Cm27 | ALA 34 | 1.28x28 | Hydrophobic |
| ASP 9 | NTc.Cm27 | ALA 34 | 1.28x28 | VdWContact |
| ASP 9 | NTc.Cm27 | LYS 38 | 1.32x32 | Anionic |
| ASP 9 | NTc.Cm27 | LYS 38 | 1.32x32 | VdWContact |
| ASP 9 | NTc.Cm27 | ARG 183 | - | Anionic |
| ASP 9 | NTc.Cm27 | ARG 183 | - | HBAcceptor |
| ASP 9 | NTc.Cm27 | ARG 183 | - | VdWContact |
| VAL 11 | NTc.Cm25 | PRO 27 | - | Hydrophobic |
| VAL 11 | NTc.Cm25 | PRO 27 | - | VdWContact |
| VAL 11 | NTc.Cm25 | PHE 29 | - | Hydrophobic |
| CYS 12 | NTc.Cm24 | CYS 28 | - | HBAcceptor |
| CYS 12 | NTc.Cm24 | CYS 28 | - | HBDonor |
| CYS 12 | NTc.Cm24 | CYS 28 | - | VdWContact |
| ARG 14 | NTc.Cm22 | CYS 28 | - | Cationic |
| ARG 14 | NTc.Cm22 | CYS 28 | - | Hydrophobic |
| ARG 14 | NTc.Cm22 | CYS 28 | - | VdWContact |
| ARG 14 | NTc.Cm22 | ARG 30 | 1.24x24 | VdWContact |
| ARG 14 | NTc.Cm22 | GLU 277 | 7.28x27 | Cationic |
| ARG 14 | NTc.Cm22 | GLU 277 | 7.28x27 | HBDonor |
| ARG 14 | NTc.Cm22 | GLU 277 | 7.28x27 | VdWContact |
| ASP 15 | NTc.Cm21 | MET 24 | - | HBDonor |
| ASP 15 | NTc.Cm21 | MET 24 | - | Hydrophobic |
| ASP 15 | NTc.Cm21 | MET 24 | - | VdWContact |
| VAL 17 | NTc.Cm19 | LYS 25 | - | Hydrophobic |
| TYR 19 | NTc.Cm17 | MET 16 | - | Hydrophobic |
| TYR 19 | NTc.Cm17 | LYS 25 | - | VdWContact |
| PRO 22 | NTc.Cm14 | TYR 12 | - | Hydrophobic |
| PRO 22 | NTc.Cm14 | TYR 12 | - | VdWContact |
| ARG 24 | NTc.Cm12 | TYR 12 | - | CationPi |
| ARG 24 | NTc.Cm12 | TYR 12 | - | VdWContact |
| SER 33 | NTc.Cm3 | ASP 181 | - | HBDonor |
| SER 33 | NTc.Cm3 | ASP 181 | - | VdWContact |
| ARG 38 | cxb1.1 | GLU 268 | 6.64x64 | Cationic |
| ARG 38 | cxb1.1 | GLU 268 | 6.64x64 | HBDonor |
| ARG 38 | cxb1.1 | GLU 268 | 6.64x64 | VdWContact |
| VAL 42 | cxb1.7 | PRO 27 | - | Hydrophobic |
| VAL 42 | cxb1.7 | PRO 27 | - | VdWContact |
| GLU 50 | B1.2 | GLU 26 | - | VdWContact |
| GLU 50 | B1.2 | PRO 27 | - | Hydrophobic |
| GLU 50 | B1.2 | PRO 27 | - | VdWContact |
| GLU 50 | B1.2 | PHE 29 | - | VdWContact |
| ILE 51 | B1.3 | LYS 25 | - | VdWContact |
| CYS 52 | B1.4 | LYS 25 | - | HBDonor |
| CYS 52 | B1.4 | LYS 25 | - | VdWContact |
