Predicted complex interactions
CXCL8_HUMAN + ACKR2
SUMMARY
- Chemokine
- CXCL8_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- ACKR2 View partner entry
- Partner description
- UniProt: O00590; Gene: ackr2_human; Family: Chemokine
- Interactions detected
- 108
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| GLU 1 | NTc.Cm33 | PHE 199 | - | Hydrophobic |
| GLU 1 | NTc.Cm33 | PHE 199 | - | VdWContact |
| GLU 1 | NTc.Cm33 | HIS 202 | 5.30x31 | VdWContact |
| GLU 1 | NTc.Cm33 | GLY 203 | 5.31x32 | HBDonor |
| GLU 1 | NTc.Cm33 | GLY 203 | 5.31x32 | VdWContact |
| GLU 1 | NTc.Cm33 | THR 204 | 5.32x33 | VdWContact |
| GLU 1 | NTc.Cm33 | ILE 205 | 5.33x34 | VdWContact |
| GLU 1 | NTc.Cm33 | TRP 206 | 5.34x35 | HBAcceptor |
| GLU 1 | NTc.Cm33 | TRP 206 | 5.34x35 | Hydrophobic |
| GLU 1 | NTc.Cm33 | TRP 206 | 5.34x35 | VdWContact |
| GLU 1 | NTc.Cm33 | LYS 207 | 5.35x36 | Hydrophobic |
| GLU 1 | NTc.Cm33 | LYS 207 | 5.35x36 | VdWContact |
| GLU 1 | NTc.Cm33 | LEU 210 | 5.38x39 | VdWContact |
| GLY 2 | NTc.Cm32 | ALA 197 | 45.52x52 | VdWContact |
| GLY 2 | NTc.Cm32 | PHE 199 | - | VdWContact |
| ALA 3 | NTc.Cm31 | ASP 179 | 4.60x61 | VdWContact |
| ALA 3 | NTc.Cm31 | PHE 199 | - | VdWContact |
| ALA 3 | NTc.Cm31 | LEU 210 | 5.38x39 | Hydrophobic |
| ALA 3 | NTc.Cm31 | LEU 210 | 5.38x39 | VdWContact |
| VAL 4 | NTc.Cm30 | TYR 124 | 3.32x32 | VdWContact |
| VAL 4 | NTc.Cm30 | ARG 211 | 5.39x40 | Hydrophobic |
| VAL 4 | NTc.Cm30 | LEU 270 | 6.55x55 | Hydrophobic |
| VAL 4 | NTc.Cm30 | LEU 270 | 6.55x55 | VdWContact |
| LEU 5 | NTc.Cm29 | TRP 102 | 2.60x60 | Hydrophobic |
| LEU 5 | NTc.Cm29 | TRP 102 | 2.60x60 | VdWContact |
| LEU 5 | NTc.Cm29 | SER 121 | 3.29x29 | VdWContact |
| LEU 5 | NTc.Cm29 | CYS 195 | 45.50x50 | VdWContact |
| LEU 5 | NTc.Cm29 | HIS 196 | 45.51x51 | Hydrophobic |
| LEU 5 | NTc.Cm29 | HIS 196 | 45.51x51 | VdWContact |
| PRO 6 | NTc.Cm28 | TYR 53 | 1.39x39 | Hydrophobic |
| PRO 6 | NTc.Cm28 | TYR 53 | 1.39x39 | VdWContact |
| PRO 6 | NTc.Cm28 | TRP 102 | 2.60x60 | Hydrophobic |
| PRO 6 | NTc.Cm28 | TRP 102 | 2.60x60 | VdWContact |
| PRO 6 | NTc.Cm28 | GLU 298 | 7.39x38 | VdWContact |
| PRO 6 | NTc.Cm28 | PHE 302 | 7.43x42 | Hydrophobic |
| ARG 7 | NTc.Cm27 | ALA 197 | 45.52x52 | VdWContact |
| SER 8 | NTc.Cm26 | LEU 294 | 7.35x34 | VdWContact |
| SER 8 | NTc.Cm26 | GLN 295 | 7.36x35 | VdWContact |
| ALA 9 | NTc.Cm25 | VAL 42 | 1.28x28 | VdWContact |
| ALA 9 | NTc.Cm25 | LEU 49 | 1.35x35 | Hydrophobic |
| ALA 9 | NTc.Cm25 | VAL 106 | 2.64x64 | Hydrophobic |
| LYS 10 | NTc.Cm24 | TRP 108 | 2.66x66 | HBDonor |
| LYS 10 | NTc.Cm24 | TRP 108 | 2.66x66 | VdWContact |
| GLU 11 | NTc.Cm23 | HIS 196 | 45.51x51 | VdWContact |
| LEU 12 | NTc.Cm22 | LYS 38 | 1.24x24 | Hydrophobic |
| ARG 13 | NTc.Cm21 | LYS 38 | 1.24x24 | VdWContact |
| ARG 13 | NTc.Cm21 | HIS 273 | 6.58x58 | CationPi |
| ARG 13 | NTc.Cm21 | HIS 273 | 6.58x58 | Hydrophobic |
| ARG 13 | NTc.Cm21 | HIS 273 | 6.58x58 | VdWContact |
| ARG 13 | NTc.Cm21 | LEU 276 | 6.61x61 | VdWContact |
| ARG 13 | NTc.Cm21 | SER 287 | 7.28x27 | HBDonor |
| ARG 13 | NTc.Cm21 | SER 287 | 7.28x27 | VdWContact |
| ARG 13 | NTc.Cm21 | LEU 290 | 7.31x30 | VdWContact |
| ARG 13 | NTc.Cm21 | ASP 291 | 7.32x31 | Cationic |
| ARG 13 | NTc.Cm21 | ASP 291 | 7.32x31 | HBDonor |
| ARG 13 | NTc.Cm21 | ASP 291 | 7.32x31 | VdWContact |
| GLN 15 | NTc.Cm19 | LEU 35 | - | Hydrophobic |
| GLN 15 | NTc.Cm19 | CYS 36 | - | HBAcceptor |
| GLN 15 | NTc.Cm19 | CYS 36 | - | VdWContact |
| ILE 17 | NTc.Cm17 | CYS 36 | - | Hydrophobic |
| TYR 20 | NTc.Cm14 | LEU 28 | - | Hydrophobic |
| TYR 20 | NTc.Cm14 | LEU 28 | - | VdWContact |
| TYR 20 | NTc.Cm14 | VAL 31 | - | Hydrophobic |
| TYR 20 | NTc.Cm14 | VAL 31 | - | VdWContact |
| TYR 20 | NTc.Cm14 | MET 34 | - | Hydrophobic |
| TYR 20 | NTc.Cm14 | MET 34 | - | VdWContact |
| PRO 23 | NTc.Cm11 | TYR 23 | - | Hydrophobic |
| PRO 23 | NTc.Cm11 | TYR 23 | - | VdWContact |
| PHE 24 | NTc.Cm10 | PHE 22 | - | VdWContact |
| HIS 25 | NTc.Cm9 | PHE 22 | - | Hydrophobic |
| HIS 25 | NTc.Cm9 | PHE 22 | - | VdWContact |
| PRO 26 | NTc.Cm8 | PHE 22 | - | Hydrophobic |
| PRO 26 | NTc.Cm8 | PHE 22 | - | VdWContact |
| PHE 28 | NTc.Cm6 | TYR 25 | - | HBAcceptor |
| PHE 28 | NTc.Cm6 | TYR 25 | - | Hydrophobic |
| PHE 28 | NTc.Cm6 | TYR 25 | - | VdWContact |
| PRO 39 | cxb1.5 | HIS 196 | 45.51x51 | Hydrophobic |
| PRO 39 | cxb1.5 | HIS 196 | 45.51x51 | VdWContact |
| PRO 39 | cxb1.5 | ALA 197 | 45.52x52 | VdWContact |
| PRO 39 | cxb1.5 | ASP 198 | - | Hydrophobic |
| PRO 39 | cxb1.5 | ASP 198 | - | VdWContact |
| PRO 39 | cxb1.5 | PHE 199 | - | Hydrophobic |
| PRO 39 | cxb1.5 | LYS 207 | 5.35x36 | HBAcceptor |
| PRO 39 | cxb1.5 | LYS 207 | 5.35x36 | VdWContact |
| ALA 42 | cxb1.8 | THR 204 | 5.32x33 | Hydrophobic |
| ALA 42 | cxb1.8 | THR 204 | 5.32x33 | VdWContact |
| ILE 47 | cxb1.16 | LEU 35 | - | Hydrophobic |
| ILE 47 | cxb1.16 | LEU 35 | - | VdWContact |
| LEU 50 | B1.3 | TYR 25 | - | Hydrophobic |
| LEU 50 | B1.3 | TYR 25 | - | VdWContact |
| LEU 50 | B1.3 | LEU 28 | - | Hydrophobic |
| ARG 54 | B1.7 | LEU 28 | - | VdWContact |
| ARG 54 | B1.7 | ASP 29 | - | Cationic |
| ARG 54 | B1.7 | ASP 29 | - | HBDonor |
| ARG 54 | B1.7 | ASP 29 | - | VdWContact |
| GLU 55 | b1b2.4 | MET 34 | - | HBAcceptor |
| GLU 55 | b1b2.4 | MET 34 | - | VdWContact |
| GLU 55 | b1b2.4 | LEU 35 | - | Hydrophobic |
| GLU 55 | b1b2.4 | LEU 35 | - | VdWContact |
| GLU 55 | b1b2.4 | ARG 37 | - | Anionic |
| GLU 55 | b1b2.4 | ARG 37 | - | HBAcceptor |
| GLU 55 | b1b2.4 | ARG 37 | - | VdWContact |
| LEU 56 | b1b2.6 | LEU 28 | - | Hydrophobic |
| LEU 56 | b1b2.6 | LEU 28 | - | VdWContact |
| LEU 56 | b1b2.6 | VAL 31 | - | Hydrophobic |
| LEU 56 | b1b2.6 | MET 34 | - | Hydrophobic |
| CYS 57 | b1b2.7 | MET 34 | - | Hydrophobic |
| VAL 68 | B2.4 | PHE 22 | - | Hydrophobic |
