Predicted complex interactions
CCL25_HUMAN + CXCR4
SUMMARY
- Chemokine
- CCL25_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR4 View partner entry
- Partner description
- UniProt: P61073; Gene: cxcr4_human; Family: Chemokine
- Interactions detected
- 92
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| GLN 1 | NTc.Cm29 | GLY 17 | - | HBDonor |
| GLN 1 | NTc.Cm29 | GLY 17 | - | VdWContact |
| GLN 1 | NTc.Cm29 | SER 18 | - | VdWContact |
| GLY 2 | NTc.Cm28 | GLY 19 | - | HBDonor |
| GLY 2 | NTc.Cm28 | GLY 19 | - | VdWContact |
| PHE 4 | NTc.Cm26 | ASP 20 | - | VdWContact |
| PHE 4 | NTc.Cm26 | TYR 21 | - | VdWContact |
| PHE 4 | NTc.Cm26 | ASP 22 | - | VdWContact |
| PHE 4 | NTc.Cm26 | SER 23 | - | VdWContact |
| PHE 4 | NTc.Cm26 | MET 24 | - | Hydrophobic |
| PHE 4 | NTc.Cm26 | MET 24 | - | VdWContact |
| GLU 5 | NTc.Cm25 | MET 24 | - | VdWContact |
| CYS 7 | NTc.Cm23 | MET 24 | - | Hydrophobic |
| CYS 7 | NTc.Cm23 | MET 24 | - | VdWContact |
| LEU 9 | NTc.Cm21 | MET 24 | - | Hydrophobic |
| LEU 9 | NTc.Cm21 | MET 24 | - | VdWContact |
| HIS 12 | NTc.Cm18 | PRO 27 | - | Hydrophobic |
| HIS 12 | NTc.Cm18 | PRO 27 | - | VdWContact |
| HIS 12 | NTc.Cm18 | PHE 29 | - | Hydrophobic |
| HIS 12 | NTc.Cm18 | PHE 29 | - | VdWContact |
| GLY 16 | NTc.Cm14 | ASP 181 | - | VdWContact |
| TRP 17 | NTc.Cm13 | GLU 179 | - | HBDonor |
| TRP 17 | NTc.Cm13 | GLU 179 | - | Hydrophobic |
| TRP 17 | NTc.Cm13 | GLU 179 | - | VdWContact |
| TRP 17 | NTc.Cm13 | ALA 180 | - | VdWContact |
| TRP 17 | NTc.Cm13 | ASP 181 | - | VdWContact |
| TRP 17 | NTc.Cm13 | ASP 182 | - | VdWContact |
| ALA 18 | NTc.Cm12 | ALA 180 | - | Hydrophobic |
| ALA 18 | NTc.Cm12 | ALA 180 | - | VdWContact |
| ALA 18 | NTc.Cm12 | ASP 181 | - | HBDonor |
| ALA 18 | NTc.Cm12 | ASP 181 | - | Hydrophobic |
| ALA 18 | NTc.Cm12 | ASP 181 | - | VdWContact |
| ARG 21 | NTc.Cm9 | SER 178 | - | HBDonor |
| ARG 21 | NTc.Cm9 | SER 178 | - | VdWContact |
| ARG 21 | NTc.Cm9 | GLU 179 | - | HBDonor |
| ARG 21 | NTc.Cm9 | GLU 179 | - | VdWContact |
| ARG 21 | NTc.Cm9 | ALA 180 | - | Hydrophobic |
| ARG 21 | NTc.Cm9 | ALA 180 | - | VdWContact |
| ARG 21 | NTc.Cm9 | ARG 183 | - | HBDonor |
| ARG 21 | NTc.Cm9 | ARG 183 | - | VdWContact |
| ARG 21 | NTc.Cm9 | TYR 184 | - | VdWContact |
| ARG 21 | NTc.Cm9 | ILE 185 | - | VdWContact |
| ARG 22 | NTc.Cm8 | ILE 185 | - | Hydrophobic |
| ARG 22 | NTc.Cm8 | ILE 185 | - | VdWContact |
| ARG 22 | NTc.Cm8 | PHE 189 | - | Hydrophobic |
| ARG 22 | NTc.Cm8 | PHE 189 | - | VdWContact |
| TRP 24 | NTc.Cm6 | TYR 190 | - | Hydrophobic |
| TRP 24 | NTc.Cm6 | TYR 190 | - | VdWContact |
| TRP 24 | NTc.Cm6 | ASN 192 | - | VdWContact |
| TRP 24 | NTc.Cm6 | ASP 193 | 5.32x33 | Hydrophobic |
| TRP 24 | NTc.Cm6 | ASP 193 | 5.32x33 | VdWContact |
| TRP 24 | NTc.Cm6 | VAL 196 | 5.35x36 | Hydrophobic |
| TRP 24 | NTc.Cm6 | VAL 196 | 5.35x36 | VdWContact |
| PRO 45 | B1.4 | PHE 189 | - | Hydrophobic |
| LYS 46 | B1.5 | ARG 30 | 1.24x24 | HBAcceptor |
| LYS 46 | B1.5 | ARG 30 | 1.24x24 | VdWContact |
| LYS 46 | B1.5 | ASP 187 | 45.51x51 | Cationic |
| LYS 46 | B1.5 | ASP 187 | 45.51x51 | HBDonor |
| LYS 46 | B1.5 | ASP 187 | 45.51x51 | VdWContact |
| LYS 46 | B1.5 | HIS 281 | 7.32x31 | Hydrophobic |
| LYS 46 | B1.5 | HIS 281 | 7.32x31 | VdWContact |
| ARG 47 | B1.6 | ARG 30 | 1.24x24 | VdWContact |
| ARG 47 | B1.6 | LEU 266 | 6.62x62 | VdWContact |
| ARG 47 | B1.6 | GLU 277 | 7.28x27 | HBDonor |
| ARG 47 | B1.6 | GLU 277 | 7.28x27 | Hydrophobic |
| ARG 47 | B1.6 | GLU 277 | 7.28x27 | VdWContact |
| ARG 47 | B1.6 | ASN 278 | 7.29x28 | HBDonor |
| ARG 47 | B1.6 | ASN 278 | 7.29x28 | VdWContact |
| ARG 47 | B1.6 | HIS 281 | 7.32x31 | Hydrophobic |
| ARG 47 | B1.6 | HIS 281 | 7.32x31 | VdWContact |
| HIS 48 | B1.7 | ASP 193 | 5.32x33 | Hydrophobic |
| HIS 48 | B1.7 | ASP 193 | 5.32x33 | VdWContact |
| HIS 48 | B1.7 | LEU 266 | 6.62x62 | Hydrophobic |
| HIS 48 | B1.7 | LEU 266 | 6.62x62 | VdWContact |
| ARG 49 | b1b2.1 | CYS 28 | - | Cationic |
| ARG 49 | b1b2.1 | CYS 28 | - | Hydrophobic |
| ARG 49 | b1b2.1 | CYS 28 | - | VdWContact |
| ARG 49 | b1b2.1 | PHE 29 | - | HBDonor |
| ARG 49 | b1b2.1 | PHE 29 | - | VdWContact |
| ARG 49 | b1b2.1 | ARG 30 | 1.24x24 | HBDonor |
| ARG 49 | b1b2.1 | ARG 30 | 1.24x24 | VdWContact |
| ARG 49 | b1b2.1 | GLU 277 | 7.28x27 | Cationic |
| ARG 49 | b1b2.1 | ASN 278 | 7.29x28 | VdWContact |
| LYS 50 | b1b2.2 | PRO 27 | - | VdWContact |
| ARG 62 | B2.1 | GLU 179 | - | Cationic |
| ARG 62 | B2.1 | GLU 179 | - | HBDonor |
| ARG 62 | B2.1 | GLU 179 | - | VdWContact |
| ARG 70 | b2b3.4 | PHE 189 | - | VdWContact |
| ARG 70 | b2b3.4 | TYR 190 | - | HBDonor |
| ARG 70 | b2b3.4 | TYR 190 | - | VdWContact |
| PHE 74 | B3.2 | PRO 191 | - | Hydrophobic |
| PHE 74 | B3.2 | PRO 191 | - | VdWContact |
