Predicted complex interactions
CCL27_HUMAN + CXCR4
SUMMARY
- Chemokine
- CCL27_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR4 View partner entry
- Partner description
- UniProt: P61073; Gene: cxcr4_human; Family: Chemokine
- Interactions detected
- 92
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| THR 7 | NTc.Cm26 | MET 1 | - | Hydrophobic |
| THR 7 | NTc.Cm26 | MET 1 | - | VdWContact |
| CYS 10 | NTc.Cm23 | PHE 29 | - | Hydrophobic |
| THR 11 | NTc.Cm22 | GLU 31 | 1.25x25 | HBDonor |
| THR 11 | NTc.Cm22 | GLU 31 | 1.25x25 | VdWContact |
| GLN 12 | NTc.Cm21 | PHE 29 | - | Hydrophobic |
| GLN 12 | NTc.Cm21 | PHE 29 | - | VdWContact |
| GLN 12 | NTc.Cm21 | GLU 31 | 1.25x25 | Hydrophobic |
| GLN 12 | NTc.Cm21 | GLU 31 | 1.25x25 | VdWContact |
| LEU 13 | NTc.Cm20 | ASP 181 | - | VdWContact |
| TYR 14 | NTc.Cm19 | PRO 27 | - | Hydrophobic |
| ARG 15 | NTc.Cm18 | ALA 180 | - | Hydrophobic |
| ARG 15 | NTc.Cm18 | ALA 180 | - | VdWContact |
| ARG 15 | NTc.Cm18 | ASP 181 | - | Cationic |
| ARG 15 | NTc.Cm18 | ASP 181 | - | HBDonor |
| ARG 15 | NTc.Cm18 | ASP 181 | - | VdWContact |
| LYS 16 | NTc.Cm17 | ILE 185 | - | Hydrophobic |
| LYS 16 | NTc.Cm17 | ILE 185 | - | VdWContact |
| LYS 16 | NTc.Cm17 | ASP 187 | 45.51x51 | Cationic |
| LYS 16 | NTc.Cm17 | ASP 187 | 45.51x51 | HBDonor |
| LYS 16 | NTc.Cm17 | ASP 187 | 45.51x51 | VdWContact |
| LYS 16 | NTc.Cm17 | PHE 189 | - | Hydrophobic |
| LYS 16 | NTc.Cm17 | PHE 189 | - | VdWContact |
| LYS 21 | NTc.Cm12 | ASP 20 | - | Cationic |
| LYS 21 | NTc.Cm12 | ASP 20 | - | HBDonor |
| LYS 21 | NTc.Cm12 | ASP 20 | - | VdWContact |
| LYS 21 | NTc.Cm12 | TYR 21 | - | HBDonor |
| LYS 21 | NTc.Cm12 | TYR 21 | - | VdWContact |
| LYS 21 | NTc.Cm12 | ASP 22 | - | Cationic |
| LYS 21 | NTc.Cm12 | ASP 22 | - | HBDonor |
| LYS 21 | NTc.Cm12 | ASP 22 | - | Hydrophobic |
| LYS 21 | NTc.Cm12 | ASP 22 | - | VdWContact |
| LYS 21 | NTc.Cm12 | MET 24 | - | VdWContact |
| LYS 21 | NTc.Cm12 | ASP 193 | 5.32x33 | Hydrophobic |
| LEU 22 | NTc.Cm11 | MET 24 | - | Hydrophobic |
| LEU 22 | NTc.Cm11 | MET 24 | - | VdWContact |
| LEU 22 | NTc.Cm11 | LYS 25 | - | VdWContact |
| LEU 22 | NTc.Cm11 | GLU 26 | - | VdWContact |
| LEU 22 | NTc.Cm11 | PRO 27 | - | Hydrophobic |
| LEU 22 | NTc.Cm11 | PRO 27 | - | VdWContact |
| ARG 24 | NTc.Cm9 | ASP 22 | - | Cationic |
| ARG 24 | NTc.Cm9 | ASP 22 | - | HBDonor |
| ARG 24 | NTc.Cm9 | ASP 22 | - | VdWContact |
| ARG 24 | NTc.Cm9 | MET 24 | - | Hydrophobic |
| ARG 24 | NTc.Cm9 | MET 24 | - | VdWContact |
| LYS 25 | NTc.Cm8 | MET 24 | - | HBDonor |
| LYS 25 | NTc.Cm8 | MET 24 | - | Hydrophobic |
| LYS 25 | NTc.Cm8 | MET 24 | - | VdWContact |
| LYS 25 | NTc.Cm8 | GLU 268 | 6.64x64 | Cationic |
| LYS 25 | NTc.Cm8 | GLU 268 | 6.64x64 | HBDonor |
| LYS 25 | NTc.Cm8 | GLU 268 | 6.64x64 | VdWContact |
| VAL 29 | NTc.Cm4 | ILE 4 | - | HBAcceptor |
| VAL 29 | NTc.Cm4 | ILE 4 | - | VdWContact |
| VAL 29 | NTc.Cm4 | ILE 6 | - | Hydrophobic |
| GLU 30 | NTc.Cm3 | GLY 3 | - | VdWContact |
| GLN 32 | NTc.Cm1 | MET 1 | - | Hydrophobic |
| LEU 47 | cxb1.18 | MET 24 | - | Hydrophobic |
| LEU 47 | cxb1.18 | GLU 26 | - | Hydrophobic |
| LEU 47 | cxb1.18 | GLU 26 | - | VdWContact |
| ALA 48 | cxb1.19 | GLU 26 | - | VdWContact |
| GLN 49 | B1.1 | GLU 26 | - | HBDonor |
| GLN 49 | B1.1 | GLU 26 | - | VdWContact |
| ARG 50 | B1.2 | GLU 26 | - | Cationic |
| ARG 50 | B1.2 | GLU 26 | - | Hydrophobic |
| ARG 50 | B1.2 | GLU 26 | - | VdWContact |
| ARG 50 | B1.2 | CYS 28 | - | Cationic |
| ARG 50 | B1.2 | CYS 28 | - | HBDonor |
| ARG 50 | B1.2 | CYS 28 | - | VdWContact |
| ARG 50 | B1.2 | CYS 274 | 7.25x24 | Hydrophobic |
| ARG 50 | B1.2 | CYS 274 | 7.25x24 | VdWContact |
| ARG 50 | B1.2 | GLU 277 | 7.28x27 | Cationic |
| ARG 50 | B1.2 | GLU 277 | 7.28x27 | HBDonor |
| ARG 50 | B1.2 | GLU 277 | 7.28x27 | VdWContact |
| ILE 52 | B1.4 | PRO 27 | - | Hydrophobic |
| ILE 52 | B1.4 | PRO 27 | - | VdWContact |
| CYS 53 | B1.5 | PHE 29 | - | Hydrophobic |
| CYS 53 | B1.5 | PHE 29 | - | VdWContact |
| TRP 64 | b1b2.14 | ILE 6 | - | Hydrophobic |
| LYS 71 | B2.6 | TYR 12 | - | Hydrophobic |
| LEU 72 | b2b3.2 | ILE 6 | - | Hydrophobic |
| LEU 76 | B3.2 | TYR 7 | - | Hydrophobic |
| LEU 76 | B3.2 | TYR 7 | - | VdWContact |
| LEU 79 | b3h.1 | ILE 4 | - | Hydrophobic |
| LEU 79 | b3h.1 | ILE 4 | - | VdWContact |
| LEU 79 | b3h.1 | ILE 6 | - | Hydrophobic |
| LEU 79 | b3h.1 | ILE 6 | - | VdWContact |
| ASN 80 | b3h.2 | ILE 4 | - | Hydrophobic |
| ASN 80 | b3h.2 | ILE 4 | - | VdWContact |
| PHE 81 | b3h.3 | ILE 4 | - | Hydrophobic |
| PHE 81 | b3h.3 | ILE 6 | - | Hydrophobic |
| LEU 84 | H.2 | ILE 4 | - | Hydrophobic |
| LEU 84 | H.2 | ILE 4 | - | VdWContact |
