Predicted complex interactions
CCL4_HUMAN + CXCR4
SUMMARY
- Chemokine
- CCL4_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR4 View partner entry
- Partner description
- UniProt: P61073; Gene: cxcr4_human; Family: Chemokine
- Interactions detected
- 76
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| ALA 1 | NTc.Cm33 | TRP 94 | 2.60x60 | Hydrophobic |
| ALA 1 | NTc.Cm33 | TRP 94 | 2.60x60 | VdWContact |
| ALA 1 | NTc.Cm33 | HIS 113 | 3.29x29 | HBDonor |
| ALA 1 | NTc.Cm33 | HIS 113 | 3.29x29 | VdWContact |
| ALA 1 | NTc.Cm33 | CYS 186 | 45.50x50 | VdWContact |
| ALA 1 | NTc.Cm33 | ASP 187 | 45.51x51 | Cationic |
| ALA 1 | NTc.Cm33 | ASP 187 | 45.51x51 | VdWContact |
| PRO 2 | NTc.Cm32 | LEU 41 | 1.35x35 | Hydrophobic |
| PRO 2 | NTc.Cm32 | TYR 45 | 1.39x39 | Hydrophobic |
| PRO 2 | NTc.Cm32 | TYR 45 | 1.39x39 | VdWContact |
| PRO 2 | NTc.Cm32 | TRP 94 | 2.60x60 | Hydrophobic |
| PRO 2 | NTc.Cm32 | TRP 94 | 2.60x60 | VdWContact |
| PRO 2 | NTc.Cm32 | GLU 288 | 7.39x38 | VdWContact |
| MET 3 | NTc.Cm31 | GLN 200 | 5.39x40 | Hydrophobic |
| MET 3 | NTc.Cm31 | ILE 259 | 6.55x55 | Hydrophobic |
| MET 3 | NTc.Cm31 | ILE 259 | 6.55x55 | VdWContact |
| MET 3 | NTc.Cm31 | ILE 284 | 7.35x34 | Hydrophobic |
| MET 3 | NTc.Cm31 | GLU 288 | 7.39x38 | HBDonor |
| MET 3 | NTc.Cm31 | GLU 288 | 7.39x38 | VdWContact |
| GLY 4 | NTc.Cm30 | ASN 37 | 1.31x31 | HBAcceptor |
| GLY 4 | NTc.Cm30 | ASN 37 | 1.31x31 | VdWContact |
| GLY 4 | NTc.Cm30 | SER 285 | 7.36x35 | VdWContact |
| SER 5 | NTc.Cm29 | ASP 187 | 45.51x51 | HBDonor |
| SER 5 | NTc.Cm29 | ASP 187 | 45.51x51 | VdWContact |
| ASP 6 | NTc.Cm28 | ALA 34 | 1.28x28 | VdWContact |
| ASP 6 | NTc.Cm28 | LYS 38 | 1.32x32 | Anionic |
| ASP 6 | NTc.Cm28 | ARG 183 | - | Anionic |
| PRO 7 | NTc.Cm27 | ARG 30 | 1.24x24 | Hydrophobic |
| PRO 7 | NTc.Cm27 | ARG 30 | 1.24x24 | VdWContact |
| PRO 8 | NTc.Cm26 | ARG 30 | 1.24x24 | VdWContact |
| THR 9 | NTc.Cm25 | PHE 29 | - | VdWContact |
| THR 9 | NTc.Cm25 | ARG 30 | 1.24x24 | HBAcceptor |
| THR 9 | NTc.Cm25 | ARG 30 | 1.24x24 | VdWContact |
| THR 9 | NTc.Cm25 | GLU 31 | 1.25x25 | Hydrophobic |
| THR 9 | NTc.Cm25 | ASP 181 | - | HBDonor |
| ALA 10 | NTc.Cm24 | PRO 27 | - | Hydrophobic |
| ALA 10 | NTc.Cm24 | PRO 27 | - | VdWContact |
| ALA 10 | NTc.Cm24 | CYS 28 | - | VdWContact |
| ALA 10 | NTc.Cm24 | PHE 29 | - | Hydrophobic |
| CYS 11 | NTc.Cm23 | CYS 28 | - | HBAcceptor |
| CYS 11 | NTc.Cm23 | CYS 28 | - | HBDonor |
| CYS 11 | NTc.Cm23 | CYS 28 | - | VdWContact |
| PHE 13 | NTc.Cm21 | CYS 28 | - | Hydrophobic |
| PHE 13 | NTc.Cm21 | CYS 28 | - | VdWContact |
| PHE 13 | NTc.Cm21 | ARG 30 | 1.24x24 | VdWContact |
| PHE 13 | NTc.Cm21 | GLU 277 | 7.28x27 | VdWContact |
| SER 14 | NTc.Cm20 | LYS 25 | - | VdWContact |
| ARG 18 | NTc.Cm16 | ASP 20 | - | Cationic |
| ARG 18 | NTc.Cm16 | ASP 20 | - | HBDonor |
| ARG 18 | NTc.Cm16 | ASP 20 | - | VdWContact |
| LEU 20 | NTc.Cm14 | MET 24 | - | Hydrophobic |
| LEU 20 | NTc.Cm14 | MET 24 | - | VdWContact |
| PRO 21 | NTc.Cm13 | MET 16 | - | Hydrophobic |
| PRO 21 | NTc.Cm13 | MET 16 | - | VdWContact |
| PHE 24 | NTc.Cm10 | MET 16 | - | Hydrophobic |
| LEU 34 | CX.1 | ALA 180 | - | Hydrophobic |
| LEU 34 | CX.1 | ALA 180 | - | VdWContact |
| LEU 34 | CX.1 | ILE 185 | - | Hydrophobic |
| LEU 34 | CX.1 | ILE 185 | - | VdWContact |
| LEU 34 | CX.1 | PHE 189 | - | Hydrophobic |
| LEU 34 | CX.1 | PHE 189 | - | VdWContact |
| VAL 41 | cxb1.8 | PRO 27 | - | Hydrophobic |
| LYS 48 | B1.2 | GLU 26 | - | Cationic |
| LYS 48 | B1.2 | GLU 26 | - | HBDonor |
| LYS 48 | B1.2 | GLU 26 | - | VdWContact |
| GLN 49 | B1.3 | GLU 26 | - | VdWContact |
| GLN 49 | B1.3 | PRO 27 | - | Hydrophobic |
| GLN 49 | B1.3 | PHE 29 | - | Hydrophobic |
| GLN 49 | B1.3 | PHE 29 | - | VdWContact |
| VAL 50 | B1.4 | MET 24 | - | Hydrophobic |
| VAL 50 | B1.4 | MET 24 | - | VdWContact |
| VAL 50 | B1.4 | LYS 25 | - | VdWContact |
| CYS 51 | B1.5 | LYS 25 | - | HBDonor |
| CYS 51 | B1.5 | LYS 25 | - | Hydrophobic |
| CYS 51 | B1.5 | LYS 25 | - | VdWContact |
| CYS 51 | B1.5 | PRO 27 | - | VdWContact |
