Predicted complex interactions
CCL5_HUMAN + CXCR4
SUMMARY
- Chemokine
- CCL5_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR4 View partner entry
- Partner description
- UniProt: P61073; Gene: cxcr4_human; Family: Chemokine
- Interactions detected
- 75
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| SER 1 | NTc.Cm32 | ASP 97 | 2.63x63 | Cationic |
| SER 1 | NTc.Cm32 | ASP 97 | 2.63x63 | VdWContact |
| SER 1 | NTc.Cm32 | GLU 288 | 7.39x38 | HBDonor |
| SER 1 | NTc.Cm32 | GLU 288 | 7.39x38 | VdWContact |
| PRO 2 | NTc.Cm31 | ASP 187 | 45.51x51 | VdWContact |
| TYR 3 | NTc.Cm30 | GLN 200 | 5.39x40 | VdWContact |
| TYR 3 | NTc.Cm30 | ILE 259 | 6.55x55 | Hydrophobic |
| TYR 3 | NTc.Cm30 | ILE 259 | 6.55x55 | VdWContact |
| TYR 3 | NTc.Cm30 | ASP 262 | 6.58x58 | HBDonor |
| TYR 3 | NTc.Cm30 | ASP 262 | 6.58x58 | VdWContact |
| TYR 3 | NTc.Cm30 | HIS 281 | 7.32x31 | Hydrophobic |
| TYR 3 | NTc.Cm30 | ILE 284 | 7.35x34 | Hydrophobic |
| SER 5 | NTc.Cm28 | ALA 34 | 1.28x28 | VdWContact |
| SER 5 | NTc.Cm28 | ASN 37 | 1.31x31 | VdWContact |
| ASP 6 | NTc.Cm27 | ARG 30 | 1.24x24 | VdWContact |
| THR 7 | NTc.Cm26 | ARG 30 | 1.24x24 | HBAcceptor |
| THR 7 | NTc.Cm26 | ARG 30 | 1.24x24 | VdWContact |
| THR 7 | NTc.Cm26 | GLU 31 | 1.25x25 | Hydrophobic |
| THR 7 | NTc.Cm26 | GLU 31 | 1.25x25 | VdWContact |
| THR 7 | NTc.Cm26 | ALA 34 | 1.28x28 | Hydrophobic |
| THR 7 | NTc.Cm26 | ALA 34 | 1.28x28 | VdWContact |
| THR 8 | NTc.Cm25 | ASP 181 | - | HBDonor |
| THR 8 | NTc.Cm25 | ASP 181 | - | VdWContact |
| PRO 9 | NTc.Cm24 | PRO 27 | - | Hydrophobic |
| PRO 9 | NTc.Cm24 | PRO 27 | - | VdWContact |
| PRO 9 | NTc.Cm24 | CYS 28 | - | VdWContact |
| PRO 9 | NTc.Cm24 | PHE 29 | - | Hydrophobic |
| PRO 9 | NTc.Cm24 | PHE 29 | - | VdWContact |
| CYS 10 | NTc.Cm23 | CYS 28 | - | HBAcceptor |
| CYS 10 | NTc.Cm23 | CYS 28 | - | HBDonor |
| CYS 10 | NTc.Cm23 | CYS 28 | - | VdWContact |
| PHE 12 | NTc.Cm21 | ARG 30 | 1.24x24 | VdWContact |
| ALA 13 | NTc.Cm20 | LYS 25 | - | Hydrophobic |
| ALA 13 | NTc.Cm20 | LYS 25 | - | VdWContact |
| TYR 14 | NTc.Cm19 | LYS 25 | - | HBAcceptor |
| TYR 14 | NTc.Cm19 | LYS 25 | - | VdWContact |
| LEU 19 | NTc.Cm14 | TYR 21 | - | Hydrophobic |
| LEU 19 | NTc.Cm14 | MET 24 | - | Hydrophobic |
| LEU 19 | NTc.Cm14 | MET 24 | - | VdWContact |
| PRO 20 | NTc.Cm13 | TYR 21 | - | Hydrophobic |
| PRO 20 | NTc.Cm13 | TYR 21 | - | VdWContact |
| HIS 23 | NTc.Cm10 | TYR 21 | - | Hydrophobic |
| HIS 23 | NTc.Cm10 | TYR 21 | - | VdWContact |
| PHE 28 | NTc.Cm5 | PRO 27 | - | Hydrophobic |
| PHE 28 | NTc.Cm5 | PHE 29 | - | Hydrophobic |
| SER 31 | NTc.Cm2 | ASP 181 | - | HBDonor |
| SER 31 | NTc.Cm2 | ASP 181 | - | VdWContact |
| LYS 33 | CX.1 | ALA 180 | - | Hydrophobic |
| LYS 33 | CX.1 | ALA 180 | - | VdWContact |
| LYS 33 | CX.1 | ASP 181 | - | Cationic |
| LYS 33 | CX.1 | ASP 181 | - | Hydrophobic |
| LYS 33 | CX.1 | ASP 181 | - | VdWContact |
| LYS 33 | CX.1 | ARG 183 | - | VdWContact |
| VAL 40 | cxb1.8 | PRO 27 | - | Hydrophobic |
| VAL 40 | cxb1.8 | PRO 27 | - | VdWContact |
| THR 43 | cxb1.14 | MET 24 | - | Hydrophobic |
| THR 43 | cxb1.14 | MET 24 | - | VdWContact |
| ARG 47 | B1.2 | TYR 21 | - | HBDonor |
| ARG 47 | B1.2 | TYR 21 | - | VdWContact |
| ARG 47 | B1.2 | ASP 22 | - | Cationic |
| ARG 47 | B1.2 | ASP 22 | - | VdWContact |
| ARG 47 | B1.2 | MET 24 | - | Hydrophobic |
| ARG 47 | B1.2 | MET 24 | - | VdWContact |
| ARG 47 | B1.2 | GLU 26 | - | Cationic |
| ARG 47 | B1.2 | GLU 26 | - | VdWContact |
| GLN 48 | B1.3 | GLU 26 | - | VdWContact |
| GLN 48 | B1.3 | PRO 27 | - | Hydrophobic |
| GLN 48 | B1.3 | PRO 27 | - | VdWContact |
| GLN 48 | B1.3 | PHE 29 | - | VdWContact |
| VAL 49 | B1.4 | MET 24 | - | Hydrophobic |
| VAL 49 | B1.4 | MET 24 | - | VdWContact |
| VAL 49 | B1.4 | LYS 25 | - | VdWContact |
| CYS 50 | B1.5 | LYS 25 | - | HBDonor |
| CYS 50 | B1.5 | LYS 25 | - | Hydrophobic |
| CYS 50 | B1.5 | LYS 25 | - | VdWContact |
