Predicted complex interactions
CXCL1_HUMAN + CXCR4
SUMMARY
- Chemokine
- CXCL1_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR4 View partner entry
- Partner description
- UniProt: P61073; Gene: cxcr4_human; Family: Chemokine
- Interactions detected
- 79
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| ARG 8 | NTc.Cm35 | GLU 179 | - | Cationic |
| ARG 8 | NTc.Cm35 | GLU 179 | - | Hydrophobic |
| ARG 8 | NTc.Cm35 | GLU 179 | - | VdWContact |
| ARG 8 | NTc.Cm35 | TYR 184 | - | VdWContact |
| CYS 9 | NTc.Cm34 | GLU 179 | - | VdWContact |
| GLN 10 | NTc.Cm33 | ALA 180 | - | VdWContact |
| LEU 12 | NTc.Cm31 | SER 178 | - | VdWContact |
| LEU 12 | NTc.Cm31 | ALA 180 | - | Hydrophobic |
| LEU 12 | NTc.Cm31 | ILE 185 | - | Hydrophobic |
| LEU 12 | NTc.Cm31 | ILE 185 | - | VdWContact |
| LEU 12 | NTc.Cm31 | PHE 189 | - | Hydrophobic |
| LEU 12 | NTc.Cm31 | PHE 189 | - | VdWContact |
| LEU 15 | NTc.Cm28 | PRO 27 | - | Hydrophobic |
| LEU 15 | NTc.Cm28 | PRO 27 | - | VdWContact |
| ILE 18 | NTc.Cm25 | PRO 27 | - | Hydrophobic |
| ILE 18 | NTc.Cm25 | PRO 27 | - | VdWContact |
| HIS 19 | NTc.Cm24 | TYR 21 | - | Hydrophobic |
| HIS 19 | NTc.Cm24 | MET 24 | - | Hydrophobic |
| PRO 20 | NTc.Cm23 | MET 16 | - | Hydrophobic |
| PRO 20 | NTc.Cm23 | TYR 21 | - | Hydrophobic |
| PRO 20 | NTc.Cm23 | TYR 21 | - | VdWContact |
| LYS 21 | NTc.Cm22 | THR 13 | - | Hydrophobic |
| ASN 22 | NTc.Cm21 | GLU 26 | - | HBDonor |
| ASN 22 | NTc.Cm21 | GLU 26 | - | VdWContact |
| ILE 23 | NTc.Cm20 | THR 8 | - | VdWContact |
| GLN 24 | NTc.Cm19 | THR 8 | - | HBAcceptor |
| GLN 24 | NTc.Cm19 | THR 8 | - | VdWContact |
| SER 25 | NTc.Cm18 | ILE 6 | - | VdWContact |
| SER 25 | NTc.Cm18 | TYR 7 | - | VdWContact |
| VAL 26 | NTc.Cm17 | ILE 4 | - | VdWContact |
| VAL 26 | NTc.Cm17 | SER 5 | - | VdWContact |
| VAL 26 | NTc.Cm17 | ILE 6 | - | HBAcceptor |
| VAL 26 | NTc.Cm17 | ILE 6 | - | HBDonor |
| VAL 26 | NTc.Cm17 | ILE 6 | - | VdWContact |
| ASN 27 | NTc.Cm16 | GLY 3 | - | VdWContact |
| ASN 27 | NTc.Cm16 | ILE 4 | - | VdWContact |
| VAL 28 | NTc.Cm15 | GLY 3 | - | VdWContact |
| VAL 28 | NTc.Cm15 | ILE 4 | - | HBAcceptor |
| VAL 28 | NTc.Cm15 | ILE 4 | - | HBDonor |
| VAL 28 | NTc.Cm15 | ILE 4 | - | VdWContact |
| VAL 28 | NTc.Cm15 | ILE 6 | - | Hydrophobic |
| LEU 44 | CX.4 | PRO 27 | - | Hydrophobic |
| LEU 44 | CX.4 | PRO 27 | - | VdWContact |
| LEU 44 | CX.4 | PHE 29 | - | Hydrophobic |
| LEU 44 | CX.4 | PHE 29 | - | VdWContact |
| LYS 45 | CX.5 | ASP 10 | - | Cationic |
| ARG 48 | cxb1.5 | PHE 29 | - | Hydrophobic |
| ARG 48 | cxb1.5 | PHE 29 | - | VdWContact |
| ARG 48 | cxb1.5 | GLU 31 | 1.25x25 | Cationic |
| ARG 48 | cxb1.5 | GLU 31 | 1.25x25 | HBDonor |
| ARG 48 | cxb1.5 | GLU 31 | 1.25x25 | VdWContact |
| LYS 49 | cxb1.6 | PHE 29 | - | VdWContact |
| ALA 50 | cxb1.8 | PRO 27 | - | Hydrophobic |
| ALA 50 | cxb1.8 | PHE 29 | - | Hydrophobic |
| ALA 50 | cxb1.8 | PHE 29 | - | VdWContact |
| ILE 58 | B1.3 | MET 24 | - | Hydrophobic |
| ILE 58 | B1.3 | MET 24 | - | VdWContact |
| LYS 61 | B1.6 | ASP 20 | - | Cationic |
| LYS 61 | B1.6 | ASP 20 | - | HBDonor |
| LYS 61 | B1.6 | ASP 20 | - | VdWContact |
| ILE 62 | B1.7 | TYR 21 | - | Hydrophobic |
| ILE 62 | B1.7 | MET 24 | - | Hydrophobic |
| ILE 63 | b1b2.4 | ILE 6 | - | Hydrophobic |
| LYS 65 | b1b2.7 | TYR 12 | - | Hydrophobic |
| LYS 65 | b1b2.7 | TYR 12 | - | VdWContact |
| LYS 65 | b1b2.7 | GLU 15 | - | HBDonor |
| LYS 65 | b1b2.7 | GLU 15 | - | VdWContact |
| LYS 65 | b1b2.7 | MET 16 | - | Hydrophobic |
| LYS 65 | b1b2.7 | MET 16 | - | VdWContact |
| MET 66 | b1b2.8 | ILE 6 | - | Hydrophobic |
| MET 66 | b1b2.8 | ILE 6 | - | VdWContact |
| MET 66 | b1b2.8 | THR 8 | - | Hydrophobic |
| MET 66 | b1b2.8 | THR 8 | - | VdWContact |
| LEU 67 | b1b2.9 | ILE 4 | - | Hydrophobic |
| LEU 67 | b1b2.9 | ILE 6 | - | Hydrophobic |
| LEU 67 | b1b2.9 | ILE 6 | - | VdWContact |
| SER 69 | b1b2.12 | TYR 12 | - | VdWContact |
| ASP 70 | b1b2.13 | ILE 6 | - | VdWContact |
| ASP 70 | b1b2.13 | TYR 7 | - | VdWContact |
