Predicted complex interactions
CXCL10_HUMAN + CXCR4
SUMMARY
- Chemokine
- CXCL10_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR4 View partner entry
- Partner description
- UniProt: P61073; Gene: cxcr4_human; Family: Chemokine
- Interactions detected
- 117
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| VAL 1 | NTc.Cm29 | TRP 94 | 2.60x60 | Hydrophobic |
| VAL 1 | NTc.Cm29 | TRP 94 | 2.60x60 | VdWContact |
| VAL 1 | NTc.Cm29 | HIS 113 | 3.29x29 | Hydrophobic |
| VAL 1 | NTc.Cm29 | HIS 113 | 3.29x29 | VdWContact |
| VAL 1 | NTc.Cm29 | TYR 116 | 3.32x32 | CationPi |
| VAL 1 | NTc.Cm29 | TYR 116 | 3.32x32 | Hydrophobic |
| VAL 1 | NTc.Cm29 | TYR 116 | 3.32x32 | VdWContact |
| VAL 1 | NTc.Cm29 | ARG 188 | 45.52x52 | VdWContact |
| VAL 1 | NTc.Cm29 | GLU 288 | 7.39x38 | Cationic |
| VAL 1 | NTc.Cm29 | GLU 288 | 7.39x38 | HBDonor |
| VAL 1 | NTc.Cm29 | GLU 288 | 7.39x38 | VdWContact |
| VAL 1 | NTc.Cm29 | PHE 292 | 7.43x42 | VdWContact |
| PRO 2 | NTc.Cm28 | TRP 94 | 2.60x60 | Hydrophobic |
| PRO 2 | NTc.Cm28 | TRP 94 | 2.60x60 | VdWContact |
| PRO 2 | NTc.Cm28 | GLU 288 | 7.39x38 | VdWContact |
| LEU 3 | NTc.Cm27 | HIS 203 | 5.42x43 | Hydrophobic |
| SER 4 | NTc.Cm26 | HIS 281 | 7.32x31 | HBAcceptor |
| SER 4 | NTc.Cm26 | HIS 281 | 7.32x31 | VdWContact |
| SER 4 | NTc.Cm26 | SER 285 | 7.36x35 | HBDonor |
| SER 4 | NTc.Cm26 | SER 285 | 7.36x35 | VdWContact |
| ARG 5 | NTc.Cm25 | ASP 97 | 2.63x63 | Cationic |
| ARG 5 | NTc.Cm25 | ASP 97 | 2.63x63 | HBDonor |
| ARG 5 | NTc.Cm25 | ASP 97 | 2.63x63 | VdWContact |
| ARG 5 | NTc.Cm25 | CYS 186 | 45.50x50 | HBDonor |
| ARG 5 | NTc.Cm25 | CYS 186 | 45.50x50 | VdWContact |
| ARG 5 | NTc.Cm25 | ASP 187 | 45.51x51 | VdWContact |
| THR 6 | NTc.Cm24 | ARG 30 | 1.24x24 | Hydrophobic |
| VAL 7 | NTc.Cm23 | ASP 187 | 45.51x51 | Hydrophobic |
| VAL 7 | NTc.Cm23 | ASP 187 | 45.51x51 | VdWContact |
| VAL 7 | NTc.Cm23 | PHE 189 | - | Hydrophobic |
| ARG 8 | NTc.Cm22 | ASP 262 | 6.58x58 | Cationic |
| ARG 8 | NTc.Cm22 | ASP 262 | 6.58x58 | HBDonor |
| ARG 8 | NTc.Cm22 | ASP 262 | 6.58x58 | VdWContact |
| ARG 8 | NTc.Cm22 | LEU 266 | 6.62x62 | VdWContact |
| CYS 9 | NTc.Cm21 | ARG 30 | 1.24x24 | HBAcceptor |
| CYS 9 | NTc.Cm21 | ARG 30 | 1.24x24 | VdWContact |
| THR 10 | NTc.Cm20 | CYS 28 | - | HBAcceptor |
| THR 10 | NTc.Cm20 | CYS 28 | - | VdWContact |
| THR 10 | NTc.Cm20 | PHE 29 | - | Hydrophobic |
| ILE 12 | NTc.Cm18 | CYS 28 | - | Hydrophobic |
| ILE 12 | NTc.Cm18 | CYS 274 | 7.25x24 | Hydrophobic |
| ILE 12 | NTc.Cm18 | GLU 277 | 7.28x27 | Hydrophobic |
| ILE 12 | NTc.Cm18 | GLU 277 | 7.28x27 | VdWContact |
| SER 13 | NTc.Cm17 | LYS 25 | - | VdWContact |
| GLN 17 | NTc.Cm13 | MET 24 | - | Hydrophobic |
| PRO 18 | NTc.Cm12 | MET 16 | - | Hydrophobic |
| ASN 20 | NTc.Cm10 | MET 16 | - | Hydrophobic |
| ASN 20 | NTc.Cm10 | MET 16 | - | VdWContact |
| PRO 21 | NTc.Cm9 | THR 8 | - | VdWContact |
| PRO 21 | NTc.Cm9 | TYR 12 | - | Hydrophobic |
| PRO 21 | NTc.Cm9 | TYR 12 | - | VdWContact |
| ARG 22 | NTc.Cm8 | TYR 12 | - | HBDonor |
| ARG 22 | NTc.Cm8 | TYR 12 | - | Hydrophobic |
| ARG 22 | NTc.Cm8 | TYR 12 | - | VdWContact |
| ARG 22 | NTc.Cm8 | THR 13 | - | VdWContact |
| ARG 22 | NTc.Cm8 | GLU 14 | - | Cationic |
| ARG 22 | NTc.Cm8 | GLU 14 | - | HBDonor |
| ARG 22 | NTc.Cm8 | GLU 14 | - | VdWContact |
| LEU 24 | NTc.Cm6 | THR 8 | - | Hydrophobic |
| LEU 24 | NTc.Cm6 | THR 8 | - | VdWContact |
| GLU 25 | NTc.Cm5 | TYR 7 | - | VdWContact |
| GLU 25 | NTc.Cm5 | THR 8 | - | HBAcceptor |
| GLU 25 | NTc.Cm5 | THR 8 | - | VdWContact |
| LYS 26 | NTc.Cm4 | SER 5 | - | VdWContact |
| LYS 26 | NTc.Cm4 | TYR 7 | - | Hydrophobic |
| LYS 26 | NTc.Cm4 | TYR 7 | - | VdWContact |
| LEU 27 | NTc.Cm3 | SER 5 | - | VdWContact |
| LEU 27 | NTc.Cm3 | ILE 6 | - | HBAcceptor |
| LEU 27 | NTc.Cm3 | ILE 6 | - | HBDonor |
| LEU 27 | NTc.Cm3 | ILE 6 | - | VdWContact |
| ILE 29 | NTc.Cm1 | GLY 3 | - | VdWContact |
| ILE 29 | NTc.Cm1 | ILE 4 | - | HBAcceptor |
| ILE 29 | NTc.Cm1 | ILE 4 | - | HBDonor |
| ILE 29 | NTc.Cm1 | ILE 4 | - | Hydrophobic |
| ILE 29 | NTc.Cm1 | ILE 4 | - | VdWContact |
| ILE 29 | NTc.Cm1 | ILE 6 | - | Hydrophobic |
| ILE 30 | CX.1 | MET 1 | - | Hydrophobic |
| ILE 30 | CX.1 | MET 1 | - | VdWContact |
| SER 33 | cxb1.1 | MET 1 | - | VdWContact |
| GLN 34 | cxb1.2 | SER 178 | - | VdWContact |
| GLN 34 | cxb1.2 | PHE 189 | - | Hydrophobic |
| GLN 34 | cxb1.2 | PHE 189 | - | VdWContact |
| PHE 35 | cxb1.5 | MET 1 | - | Hydrophobic |
| PHE 35 | cxb1.5 | MET 1 | - | VdWContact |
| PHE 35 | cxb1.5 | GLU 179 | - | VdWContact |
| PHE 35 | cxb1.5 | ALA 180 | - | Hydrophobic |
| PHE 35 | cxb1.5 | ALA 180 | - | VdWContact |
| PHE 35 | cxb1.5 | ILE 185 | - | Hydrophobic |
| PHE 35 | cxb1.5 | ILE 185 | - | VdWContact |
| PHE 35 | cxb1.5 | PHE 189 | - | Hydrophobic |
| PHE 35 | cxb1.5 | PHE 189 | - | VdWContact |
| CYS 36 | cxb1.6 | MET 1 | - | Hydrophobic |
| PRO 37 | cxb1.7 | ASN 192 | - | VdWContact |
| ARG 38 | cxb1.8 | ASP 193 | 5.32x33 | Cationic |
| ARG 38 | cxb1.8 | ASP 193 | 5.32x33 | HBDonor |
| ARG 38 | cxb1.8 | ASP 193 | 5.32x33 | VdWContact |
| ILE 42 | cxb1.15 | PRO 27 | - | Hydrophobic |
| ILE 42 | cxb1.15 | PHE 29 | - | Hydrophobic |
| LYS 46 | B1.3 | THR 8 | - | VdWContact |
| LYS 46 | B1.3 | ASP 10 | - | Cationic |
| LYS 46 | B1.3 | ASP 10 | - | HBDonor |
| LYS 46 | B1.3 | ASP 10 | - | VdWContact |
| LYS 51 | b1b2.4 | GLU 26 | - | VdWContact |
| LYS 51 | b1b2.4 | PRO 27 | - | Hydrophobic |
| LYS 51 | b1b2.4 | PHE 29 | - | Hydrophobic |
| LYS 51 | b1b2.4 | PHE 29 | - | VdWContact |
| ARG 52 | b1b2.6 | TYR 21 | - | VdWContact |
| ARG 52 | b1b2.6 | MET 24 | - | Hydrophobic |
| ARG 52 | b1b2.6 | MET 24 | - | VdWContact |
| CYS 53 | b1b2.7 | LYS 25 | - | VdWContact |
| VAL 68 | b2b3.3 | ILE 6 | - | Hydrophobic |
| VAL 68 | b2b3.3 | ILE 6 | - | VdWContact |
| VAL 68 | b2b3.3 | THR 8 | - | Hydrophobic |
| GLU 71 | b2b3.12 | SER 9 | - | HBAcceptor |
| GLU 71 | b2b3.12 | SER 9 | - | VdWContact |
| GLU 71 | b2b3.12 | TYR 12 | - | Hydrophobic |
| ARG 75 | B3.4 | SER 9 | - | VdWContact |
