Predicted complex interactions
CXCL11_HUMAN + CXCR4
SUMMARY
- Chemokine
- CXCL11_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR4 View partner entry
- Partner description
- UniProt: P61073; Gene: cxcr4_human; Family: Chemokine
- Interactions detected
- 107
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| PHE 1 | NTc.Cm29 | TYR 45 | 1.39x39 | Hydrophobic |
| PHE 1 | NTc.Cm29 | TYR 45 | 1.39x39 | VdWContact |
| PHE 1 | NTc.Cm29 | PHE 87 | 2.53x53 | Hydrophobic |
| PHE 1 | NTc.Cm29 | TRP 94 | 2.60x60 | Hydrophobic |
| PHE 1 | NTc.Cm29 | TRP 94 | 2.60x60 | VdWContact |
| PHE 1 | NTc.Cm29 | TYR 116 | 3.32x32 | Hydrophobic |
| PHE 1 | NTc.Cm29 | TYR 116 | 3.32x32 | PiStacking |
| PHE 1 | NTc.Cm29 | TYR 116 | 3.32x32 | VdWContact |
| PHE 1 | NTc.Cm29 | GLU 288 | 7.39x38 | Cationic |
| PHE 1 | NTc.Cm29 | GLU 288 | 7.39x38 | VdWContact |
| PHE 1 | NTc.Cm29 | PHE 292 | 7.43x42 | Hydrophobic |
| PHE 1 | NTc.Cm29 | PHE 292 | 7.43x42 | VdWContact |
| MET 3 | NTc.Cm27 | TYR 116 | 3.32x32 | Hydrophobic |
| MET 3 | NTc.Cm27 | TYR 116 | 3.32x32 | VdWContact |
| MET 3 | NTc.Cm27 | ASP 187 | 45.51x51 | VdWContact |
| MET 3 | NTc.Cm27 | ARG 188 | 45.52x52 | VdWContact |
| MET 3 | NTc.Cm27 | HIS 203 | 5.42x43 | Hydrophobic |
| MET 3 | NTc.Cm27 | HIS 203 | 5.42x43 | VdWContact |
| MET 3 | NTc.Cm27 | TYR 255 | 6.51x51 | Hydrophobic |
| MET 3 | NTc.Cm27 | TYR 255 | 6.51x51 | VdWContact |
| PHE 4 | NTc.Cm26 | VAL 196 | 5.35x36 | Hydrophobic |
| PHE 4 | NTc.Cm26 | VAL 196 | 5.35x36 | VdWContact |
| PHE 4 | NTc.Cm26 | GLN 200 | 5.39x40 | Hydrophobic |
| PHE 4 | NTc.Cm26 | GLN 200 | 5.39x40 | VdWContact |
| PHE 4 | NTc.Cm26 | ILE 259 | 6.55x55 | Hydrophobic |
| LYS 5 | NTc.Cm25 | ASP 97 | 2.63x63 | Cationic |
| LYS 5 | NTc.Cm25 | ASP 97 | 2.63x63 | HBDonor |
| LYS 5 | NTc.Cm25 | ASP 97 | 2.63x63 | VdWContact |
| LYS 5 | NTc.Cm25 | ALA 98 | 2.64x64 | VdWContact |
| LYS 5 | NTc.Cm25 | ASP 187 | 45.51x51 | VdWContact |
| ARG 6 | NTc.Cm24 | ASP 187 | 45.51x51 | HBDonor |
| ARG 6 | NTc.Cm24 | ASP 187 | 45.51x51 | VdWContact |
| ARG 6 | NTc.Cm24 | TYR 190 | - | HBDonor |
| ARG 6 | NTc.Cm24 | TYR 190 | - | VdWContact |
| ARG 6 | NTc.Cm24 | ASP 193 | 5.32x33 | Cationic |
| ARG 6 | NTc.Cm24 | VAL 196 | 5.35x36 | VdWContact |
| ARG 8 | NTc.Cm22 | ARG 30 | 1.24x24 | VdWContact |
| ARG 8 | NTc.Cm22 | ASP 262 | 6.58x58 | Cationic |
| ARG 8 | NTc.Cm22 | ASP 262 | 6.58x58 | HBDonor |
| ARG 8 | NTc.Cm22 | ASP 262 | 6.58x58 | VdWContact |
| ARG 8 | NTc.Cm22 | LEU 266 | 6.62x62 | VdWContact |
| ARG 8 | NTc.Cm22 | GLU 277 | 7.28x27 | Cationic |
| ARG 8 | NTc.Cm22 | HIS 281 | 7.32x31 | VdWContact |
| CYS 9 | NTc.Cm21 | ARG 30 | 1.24x24 | HBAcceptor |
| CYS 9 | NTc.Cm21 | ARG 30 | 1.24x24 | VdWContact |
| LEU 10 | NTc.Cm20 | MET 1 | - | Hydrophobic |
| LEU 10 | NTc.Cm20 | PRO 27 | - | Hydrophobic |
| LEU 10 | NTc.Cm20 | PRO 27 | - | VdWContact |
| LEU 10 | NTc.Cm20 | CYS 28 | - | HBAcceptor |
| LEU 10 | NTc.Cm20 | CYS 28 | - | VdWContact |
| LEU 10 | NTc.Cm20 | PHE 29 | - | Hydrophobic |
| LEU 10 | NTc.Cm20 | PHE 29 | - | VdWContact |
| ILE 12 | NTc.Cm18 | CYS 28 | - | Hydrophobic |
| ILE 12 | NTc.Cm18 | CYS 28 | - | VdWContact |
| ILE 12 | NTc.Cm18 | CYS 274 | 7.25x24 | Hydrophobic |
| ILE 12 | NTc.Cm18 | CYS 274 | 7.25x24 | VdWContact |
| ILE 12 | NTc.Cm18 | GLU 277 | 7.28x27 | Hydrophobic |
| ILE 12 | NTc.Cm18 | GLU 277 | 7.28x27 | VdWContact |
| VAL 16 | NTc.Cm14 | LYS 25 | - | Hydrophobic |
| VAL 16 | NTc.Cm14 | LYS 25 | - | VdWContact |
| LYS 20 | NTc.Cm10 | MET 16 | - | Hydrophobic |
| LYS 20 | NTc.Cm10 | MET 16 | - | VdWContact |
| VAL 21 | NTc.Cm9 | THR 8 | - | VdWContact |
| VAL 21 | NTc.Cm9 | TYR 12 | - | Hydrophobic |
| LYS 26 | NTc.Cm4 | GLY 3 | - | VdWContact |
| ALA 27 | NTc.Cm3 | GLY 3 | - | VdWContact |
| ALA 27 | NTc.Cm3 | ILE 4 | - | HBAcceptor |
| ALA 27 | NTc.Cm3 | ILE 4 | - | VdWContact |
| ALA 27 | NTc.Cm3 | ILE 6 | - | Hydrophobic |
| ALA 27 | NTc.Cm3 | ILE 6 | - | VdWContact |
| MET 30 | CX.1 | MET 1 | - | Hydrophobic |
| MET 30 | CX.1 | MET 1 | - | VdWContact |
| ASN 34 | cxb1.2 | SER 178 | - | HBDonor |
| ASN 34 | cxb1.2 | SER 178 | - | VdWContact |
| ASN 34 | cxb1.2 | PHE 189 | - | Hydrophobic |
| ASN 34 | cxb1.2 | PHE 189 | - | VdWContact |
| LYS 38 | cxb1.8 | GLU 268 | 6.64x64 | Cationic |
| ILE 42 | cxb1.15 | PRO 27 | - | Hydrophobic |
| LEU 45 | B1.2 | TYR 21 | - | Hydrophobic |
| GLN 51 | b1b2.4 | GLU 26 | - | VdWContact |
| GLN 51 | b1b2.4 | PRO 27 | - | Hydrophobic |
| GLN 51 | b1b2.4 | PRO 27 | - | VdWContact |
| GLN 51 | b1b2.4 | PHE 29 | - | VdWContact |
| ARG 52 | b1b2.6 | TYR 21 | - | VdWContact |
| ARG 52 | b1b2.6 | LYS 25 | - | VdWContact |
| ARG 52 | b1b2.6 | GLU 26 | - | Cationic |
| ARG 52 | b1b2.6 | GLU 26 | - | HBDonor |
| ARG 52 | b1b2.6 | GLU 26 | - | VdWContact |
| CYS 53 | b1b2.7 | LYS 25 | - | HBDonor |
| CYS 53 | b1b2.7 | LYS 25 | - | VdWContact |
| LYS 59 | b1b2.14 | GLU 15 | - | Cationic |
| LEU 63 | B2.3 | TYR 12 | - | Hydrophobic |
| LEU 63 | B2.3 | TYR 12 | - | VdWContact |
| ILE 64 | B2.4 | ILE 6 | - | Hydrophobic |
| ILE 64 | B2.4 | ILE 6 | - | VdWContact |
| LYS 67 | b2b3.2 | ILE 6 | - | Hydrophobic |
| LYS 67 | b2b3.2 | ILE 6 | - | VdWContact |
| LYS 67 | b2b3.2 | TYR 7 | - | HBDonor |
| LYS 67 | b2b3.2 | TYR 7 | - | VdWContact |
| LYS 67 | b2b3.2 | THR 8 | - | HBDonor |
| LYS 67 | b2b3.2 | THR 8 | - | VdWContact |
| VAL 68 | b2b3.3 | ILE 4 | - | Hydrophobic |
| VAL 68 | b2b3.3 | ILE 4 | - | VdWContact |
| VAL 68 | b2b3.3 | ILE 6 | - | Hydrophobic |
| LYS 71 | b2b3.12 | ILE 4 | - | Hydrophobic |
| LYS 71 | b2b3.12 | SER 5 | - | HBDonor |
| LYS 71 | b2b3.12 | SER 5 | - | VdWContact |
