Predicted complex interactions
CXCL12_HUMAN + CXCR4
SUMMARY
- Chemokine
- CXCL12_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR4 View partner entry
- Partner description
- UniProt: P61073; Gene: cxcr4_human; Family: Chemokine
- Interactions detected
- 131
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| LYS 1 | NTc.Cm29 | TRP 94 | 2.60x60 | Hydrophobic |
| LYS 1 | NTc.Cm29 | TRP 94 | 2.60x60 | VdWContact |
| LYS 1 | NTc.Cm29 | ASP 97 | 2.63x63 | Cationic |
| LYS 1 | NTc.Cm29 | ASP 97 | 2.63x63 | HBDonor |
| LYS 1 | NTc.Cm29 | ASP 97 | 2.63x63 | VdWContact |
| LYS 1 | NTc.Cm29 | HIS 113 | 3.29x29 | HBDonor |
| LYS 1 | NTc.Cm29 | HIS 113 | 3.29x29 | Hydrophobic |
| LYS 1 | NTc.Cm29 | HIS 113 | 3.29x29 | VdWContact |
| LYS 1 | NTc.Cm29 | CYS 186 | 45.50x50 | HBDonor |
| LYS 1 | NTc.Cm29 | CYS 186 | 45.50x50 | VdWContact |
| LYS 1 | NTc.Cm29 | ASP 187 | 45.51x51 | Hydrophobic |
| PRO 2 | NTc.Cm28 | TYR 45 | 1.39x39 | Hydrophobic |
| PRO 2 | NTc.Cm28 | TRP 94 | 2.60x60 | Hydrophobic |
| PRO 2 | NTc.Cm28 | PHE 292 | 7.43x42 | Hydrophobic |
| VAL 3 | NTc.Cm27 | ILE 259 | 6.55x55 | Hydrophobic |
| VAL 3 | NTc.Cm27 | ILE 284 | 7.35x34 | Hydrophobic |
| VAL 3 | NTc.Cm27 | GLU 288 | 7.39x38 | HBDonor |
| VAL 3 | NTc.Cm27 | GLU 288 | 7.39x38 | VdWContact |
| SER 4 | NTc.Cm26 | ASN 37 | 1.31x31 | VdWContact |
| SER 4 | NTc.Cm26 | SER 285 | 7.36x35 | VdWContact |
| SER 4 | NTc.Cm26 | GLU 288 | 7.39x38 | HBDonor |
| SER 4 | NTc.Cm26 | GLU 288 | 7.39x38 | VdWContact |
| LEU 5 | NTc.Cm25 | LEU 41 | 1.35x35 | Hydrophobic |
| LEU 5 | NTc.Cm25 | TYR 45 | 1.39x39 | Hydrophobic |
| LEU 5 | NTc.Cm25 | ALA 98 | 2.64x64 | Hydrophobic |
| SER 6 | NTc.Cm24 | ASP 187 | 45.51x51 | VdWContact |
| TYR 7 | NTc.Cm23 | MET 1 | - | Hydrophobic |
| TYR 7 | NTc.Cm23 | MET 1 | - | VdWContact |
| TYR 7 | NTc.Cm23 | ASP 187 | 45.51x51 | HBDonor |
| TYR 7 | NTc.Cm23 | ASP 187 | 45.51x51 | VdWContact |
| ARG 8 | NTc.Cm22 | ARG 30 | 1.24x24 | VdWContact |
| ARG 8 | NTc.Cm22 | GLN 200 | 5.39x40 | VdWContact |
| ARG 8 | NTc.Cm22 | ASP 262 | 6.58x58 | Cationic |
| ARG 8 | NTc.Cm22 | ASP 262 | 6.58x58 | HBDonor |
| ARG 8 | NTc.Cm22 | ASP 262 | 6.58x58 | VdWContact |
| ARG 8 | NTc.Cm22 | LEU 266 | 6.62x62 | VdWContact |
| PRO 10 | NTc.Cm20 | PRO 27 | - | Hydrophobic |
| PRO 10 | NTc.Cm20 | PRO 27 | - | VdWContact |
| PRO 10 | NTc.Cm20 | CYS 28 | - | HBAcceptor |
| PRO 10 | NTc.Cm20 | CYS 28 | - | VdWContact |
| PRO 10 | NTc.Cm20 | PHE 29 | - | Hydrophobic |
| ARG 12 | NTc.Cm18 | ILE 265 | 6.61x61 | HBDonor |
| ARG 12 | NTc.Cm18 | ILE 265 | 6.61x61 | VdWContact |
| ARG 12 | NTc.Cm18 | GLN 272 | - | HBDonor |
| ARG 12 | NTc.Cm18 | GLN 272 | - | VdWContact |
| ARG 12 | NTc.Cm18 | GLU 277 | 7.28x27 | Cationic |
| ARG 12 | NTc.Cm18 | GLU 277 | 7.28x27 | HBDonor |
| ARG 12 | NTc.Cm18 | GLU 277 | 7.28x27 | VdWContact |
| PHE 13 | NTc.Cm17 | LYS 25 | - | Hydrophobic |
| PHE 13 | NTc.Cm17 | LYS 25 | - | PiCation |
| PHE 13 | NTc.Cm17 | LYS 25 | - | VdWContact |
| PHE 13 | NTc.Cm17 | GLU 268 | 6.64x64 | Hydrophobic |
| PHE 13 | NTc.Cm17 | LYS 271 | - | Hydrophobic |
| GLU 15 | NTc.Cm15 | MET 24 | - | Hydrophobic |
| GLU 15 | NTc.Cm15 | MET 24 | - | VdWContact |
| VAL 18 | NTc.Cm12 | TYR 21 | - | Hydrophobic |
| VAL 18 | NTc.Cm12 | MET 24 | - | Hydrophobic |
| ARG 20 | NTc.Cm10 | TYR 12 | - | CationPi |
| ARG 20 | NTc.Cm10 | TYR 12 | - | HBDonor |
| ARG 20 | NTc.Cm10 | TYR 12 | - | VdWContact |
| ARG 20 | NTc.Cm10 | GLU 14 | - | VdWContact |
| ALA 21 | NTc.Cm9 | GLU 14 | - | Hydrophobic |
| ASN 22 | NTc.Cm8 | MET 16 | - | VdWContact |
| ASN 22 | NTc.Cm8 | GLY 17 | - | HBDonor |
| ASN 22 | NTc.Cm8 | GLY 17 | - | VdWContact |
| ASN 22 | NTc.Cm8 | TYR 21 | - | HBDonor |
| ASN 22 | NTc.Cm8 | TYR 21 | - | Hydrophobic |
| ASN 22 | NTc.Cm8 | TYR 21 | - | VdWContact |
| VAL 23 | NTc.Cm7 | THR 8 | - | HBAcceptor |
| VAL 23 | NTc.Cm7 | THR 8 | - | Hydrophobic |
| VAL 23 | NTc.Cm7 | THR 8 | - | VdWContact |
| LYS 24 | NTc.Cm6 | THR 8 | - | VdWContact |
| HIS 25 | NTc.Cm5 | ILE 6 | - | VdWContact |
| HIS 25 | NTc.Cm5 | TYR 7 | - | Hydrophobic |
| LEU 26 | NTc.Cm4 | SER 5 | - | VdWContact |
| LEU 26 | NTc.Cm4 | ILE 6 | - | HBAcceptor |
| LEU 26 | NTc.Cm4 | ILE 6 | - | HBDonor |
| LEU 26 | NTc.Cm4 | ILE 6 | - | Hydrophobic |
| LEU 26 | NTc.Cm4 | ILE 6 | - | VdWContact |
| LEU 26 | NTc.Cm4 | THR 8 | - | Hydrophobic |
| LYS 27 | NTc.Cm3 | MET 1 | - | HBDonor |
| LYS 27 | NTc.Cm3 | MET 1 | - | VdWContact |
| LYS 27 | NTc.Cm3 | GLY 3 | - | VdWContact |
| LYS 27 | NTc.Cm3 | ILE 4 | - | VdWContact |
| ILE 28 | NTc.Cm2 | GLY 3 | - | VdWContact |
| ILE 28 | NTc.Cm2 | ILE 4 | - | HBAcceptor |
| ILE 28 | NTc.Cm2 | ILE 4 | - | HBDonor |
| ILE 28 | NTc.Cm2 | ILE 4 | - | Hydrophobic |
| ILE 28 | NTc.Cm2 | ILE 4 | - | VdWContact |
| ILE 28 | NTc.Cm2 | ILE 6 | - | Hydrophobic |
| LEU 29 | NTc.Cm1 | PHE 29 | - | Hydrophobic |
| LEU 29 | NTc.Cm1 | PHE 29 | - | VdWContact |
| THR 31 | CX.4 | MET 1 | - | Hydrophobic |
| THR 31 | CX.4 | MET 1 | - | VdWContact |
| PRO 32 | CX.5 | SER 178 | - | VdWContact |
| PRO 32 | CX.5 | PHE 189 | - | Hydrophobic |
| PRO 32 | CX.5 | PHE 189 | - | VdWContact |
| ASN 33 | cxb1.1 | ASP 187 | 45.51x51 | HBDonor |
| ASN 33 | cxb1.1 | ASP 187 | 45.51x51 | VdWContact |
| ASN 33 | cxb1.1 | PHE 189 | - | Hydrophobic |
| ASN 33 | cxb1.1 | PHE 189 | - | VdWContact |
| VAL 39 | cxb1.11 | PRO 27 | - | Hydrophobic |
| VAL 39 | cxb1.11 | PRO 27 | - | VdWContact |
| VAL 39 | cxb1.11 | PHE 29 | - | Hydrophobic |
| LEU 42 | cxb1.16 | TYR 21 | - | Hydrophobic |
| LYS 43 | B1.1 | ASP 10 | - | Cationic |
| LYS 43 | B1.1 | ASP 10 | - | HBDonor |
| LYS 43 | B1.1 | ASP 10 | - | VdWContact |
| LYS 43 | B1.1 | MET 16 | - | Hydrophobic |
| ASN 44 | B1.2 | TYR 21 | - | VdWContact |
| ASN 45 | B1.3 | ASP 22 | - | HBDonor |
| ASN 45 | B1.3 | ASP 22 | - | VdWContact |
| ARG 47 | B1.5 | ASP 22 | - | Cationic |
| ARG 47 | B1.5 | ASP 22 | - | HBDonor |
| ARG 47 | B1.5 | ASP 22 | - | VdWContact |
| ARG 47 | B1.5 | MET 24 | - | VdWContact |
| ARG 47 | B1.5 | GLU 26 | - | Cationic |
| ARG 47 | B1.5 | GLU 26 | - | HBDonor |
| ARG 47 | B1.5 | GLU 26 | - | VdWContact |
| GLN 48 | B1.6 | GLU 26 | - | HBDonor |
| GLN 48 | B1.6 | GLU 26 | - | VdWContact |
| GLN 48 | B1.6 | PRO 27 | - | Hydrophobic |
| GLN 48 | B1.6 | PRO 27 | - | VdWContact |
| VAL 49 | B1.7 | MET 24 | - | Hydrophobic |
| CYS 50 | b1b2.4 | PRO 27 | - | VdWContact |
| TYR 61 | B2.4 | ILE 6 | - | Hydrophobic |
| TYR 61 | B2.4 | THR 8 | - | Hydrophobic |
| TYR 61 | B2.4 | THR 8 | - | VdWContact |
| ALA 65 | b2b3.3 | ILE 6 | - | Hydrophobic |
| ALA 65 | b2b3.3 | ILE 6 | - | VdWContact |
| ARG 69 | B3.1 | ILE 4 | - | VdWContact |
