Predicted complex interactions
CXCL13_HUMAN + CXCR4
SUMMARY
- Chemokine
- CXCL13_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR4 View partner entry
- Partner description
- UniProt: P61073; Gene: cxcr4_human; Family: Chemokine
- Interactions detected
- 141
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| VAL 1 | NTc.Cm32 | LEU 41 | 1.35x35 | Hydrophobic |
| VAL 1 | NTc.Cm32 | LEU 41 | 1.35x35 | VdWContact |
| VAL 1 | NTc.Cm32 | TYR 45 | 1.39x39 | Hydrophobic |
| VAL 1 | NTc.Cm32 | TYR 45 | 1.39x39 | VdWContact |
| VAL 1 | NTc.Cm32 | TRP 94 | 2.60x60 | Hydrophobic |
| VAL 1 | NTc.Cm32 | TRP 94 | 2.60x60 | VdWContact |
| VAL 1 | NTc.Cm32 | ALA 98 | 2.64x64 | Hydrophobic |
| VAL 1 | NTc.Cm32 | GLU 288 | 7.39x38 | Cationic |
| VAL 1 | NTc.Cm32 | GLU 288 | 7.39x38 | HBDonor |
| VAL 1 | NTc.Cm32 | GLU 288 | 7.39x38 | VdWContact |
| LEU 2 | NTc.Cm31 | TRP 94 | 2.60x60 | Hydrophobic |
| LEU 2 | NTc.Cm31 | TRP 94 | 2.60x60 | VdWContact |
| LEU 2 | NTc.Cm31 | HIS 113 | 3.29x29 | Hydrophobic |
| LEU 2 | NTc.Cm31 | HIS 113 | 3.29x29 | VdWContact |
| LEU 2 | NTc.Cm31 | TYR 116 | 3.32x32 | Hydrophobic |
| LEU 2 | NTc.Cm31 | TYR 116 | 3.32x32 | VdWContact |
| LEU 2 | NTc.Cm31 | ARG 188 | 45.52x52 | VdWContact |
| LEU 2 | NTc.Cm31 | GLU 288 | 7.39x38 | HBDonor |
| LEU 2 | NTc.Cm31 | PHE 292 | 7.43x42 | Hydrophobic |
| GLU 3 | NTc.Cm30 | GLN 200 | 5.39x40 | HBAcceptor |
| GLU 3 | NTc.Cm30 | GLN 200 | 5.39x40 | VdWContact |
| GLU 3 | NTc.Cm30 | TYR 255 | 6.51x51 | VdWContact |
| GLU 3 | NTc.Cm30 | ILE 259 | 6.55x55 | Hydrophobic |
| GLU 3 | NTc.Cm30 | ILE 259 | 6.55x55 | VdWContact |
| GLU 3 | NTc.Cm30 | ILE 284 | 7.35x34 | Hydrophobic |
| VAL 4 | NTc.Cm29 | ASN 37 | 1.31x31 | VdWContact |
| VAL 4 | NTc.Cm29 | SER 285 | 7.36x35 | VdWContact |
| TYR 5 | NTc.Cm28 | ASP 97 | 2.63x63 | HBDonor |
| TYR 5 | NTc.Cm28 | ASP 97 | 2.63x63 | VdWContact |
| TYR 5 | NTc.Cm28 | ALA 98 | 2.64x64 | VdWContact |
| TYR 5 | NTc.Cm28 | ILE 185 | - | Hydrophobic |
| TYR 6 | NTc.Cm27 | ASP 187 | 45.51x51 | VdWContact |
| TYR 6 | NTc.Cm27 | ARG 188 | 45.52x52 | Hydrophobic |
| TYR 6 | NTc.Cm27 | ARG 188 | 45.52x52 | VdWContact |
| TYR 6 | NTc.Cm27 | TYR 190 | - | Hydrophobic |
| TYR 6 | NTc.Cm27 | TYR 190 | - | VdWContact |
| TYR 6 | NTc.Cm27 | VAL 196 | 5.35x36 | Hydrophobic |
| THR 7 | NTc.Cm26 | ARG 30 | 1.24x24 | HBAcceptor |
| THR 7 | NTc.Cm26 | ARG 30 | 1.24x24 | VdWContact |
| THR 7 | NTc.Cm26 | HIS 281 | 7.32x31 | Hydrophobic |
| THR 7 | NTc.Cm26 | HIS 281 | 7.32x31 | VdWContact |
| LEU 9 | NTc.Cm24 | ALA 180 | - | Hydrophobic |
| LEU 9 | NTc.Cm24 | ILE 185 | - | Hydrophobic |
| LEU 9 | NTc.Cm24 | ILE 185 | - | VdWContact |
| LEU 9 | NTc.Cm24 | PHE 189 | - | Hydrophobic |
| LEU 9 | NTc.Cm24 | PHE 189 | - | VdWContact |
| ARG 10 | NTc.Cm23 | ARG 30 | 1.24x24 | HBAcceptor |
| ARG 10 | NTc.Cm23 | ARG 30 | 1.24x24 | VdWContact |
| ARG 10 | NTc.Cm23 | ASP 262 | 6.58x58 | Cationic |
| ARG 10 | NTc.Cm23 | ASP 262 | 6.58x58 | HBDonor |
| ARG 10 | NTc.Cm23 | ASP 262 | 6.58x58 | VdWContact |
| ARG 10 | NTc.Cm23 | HIS 281 | 7.32x31 | VdWContact |
| CYS 11 | NTc.Cm22 | ARG 30 | 1.24x24 | HBAcceptor |
| CYS 11 | NTc.Cm22 | ARG 30 | 1.24x24 | VdWContact |
| ARG 12 | NTc.Cm21 | PRO 27 | - | Hydrophobic |
| ARG 12 | NTc.Cm21 | CYS 28 | - | HBAcceptor |
| ARG 12 | NTc.Cm21 | CYS 28 | - | VdWContact |
| ARG 12 | NTc.Cm21 | ASP 181 | - | Cationic |
| ARG 12 | NTc.Cm21 | ASP 181 | - | HBDonor |
| ARG 12 | NTc.Cm21 | ASP 181 | - | VdWContact |
| VAL 14 | NTc.Cm19 | CYS 28 | - | Hydrophobic |
| VAL 14 | NTc.Cm19 | CYS 274 | 7.25x24 | Hydrophobic |
| GLN 15 | NTc.Cm18 | LYS 25 | - | Hydrophobic |
| GLN 15 | NTc.Cm18 | LYS 25 | - | VdWContact |
| SER 17 | NTc.Cm16 | MET 24 | - | VdWContact |
| VAL 19 | NTc.Cm14 | TYR 21 | - | Hydrophobic |
| VAL 19 | NTc.Cm14 | MET 24 | - | Hydrophobic |
| VAL 19 | NTc.Cm14 | MET 24 | - | VdWContact |
| PHE 20 | NTc.Cm13 | MET 16 | - | Hydrophobic |
| PHE 20 | NTc.Cm13 | MET 16 | - | VdWContact |
| PHE 20 | NTc.Cm13 | TYR 21 | - | HBAcceptor |
| PHE 20 | NTc.Cm13 | TYR 21 | - | VdWContact |
| ILE 21 | NTc.Cm12 | TYR 21 | - | Hydrophobic |
| ILE 21 | NTc.Cm12 | TYR 21 | - | VdWContact |
| PRO 22 | NTc.Cm11 | MET 16 | - | Hydrophobic |
| PRO 22 | NTc.Cm11 | MET 16 | - | VdWContact |
| PRO 22 | NTc.Cm11 | TYR 21 | - | VdWContact |
| ARG 23 | NTc.Cm10 | THR 8 | - | Hydrophobic |
| ARG 23 | NTc.Cm10 | TYR 12 | - | CationPi |
| ARG 23 | NTc.Cm10 | TYR 12 | - | HBDonor |
| ARG 23 | NTc.Cm10 | TYR 12 | - | Hydrophobic |
| ARG 23 | NTc.Cm10 | TYR 12 | - | VdWContact |
| ARG 24 | NTc.Cm9 | TYR 12 | - | VdWContact |
| ARG 24 | NTc.Cm9 | GLU 14 | - | VdWContact |
| ARG 24 | NTc.Cm9 | GLU 15 | - | VdWContact |
| ARG 24 | NTc.Cm9 | MET 16 | - | HBDonor |
| ARG 24 | NTc.Cm9 | MET 16 | - | VdWContact |
| ILE 26 | NTc.Cm7 | THR 8 | - | HBAcceptor |
| ILE 26 | NTc.Cm7 | THR 8 | - | Hydrophobic |
| ILE 26 | NTc.Cm7 | THR 8 | - | VdWContact |
| ASP 27 | NTc.Cm6 | TYR 7 | - | VdWContact |
| ASP 27 | NTc.Cm6 | THR 8 | - | HBAcceptor |
| ASP 27 | NTc.Cm6 | THR 8 | - | VdWContact |
| ARG 28 | NTc.Cm5 | SER 5 | - | HBDonor |
| ARG 28 | NTc.Cm5 | SER 5 | - | VdWContact |
| ARG 28 | NTc.Cm5 | ILE 6 | - | VdWContact |
| ARG 28 | NTc.Cm5 | TYR 7 | - | Hydrophobic |
| ARG 28 | NTc.Cm5 | TYR 7 | - | VdWContact |
| ILE 29 | NTc.Cm4 | SER 5 | - | VdWContact |
| ILE 29 | NTc.Cm4 | ILE 6 | - | HBAcceptor |
| ILE 29 | NTc.Cm4 | ILE 6 | - | HBDonor |
| ILE 29 | NTc.Cm4 | ILE 6 | - | VdWContact |
| ILE 29 | NTc.Cm4 | THR 8 | - | Hydrophobic |
| GLN 30 | NTc.Cm3 | ILE 4 | - | VdWContact |
| ILE 31 | NTc.Cm2 | GLY 3 | - | VdWContact |
| ILE 31 | NTc.Cm2 | ILE 4 | - | HBAcceptor |
| ILE 31 | NTc.Cm2 | ILE 4 | - | HBDonor |
| ILE 31 | NTc.Cm2 | ILE 4 | - | VdWContact |
| ILE 31 | NTc.Cm2 | ILE 6 | - | Hydrophobic |
| PRO 33 | CX.1 | MET 1 | - | Hydrophobic |
| PRO 33 | CX.1 | MET 1 | - | VdWContact |
| ASN 36 | cxb1.1 | PHE 189 | - | Hydrophobic |
| ASN 36 | cxb1.1 | PHE 189 | - | VdWContact |
| PRO 39 | cxb1.6 | ASN 192 | - | Hydrophobic |
| ILE 44 | cxb1.14 | PRO 27 | - | Hydrophobic |
| ILE 44 | cxb1.14 | PHE 29 | - | Hydrophobic |
| TRP 46 | cxb1.16 | PHE 29 | - | Hydrophobic |
| LYS 47 | B1.1 | TYR 21 | - | VdWContact |
| LYS 48 | B1.2 | ASP 10 | - | Cationic |
| LYS 48 | B1.2 | ASP 10 | - | HBDonor |
| LYS 48 | B1.2 | ASP 10 | - | VdWContact |
| ILE 52 | B1.6 | GLU 26 | - | VdWContact |
| ILE 52 | B1.6 | PRO 27 | - | Hydrophobic |
| ILE 52 | B1.6 | PRO 27 | - | VdWContact |
| ILE 52 | B1.6 | PHE 29 | - | Hydrophobic |
| ILE 52 | B1.6 | PHE 29 | - | VdWContact |
| VAL 53 | B1.7 | MET 24 | - | Hydrophobic |
| VAL 53 | B1.7 | MET 24 | - | VdWContact |
| CYS 54 | b1b2.4 | PRO 27 | - | VdWContact |
| MET 66 | B2.3 | ILE 6 | - | Hydrophobic |
| MET 66 | B2.3 | ILE 6 | - | VdWContact |
| LEU 69 | B2.6 | ILE 6 | - | Hydrophobic |
| LEU 69 | B2.6 | ILE 6 | - | VdWContact |
| ARG 72 | b2b3.11 | TYR 12 | - | VdWContact |
| LYS 85 | H.4 | GLU 2 | - | VdWContact |
| ILE 86 | H.5 | ASP 181 | - | Hydrophobic |
| ILE 86 | H.5 | ASP 181 | - | VdWContact |
| ILE 86 | H.5 | ASP 182 | - | Hydrophobic |
| ILE 86 | H.5 | ASP 182 | - | VdWContact |
| PRO 87 | H.6 | ASP 182 | - | Hydrophobic |
| PRO 87 | H.6 | ASP 182 | - | VdWContact |
