Predicted complex interactions
CXCL16_HUMAN + CXCR4
SUMMARY
- Chemokine
- CXCL16_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR4 View partner entry
- Partner description
- UniProt: P61073; Gene: cxcr4_human; Family: Chemokine
- Interactions detected
- 96
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| ASN 1 | NTc.Cm56 | CYS 186 | 45.50x50 | HBDonor |
| ASN 1 | NTc.Cm56 | CYS 186 | 45.50x50 | VdWContact |
| ASN 1 | NTc.Cm56 | ASP 187 | 45.51x51 | Cationic |
| ASN 1 | NTc.Cm56 | ASP 187 | 45.51x51 | HBDonor |
| ASN 1 | NTc.Cm56 | ASP 187 | 45.51x51 | VdWContact |
| GLU 2 | NTc.Cm55 | ASN 37 | 1.31x31 | HBAcceptor |
| GLU 2 | NTc.Cm55 | ASN 37 | 1.31x31 | VdWContact |
| GLY 3 | NTc.Cm54 | LEU 41 | 1.35x35 | VdWContact |
| GLY 3 | NTc.Cm54 | TYR 45 | 1.39x39 | HBAcceptor |
| GLY 3 | NTc.Cm54 | TYR 45 | 1.39x39 | VdWContact |
| SER 4 | NTc.Cm53 | GLU 288 | 7.39x38 | HBDonor |
| SER 4 | NTc.Cm53 | GLU 288 | 7.39x38 | VdWContact |
| VAL 5 | NTc.Cm52 | TRP 94 | 2.60x60 | Hydrophobic |
| VAL 5 | NTc.Cm52 | TRP 94 | 2.60x60 | VdWContact |
| VAL 5 | NTc.Cm52 | TYR 116 | 3.32x32 | Hydrophobic |
| VAL 5 | NTc.Cm52 | GLU 288 | 7.39x38 | HBDonor |
| VAL 5 | NTc.Cm52 | GLU 288 | 7.39x38 | VdWContact |
| VAL 5 | NTc.Cm52 | PHE 292 | 7.43x42 | Hydrophobic |
| VAL 5 | NTc.Cm52 | PHE 292 | 7.43x42 | VdWContact |
| THR 6 | NTc.Cm51 | HIS 203 | 5.42x43 | Hydrophobic |
| THR 6 | NTc.Cm51 | TYR 255 | 6.51x51 | HBAcceptor |
| THR 6 | NTc.Cm51 | TYR 255 | 6.51x51 | Hydrophobic |
| THR 6 | NTc.Cm51 | TYR 255 | 6.51x51 | VdWContact |
| THR 6 | NTc.Cm51 | ILE 259 | 6.55x55 | Hydrophobic |
| THR 6 | NTc.Cm51 | GLU 288 | 7.39x38 | HBDonor |
| THR 6 | NTc.Cm51 | GLU 288 | 7.39x38 | VdWContact |
| SER 8 | NTc.Cm49 | ARG 30 | 1.24x24 | HBAcceptor |
| SER 8 | NTc.Cm49 | ARG 30 | 1.24x24 | VdWContact |
| SER 8 | NTc.Cm49 | HIS 281 | 7.32x31 | VdWContact |
| TYR 10 | NTc.Cm47 | TYR 190 | - | Hydrophobic |
| TYR 10 | NTc.Cm47 | VAL 196 | 5.35x36 | Hydrophobic |
| TYR 10 | NTc.Cm47 | VAL 196 | 5.35x36 | VdWContact |
| TYR 10 | NTc.Cm47 | GLN 200 | 5.39x40 | HBAcceptor |
| TYR 10 | NTc.Cm47 | GLN 200 | 5.39x40 | VdWContact |
| CYS 11 | NTc.Cm46 | PHE 189 | - | Hydrophobic |
| GLY 12 | NTc.Cm45 | TYR 190 | - | VdWContact |
| ARG 14 | NTc.Cm43 | SER 178 | - | HBDonor |
| ARG 14 | NTc.Cm43 | SER 178 | - | VdWContact |
| ARG 14 | NTc.Cm43 | GLU 179 | - | HBDonor |
| ARG 14 | NTc.Cm43 | GLU 179 | - | VdWContact |
| ARG 14 | NTc.Cm43 | ILE 185 | - | VdWContact |
| ARG 14 | NTc.Cm43 | PHE 189 | - | VdWContact |
| ARG 34 | NTc.Cm23 | GLU 268 | 6.64x64 | Cationic |
| ARG 34 | NTc.Cm23 | GLU 268 | 6.64x64 | HBDonor |
| ARG 34 | NTc.Cm23 | GLU 268 | 6.64x64 | VdWContact |
| ALA 35 | NTc.Cm22 | LYS 25 | - | Hydrophobic |
| TYR 36 | NTc.Cm21 | PRO 27 | - | Hydrophobic |
| TYR 36 | NTc.Cm21 | PRO 27 | - | VdWContact |
| TYR 36 | NTc.Cm21 | CYS 28 | - | HBAcceptor |
| TYR 36 | NTc.Cm21 | CYS 28 | - | VdWContact |
| TYR 36 | NTc.Cm21 | PHE 29 | - | Hydrophobic |
| HIS 37 | NTc.Cm20 | CYS 28 | - | Hydrophobic |
| HIS 37 | NTc.Cm20 | CYS 28 | - | VdWContact |
| HIS 37 | NTc.Cm20 | ARG 30 | 1.24x24 | Hydrophobic |
| HIS 37 | NTc.Cm20 | ARG 30 | 1.24x24 | VdWContact |
| HIS 37 | NTc.Cm20 | GLU 277 | 7.28x27 | VdWContact |
| ARG 38 | NTc.Cm19 | CYS 28 | - | HBDonor |
| ARG 38 | NTc.Cm19 | CYS 28 | - | VdWContact |
| ARG 38 | NTc.Cm19 | PHE 29 | - | VdWContact |
| ARG 38 | NTc.Cm19 | ARG 30 | 1.24x24 | HBAcceptor |
| ARG 38 | NTc.Cm19 | ARG 30 | 1.24x24 | VdWContact |
| ARG 38 | NTc.Cm19 | GLU 31 | 1.25x25 | Cationic |
| ARG 38 | NTc.Cm19 | GLU 31 | 1.25x25 | HBDonor |
| ARG 38 | NTc.Cm19 | GLU 31 | 1.25x25 | VdWContact |
| LEU 40 | NTc.Cm17 | ALA 34 | 1.28x28 | Hydrophobic |
| LEU 40 | NTc.Cm17 | ALA 34 | 1.28x28 | VdWContact |
| LEU 40 | NTc.Cm17 | LYS 38 | 1.32x32 | Hydrophobic |
| LEU 40 | NTc.Cm17 | LYS 38 | 1.32x32 | VdWContact |
| TYR 41 | NTc.Cm16 | ALA 100 | 2.66x66 | VdWContact |
| TYR 41 | NTc.Cm16 | ALA 180 | - | Hydrophobic |
| TYR 41 | NTc.Cm16 | ASP 181 | - | Hydrophobic |
| TYR 41 | NTc.Cm16 | ASP 181 | - | VdWContact |
| TYR 41 | NTc.Cm16 | ARG 183 | - | Hydrophobic |
| TYR 41 | NTc.Cm16 | ARG 183 | - | VdWContact |
| TYR 41 | NTc.Cm16 | ILE 185 | - | Hydrophobic |
| TYR 41 | NTc.Cm16 | ILE 185 | - | VdWContact |
| TYR 42 | NTc.Cm15 | ALA 180 | - | Hydrophobic |
| TYR 42 | NTc.Cm15 | ILE 185 | - | Hydrophobic |
| TYR 42 | NTc.Cm15 | ILE 185 | - | VdWContact |
| ARG 44 | NTc.Cm13 | ASP 193 | 5.32x33 | Cationic |
| ARG 44 | NTc.Cm13 | ASP 193 | 5.32x33 | HBDonor |
| ARG 44 | NTc.Cm13 | ASP 193 | 5.32x33 | VdWContact |
| ARG 44 | NTc.Cm13 | LEU 266 | 6.62x62 | VdWContact |
| TRP 50 | NTc.Cm7 | ASN 192 | - | Hydrophobic |
| SER 51 | NTc.Cm6 | ASP 193 | 5.32x33 | HBDonor |
| SER 51 | NTc.Cm6 | ASP 193 | 5.32x33 | VdWContact |
| LYS 57 | CX.1 | ASP 181 | - | Cationic |
| LYS 57 | CX.1 | ASP 181 | - | HBDonor |
| LYS 57 | CX.1 | ASP 181 | - | VdWContact |
| LYS 57 | CX.1 | ASP 182 | - | Cationic |
| LYS 57 | CX.1 | ASP 182 | - | VdWContact |
| MET 65 | cxb1.8 | PHE 29 | - | Hydrophobic |
| ASP 69 | cxb1.15 | PRO 27 | - | VdWContact |
| LYS 71 | B1.1 | MET 24 | - | Hydrophobic |
| LYS 71 | B1.1 | MET 24 | - | VdWContact |
| ALA 76 | B1.6 | MET 24 | - | Hydrophobic |
