Predicted complex interactions
CXCL3_HUMAN + CXCR4
SUMMARY
- Chemokine
- CXCL3_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR4 View partner entry
- Partner description
- UniProt: P61073; Gene: cxcr4_human; Family: Chemokine
- Interactions detected
- 127
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| ALA 1 | NTc.Cm42 | TRP 94 | 2.60x60 | Hydrophobic |
| ALA 1 | NTc.Cm42 | TRP 94 | 2.60x60 | VdWContact |
| ALA 1 | NTc.Cm42 | TYR 116 | 3.32x32 | CationPi |
| ALA 1 | NTc.Cm42 | TYR 116 | 3.32x32 | Hydrophobic |
| ALA 1 | NTc.Cm42 | TYR 116 | 3.32x32 | VdWContact |
| ALA 1 | NTc.Cm42 | GLU 288 | 7.39x38 | Cationic |
| ALA 1 | NTc.Cm42 | GLU 288 | 7.39x38 | VdWContact |
| ALA 1 | NTc.Cm42 | PHE 292 | 7.43x42 | Hydrophobic |
| ALA 1 | NTc.Cm42 | PHE 292 | 7.43x42 | VdWContact |
| SER 2 | NTc.Cm41 | GLU 288 | 7.39x38 | HBDonor |
| SER 2 | NTc.Cm41 | GLU 288 | 7.39x38 | VdWContact |
| VAL 3 | NTc.Cm40 | TRP 94 | 2.60x60 | Hydrophobic |
| VAL 3 | NTc.Cm40 | ASP 97 | 2.63x63 | VdWContact |
| VAL 4 | NTc.Cm39 | HIS 281 | 7.32x31 | Hydrophobic |
| VAL 4 | NTc.Cm39 | HIS 281 | 7.32x31 | VdWContact |
| VAL 4 | NTc.Cm39 | ILE 284 | 7.35x34 | Hydrophobic |
| VAL 4 | NTc.Cm39 | SER 285 | 7.36x35 | VdWContact |
| THR 5 | NTc.Cm38 | ARG 183 | - | VdWContact |
| THR 5 | NTc.Cm38 | ILE 185 | - | Hydrophobic |
| GLU 6 | NTc.Cm37 | ARG 30 | 1.24x24 | Anionic |
| GLU 6 | NTc.Cm37 | ARG 30 | 1.24x24 | HBAcceptor |
| GLU 6 | NTc.Cm37 | ARG 30 | 1.24x24 | Hydrophobic |
| GLU 6 | NTc.Cm37 | ARG 30 | 1.24x24 | VdWContact |
| GLU 6 | NTc.Cm37 | ASN 33 | 1.27x27 | HBAcceptor |
| GLU 6 | NTc.Cm37 | ASN 33 | 1.27x27 | VdWContact |
| GLU 6 | NTc.Cm37 | HIS 281 | 7.32x31 | Hydrophobic |
| GLU 6 | NTc.Cm37 | HIS 281 | 7.32x31 | VdWContact |
| LEU 7 | NTc.Cm36 | ILE 185 | - | Hydrophobic |
| LEU 7 | NTc.Cm36 | ILE 185 | - | VdWContact |
| ARG 8 | NTc.Cm35 | ARG 30 | 1.24x24 | VdWContact |
| ARG 8 | NTc.Cm35 | ASP 262 | 6.58x58 | Cationic |
| ARG 8 | NTc.Cm35 | ASP 262 | 6.58x58 | HBDonor |
| ARG 8 | NTc.Cm35 | ASP 262 | 6.58x58 | VdWContact |
| ARG 8 | NTc.Cm35 | LEU 266 | 6.62x62 | VdWContact |
| ARG 8 | NTc.Cm35 | GLU 277 | 7.28x27 | Cationic |
| ARG 8 | NTc.Cm35 | HIS 281 | 7.32x31 | VdWContact |
| GLN 10 | NTc.Cm33 | PRO 27 | - | Hydrophobic |
| GLN 10 | NTc.Cm33 | CYS 28 | - | HBAcceptor |
| GLN 10 | NTc.Cm33 | CYS 28 | - | VdWContact |
| LEU 12 | NTc.Cm31 | CYS 28 | - | Hydrophobic |
| LEU 12 | NTc.Cm31 | CYS 274 | 7.25x24 | Hydrophobic |
| LEU 12 | NTc.Cm31 | GLU 277 | 7.28x27 | Hydrophobic |
| LEU 12 | NTc.Cm31 | GLU 277 | 7.28x27 | VdWContact |
| GLN 13 | NTc.Cm30 | LYS 25 | - | HBAcceptor |
| GLN 13 | NTc.Cm30 | LYS 25 | - | Hydrophobic |
| GLN 13 | NTc.Cm30 | LYS 25 | - | VdWContact |
| LEU 15 | NTc.Cm28 | MET 24 | - | Hydrophobic |
| LEU 15 | NTc.Cm28 | MET 24 | - | VdWContact |
| LEU 15 | NTc.Cm28 | LYS 25 | - | Hydrophobic |
| ILE 18 | NTc.Cm25 | TYR 21 | - | Hydrophobic |
| ILE 18 | NTc.Cm25 | MET 24 | - | Hydrophobic |
| ILE 18 | NTc.Cm25 | MET 24 | - | VdWContact |
| HIS 19 | NTc.Cm24 | GLU 14 | - | Hydrophobic |
| HIS 19 | NTc.Cm24 | GLU 14 | - | VdWContact |
| HIS 19 | NTc.Cm24 | MET 16 | - | HBAcceptor |
| HIS 19 | NTc.Cm24 | MET 16 | - | Hydrophobic |
| HIS 19 | NTc.Cm24 | MET 16 | - | VdWContact |
| LEU 20 | NTc.Cm23 | THR 8 | - | Hydrophobic |
| LYS 21 | NTc.Cm22 | TYR 12 | - | VdWContact |
| LYS 21 | NTc.Cm22 | THR 13 | - | HBDonor |
| LYS 21 | NTc.Cm22 | THR 13 | - | VdWContact |
| LYS 21 | NTc.Cm22 | GLU 14 | - | HBDonor |
| LYS 21 | NTc.Cm22 | GLU 14 | - | VdWContact |
| ASN 22 | NTc.Cm21 | TYR 21 | - | HBDonor |
| ASN 22 | NTc.Cm21 | TYR 21 | - | VdWContact |
| ILE 23 | NTc.Cm20 | THR 8 | - | Hydrophobic |
| ILE 23 | NTc.Cm20 | THR 8 | - | VdWContact |
| GLN 24 | NTc.Cm19 | TYR 7 | - | VdWContact |
| GLN 24 | NTc.Cm19 | THR 8 | - | HBAcceptor |
| GLN 24 | NTc.Cm19 | THR 8 | - | VdWContact |
| SER 25 | NTc.Cm18 | ILE 6 | - | VdWContact |
| SER 25 | NTc.Cm18 | TYR 7 | - | VdWContact |
| VAL 26 | NTc.Cm17 | ILE 4 | - | VdWContact |
| VAL 26 | NTc.Cm17 | SER 5 | - | VdWContact |
| VAL 26 | NTc.Cm17 | ILE 6 | - | HBAcceptor |
| VAL 26 | NTc.Cm17 | ILE 6 | - | HBDonor |
| VAL 26 | NTc.Cm17 | ILE 6 | - | Hydrophobic |
| VAL 26 | NTc.Cm17 | ILE 6 | - | VdWContact |
| ASN 27 | NTc.Cm16 | GLY 3 | - | VdWContact |
| VAL 28 | NTc.Cm15 | GLY 3 | - | VdWContact |
| ARG 29 | NTc.Cm14 | ASP 181 | - | Cationic |
| ARG 29 | NTc.Cm14 | ASP 181 | - | HBDonor |
| ARG 29 | NTc.Cm14 | ASP 181 | - | VdWContact |
| SER 30 | NTc.Cm13 | MET 1 | - | VdWContact |
| PRO 33 | NTc.Cm10 | SER 178 | - | VdWContact |
| PRO 33 | NTc.Cm10 | PHE 189 | - | Hydrophobic |
| PRO 33 | NTc.Cm10 | PHE 189 | - | VdWContact |
| HIS 34 | NTc.Cm9 | ALA 180 | - | Hydrophobic |
| HIS 34 | NTc.Cm9 | ALA 180 | - | VdWContact |
| HIS 34 | NTc.Cm9 | ILE 185 | - | Hydrophobic |
| HIS 34 | NTc.Cm9 | ILE 185 | - | VdWContact |
| HIS 34 | NTc.Cm9 | PHE 189 | - | Hydrophobic |
| HIS 34 | NTc.Cm9 | PHE 189 | - | VdWContact |
| ILE 41 | NTc.Cm2 | PRO 27 | - | Hydrophobic |
| ILE 41 | NTc.Cm2 | PRO 27 | - | VdWContact |
| LEU 44 | CX.4 | TYR 21 | - | Hydrophobic |
| LEU 44 | CX.4 | MET 24 | - | Hydrophobic |
| LEU 44 | CX.4 | MET 24 | - | VdWContact |
| LYS 45 | CX.5 | ASP 10 | - | Cationic |
| LYS 45 | CX.5 | ASP 10 | - | HBDonor |
| LYS 45 | CX.5 | ASP 10 | - | VdWContact |
| LYS 48 | cxb1.5 | ASP 22 | - | Cationic |
| LYS 49 | cxb1.6 | GLU 26 | - | VdWContact |
| LYS 49 | cxb1.6 | PRO 27 | - | Hydrophobic |
| LYS 49 | cxb1.6 | PRO 27 | - | VdWContact |
| LYS 49 | cxb1.6 | PHE 29 | - | Hydrophobic |
| LYS 49 | cxb1.6 | PHE 29 | - | VdWContact |
| ALA 50 | cxb1.8 | MET 24 | - | Hydrophobic |
| CYS 51 | cxb1.10 | LYS 25 | - | HBDonor |
| CYS 51 | cxb1.10 | LYS 25 | - | VdWContact |
| CYS 51 | cxb1.10 | PRO 27 | - | VdWContact |
| MET 58 | B1.3 | MET 16 | - | Hydrophobic |
| MET 58 | B1.3 | MET 16 | - | VdWContact |
| ILE 63 | b1b2.4 | ILE 6 | - | Hydrophobic |
| LYS 65 | b1b2.7 | TYR 12 | - | CationPi |
| LYS 65 | b1b2.7 | TYR 12 | - | Hydrophobic |
| LYS 65 | b1b2.7 | TYR 12 | - | VdWContact |
| ILE 66 | b1b2.8 | ILE 6 | - | Hydrophobic |
| ILE 66 | b1b2.8 | ILE 6 | - | VdWContact |
| ILE 66 | b1b2.8 | TYR 7 | - | VdWContact |
| ILE 66 | b1b2.8 | THR 8 | - | Hydrophobic |
| ILE 66 | b1b2.8 | THR 8 | - | VdWContact |
| LEU 67 | b1b2.9 | ILE 4 | - | Hydrophobic |
| LEU 67 | b1b2.9 | ILE 6 | - | Hydrophobic |
| LYS 69 | b1b2.12 | SER 9 | - | HBDonor |
| LYS 69 | b1b2.12 | SER 9 | - | VdWContact |
| LYS 69 | b1b2.12 | TYR 12 | - | VdWContact |
