Predicted complex interactions
CXCL4_HUMAN + CXCR4
SUMMARY
- Chemokine
- CXCL4_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR4 View partner entry
- Partner description
- UniProt: P61073; Gene: cxcr4_human; Family: Chemokine
- Interactions detected
- 108
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| ASP 7 | NTc.Cm34 | SER 18 | - | HBAcceptor |
| ASP 7 | NTc.Cm34 | SER 18 | - | VdWContact |
| GLN 9 | NTc.Cm32 | GLU 15 | - | HBDonor |
| GLN 9 | NTc.Cm32 | GLU 15 | - | VdWContact |
| GLN 9 | NTc.Cm32 | MET 16 | - | VdWContact |
| GLN 9 | NTc.Cm32 | GLY 17 | - | HBAcceptor |
| GLN 9 | NTc.Cm32 | GLY 17 | - | VdWContact |
| LEU 11 | NTc.Cm30 | MET 16 | - | Hydrophobic |
| LEU 11 | NTc.Cm30 | MET 16 | - | VdWContact |
| LEU 11 | NTc.Cm30 | TYR 21 | - | VdWContact |
| CYS 12 | NTc.Cm29 | TYR 21 | - | VdWContact |
| VAL 13 | NTc.Cm28 | ASP 20 | - | VdWContact |
| VAL 13 | NTc.Cm28 | TYR 21 | - | VdWContact |
| LYS 14 | NTc.Cm27 | ASP 20 | - | Cationic |
| LYS 14 | NTc.Cm27 | ASP 20 | - | HBDonor |
| LYS 14 | NTc.Cm27 | ASP 20 | - | VdWContact |
| LYS 14 | NTc.Cm27 | ASP 22 | - | Cationic |
| LYS 14 | NTc.Cm27 | ASP 22 | - | HBDonor |
| LYS 14 | NTc.Cm27 | ASP 22 | - | Hydrophobic |
| LYS 14 | NTc.Cm27 | ASP 22 | - | VdWContact |
| LYS 14 | NTc.Cm27 | SER 23 | - | VdWContact |
| THR 15 | NTc.Cm26 | MET 24 | - | Hydrophobic |
| THR 15 | NTc.Cm26 | MET 24 | - | VdWContact |
| SER 17 | NTc.Cm24 | LYS 25 | - | VdWContact |
| SER 17 | NTc.Cm24 | GLU 26 | - | HBDonor |
| SER 17 | NTc.Cm24 | GLU 26 | - | VdWContact |
| SER 17 | NTc.Cm24 | PRO 27 | - | VdWContact |
| SER 17 | NTc.Cm24 | CYS 28 | - | HBAcceptor |
| SER 17 | NTc.Cm24 | CYS 28 | - | VdWContact |
| GLN 18 | NTc.Cm23 | LYS 25 | - | HBAcceptor |
| GLN 18 | NTc.Cm23 | LYS 25 | - | Hydrophobic |
| GLN 18 | NTc.Cm23 | LYS 25 | - | VdWContact |
| GLN 18 | NTc.Cm23 | ARG 30 | 1.24x24 | HBAcceptor |
| GLN 18 | NTc.Cm23 | ARG 30 | 1.24x24 | VdWContact |
| GLN 18 | NTc.Cm23 | ILE 265 | 6.61x61 | Hydrophobic |
| GLN 18 | NTc.Cm23 | ILE 265 | 6.61x61 | VdWContact |
| GLN 18 | NTc.Cm23 | GLN 272 | - | VdWContact |
| GLN 18 | NTc.Cm23 | GLU 277 | 7.28x27 | VdWContact |
| ARG 20 | NTc.Cm21 | ARG 30 | 1.24x24 | VdWContact |
| ARG 20 | NTc.Cm21 | ASP 262 | 6.58x58 | Cationic |
| ARG 20 | NTc.Cm21 | ASP 262 | 6.58x58 | HBDonor |
| ARG 20 | NTc.Cm21 | ASP 262 | 6.58x58 | VdWContact |
| ARG 20 | NTc.Cm21 | HIS 281 | 7.32x31 | CationPi |
| PRO 21 | NTc.Cm20 | PHE 29 | - | Hydrophobic |
| PRO 21 | NTc.Cm20 | PHE 29 | - | VdWContact |
| PRO 21 | NTc.Cm20 | ARG 30 | 1.24x24 | VdWContact |
| ARG 22 | NTc.Cm19 | ASP 97 | 2.63x63 | Cationic |
| ARG 22 | NTc.Cm19 | ASP 97 | 2.63x63 | HBDonor |
| ARG 22 | NTc.Cm19 | ASP 97 | 2.63x63 | VdWContact |
| ARG 22 | NTc.Cm19 | ILE 185 | - | Hydrophobic |
| ILE 24 | NTc.Cm17 | ALA 180 | - | VdWContact |
| THR 25 | NTc.Cm16 | SER 178 | - | VdWContact |
| THR 25 | NTc.Cm16 | GLU 179 | - | VdWContact |
| THR 25 | NTc.Cm16 | ALA 180 | - | VdWContact |
| LEU 27 | NTc.Cm14 | ILE 4 | - | Hydrophobic |
| LEU 27 | NTc.Cm14 | ILE 4 | - | VdWContact |
| LEU 27 | NTc.Cm14 | ILE 6 | - | VdWContact |
| GLU 28 | NTc.Cm13 | TYR 7 | - | Hydrophobic |
| VAL 29 | NTc.Cm12 | ILE 6 | - | Hydrophobic |
| VAL 29 | NTc.Cm12 | ILE 6 | - | VdWContact |
| VAL 29 | NTc.Cm12 | THR 8 | - | VdWContact |
| ILE 30 | NTc.Cm11 | SER 9 | - | VdWContact |
| LYS 31 | NTc.Cm10 | THR 8 | - | Hydrophobic |
| LYS 31 | NTc.Cm10 | THR 8 | - | VdWContact |
| LYS 31 | NTc.Cm10 | SER 9 | - | VdWContact |
| LYS 31 | NTc.Cm10 | ASN 11 | - | VdWContact |
| GLY 33 | NTc.Cm8 | ASN 11 | - | HBAcceptor |
| GLY 33 | NTc.Cm8 | ASN 11 | - | VdWContact |
| PRO 34 | NTc.Cm7 | ASN 11 | - | VdWContact |
| PRO 34 | NTc.Cm7 | TYR 12 | - | Hydrophobic |
| HIS 35 | NTc.Cm6 | ASN 11 | - | HBDonor |
| HIS 35 | NTc.Cm6 | ASN 11 | - | VdWContact |
| HIS 35 | NTc.Cm6 | TYR 12 | - | HBDonor |
| HIS 35 | NTc.Cm6 | TYR 12 | - | VdWContact |
| HIS 35 | NTc.Cm6 | THR 13 | - | VdWContact |
| CYS 36 | NTc.Cm5 | ASN 11 | - | HBAcceptor |
| CYS 36 | NTc.Cm5 | ASN 11 | - | VdWContact |
| LYS 46 | cxb1.5 | ILE 185 | - | VdWContact |
| LYS 46 | cxb1.5 | ASP 187 | 45.51x51 | Cationic |
| LYS 46 | cxb1.5 | ASP 187 | 45.51x51 | HBDonor |
| LYS 46 | cxb1.5 | ASP 187 | 45.51x51 | VdWContact |
| LYS 46 | cxb1.5 | PHE 189 | - | Hydrophobic |
| LYS 46 | cxb1.5 | PHE 189 | - | VdWContact |
| ASN 47 | cxb1.6 | PHE 189 | - | Hydrophobic |
| ASN 47 | cxb1.6 | PHE 189 | - | VdWContact |
| ASN 47 | cxb1.6 | TYR 190 | - | HBDonor |
| ASN 47 | cxb1.6 | TYR 190 | - | VdWContact |
| ARG 49 | cxb1.10 | PRO 191 | - | VdWContact |
| ARG 49 | cxb1.10 | ASP 193 | 5.32x33 | Cationic |
| ARG 49 | cxb1.10 | ASP 193 | 5.32x33 | HBDonor |
| ARG 49 | cxb1.10 | ASP 193 | 5.32x33 | VdWContact |
| ASP 54 | B1.1 | PRO 27 | - | Hydrophobic |
| ALA 57 | B1.4 | PRO 27 | - | Hydrophobic |
| ALA 57 | B1.4 | PRO 27 | - | VdWContact |
| PRO 58 | B1.5 | GLU 26 | - | VdWContact |
| LEU 59 | B1.6 | PRO 27 | - | Hydrophobic |
| LEU 59 | B1.6 | PRO 27 | - | VdWContact |
| LEU 59 | B1.6 | CYS 28 | - | VdWContact |
| LEU 59 | B1.6 | PHE 29 | - | Hydrophobic |
| LEU 59 | B1.6 | PHE 29 | - | VdWContact |
| TYR 60 | B1.7 | PRO 27 | - | Hydrophobic |
| TYR 60 | B1.7 | PRO 27 | - | VdWContact |
| TYR 60 | B1.7 | PHE 29 | - | Hydrophobic |
| TYR 60 | B1.7 | PHE 29 | - | VdWContact |
| ILE 63 | b1b2.7 | ILE 4 | - | Hydrophobic |
| ILE 63 | b1b2.7 | PHE 29 | - | Hydrophobic |
| ILE 63 | b1b2.7 | PHE 29 | - | VdWContact |
| LEU 67 | b1b2.12 | ILE 6 | - | Hydrophobic |
