Predicted complex interactions
CXCL5_HUMAN + CXCR4
SUMMARY
- Chemokine
- CXCL5_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR4 View partner entry
- Partner description
- UniProt: P61073; Gene: cxcr4_human; Family: Chemokine
- Interactions detected
- 137
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| ALA 1 | NTc.Cm48 | ARG 188 | 45.52x52 | VdWContact |
| GLY 2 | NTc.Cm47 | TYR 116 | 3.32x32 | VdWContact |
| GLY 2 | NTc.Cm47 | ARG 188 | 45.52x52 | VdWContact |
| PRO 3 | NTc.Cm46 | TYR 45 | 1.39x39 | Hydrophobic |
| PRO 3 | NTc.Cm46 | TYR 45 | 1.39x39 | VdWContact |
| PRO 3 | NTc.Cm46 | TRP 94 | 2.60x60 | Hydrophobic |
| PRO 3 | NTc.Cm46 | TRP 94 | 2.60x60 | VdWContact |
| PRO 3 | NTc.Cm46 | GLU 288 | 7.39x38 | VdWContact |
| PRO 3 | NTc.Cm46 | PHE 292 | 7.43x42 | Hydrophobic |
| PRO 3 | NTc.Cm46 | PHE 292 | 7.43x42 | VdWContact |
| ALA 4 | NTc.Cm45 | ILE 284 | 7.35x34 | Hydrophobic |
| ALA 4 | NTc.Cm45 | GLU 288 | 7.39x38 | HBDonor |
| ALA 4 | NTc.Cm45 | GLU 288 | 7.39x38 | VdWContact |
| ALA 5 | NTc.Cm44 | ASN 37 | 1.31x31 | VdWContact |
| ALA 5 | NTc.Cm44 | LEU 41 | 1.35x35 | Hydrophobic |
| ALA 5 | NTc.Cm44 | LEU 41 | 1.35x35 | VdWContact |
| ALA 5 | NTc.Cm44 | SER 285 | 7.36x35 | VdWContact |
| ALA 5 | NTc.Cm44 | GLU 288 | 7.39x38 | HBDonor |
| ALA 5 | NTc.Cm44 | GLU 288 | 7.39x38 | VdWContact |
| VAL 7 | NTc.Cm42 | ASP 97 | 2.63x63 | VdWContact |
| VAL 7 | NTc.Cm42 | ALA 98 | 2.64x64 | VdWContact |
| VAL 7 | NTc.Cm42 | ARG 183 | - | VdWContact |
| LEU 8 | NTc.Cm41 | ALA 180 | - | Hydrophobic |
| LEU 8 | NTc.Cm41 | ILE 185 | - | Hydrophobic |
| LEU 8 | NTc.Cm41 | ILE 185 | - | VdWContact |
| ARG 9 | NTc.Cm40 | MET 1 | - | VdWContact |
| ARG 9 | NTc.Cm40 | ASP 181 | - | Cationic |
| ARG 9 | NTc.Cm40 | ASP 181 | - | HBDonor |
| ARG 9 | NTc.Cm40 | ASP 181 | - | VdWContact |
| GLU 10 | NTc.Cm39 | ARG 30 | 1.24x24 | Anionic |
| GLU 10 | NTc.Cm39 | ARG 30 | 1.24x24 | VdWContact |
| GLU 10 | NTc.Cm39 | ASN 33 | 1.27x27 | HBAcceptor |
| GLU 10 | NTc.Cm39 | ASN 33 | 1.27x27 | VdWContact |
| GLU 10 | NTc.Cm39 | HIS 281 | 7.32x31 | Hydrophobic |
| GLU 10 | NTc.Cm39 | HIS 281 | 7.32x31 | VdWContact |
| LEU 11 | NTc.Cm38 | ASP 187 | 45.51x51 | Hydrophobic |
| LEU 11 | NTc.Cm38 | PHE 189 | - | Hydrophobic |
| ARG 12 | NTc.Cm37 | ARG 30 | 1.24x24 | HBAcceptor |
| ARG 12 | NTc.Cm37 | ARG 30 | 1.24x24 | VdWContact |
| ARG 12 | NTc.Cm37 | ASP 262 | 6.58x58 | Cationic |
| ARG 12 | NTc.Cm37 | ASP 262 | 6.58x58 | HBDonor |
| ARG 12 | NTc.Cm37 | ASP 262 | 6.58x58 | VdWContact |
| ARG 12 | NTc.Cm37 | ILE 265 | 6.61x61 | VdWContact |
| ARG 12 | NTc.Cm37 | GLU 277 | 7.28x27 | Cationic |
| ARG 12 | NTc.Cm37 | GLU 277 | 7.28x27 | VdWContact |
| ARG 12 | NTc.Cm37 | HIS 281 | 7.32x31 | VdWContact |
| CYS 13 | NTc.Cm36 | ARG 30 | 1.24x24 | HBAcceptor |
| CYS 13 | NTc.Cm36 | ARG 30 | 1.24x24 | VdWContact |
| VAL 14 | NTc.Cm35 | PRO 27 | - | Hydrophobic |
| VAL 14 | NTc.Cm35 | PRO 27 | - | VdWContact |
| VAL 14 | NTc.Cm35 | CYS 28 | - | HBAcceptor |
| VAL 14 | NTc.Cm35 | CYS 28 | - | VdWContact |
| VAL 14 | NTc.Cm35 | PHE 29 | - | Hydrophobic |
| LEU 16 | NTc.Cm33 | CYS 28 | - | VdWContact |
| LEU 16 | NTc.Cm33 | GLU 277 | 7.28x27 | Hydrophobic |
| LEU 16 | NTc.Cm33 | GLU 277 | 7.28x27 | VdWContact |
| GLN 17 | NTc.Cm32 | LYS 25 | - | HBAcceptor |
| GLN 17 | NTc.Cm32 | LYS 25 | - | Hydrophobic |
| GLN 17 | NTc.Cm32 | LYS 25 | - | VdWContact |
| THR 19 | NTc.Cm30 | MET 24 | - | Hydrophobic |
| THR 19 | NTc.Cm30 | LYS 25 | - | HBAcceptor |
| THR 19 | NTc.Cm30 | LYS 25 | - | VdWContact |
| VAL 22 | NTc.Cm27 | MET 24 | - | Hydrophobic |
| HIS 23 | NTc.Cm26 | TYR 12 | - | VdWContact |
| HIS 23 | NTc.Cm26 | MET 16 | - | Hydrophobic |
| HIS 23 | NTc.Cm26 | MET 16 | - | VdWContact |
| PRO 24 | NTc.Cm25 | TYR 12 | - | Hydrophobic |
| PRO 24 | NTc.Cm25 | TYR 12 | - | VdWContact |
| PRO 24 | NTc.Cm25 | MET 16 | - | Hydrophobic |
| LYS 25 | NTc.Cm24 | TYR 12 | - | Hydrophobic |
| LYS 25 | NTc.Cm24 | TYR 12 | - | VdWContact |
| MET 26 | NTc.Cm23 | TYR 21 | - | Hydrophobic |
| MET 26 | NTc.Cm23 | TYR 21 | - | VdWContact |
| MET 26 | NTc.Cm23 | MET 24 | - | Hydrophobic |
| ILE 27 | NTc.Cm22 | THR 8 | - | HBAcceptor |
| ILE 27 | NTc.Cm22 | THR 8 | - | Hydrophobic |
| ILE 27 | NTc.Cm22 | THR 8 | - | VdWContact |
| SER 28 | NTc.Cm21 | TYR 7 | - | VdWContact |
| ASN 29 | NTc.Cm20 | SER 5 | - | HBDonor |
| ASN 29 | NTc.Cm20 | SER 5 | - | VdWContact |
| ASN 29 | NTc.Cm20 | TYR 7 | - | Hydrophobic |
| LEU 30 | NTc.Cm19 | ILE 4 | - | VdWContact |
| LEU 30 | NTc.Cm19 | SER 5 | - | VdWContact |
| LEU 30 | NTc.Cm19 | ILE 6 | - | HBAcceptor |
| LEU 30 | NTc.Cm19 | ILE 6 | - | HBDonor |
| LEU 30 | NTc.Cm19 | ILE 6 | - | Hydrophobic |
| LEU 30 | NTc.Cm19 | ILE 6 | - | VdWContact |
| LEU 30 | NTc.Cm19 | THR 8 | - | Hydrophobic |
| GLN 31 | NTc.Cm18 | GLY 3 | - | VdWContact |
| GLN 31 | NTc.Cm18 | ILE 4 | - | VdWContact |
| VAL 32 | NTc.Cm17 | GLY 3 | - | VdWContact |
| VAL 32 | NTc.Cm17 | ILE 4 | - | HBAcceptor |
| VAL 32 | NTc.Cm17 | ILE 4 | - | HBDonor |
| VAL 32 | NTc.Cm17 | ILE 4 | - | VdWContact |
| VAL 32 | NTc.Cm17 | ILE 6 | - | Hydrophobic |
| PHE 33 | NTc.Cm16 | MET 1 | - | Hydrophobic |
| PHE 33 | NTc.Cm16 | MET 1 | - | VdWContact |
| PRO 37 | NTc.Cm12 | SER 178 | - | VdWContact |
| PRO 37 | NTc.Cm12 | ALA 180 | - | Hydrophobic |
| PRO 37 | NTc.Cm12 | PHE 189 | - | Hydrophobic |
| PRO 37 | NTc.Cm12 | PHE 189 | - | VdWContact |
| GLN 38 | NTc.Cm11 | MET 1 | - | Hydrophobic |
| GLN 38 | NTc.Cm11 | ALA 180 | - | Hydrophobic |
| GLN 38 | NTc.Cm11 | ALA 180 | - | VdWContact |
| CYS 39 | NTc.Cm10 | MET 1 | - | Hydrophobic |
| VAL 45 | NTc.Cm4 | PRO 27 | - | Hydrophobic |
| LEU 48 | NTc.Cm1 | MET 24 | - | Hydrophobic |
| LYS 49 | CX.1 | ASP 10 | - | Cationic |
| LYS 49 | CX.1 | ASP 10 | - | HBDonor |
| LYS 49 | CX.1 | ASP 10 | - | VdWContact |
| LYS 52 | cxb1.1 | GLU 26 | - | Cationic |
| LYS 52 | cxb1.1 | GLU 26 | - | HBDonor |
| LYS 52 | cxb1.1 | GLU 26 | - | VdWContact |
| GLU 53 | cxb1.2 | GLU 26 | - | VdWContact |
| GLU 53 | cxb1.2 | PRO 27 | - | Hydrophobic |
| GLU 53 | cxb1.2 | PRO 27 | - | VdWContact |
| GLU 53 | cxb1.2 | PHE 29 | - | VdWContact |
| ILE 54 | cxb1.5 | MET 24 | - | Hydrophobic |
| ILE 54 | cxb1.5 | LYS 25 | - | VdWContact |
| CYS 55 | cxb1.6 | LYS 25 | - | HBDonor |
| CYS 55 | cxb1.6 | LYS 25 | - | VdWContact |
| PHE 62 | B1.1 | MET 16 | - | Hydrophobic |
| PHE 62 | B1.1 | MET 16 | - | VdWContact |
| VAL 66 | B1.5 | THR 8 | - | Hydrophobic |
| VAL 66 | B1.5 | TYR 12 | - | Hydrophobic |
| VAL 66 | B1.5 | TYR 12 | - | VdWContact |
| ILE 67 | B1.6 | ILE 6 | - | Hydrophobic |
| LYS 69 | b1b2.4 | ASN 11 | - | HBDonor |
| LYS 69 | b1b2.4 | ASN 11 | - | VdWContact |
| LYS 69 | b1b2.4 | TYR 12 | - | CationPi |
| LYS 69 | b1b2.4 | TYR 12 | - | Hydrophobic |
| LYS 69 | b1b2.4 | TYR 12 | - | VdWContact |
| ILE 70 | b1b2.6 | ILE 6 | - | Hydrophobic |
| ILE 70 | b1b2.6 | ILE 6 | - | VdWContact |
| ILE 70 | b1b2.6 | THR 8 | - | Hydrophobic |
| ILE 70 | b1b2.6 | THR 8 | - | VdWContact |
| ILE 70 | b1b2.6 | TYR 12 | - | VdWContact |
