Predicted complex interactions
CXCL6_HUMAN + CXCR4
SUMMARY
- Chemokine
- CXCL6_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR4 View partner entry
- Partner description
- UniProt: P61073; Gene: cxcr4_human; Family: Chemokine
- Interactions detected
- 102
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| GLY 1 | NTc.Cm48 | TRP 94 | 2.60x60 | VdWContact |
| GLY 1 | NTc.Cm48 | HIS 113 | 3.29x29 | HBDonor |
| GLY 1 | NTc.Cm48 | HIS 113 | 3.29x29 | VdWContact |
| GLY 1 | NTc.Cm48 | TYR 116 | 3.32x32 | CationPi |
| PRO 2 | NTc.Cm47 | TYR 45 | 1.39x39 | VdWContact |
| PRO 2 | NTc.Cm47 | TRP 94 | 2.60x60 | Hydrophobic |
| PRO 2 | NTc.Cm47 | TRP 94 | 2.60x60 | VdWContact |
| PRO 2 | NTc.Cm47 | GLU 288 | 7.39x38 | VdWContact |
| VAL 3 | NTc.Cm46 | GLU 288 | 7.39x38 | HBDonor |
| VAL 3 | NTc.Cm46 | GLU 288 | 7.39x38 | VdWContact |
| SER 4 | NTc.Cm45 | ILE 284 | 7.35x34 | VdWContact |
| SER 4 | NTc.Cm45 | SER 285 | 7.36x35 | HBDonor |
| SER 4 | NTc.Cm45 | SER 285 | 7.36x35 | VdWContact |
| ALA 5 | NTc.Cm44 | LEU 41 | 1.35x35 | Hydrophobic |
| ALA 5 | NTc.Cm44 | LEU 41 | 1.35x35 | VdWContact |
| VAL 6 | NTc.Cm43 | ILE 185 | - | Hydrophobic |
| VAL 6 | NTc.Cm43 | ASP 187 | 45.51x51 | Hydrophobic |
| LEU 7 | NTc.Cm42 | ALA 34 | 1.28x28 | Hydrophobic |
| LEU 7 | NTc.Cm42 | ALA 34 | 1.28x28 | VdWContact |
| LEU 7 | NTc.Cm42 | LYS 38 | 1.32x32 | Hydrophobic |
| LEU 7 | NTc.Cm42 | LYS 38 | 1.32x32 | VdWContact |
| LEU 7 | NTc.Cm42 | ARG 183 | - | VdWContact |
| GLU 9 | NTc.Cm40 | ARG 30 | 1.24x24 | Anionic |
| GLU 9 | NTc.Cm40 | ARG 30 | 1.24x24 | VdWContact |
| GLU 9 | NTc.Cm40 | ASN 33 | 1.27x27 | HBAcceptor |
| GLU 9 | NTc.Cm40 | ASN 33 | 1.27x27 | VdWContact |
| GLU 9 | NTc.Cm40 | HIS 281 | 7.32x31 | Hydrophobic |
| GLU 9 | NTc.Cm40 | HIS 281 | 7.32x31 | VdWContact |
| LEU 10 | NTc.Cm39 | ILE 185 | - | Hydrophobic |
| LEU 10 | NTc.Cm39 | ASP 187 | 45.51x51 | Hydrophobic |
| LEU 10 | NTc.Cm39 | PHE 189 | - | Hydrophobic |
| ARG 11 | NTc.Cm38 | ARG 30 | 1.24x24 | VdWContact |
| ARG 11 | NTc.Cm38 | ASP 262 | 6.58x58 | Cationic |
| ARG 11 | NTc.Cm38 | ASP 262 | 6.58x58 | HBDonor |
| ARG 11 | NTc.Cm38 | ASP 262 | 6.58x58 | VdWContact |
| ARG 11 | NTc.Cm38 | LEU 266 | 6.62x62 | VdWContact |
| ARG 11 | NTc.Cm38 | HIS 281 | 7.32x31 | Hydrophobic |
| CYS 12 | NTc.Cm37 | ARG 30 | 1.24x24 | HBAcceptor |
| CYS 12 | NTc.Cm37 | ARG 30 | 1.24x24 | VdWContact |
| THR 13 | NTc.Cm36 | PRO 27 | - | Hydrophobic |
| THR 13 | NTc.Cm36 | PRO 27 | - | VdWContact |
| THR 13 | NTc.Cm36 | CYS 28 | - | HBAcceptor |
| THR 13 | NTc.Cm36 | CYS 28 | - | VdWContact |
| THR 13 | NTc.Cm36 | PHE 29 | - | Hydrophobic |
| LEU 15 | NTc.Cm34 | CYS 28 | - | Hydrophobic |
| LEU 15 | NTc.Cm34 | ARG 30 | 1.24x24 | VdWContact |
| LEU 15 | NTc.Cm34 | CYS 274 | 7.25x24 | Hydrophobic |
| LEU 15 | NTc.Cm34 | GLU 277 | 7.28x27 | VdWContact |
| ARG 16 | NTc.Cm33 | LYS 25 | - | Hydrophobic |
| ARG 16 | NTc.Cm33 | LYS 271 | - | VdWContact |
| THR 18 | NTc.Cm31 | MET 24 | - | Hydrophobic |
| THR 18 | NTc.Cm31 | MET 24 | - | VdWContact |
| VAL 21 | NTc.Cm28 | MET 24 | - | Hydrophobic |
| PRO 23 | NTc.Cm26 | TYR 12 | - | Hydrophobic |
| PRO 23 | NTc.Cm26 | MET 16 | - | Hydrophobic |
| PRO 23 | NTc.Cm26 | MET 16 | - | VdWContact |
| LYS 24 | NTc.Cm25 | TYR 12 | - | VdWContact |
| LYS 24 | NTc.Cm25 | THR 13 | - | HBDonor |
| LYS 24 | NTc.Cm25 | THR 13 | - | VdWContact |
| ILE 26 | NTc.Cm23 | THR 8 | - | Hydrophobic |
| GLY 27 | NTc.Cm22 | TYR 7 | - | VdWContact |
| LYS 28 | NTc.Cm21 | SER 5 | - | VdWContact |
| LYS 28 | NTc.Cm21 | ILE 6 | - | VdWContact |
| LYS 28 | NTc.Cm21 | TYR 7 | - | Hydrophobic |
| LEU 29 | NTc.Cm20 | SER 5 | - | VdWContact |
| LEU 29 | NTc.Cm20 | ILE 6 | - | HBAcceptor |
| LEU 29 | NTc.Cm20 | ILE 6 | - | HBDonor |
| LEU 29 | NTc.Cm20 | ILE 6 | - | Hydrophobic |
| LEU 29 | NTc.Cm20 | ILE 6 | - | VdWContact |
| GLN 30 | NTc.Cm19 | ILE 4 | - | VdWContact |
| VAL 31 | NTc.Cm18 | GLY 3 | - | VdWContact |
| VAL 31 | NTc.Cm18 | ILE 4 | - | HBAcceptor |
| VAL 31 | NTc.Cm18 | ILE 4 | - | HBDonor |
| VAL 31 | NTc.Cm18 | ILE 4 | - | VdWContact |
| PHE 32 | NTc.Cm17 | MET 1 | - | Hydrophobic |
| PHE 32 | NTc.Cm17 | MET 1 | - | VdWContact |
| PRO 33 | NTc.Cm16 | MET 1 | - | Hydrophobic |
| PRO 36 | NTc.Cm13 | SER 178 | - | VdWContact |
| PRO 36 | NTc.Cm13 | PHE 189 | - | Hydrophobic |
| PRO 36 | NTc.Cm13 | PHE 189 | - | VdWContact |
| VAL 44 | NTc.Cm5 | PRO 27 | - | Hydrophobic |
| VAL 44 | NTc.Cm5 | PHE 29 | - | Hydrophobic |
| LEU 47 | NTc.Cm2 | MET 24 | - | Hydrophobic |
| LYS 48 | NTc.Cm1 | ASP 10 | - | Cationic |
| LYS 48 | NTc.Cm1 | ASP 10 | - | HBDonor |
| LYS 48 | NTc.Cm1 | ASP 10 | - | VdWContact |
| GLN 52 | cxb1.1 | GLU 26 | - | VdWContact |
| GLN 52 | cxb1.1 | PRO 27 | - | Hydrophobic |
| GLN 52 | cxb1.1 | PRO 27 | - | VdWContact |
| VAL 53 | cxb1.2 | MET 24 | - | Hydrophobic |
| VAL 53 | cxb1.2 | MET 24 | - | VdWContact |
| PHE 61 | cxb1.16 | MET 16 | - | Hydrophobic |
| LYS 64 | B1.3 | GLU 14 | - | Cationic |
| VAL 65 | B1.4 | ILE 6 | - | Hydrophobic |
| VAL 65 | B1.4 | THR 8 | - | Hydrophobic |
| VAL 65 | B1.4 | TYR 12 | - | Hydrophobic |
| VAL 65 | B1.4 | TYR 12 | - | VdWContact |
| ILE 66 | B1.5 | ILE 6 | - | Hydrophobic |
| LYS 68 | B1.7 | TYR 12 | - | Hydrophobic |
| LYS 68 | B1.7 | TYR 12 | - | VdWContact |
| ILE 69 | b1b2.4 | ILE 6 | - | Hydrophobic |
| ILE 69 | b1b2.4 | ILE 6 | - | VdWContact |
