Predicted complex interactions
CXCL7_HUMAN + CXCR4
SUMMARY
- Chemokine
- CXCL7_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR4 View partner entry
- Partner description
- UniProt: P61073; Gene: cxcr4_human; Family: Chemokine
- Interactions detected
- 182
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| SER 1 | NTc.Cm62 | TYR 45 | 1.39x39 | VdWContact |
| SER 1 | NTc.Cm62 | TRP 94 | 2.60x60 | VdWContact |
| SER 1 | NTc.Cm62 | GLU 288 | 7.39x38 | Cationic |
| SER 1 | NTc.Cm62 | GLU 288 | 7.39x38 | HBDonor |
| SER 1 | NTc.Cm62 | GLU 288 | 7.39x38 | VdWContact |
| SER 1 | NTc.Cm62 | PHE 292 | 7.43x42 | VdWContact |
| SER 2 | NTc.Cm61 | TYR 116 | 3.32x32 | HBDonor |
| SER 2 | NTc.Cm61 | TYR 116 | 3.32x32 | VdWContact |
| SER 2 | NTc.Cm61 | TYR 255 | 6.51x51 | HBAcceptor |
| SER 2 | NTc.Cm61 | TYR 255 | 6.51x51 | VdWContact |
| SER 2 | NTc.Cm61 | GLU 288 | 7.39x38 | VdWContact |
| THR 3 | NTc.Cm60 | ILE 284 | 7.35x34 | Hydrophobic |
| THR 3 | NTc.Cm60 | ILE 284 | 7.35x34 | VdWContact |
| THR 3 | NTc.Cm60 | SER 285 | 7.36x35 | VdWContact |
| THR 3 | NTc.Cm60 | GLU 288 | 7.39x38 | HBDonor |
| THR 3 | NTc.Cm60 | GLU 288 | 7.39x38 | Hydrophobic |
| THR 3 | NTc.Cm60 | GLU 288 | 7.39x38 | VdWContact |
| LYS 4 | NTc.Cm59 | TRP 94 | 2.60x60 | Hydrophobic |
| LYS 4 | NTc.Cm59 | TRP 94 | 2.60x60 | VdWContact |
| LYS 4 | NTc.Cm59 | ASP 97 | 2.63x63 | Cationic |
| LYS 4 | NTc.Cm59 | ASP 97 | 2.63x63 | HBDonor |
| LYS 4 | NTc.Cm59 | ASP 97 | 2.63x63 | VdWContact |
| LYS 4 | NTc.Cm59 | HIS 113 | 3.29x29 | Hydrophobic |
| LYS 4 | NTc.Cm59 | HIS 113 | 3.29x29 | VdWContact |
| LYS 4 | NTc.Cm59 | CYS 186 | 45.50x50 | Cationic |
| LYS 4 | NTc.Cm59 | CYS 186 | 45.50x50 | HBDonor |
| LYS 4 | NTc.Cm59 | CYS 186 | 45.50x50 | VdWContact |
| LYS 4 | NTc.Cm59 | ASP 187 | 45.51x51 | Hydrophobic |
| LYS 4 | NTc.Cm59 | ASP 187 | 45.51x51 | VdWContact |
| LYS 4 | NTc.Cm59 | ARG 188 | 45.52x52 | HBAcceptor |
| LYS 4 | NTc.Cm59 | ARG 188 | 45.52x52 | VdWContact |
| GLY 5 | NTc.Cm58 | GLN 200 | 5.39x40 | HBAcceptor |
| GLY 5 | NTc.Cm58 | GLN 200 | 5.39x40 | VdWContact |
| GLN 6 | NTc.Cm57 | ASP 187 | 45.51x51 | HBDonor |
| GLN 6 | NTc.Cm57 | ASP 187 | 45.51x51 | Hydrophobic |
| GLN 6 | NTc.Cm57 | ASP 187 | 45.51x51 | VdWContact |
| GLN 6 | NTc.Cm57 | ARG 188 | 45.52x52 | VdWContact |
| GLN 6 | NTc.Cm57 | PHE 189 | - | VdWContact |
| GLN 6 | NTc.Cm57 | VAL 196 | 5.35x36 | VdWContact |
| THR 7 | NTc.Cm56 | ASP 193 | 5.32x33 | Hydrophobic |
| THR 7 | NTc.Cm56 | ASP 193 | 5.32x33 | VdWContact |
| THR 7 | NTc.Cm56 | VAL 196 | 5.35x36 | Hydrophobic |
| THR 7 | NTc.Cm56 | VAL 196 | 5.35x36 | VdWContact |
| THR 7 | NTc.Cm56 | VAL 197 | 5.36x37 | Hydrophobic |
| THR 7 | NTc.Cm56 | LEU 266 | 6.62x62 | Hydrophobic |
| THR 7 | NTc.Cm56 | LEU 266 | 6.62x62 | VdWContact |
| LYS 8 | NTc.Cm55 | PHE 189 | - | VdWContact |
| LYS 8 | NTc.Cm55 | TYR 190 | - | VdWContact |
| LYS 8 | NTc.Cm55 | PRO 191 | - | VdWContact |
| LYS 8 | NTc.Cm55 | ASN 192 | - | VdWContact |
| LYS 8 | NTc.Cm55 | ASP 193 | 5.32x33 | VdWContact |
| ARG 9 | NTc.Cm54 | ASN 192 | - | VdWContact |
| ARG 9 | NTc.Cm54 | ASP 193 | 5.32x33 | Cationic |
| ARG 9 | NTc.Cm54 | ASP 193 | 5.32x33 | HBDonor |
| ARG 9 | NTc.Cm54 | ASP 193 | 5.32x33 | Hydrophobic |
| ARG 9 | NTc.Cm54 | ASP 193 | 5.32x33 | VdWContact |
| ARG 9 | NTc.Cm54 | LEU 266 | 6.62x62 | HBDonor |
| ARG 9 | NTc.Cm54 | LEU 266 | 6.62x62 | VdWContact |
| ARG 9 | NTc.Cm54 | GLU 268 | 6.64x64 | Cationic |
| ARG 9 | NTc.Cm54 | GLU 268 | 6.64x64 | HBDonor |
| ARG 9 | NTc.Cm54 | GLU 268 | 6.64x64 | VdWContact |
| ASN 10 | NTc.Cm53 | ASN 192 | - | VdWContact |
| LEU 27 | NTc.Cm36 | TYR 12 | - | Hydrophobic |
| LEU 27 | NTc.Cm36 | TYR 12 | - | VdWContact |
| ARG 28 | NTc.Cm35 | TYR 12 | - | VdWContact |
| ARG 28 | NTc.Cm35 | GLU 14 | - | Cationic |
| CYS 29 | NTc.Cm34 | MET 16 | - | Hydrophobic |
| CYS 29 | NTc.Cm34 | MET 16 | - | VdWContact |
| THR 34 | NTc.Cm29 | MET 24 | - | VdWContact |
| THR 35 | NTc.Cm28 | PRO 27 | - | VdWContact |
| SER 36 | NTc.Cm27 | LYS 25 | - | HBDonor |
| SER 36 | NTc.Cm27 | LYS 25 | - | VdWContact |
| SER 36 | NTc.Cm27 | GLU 26 | - | VdWContact |
| SER 36 | NTc.Cm27 | PRO 27 | - | VdWContact |
| HIS 39 | NTc.Cm24 | ARG 30 | 1.24x24 | Hydrophobic |
| HIS 39 | NTc.Cm24 | ARG 30 | 1.24x24 | PiCation |
| HIS 39 | NTc.Cm24 | ARG 30 | 1.24x24 | VdWContact |
| HIS 39 | NTc.Cm24 | HIS 281 | 7.32x31 | Hydrophobic |
| HIS 39 | NTc.Cm24 | HIS 281 | 7.32x31 | VdWContact |
| PRO 40 | NTc.Cm23 | CYS 28 | - | VdWContact |
| PRO 40 | NTc.Cm23 | PHE 29 | - | Hydrophobic |
| PRO 40 | NTc.Cm23 | PHE 29 | - | VdWContact |
| PRO 40 | NTc.Cm23 | ARG 30 | 1.24x24 | Hydrophobic |
| PRO 40 | NTc.Cm23 | ARG 30 | 1.24x24 | VdWContact |
| ILE 43 | NTc.Cm20 | PHE 29 | - | Hydrophobic |
| ILE 43 | NTc.Cm20 | ALA 180 | - | VdWContact |
| GLN 44 | NTc.Cm19 | SER 178 | - | HBAcceptor |
| GLN 44 | NTc.Cm19 | SER 178 | - | VdWContact |
| GLN 44 | NTc.Cm19 | GLU 179 | - | VdWContact |
| GLN 44 | NTc.Cm19 | ALA 180 | - | VdWContact |
| LEU 46 | NTc.Cm17 | ILE 4 | - | Hydrophobic |
| LEU 46 | NTc.Cm17 | ILE 4 | - | VdWContact |
| LEU 46 | NTc.Cm17 | PHE 29 | - | Hydrophobic |
| LEU 46 | NTc.Cm17 | PHE 29 | - | VdWContact |
| GLU 47 | NTc.Cm16 | TYR 7 | - | Hydrophobic |
| GLU 47 | NTc.Cm16 | TYR 7 | - | VdWContact |
| VAL 48 | NTc.Cm15 | ILE 6 | - | Hydrophobic |
| VAL 48 | NTc.Cm15 | ILE 6 | - | VdWContact |
| VAL 48 | NTc.Cm15 | TYR 7 | - | HBAcceptor |
| VAL 48 | NTc.Cm15 | TYR 7 | - | VdWContact |
| ILE 49 | NTc.Cm14 | TYR 7 | - | VdWContact |
| ILE 49 | NTc.Cm14 | SER 9 | - | VdWContact |
| GLY 50 | NTc.Cm13 | THR 8 | - | VdWContact |
| GLY 50 | NTc.Cm13 | SER 9 | - | VdWContact |
| GLY 52 | NTc.Cm11 | ASP 10 | - | VdWContact |
| GLY 52 | NTc.Cm11 | TYR 12 | - | HBAcceptor |
| GLY 52 | NTc.Cm11 | TYR 12 | - | HBDonor |
| GLY 52 | NTc.Cm11 | TYR 12 | - | VdWContact |
| GLY 52 | NTc.Cm11 | THR 13 | - | VdWContact |
| THR 53 | NTc.Cm10 | ASP 10 | - | HBDonor |
| THR 53 | NTc.Cm10 | ASP 10 | - | VdWContact |
| THR 53 | NTc.Cm10 | ASN 11 | - | VdWContact |
| THR 53 | NTc.Cm10 | TYR 12 | - | VdWContact |
| THR 53 | NTc.Cm10 | THR 13 | - | VdWContact |
| HIS 54 | NTc.Cm9 | ASN 11 | - | HBDonor |
| HIS 54 | NTc.Cm9 | ASN 11 | - | Hydrophobic |
| HIS 54 | NTc.Cm9 | ASN 11 | - | VdWContact |
| HIS 54 | NTc.Cm9 | TYR 12 | - | HBDonor |
| HIS 54 | NTc.Cm9 | TYR 12 | - | Hydrophobic |
| HIS 54 | NTc.Cm9 | TYR 12 | - | VdWContact |
| HIS 54 | NTc.Cm9 | THR 13 | - | HBAcceptor |
| HIS 54 | NTc.Cm9 | THR 13 | - | VdWContact |
| HIS 54 | NTc.Cm9 | GLU 14 | - | VdWContact |
| CYS 55 | NTc.Cm8 | TYR 12 | - | Hydrophobic |
| CYS 55 | NTc.Cm8 | TYR 12 | - | VdWContact |
| CYS 55 | NTc.Cm8 | THR 13 | - | HBDonor |
| CYS 55 | NTc.Cm8 | THR 13 | - | VdWContact |
| CYS 55 | NTc.Cm8 | GLU 14 | - | HBAcceptor |
| CYS 55 | NTc.Cm8 | GLU 14 | - | VdWContact |
| ASN 56 | NTc.Cm7 | TYR 12 | - | VdWContact |
| ASN 56 | NTc.Cm7 | THR 13 | - | VdWContact |
| ASN 56 | NTc.Cm7 | GLU 14 | - | HBDonor |
| ASN 56 | NTc.Cm7 | GLU 14 | - | VdWContact |
| GLN 57 | NTc.Cm6 | MET 16 | - | Hydrophobic |
| LYS 65 | CX.5 | SER 178 | - | VdWContact |
| LYS 65 | CX.5 | ILE 185 | - | Hydrophobic |
| LYS 65 | CX.5 | ILE 185 | - | VdWContact |
| LYS 65 | CX.5 | ASP 187 | 45.51x51 | Hydrophobic |
| LYS 65 | CX.5 | PHE 189 | - | Hydrophobic |
| LYS 65 | CX.5 | PHE 189 | - | VdWContact |
| ASP 66 | cxb1.1 | PHE 189 | - | Hydrophobic |
| ASP 66 | cxb1.1 | PHE 189 | - | VdWContact |
| ARG 68 | cxb1.5 | PRO 191 | - | VdWContact |
| LEU 72 | cxb1.11 | PRO 27 | - | Hydrophobic |
| ASP 73 | cxb1.14 | MET 24 | - | Hydrophobic |
| ASP 73 | cxb1.14 | MET 24 | - | VdWContact |
| ASP 73 | cxb1.14 | PRO 27 | - | Hydrophobic |
| ALA 76 | B1.1 | GLU 26 | - | Hydrophobic |
| ALA 76 | B1.1 | GLU 26 | - | VdWContact |
| ALA 76 | B1.1 | PRO 27 | - | VdWContact |
| PRO 77 | B1.2 | GLU 26 | - | VdWContact |
| ARG 78 | B1.3 | PRO 27 | - | VdWContact |
| ARG 78 | B1.3 | CYS 28 | - | Cationic |
| ARG 78 | B1.3 | CYS 28 | - | VdWContact |
| ARG 78 | B1.3 | PHE 29 | - | HBDonor |
| ARG 78 | B1.3 | PHE 29 | - | Hydrophobic |
| ARG 78 | B1.3 | PHE 29 | - | VdWContact |
| ARG 78 | B1.3 | CYS 274 | 7.25x24 | Cationic |
| ARG 78 | B1.3 | CYS 274 | 7.25x24 | HBDonor |
| ARG 78 | B1.3 | CYS 274 | 7.25x24 | VdWContact |
| ARG 78 | B1.3 | ASN 278 | 7.29x28 | HBDonor |
| ARG 78 | B1.3 | ASN 278 | 7.29x28 | VdWContact |
| ILE 79 | B1.4 | PRO 27 | - | Hydrophobic |
| ILE 79 | B1.4 | PRO 27 | - | VdWContact |
| ILE 79 | B1.4 | PHE 29 | - | Hydrophobic |
| ILE 79 | B1.4 | PHE 29 | - | VdWContact |
| ILE 82 | B1.7 | ILE 4 | - | Hydrophobic |
| ILE 82 | B1.7 | ILE 4 | - | VdWContact |
| ILE 82 | B1.7 | PHE 29 | - | Hydrophobic |
| ILE 82 | B1.7 | PHE 29 | - | VdWContact |
| LYS 86 | b1b2.8 | ILE 4 | - | HBDonor |
| LYS 86 | b1b2.8 | ILE 4 | - | Hydrophobic |
| LYS 86 | b1b2.8 | ILE 4 | - | VdWContact |
| LYS 86 | b1b2.8 | SER 5 | - | VdWContact |
| LYS 86 | b1b2.8 | ILE 6 | - | HBDonor |
| LYS 86 | b1b2.8 | ILE 6 | - | Hydrophobic |
| LYS 86 | b1b2.8 | ILE 6 | - | VdWContact |
| LEU 87 | b1b2.9 | ILE 6 | - | Hydrophobic |
| LEU 87 | b1b2.9 | THR 8 | - | Hydrophobic |
| ASP 90 | b1b2.13 | ILE 6 | - | VdWContact |
| ASP 90 | b1b2.13 | THR 8 | - | Hydrophobic |
| ASP 90 | b1b2.13 | THR 8 | - | VdWContact |
