Predicted complex interactions
CXCL8_HUMAN + CXCR4
SUMMARY
- Chemokine
- CXCL8_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR4 View partner entry
- Partner description
- UniProt: P61073; Gene: cxcr4_human; Family: Chemokine
- Interactions detected
- 86
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| ARG 7 | NTc.Cm27 | GLU 2 | - | Cationic |
| ARG 7 | NTc.Cm27 | GLU 2 | - | HBDonor |
| ARG 7 | NTc.Cm27 | GLU 2 | - | VdWContact |
| ARG 13 | NTc.Cm21 | ASP 182 | - | Cationic |
| ILE 17 | NTc.Cm17 | GLU 179 | - | Hydrophobic |
| ILE 17 | NTc.Cm17 | GLU 179 | - | VdWContact |
| ILE 17 | NTc.Cm17 | ALA 180 | - | VdWContact |
| ILE 17 | NTc.Cm17 | ASP 181 | - | VdWContact |
| ILE 17 | NTc.Cm17 | ASP 182 | - | Hydrophobic |
| ILE 17 | NTc.Cm17 | ASP 182 | - | VdWContact |
| LYS 18 | NTc.Cm16 | ALA 180 | - | Hydrophobic |
| LYS 18 | NTc.Cm16 | ALA 180 | - | VdWContact |
| LYS 18 | NTc.Cm16 | ASP 181 | - | Cationic |
| LYS 18 | NTc.Cm16 | ASP 181 | - | VdWContact |
| TYR 20 | NTc.Cm14 | CYS 28 | - | HBAcceptor |
| TYR 20 | NTc.Cm14 | CYS 28 | - | VdWContact |
| LYS 22 | NTc.Cm12 | GLU 277 | 7.28x27 | Cationic |
| LYS 22 | NTc.Cm12 | GLU 277 | 7.28x27 | HBDonor |
| LYS 22 | NTc.Cm12 | GLU 277 | 7.28x27 | VdWContact |
| PRO 23 | NTc.Cm11 | MET 24 | - | Hydrophobic |
| PHE 24 | NTc.Cm10 | MET 24 | - | VdWContact |
| PHE 24 | NTc.Cm10 | LYS 25 | - | VdWContact |
| PHE 24 | NTc.Cm10 | PRO 27 | - | Hydrophobic |
| PHE 24 | NTc.Cm10 | PRO 27 | - | VdWContact |
| HIS 25 | NTc.Cm9 | TYR 21 | - | Hydrophobic |
| HIS 25 | NTc.Cm9 | TYR 21 | - | VdWContact |
| HIS 25 | NTc.Cm9 | MET 24 | - | Hydrophobic |
| HIS 25 | NTc.Cm9 | MET 24 | - | VdWContact |
| HIS 25 | NTc.Cm9 | LYS 25 | - | HBDonor |
| HIS 25 | NTc.Cm9 | LYS 25 | - | VdWContact |
| PRO 26 | NTc.Cm8 | MET 16 | - | Hydrophobic |
| PRO 26 | NTc.Cm8 | TYR 21 | - | Hydrophobic |
| PRO 26 | NTc.Cm8 | TYR 21 | - | VdWContact |
| PHE 28 | NTc.Cm6 | LYS 25 | - | VdWContact |
| PHE 28 | NTc.Cm6 | GLU 26 | - | Hydrophobic |
| PHE 28 | NTc.Cm6 | GLU 26 | - | VdWContact |
| PHE 28 | NTc.Cm6 | PRO 27 | - | Hydrophobic |
| PHE 28 | NTc.Cm6 | PRO 27 | - | VdWContact |
| LYS 30 | NTc.Cm4 | THR 8 | - | HBAcceptor |
| LYS 30 | NTc.Cm4 | THR 8 | - | VdWContact |
| GLU 31 | NTc.Cm3 | ILE 6 | - | VdWContact |
| GLU 31 | NTc.Cm3 | TYR 7 | - | HBAcceptor |
| GLU 31 | NTc.Cm3 | TYR 7 | - | Hydrophobic |
| GLU 31 | NTc.Cm3 | TYR 7 | - | VdWContact |
| LEU 32 | NTc.Cm2 | ILE 6 | - | HBAcceptor |
| LEU 32 | NTc.Cm2 | ILE 6 | - | HBDonor |
| LEU 32 | NTc.Cm2 | ILE 6 | - | Hydrophobic |
| LEU 32 | NTc.Cm2 | ILE 6 | - | VdWContact |
| ARG 33 | NTc.Cm1 | ILE 4 | - | VdWContact |
| VAL 34 | CX.1 | GLY 3 | - | VdWContact |
| VAL 34 | CX.1 | ILE 4 | - | HBAcceptor |
| VAL 34 | CX.1 | ILE 4 | - | HBDonor |
| VAL 34 | CX.1 | ILE 4 | - | VdWContact |
| HIS 40 | cxb1.6 | MET 1 | - | Hydrophobic |
| LEU 50 | B1.3 | PRO 27 | - | Hydrophobic |
| LEU 50 | B1.3 | PRO 27 | - | VdWContact |
| LEU 50 | B1.3 | PHE 29 | - | Hydrophobic |
| LEU 50 | B1.3 | PHE 29 | - | VdWContact |
| ARG 54 | B1.7 | PHE 29 | - | CationPi |
| ARG 54 | B1.7 | PHE 29 | - | Hydrophobic |
| ARG 54 | B1.7 | PHE 29 | - | VdWContact |
| LEU 56 | b1b2.6 | PRO 27 | - | Hydrophobic |
| LEU 56 | b1b2.6 | PHE 29 | - | Hydrophobic |
| LEU 56 | b1b2.6 | PHE 29 | - | VdWContact |
| TRP 64 | b1b2.16 | MET 24 | - | Hydrophobic |
| ARG 67 | B2.3 | ASP 20 | - | Cationic |
| ARG 67 | B2.3 | TYR 21 | - | Hydrophobic |
| ARG 67 | B2.3 | TYR 21 | - | VdWContact |
| VAL 68 | B2.4 | TYR 21 | - | Hydrophobic |
| LYS 71 | b2b3.2 | TYR 21 | - | Hydrophobic |
| LYS 71 | b2b3.2 | TYR 21 | - | VdWContact |
| PHE 72 | b2b3.4 | ILE 6 | - | Hydrophobic |
| PHE 72 | b2b3.4 | ILE 6 | - | VdWContact |
| PHE 72 | b2b3.4 | THR 8 | - | Hydrophobic |
| PHE 72 | b2b3.4 | THR 8 | - | VdWContact |
| PHE 72 | b2b3.4 | MET 16 | - | Hydrophobic |
| LEU 73 | b2b3.11 | ILE 6 | - | Hydrophobic |
| LEU 73 | b2b3.11 | ILE 6 | - | VdWContact |
| ARG 75 | B3.1 | TYR 12 | - | CationPi |
| ARG 75 | B3.1 | TYR 12 | - | HBDonor |
| ARG 75 | B3.1 | TYR 12 | - | Hydrophobic |
| ARG 75 | B3.1 | TYR 12 | - | VdWContact |
| ARG 75 | B3.1 | MET 16 | - | VdWContact |
| ALA 76 | B3.2 | ILE 6 | - | Hydrophobic |
| ALA 76 | B3.2 | ILE 6 | - | VdWContact |
| SER 79 | b3h.1 | TYR 12 | - | VdWContact |
