Predicted complex interactions
XCL2_HUMAN + CXCR4
SUMMARY
- Chemokine
- XCL2_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR4 View partner entry
- Partner description
- UniProt: P61073; Gene: cxcr4_human; Family: Chemokine
- Interactions detected
- 84
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| VAL 1 | NTc.Cm30 | TRP 94 | 2.60x60 | Hydrophobic |
| VAL 1 | NTc.Cm30 | TRP 94 | 2.60x60 | VdWContact |
| VAL 1 | NTc.Cm30 | GLU 288 | 7.39x38 | Cationic |
| VAL 1 | NTc.Cm30 | GLU 288 | 7.39x38 | VdWContact |
| VAL 1 | NTc.Cm30 | PHE 292 | 7.43x42 | Hydrophobic |
| GLY 2 | NTc.Cm29 | GLU 288 | 7.39x38 | HBDonor |
| GLY 2 | NTc.Cm29 | GLU 288 | 7.39x38 | VdWContact |
| GLU 4 | NTc.Cm27 | ASP 187 | 45.51x51 | Hydrophobic |
| GLU 4 | NTc.Cm27 | ASP 187 | 45.51x51 | VdWContact |
| GLU 4 | NTc.Cm27 | ARG 188 | 45.52x52 | Anionic |
| GLU 4 | NTc.Cm27 | ARG 188 | 45.52x52 | HBAcceptor |
| GLU 4 | NTc.Cm27 | ARG 188 | 45.52x52 | VdWContact |
| VAL 5 | NTc.Cm26 | ARG 30 | 1.24x24 | HBAcceptor |
| VAL 5 | NTc.Cm26 | ARG 30 | 1.24x24 | VdWContact |
| VAL 5 | NTc.Cm26 | HIS 281 | 7.32x31 | Hydrophobic |
| VAL 5 | NTc.Cm26 | HIS 281 | 7.32x31 | VdWContact |
| VAL 5 | NTc.Cm26 | ILE 284 | 7.35x34 | Hydrophobic |
| HIS 7 | NTc.Cm24 | ILE 185 | - | Hydrophobic |
| HIS 7 | NTc.Cm24 | ILE 185 | - | VdWContact |
| ARG 8 | NTc.Cm23 | ARG 30 | 1.24x24 | VdWContact |
| ARG 8 | NTc.Cm23 | VAL 196 | 5.35x36 | VdWContact |
| ARG 8 | NTc.Cm23 | ASP 262 | 6.58x58 | Cationic |
| ARG 9 | NTc.Cm22 | ARG 30 | 1.24x24 | HBDonor |
| ARG 9 | NTc.Cm22 | ARG 30 | 1.24x24 | Hydrophobic |
| ARG 9 | NTc.Cm22 | ARG 30 | 1.24x24 | VdWContact |
| ARG 9 | NTc.Cm22 | GLU 31 | 1.25x25 | Cationic |
| ARG 9 | NTc.Cm22 | GLU 31 | 1.25x25 | VdWContact |
| ARG 9 | NTc.Cm22 | ALA 34 | 1.28x28 | VdWContact |
| THR 10 | NTc.Cm21 | PRO 27 | - | VdWContact |
| THR 15 | NTc.Cm16 | MET 24 | - | Hydrophobic |
| GLN 17 | NTc.Cm14 | MET 24 | - | Hydrophobic |
| GLN 17 | NTc.Cm14 | MET 24 | - | VdWContact |
| ARG 18 | NTc.Cm13 | TYR 21 | - | VdWContact |
| ARG 18 | NTc.Cm13 | MET 24 | - | VdWContact |
| LEU 19 | NTc.Cm12 | MET 24 | - | Hydrophobic |
| LEU 19 | NTc.Cm12 | MET 24 | - | VdWContact |
| PRO 20 | NTc.Cm11 | MET 16 | - | Hydrophobic |
| PRO 20 | NTc.Cm11 | TYR 21 | - | Hydrophobic |
| PRO 20 | NTc.Cm11 | TYR 21 | - | VdWContact |
| ARG 23 | NTc.Cm8 | SER 18 | - | VdWContact |
| ARG 23 | NTc.Cm8 | TYR 21 | - | VdWContact |
| ARG 23 | NTc.Cm8 | ASP 22 | - | Cationic |
| LYS 25 | NTc.Cm6 | TYR 7 | - | VdWContact |
| LYS 25 | NTc.Cm6 | SER 9 | - | HBAcceptor |
| LYS 25 | NTc.Cm6 | SER 9 | - | VdWContact |
| THR 26 | NTc.Cm5 | ILE 6 | - | Hydrophobic |
| THR 28 | NTc.Cm3 | ILE 4 | - | Hydrophobic |
| THR 30 | NTc.Cm1 | ASP 181 | - | VdWContact |
| GLU 31 | CX.4 | ASP 181 | - | HBAcceptor |
| GLU 31 | CX.4 | ASP 181 | - | VdWContact |
| GLY 32 | CX.5 | ALA 180 | - | VdWContact |
| SER 33 | cxb1.1 | SER 178 | - | VdWContact |
| SER 33 | cxb1.1 | GLU 179 | - | HBDonor |
| SER 33 | cxb1.1 | GLU 179 | - | VdWContact |
| ILE 38 | cxb1.8 | PHE 29 | - | Hydrophobic |
| ILE 38 | cxb1.8 | PHE 29 | - | VdWContact |
| LYS 42 | cxb1.15 | ASP 10 | - | HBDonor |
| LYS 42 | cxb1.15 | ASP 10 | - | VdWContact |
| ARG 43 | cxb1.16 | ASP 22 | - | Cationic |
| ARG 43 | cxb1.16 | ASP 22 | - | HBDonor |
| ARG 43 | cxb1.16 | ASP 22 | - | VdWContact |
| LEU 45 | B1.2 | MET 24 | - | VdWContact |
| LEU 45 | B1.2 | GLU 26 | - | Hydrophobic |
| LEU 45 | B1.2 | GLU 26 | - | VdWContact |
| LYS 46 | B1.3 | GLU 26 | - | VdWContact |
| LYS 46 | B1.3 | PRO 27 | - | VdWContact |
| LYS 46 | B1.3 | PHE 29 | - | CationPi |
| LYS 46 | B1.3 | PHE 29 | - | Hydrophobic |
| LYS 46 | B1.3 | PHE 29 | - | VdWContact |
| LYS 46 | B1.3 | GLU 31 | 1.25x25 | Cationic |
| VAL 47 | B1.4 | PRO 27 | - | VdWContact |
| CYS 48 | B1.5 | PRO 27 | - | Hydrophobic |
| CYS 48 | B1.5 | PRO 27 | - | VdWContact |
| MET 63 | b2b3.2 | SER 9 | - | VdWContact |
| LYS 66 | b2b3.12 | SER 9 | - | HBDonor |
| LYS 66 | b2b3.12 | SER 9 | - | VdWContact |
| LYS 66 | b2b3.12 | TYR 12 | - | Hydrophobic |
| LYS 66 | b2b3.12 | TYR 12 | - | VdWContact |
| SER 67 | B3.1 | TYR 7 | - | VdWContact |
| ARG 70 | B3.4 | THR 8 | - | HBDonor |
| ARG 70 | B3.4 | THR 8 | - | VdWContact |
| ARG 70 | B3.4 | ASP 10 | - | Cationic |
| ARG 70 | B3.4 | ASP 10 | - | HBDonor |
| ARG 70 | B3.4 | ASP 10 | - | VdWContact |
