Predicted complex interactions
CXCL12_HUMAN + CXCR5
SUMMARY
- Chemokine
- CXCL12_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR5 View partner entry
- Partner description
- UniProt: P32302; Gene: cxcr5_human; Family: Chemokine
- Interactions detected
- 115
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| LYS 1 | NTc.Cm29 | GLU 110 | 2.63x63 | Cationic |
| LYS 1 | NTc.Cm29 | GLU 110 | 2.63x63 | HBDonor |
| LYS 1 | NTc.Cm29 | GLU 110 | 2.63x63 | VdWContact |
| LYS 1 | NTc.Cm29 | ILE 126 | 3.29x29 | Hydrophobic |
| LYS 1 | NTc.Cm29 | ILE 126 | 3.29x29 | VdWContact |
| LYS 1 | NTc.Cm29 | CYS 202 | 45.50x50 | Cationic |
| LYS 1 | NTc.Cm29 | CYS 202 | 45.50x50 | HBDonor |
| LYS 1 | NTc.Cm29 | CYS 202 | 45.50x50 | VdWContact |
| LYS 1 | NTc.Cm29 | GLU 308 | 7.39x38 | Cationic |
| LYS 1 | NTc.Cm29 | GLU 308 | 7.39x38 | HBDonor |
| LYS 1 | NTc.Cm29 | GLU 308 | 7.39x38 | VdWContact |
| PRO 2 | NTc.Cm28 | TYR 58 | 1.39x39 | Hydrophobic |
| PRO 2 | NTc.Cm28 | TYR 58 | 1.39x39 | VdWContact |
| PRO 2 | NTc.Cm28 | ALA 107 | 2.60x60 | Hydrophobic |
| PRO 2 | NTc.Cm28 | ALA 107 | 2.60x60 | VdWContact |
| PRO 2 | NTc.Cm28 | GLU 308 | 7.39x38 | VdWContact |
| PRO 2 | NTc.Cm28 | LEU 312 | 7.43x42 | Hydrophobic |
| VAL 3 | NTc.Cm27 | VAL 54 | 1.35x35 | Hydrophobic |
| VAL 3 | NTc.Cm27 | VAL 54 | 1.35x35 | VdWContact |
| VAL 3 | NTc.Cm27 | TYR 58 | 1.39x39 | Hydrophobic |
| VAL 3 | NTc.Cm27 | TYR 58 | 1.39x39 | VdWContact |
| VAL 3 | NTc.Cm27 | ALA 107 | 2.60x60 | Hydrophobic |
| VAL 3 | NTc.Cm27 | ALA 107 | 2.60x60 | VdWContact |
| LEU 5 | NTc.Cm25 | LYS 50 | 1.31x31 | Hydrophobic |
| LEU 5 | NTc.Cm25 | ARG 201 | - | HBAcceptor |
| LEU 5 | NTc.Cm25 | ARG 201 | - | VdWContact |
| SER 6 | NTc.Cm24 | PRO 301 | 7.32x31 | VdWContact |
| TYR 7 | NTc.Cm23 | THR 41 | - | Hydrophobic |
| TYR 7 | NTc.Cm23 | ARG 201 | - | VdWContact |
| ARG 8 | NTc.Cm22 | ASP 282 | 6.58x58 | Cationic |
| ARG 8 | NTc.Cm22 | ASP 282 | 6.58x58 | HBDonor |
| ARG 8 | NTc.Cm22 | ASP 282 | 6.58x58 | VdWContact |
| ARG 8 | NTc.Cm22 | LEU 300 | 7.31x30 | VdWContact |
| ARG 8 | NTc.Cm22 | PRO 301 | 7.32x31 | Hydrophobic |
| ARG 8 | NTc.Cm22 | PRO 301 | 7.32x31 | VdWContact |
| PRO 10 | NTc.Cm20 | LEU 37 | - | Hydrophobic |
| PRO 10 | NTc.Cm20 | CYS 38 | - | HBAcceptor |
| PRO 10 | NTc.Cm20 | CYS 38 | - | VdWContact |
| PRO 10 | NTc.Cm20 | ALA 40 | - | Hydrophobic |
| PRO 10 | NTc.Cm20 | ALA 40 | - | VdWContact |
| ARG 12 | NTc.Cm18 | ASN 297 | 7.28x27 | HBDonor |
| ARG 12 | NTc.Cm18 | ASN 297 | 7.28x27 | VdWContact |
| PHE 13 | NTc.Cm17 | LYS 288 | 6.64x64 | Hydrophobic |
| PHE 13 | NTc.Cm17 | LYS 288 | 6.64x64 | VdWContact |
| PHE 13 | NTc.Cm17 | ASN 292 | - | Hydrophobic |
| PHE 13 | NTc.Cm17 | ASN 292 | - | VdWContact |
| LYS 24 | NTc.Cm6 | ASP 29 | - | Cationic |
| LYS 24 | NTc.Cm6 | ASP 29 | - | HBDonor |
| LYS 24 | NTc.Cm6 | ASP 29 | - | VdWContact |
| LEU 26 | NTc.Cm4 | LEU 21 | - | Hydrophobic |
| LYS 27 | NTc.Cm3 | ASP 25 | - | Cationic |
| LYS 27 | NTc.Cm3 | ASP 25 | - | HBDonor |
| LYS 27 | NTc.Cm3 | ASP 25 | - | VdWContact |
| ILE 28 | NTc.Cm2 | LEU 17 | - | Hydrophobic |
| ILE 28 | NTc.Cm2 | PHE 18 | - | Hydrophobic |
| ILE 28 | NTc.Cm2 | PHE 18 | - | VdWContact |
| ILE 28 | NTc.Cm2 | LEU 21 | - | Hydrophobic |
| ILE 28 | NTc.Cm2 | LEU 21 | - | VdWContact |
| LEU 29 | NTc.Cm1 | LEU 37 | - | Hydrophobic |
| LEU 29 | NTc.Cm1 | LEU 37 | - | VdWContact |
| ASN 30 | CX.1 | PHE 18 | - | Hydrophobic |
| ASN 30 | CX.1 | PHE 18 | - | VdWContact |
| ASN 30 | CX.1 | ASN 196 | - | HBAcceptor |
| ASN 30 | CX.1 | ASN 196 | - | Hydrophobic |
| ASN 30 | CX.1 | ASN 196 | - | VdWContact |
| THR 31 | CX.4 | ALA 40 | - | Hydrophobic |
| THR 31 | CX.4 | ALA 40 | - | VdWContact |
| PRO 32 | CX.5 | ASN 196 | - | VdWContact |
| ASN 33 | cxb1.1 | SER 198 | - | HBDonor |
| ASN 33 | cxb1.1 | SER 198 | - | VdWContact |
| ASN 33 | cxb1.1 | ARG 201 | - | HBAcceptor |
| ASN 33 | cxb1.1 | ARG 201 | - | VdWContact |
| CYS 34 | cxb1.2 | ASN 196 | - | HBAcceptor |
| CYS 34 | cxb1.2 | ASN 196 | - | VdWContact |
| LEU 36 | cxb1.6 | LEU 14 | - | Hydrophobic |
| LEU 36 | cxb1.6 | LEU 14 | - | VdWContact |
| LEU 36 | cxb1.6 | PHE 18 | - | Hydrophobic |
| VAL 39 | cxb1.11 | LEU 37 | - | Hydrophobic |
| VAL 39 | cxb1.11 | LEU 37 | - | VdWContact |
| ARG 41 | cxb1.15 | ASP 29 | - | Cationic |
| ARG 41 | cxb1.15 | ASP 29 | - | HBDonor |
| ARG 41 | cxb1.15 | ASP 29 | - | VdWContact |
| ASN 46 | B1.4 | ASP 29 | - | HBDonor |
| ASN 46 | B1.4 | ASP 29 | - | VdWContact |
| ASN 46 | B1.4 | SER 31 | - | HBDonor |
| ASN 46 | B1.4 | SER 31 | - | VdWContact |
| ASN 46 | B1.4 | VAL 33 | - | Hydrophobic |
| ASN 46 | B1.4 | VAL 33 | - | VdWContact |
| ARG 47 | B1.5 | VAL 33 | - | VdWContact |
| ARG 47 | B1.5 | GLU 34 | - | Cationic |
| ARG 47 | B1.5 | GLU 34 | - | HBDonor |
| ARG 47 | B1.5 | GLU 34 | - | Hydrophobic |
| ARG 47 | B1.5 | GLU 34 | - | VdWContact |
| GLN 48 | B1.6 | VAL 33 | - | Hydrophobic |
| GLN 48 | B1.6 | VAL 33 | - | VdWContact |
| GLN 48 | B1.6 | ASN 35 | - | VdWContact |
| GLN 48 | B1.6 | HIS 36 | - | HBAcceptor |
| GLN 48 | B1.6 | HIS 36 | - | VdWContact |
| LYS 54 | b1b2.10 | LEU 5 | - | VdWContact |
| GLN 59 | B2.2 | LEU 7 | - | Hydrophobic |
| GLN 59 | B2.2 | LEU 7 | - | VdWContact |
| TYR 61 | B2.4 | LEU 24 | - | Hydrophobic |
| LEU 62 | B2.5 | LEU 17 | - | Hydrophobic |
| LEU 62 | B2.5 | LEU 17 | - | VdWContact |
| ALA 65 | b2b3.3 | LEU 17 | - | Hydrophobic |
| ALA 65 | b2b3.3 | GLU 20 | - | VdWContact |
| LEU 66 | b2b3.4 | MET 9 | - | Hydrophobic |
| LEU 66 | b2b3.4 | ASN 13 | - | Hydrophobic |
| LEU 66 | b2b3.4 | ASN 13 | - | VdWContact |
| LEU 66 | b2b3.4 | LEU 17 | - | Hydrophobic |
| ARG 69 | B3.1 | ASP 16 | - | Cationic |
| ARG 69 | B3.1 | ASP 16 | - | HBDonor |
| ARG 69 | B3.1 | ASP 16 | - | VdWContact |
| ARG 69 | B3.1 | TRP 19 | - | VdWContact |
| ARG 69 | B3.1 | GLU 20 | - | VdWContact |
