Predicted complex interactions
CXCL2_HUMAN + CXCR5
SUMMARY
- Chemokine
- CXCL2_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR5 View partner entry
- Partner description
- UniProt: P32302; Gene: cxcr5_human; Family: Chemokine
- Interactions detected
- 127
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| ALA 1 | NTc.Cm42 | ALA 107 | 2.60x60 | Hydrophobic |
| PRO 2 | NTc.Cm41 | GLU 308 | 7.39x38 | VdWContact |
| LEU 3 | NTc.Cm40 | VAL 54 | 1.35x35 | Hydrophobic |
| LEU 3 | NTc.Cm40 | VAL 54 | 1.35x35 | VdWContact |
| LEU 3 | NTc.Cm40 | TYR 58 | 1.39x39 | Hydrophobic |
| LEU 3 | NTc.Cm40 | TYR 58 | 1.39x39 | VdWContact |
| LEU 3 | NTc.Cm40 | ALA 107 | 2.60x60 | Hydrophobic |
| LEU 3 | NTc.Cm40 | ALA 107 | 2.60x60 | VdWContact |
| LEU 3 | NTc.Cm40 | THR 305 | 7.36x35 | Hydrophobic |
| ALA 4 | NTc.Cm39 | THR 203 | 45.51x51 | Hydrophobic |
| THR 5 | NTc.Cm38 | GLU 42 | - | VdWContact |
| THR 5 | NTc.Cm38 | ARG 201 | - | HBAcceptor |
| THR 5 | NTc.Cm38 | ARG 201 | - | VdWContact |
| GLU 6 | NTc.Cm37 | ARG 219 | 5.39x40 | Anionic |
| GLU 6 | NTc.Cm37 | ARG 219 | 5.39x40 | VdWContact |
| GLU 6 | NTc.Cm37 | ARG 286 | 6.62x62 | Anionic |
| GLU 6 | NTc.Cm37 | ARG 286 | 6.62x62 | HBAcceptor |
| GLU 6 | NTc.Cm37 | ARG 286 | 6.62x62 | VdWContact |
| ARG 8 | NTc.Cm35 | ASP 282 | 6.58x58 | Cationic |
| ARG 8 | NTc.Cm35 | ASP 282 | 6.58x58 | VdWContact |
| ARG 8 | NTc.Cm35 | ASN 297 | 7.28x27 | HBDonor |
| ARG 8 | NTc.Cm35 | ASN 297 | 7.28x27 | VdWContact |
| ARG 8 | NTc.Cm35 | LEU 300 | 7.31x30 | VdWContact |
| ARG 8 | NTc.Cm35 | PRO 301 | 7.32x31 | VdWContact |
| CYS 9 | NTc.Cm34 | ASN 297 | 7.28x27 | HBAcceptor |
| CYS 9 | NTc.Cm34 | ASN 297 | 7.28x27 | VdWContact |
| GLN 10 | NTc.Cm33 | LEU 37 | - | Hydrophobic |
| GLN 10 | NTc.Cm33 | CYS 38 | - | HBAcceptor |
| GLN 10 | NTc.Cm33 | CYS 38 | - | HBDonor |
| GLN 10 | NTc.Cm33 | CYS 38 | - | VdWContact |
| GLN 10 | NTc.Cm33 | ALA 40 | - | Hydrophobic |
| GLN 10 | NTc.Cm33 | ALA 40 | - | VdWContact |
| LEU 12 | NTc.Cm31 | CYS 38 | - | VdWContact |
| LEU 12 | NTc.Cm31 | ASN 292 | - | Hydrophobic |
| LEU 12 | NTc.Cm31 | ASN 292 | - | VdWContact |
| LEU 12 | NTc.Cm31 | ASN 297 | 7.28x27 | Hydrophobic |
| GLN 13 | NTc.Cm30 | HIS 36 | - | Hydrophobic |
| GLN 13 | NTc.Cm30 | HIS 36 | - | VdWContact |
| LEU 15 | NTc.Cm28 | VAL 33 | - | Hydrophobic |
| GLN 16 | NTc.Cm27 | TYR 27 | - | Hydrophobic |
| GLN 16 | NTc.Cm27 | TYR 27 | - | VdWContact |
| GLY 17 | NTc.Cm26 | TYR 27 | - | VdWContact |
| ILE 18 | NTc.Cm25 | VAL 33 | - | Hydrophobic |
| HIS 19 | NTc.Cm24 | PHE 18 | - | Hydrophobic |
| HIS 19 | NTc.Cm24 | PHE 18 | - | VdWContact |
| LEU 20 | NTc.Cm23 | LEU 11 | - | Hydrophobic |
| LEU 20 | NTc.Cm23 | LEU 11 | - | VdWContact |
| LEU 20 | NTc.Cm23 | PHE 18 | - | Hydrophobic |
| LEU 20 | NTc.Cm23 | PHE 18 | - | VdWContact |
| LEU 20 | NTc.Cm23 | LEU 21 | - | Hydrophobic |
| LEU 20 | NTc.Cm23 | LEU 21 | - | VdWContact |
| LYS 21 | NTc.Cm22 | PHE 18 | - | Hydrophobic |
| LYS 21 | NTc.Cm22 | PHE 18 | - | VdWContact |
| LYS 21 | NTc.Cm22 | ASP 22 | - | Cationic |
| ILE 23 | NTc.Cm20 | LEU 11 | - | Hydrophobic |
| ILE 23 | NTc.Cm20 | LEU 11 | - | VdWContact |
| GLN 24 | NTc.Cm19 | LEU 11 | - | HBAcceptor |
| GLN 24 | NTc.Cm19 | LEU 11 | - | VdWContact |
| SER 25 | NTc.Cm18 | ASP 10 | - | VdWContact |
| VAL 26 | NTc.Cm17 | GLU 8 | - | VdWContact |
| VAL 26 | NTc.Cm17 | MET 9 | - | HBAcceptor |
| VAL 26 | NTc.Cm17 | MET 9 | - | HBDonor |
| VAL 26 | NTc.Cm17 | MET 9 | - | VdWContact |
| VAL 26 | NTc.Cm17 | LEU 14 | - | Hydrophobic |
| LYS 27 | NTc.Cm16 | LEU 7 | - | VdWContact |
| LYS 27 | NTc.Cm16 | GLU 8 | - | Cationic |
| LYS 27 | NTc.Cm16 | GLU 8 | - | HBDonor |
| LYS 27 | NTc.Cm16 | GLU 8 | - | Hydrophobic |
| LYS 27 | NTc.Cm16 | GLU 8 | - | VdWContact |
| LYS 27 | NTc.Cm16 | HIS 195 | - | VdWContact |
| VAL 28 | NTc.Cm15 | THR 6 | - | VdWContact |
| VAL 28 | NTc.Cm15 | LEU 7 | - | HBAcceptor |
| VAL 28 | NTc.Cm15 | LEU 7 | - | HBDonor |
| VAL 28 | NTc.Cm15 | LEU 7 | - | Hydrophobic |
| VAL 28 | NTc.Cm15 | LEU 7 | - | VdWContact |
| LYS 29 | NTc.Cm14 | THR 6 | - | Hydrophobic |
| LYS 29 | NTc.Cm14 | THR 6 | - | VdWContact |
| SER 30 | NTc.Cm13 | LEU 5 | - | HBDonor |
| SER 30 | NTc.Cm13 | LEU 5 | - | VdWContact |
| GLY 32 | NTc.Cm11 | GLN 206 | - | VdWContact |
| PRO 33 | NTc.Cm10 | SER 191 | - | VdWContact |
| PRO 33 | NTc.Cm10 | GLN 206 | - | VdWContact |
| PRO 33 | NTc.Cm10 | GLU 207 | - | Hydrophobic |
| HIS 34 | NTc.Cm9 | THR 203 | 45.51x51 | Hydrophobic |
| HIS 34 | NTc.Cm9 | THR 203 | 45.51x51 | VdWContact |
| HIS 34 | NTc.Cm9 | ARG 286 | 6.62x62 | HBAcceptor |
| HIS 34 | NTc.Cm9 | ARG 286 | 6.62x62 | VdWContact |
| ALA 36 | NTc.Cm7 | THR 212 | - | Hydrophobic |
| GLN 37 | NTc.Cm6 | LYS 288 | 6.64x64 | HBAcceptor |
| GLN 37 | NTc.Cm6 | LYS 288 | 6.64x64 | VdWContact |
| ILE 41 | NTc.Cm2 | LEU 37 | - | Hydrophobic |
| ILE 41 | NTc.Cm2 | LEU 37 | - | VdWContact |
| LEU 44 | CX.4 | VAL 33 | - | Hydrophobic |
| LYS 49 | cxb1.6 | ASN 35 | - | HBDonor |
| LYS 49 | cxb1.6 | ASN 35 | - | VdWContact |
| LYS 49 | cxb1.6 | LEU 37 | - | Hydrophobic |
| ALA 50 | cxb1.8 | VAL 33 | - | Hydrophobic |
| ALA 50 | cxb1.8 | VAL 33 | - | VdWContact |
| CYS 51 | cxb1.10 | LEU 37 | - | VdWContact |
| MET 58 | B1.3 | LEU 21 | - | Hydrophobic |
| MET 58 | B1.3 | LEU 21 | - | VdWContact |
| MET 58 | B1.3 | TYR 27 | - | Hydrophobic |
| LYS 61 | B1.6 | LEU 17 | - | Hydrophobic |
| LYS 61 | B1.6 | GLU 20 | - | Cationic |
| LYS 61 | B1.6 | LEU 21 | - | Hydrophobic |
| LYS 61 | B1.6 | LEU 24 | - | Hydrophobic |
| LYS 61 | B1.6 | LEU 24 | - | VdWContact |
| ILE 62 | B1.7 | MET 9 | - | Hydrophobic |
| ILE 62 | B1.7 | LEU 14 | - | Hydrophobic |
| ILE 62 | B1.7 | LEU 17 | - | Hydrophobic |
| ILE 62 | B1.7 | LEU 21 | - | Hydrophobic |
| ILE 63 | b1b2.4 | TYR 3 | - | Hydrophobic |
| LYS 65 | b1b2.7 | ASN 13 | - | VdWContact |
| LYS 65 | b1b2.7 | LEU 14 | - | Hydrophobic |
| LYS 65 | b1b2.7 | LEU 14 | - | VdWContact |
| LYS 65 | b1b2.7 | ASP 16 | - | Cationic |
| LYS 65 | b1b2.7 | ASP 16 | - | HBDonor |
| LYS 65 | b1b2.7 | ASP 16 | - | VdWContact |
| LYS 65 | b1b2.7 | LEU 17 | - | HBDonor |
| LYS 65 | b1b2.7 | LEU 17 | - | Hydrophobic |
| LYS 65 | b1b2.7 | LEU 17 | - | VdWContact |
| MET 66 | b1b2.8 | LEU 7 | - | Hydrophobic |
| MET 66 | b1b2.8 | MET 9 | - | Hydrophobic |
| MET 66 | b1b2.8 | MET 9 | - | VdWContact |
| LEU 67 | b1b2.9 | TYR 3 | - | Hydrophobic |
| LEU 67 | b1b2.9 | TYR 3 | - | VdWContact |
| LEU 67 | b1b2.9 | LEU 7 | - | Hydrophobic |
