Predicted complex interactions
CXCL8_HUMAN + CXCR5
SUMMARY
- Chemokine
- CXCL8_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR5 View partner entry
- Partner description
- UniProt: P32302; Gene: cxcr5_human; Family: Chemokine
- Interactions detected
- 140
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| ALA 3 | NTc.Cm31 | ALA 47 | - | VdWContact |
| ALA 3 | NTc.Cm31 | ALA 51 | 1.32x32 | Hydrophobic |
| VAL 4 | NTc.Cm30 | GLY 111 | 2.64x64 | VdWContact |
| VAL 4 | NTc.Cm30 | LEU 199 | - | Hydrophobic |
| VAL 4 | NTc.Cm30 | LEU 199 | - | VdWContact |
| LEU 5 | NTc.Cm29 | GLU 42 | - | VdWContact |
| LEU 5 | NTc.Cm29 | MET 46 | - | VdWContact |
| LEU 5 | NTc.Cm29 | ALA 47 | - | Hydrophobic |
| LEU 5 | NTc.Cm29 | ALA 47 | - | VdWContact |
| LEU 5 | NTc.Cm29 | LYS 50 | 1.31x31 | Hydrophobic |
| LEU 5 | NTc.Cm29 | LYS 50 | 1.31x31 | VdWContact |
| LEU 5 | NTc.Cm29 | ALA 51 | 1.32x32 | Hydrophobic |
| LEU 5 | NTc.Cm29 | ALA 51 | 1.32x32 | VdWContact |
| PRO 6 | NTc.Cm28 | VAL 54 | 1.35x35 | Hydrophobic |
| PRO 6 | NTc.Cm28 | VAL 54 | 1.35x35 | VdWContact |
| PRO 6 | NTc.Cm28 | ALA 107 | 2.60x60 | VdWContact |
| PRO 6 | NTc.Cm28 | GLY 111 | 2.64x64 | VdWContact |
| ARG 7 | NTc.Cm27 | ARG 201 | - | Hydrophobic |
| ARG 7 | NTc.Cm27 | ARG 201 | - | VdWContact |
| SER 8 | NTc.Cm26 | LYS 50 | 1.31x31 | HBAcceptor |
| SER 8 | NTc.Cm26 | LYS 50 | 1.31x31 | VdWContact |
| SER 8 | NTc.Cm26 | THR 305 | 7.36x35 | VdWContact |
| ALA 9 | NTc.Cm25 | THR 203 | 45.51x51 | Hydrophobic |
| ALA 9 | NTc.Cm25 | THR 203 | 45.51x51 | VdWContact |
| LYS 10 | NTc.Cm24 | GLU 42 | - | Cationic |
| LYS 10 | NTc.Cm24 | GLU 42 | - | VdWContact |
| LYS 10 | NTc.Cm24 | ARG 201 | - | HBAcceptor |
| LYS 10 | NTc.Cm24 | ARG 201 | - | VdWContact |
| GLU 11 | NTc.Cm23 | GLN 206 | - | HBAcceptor |
| GLU 11 | NTc.Cm23 | TRP 215 | 5.35x36 | HBAcceptor |
| GLU 11 | NTc.Cm23 | TRP 215 | 5.35x36 | VdWContact |
| GLU 11 | NTc.Cm23 | ARG 219 | 5.39x40 | Anionic |
| GLU 11 | NTc.Cm23 | ARG 286 | 6.62x62 | Anionic |
| GLU 11 | NTc.Cm23 | ARG 286 | 6.62x62 | VdWContact |
| LEU 12 | NTc.Cm22 | ARG 286 | 6.62x62 | HBAcceptor |
| LEU 12 | NTc.Cm22 | ARG 286 | 6.62x62 | VdWContact |
| ARG 13 | NTc.Cm21 | ASP 282 | 6.58x58 | Cationic |
| ARG 13 | NTc.Cm21 | ASP 282 | 6.58x58 | HBDonor |
| ARG 13 | NTc.Cm21 | ASP 282 | 6.58x58 | VdWContact |
| ARG 13 | NTc.Cm21 | ASN 297 | 7.28x27 | VdWContact |
| ARG 13 | NTc.Cm21 | LEU 300 | 7.31x30 | VdWContact |
| ARG 13 | NTc.Cm21 | PRO 301 | 7.32x31 | VdWContact |
| CYS 14 | NTc.Cm20 | LYS 288 | 6.64x64 | Anionic |
| CYS 14 | NTc.Cm20 | LYS 288 | 6.64x64 | VdWContact |
| CYS 14 | NTc.Cm20 | ASN 297 | 7.28x27 | VdWContact |
| GLN 15 | NTc.Cm19 | LEU 37 | - | Hydrophobic |
| GLN 15 | NTc.Cm19 | LEU 37 | - | VdWContact |
| GLN 15 | NTc.Cm19 | CYS 38 | - | HBAcceptor |
| GLN 15 | NTc.Cm19 | CYS 38 | - | VdWContact |
| ILE 17 | NTc.Cm17 | CYS 38 | - | VdWContact |
| ILE 17 | NTc.Cm17 | ASN 292 | - | Hydrophobic |
| ILE 17 | NTc.Cm17 | ASN 292 | - | VdWContact |
| ILE 17 | NTc.Cm17 | THR 293 | 7.24x23 | VdWContact |
| ILE 17 | NTc.Cm17 | CYS 294 | 7.25x24 | VdWContact |
| ILE 17 | NTc.Cm17 | ASN 297 | 7.28x27 | VdWContact |
| LYS 18 | NTc.Cm16 | HIS 36 | - | Hydrophobic |
| LYS 18 | NTc.Cm16 | HIS 36 | - | VdWContact |
| TYR 20 | NTc.Cm14 | VAL 33 | - | Hydrophobic |
| TYR 20 | NTc.Cm14 | VAL 33 | - | VdWContact |
| PRO 23 | NTc.Cm11 | LEU 24 | - | Hydrophobic |
| PRO 23 | NTc.Cm11 | LEU 24 | - | VdWContact |
| PRO 23 | NTc.Cm11 | TYR 27 | - | VdWContact |
| PHE 24 | NTc.Cm10 | THR 30 | - | Hydrophobic |
| HIS 25 | NTc.Cm9 | PHE 18 | - | Hydrophobic |
| HIS 25 | NTc.Cm9 | PHE 18 | - | VdWContact |
| PRO 26 | NTc.Cm8 | LEU 14 | - | Hydrophobic |
| PRO 26 | NTc.Cm8 | LEU 17 | - | Hydrophobic |
| PRO 26 | NTc.Cm8 | LEU 21 | - | Hydrophobic |
| LYS 27 | NTc.Cm7 | LEU 11 | - | Hydrophobic |
| LYS 27 | NTc.Cm7 | LEU 11 | - | VdWContact |
| LYS 27 | NTc.Cm7 | PHE 18 | - | Hydrophobic |
| LYS 27 | NTc.Cm7 | PHE 18 | - | VdWContact |
| LYS 27 | NTc.Cm7 | ASN 28 | - | HBDonor |
| LYS 27 | NTc.Cm7 | ASN 28 | - | VdWContact |
| PHE 28 | NTc.Cm6 | THR 30 | - | Hydrophobic |
| ILE 29 | NTc.Cm5 | MET 9 | - | Hydrophobic |
| ILE 29 | NTc.Cm5 | MET 9 | - | VdWContact |
| ILE 29 | NTc.Cm5 | LEU 11 | - | VdWContact |
| LYS 30 | NTc.Cm4 | MET 9 | - | HBAcceptor |
| LYS 30 | NTc.Cm4 | MET 9 | - | VdWContact |
| GLU 31 | NTc.Cm3 | GLU 8 | - | Hydrophobic |
| LEU 32 | NTc.Cm2 | THR 6 | - | VdWContact |
| LEU 32 | NTc.Cm2 | LEU 7 | - | HBAcceptor |
| LEU 32 | NTc.Cm2 | LEU 7 | - | HBDonor |
| LEU 32 | NTc.Cm2 | LEU 7 | - | VdWContact |
| ARG 33 | NTc.Cm1 | PRO 4 | - | Hydrophobic |
| ARG 33 | NTc.Cm1 | LEU 5 | - | VdWContact |
| ARG 33 | NTc.Cm1 | THR 6 | - | Hydrophobic |
| ARG 33 | NTc.Cm1 | THR 6 | - | VdWContact |
| ARG 33 | NTc.Cm1 | HIS 195 | - | CationPi |
| ARG 33 | NTc.Cm1 | HIS 195 | - | HBDonor |
| ARG 33 | NTc.Cm1 | HIS 195 | - | VdWContact |
| VAL 34 | CX.1 | PRO 4 | - | VdWContact |
| VAL 34 | CX.1 | LEU 5 | - | HBAcceptor |
| VAL 34 | CX.1 | LEU 5 | - | HBDonor |
| VAL 34 | CX.1 | LEU 5 | - | VdWContact |
| ILE 35 | CX.4 | PRO 4 | - | Hydrophobic |
| ILE 35 | CX.4 | PRO 4 | - | VdWContact |
| GLU 36 | CX.5 | ASN 2 | - | HBAcceptor |
| GLU 36 | CX.5 | ASN 2 | - | VdWContact |
| GLY 38 | cxb1.2 | THR 212 | - | VdWContact |
| PRO 39 | cxb1.5 | GLN 206 | - | Hydrophobic |
| PRO 39 | cxb1.5 | GLN 206 | - | VdWContact |
| PRO 39 | cxb1.5 | THR 212 | - | Hydrophobic |
| PRO 39 | cxb1.5 | THR 212 | - | VdWContact |
| PRO 39 | cxb1.5 | TRP 215 | 5.35x36 | Hydrophobic |
| PRO 39 | cxb1.5 | TRP 215 | 5.35x36 | VdWContact |
| PRO 39 | cxb1.5 | ARG 286 | 6.62x62 | HBAcceptor |
| PRO 39 | cxb1.5 | ARG 286 | 6.62x62 | VdWContact |
| HIS 40 | cxb1.6 | GLN 206 | - | VdWContact |
| HIS 40 | cxb1.6 | ARG 286 | 6.62x62 | VdWContact |
| CYS 41 | cxb1.7 | LYS 288 | 6.64x64 | Anionic |
| ALA 42 | cxb1.8 | ARG 286 | 6.62x62 | HBDonor |
| ALA 42 | cxb1.8 | ARG 286 | 6.62x62 | VdWContact |
| ASN 43 | cxb1.10 | LYS 288 | 6.64x64 | VdWContact |
| ILE 47 | cxb1.16 | LEU 37 | - | Hydrophobic |
| LEU 50 | B1.3 | THR 30 | - | Hydrophobic |
| ARG 54 | B1.7 | THR 30 | - | HBDonor |
| ARG 54 | B1.7 | THR 30 | - | VdWContact |
| ARG 54 | B1.7 | SER 31 | - | HBDonor |
| GLU 55 | b1b2.4 | LEU 37 | - | Hydrophobic |
| LEU 56 | b1b2.6 | VAL 33 | - | Hydrophobic |
| LEU 56 | b1b2.6 | VAL 33 | - | VdWContact |
| TRP 64 | b1b2.16 | LEU 21 | - | Hydrophobic |
| ARG 67 | B2.3 | GLU 20 | - | Cationic |
| ARG 67 | B2.3 | GLU 20 | - | VdWContact |
| VAL 68 | B2.4 | LEU 17 | - | Hydrophobic |
| LYS 71 | b2b3.2 | ASP 16 | - | VdWContact |
| LYS 71 | b2b3.2 | LEU 17 | - | Hydrophobic |
| LYS 71 | b2b3.2 | LEU 17 | - | VdWContact |
| PHE 72 | b2b3.4 | LEU 7 | - | Hydrophobic |
| PHE 72 | b2b3.4 | LEU 7 | - | VdWContact |
| PHE 72 | b2b3.4 | MET 9 | - | Hydrophobic |
| PHE 72 | b2b3.4 | MET 9 | - | VdWContact |
| LEU 73 | b2b3.11 | LEU 5 | - | Hydrophobic |
| LEU 73 | b2b3.11 | LEU 7 | - | Hydrophobic |
| ARG 75 | B3.1 | ASP 10 | - | HBDonor |
| ARG 75 | B3.1 | ASP 10 | - | VdWContact |
| ALA 76 | B3.2 | LEU 7 | - | Hydrophobic |
| ALA 76 | B3.2 | LEU 7 | - | VdWContact |
