Predicted complex interactions
CXCL12_HUMAN + CXCR6
SUMMARY
- Chemokine
- CXCL12_HUMAN View chemokine entry
- Chemokine organism
- Homo sapiens
- Partner
- CXCR6 View partner entry
- Partner description
- UniProt: O00574; Gene: cxcr6_human; Family: Chemokine
- Interactions detected
- 101
3D VIEW
Model confidence legend
- Very high confidence (pLDDT > 90)
- High confidence (70 ≤ pLDDT < 90)
- Low confidence (50 ≤ pLDDT < 70)
- Very low confidence (pLDDT < 50)
RESIDUE CONTACTS
Residues are ordered by chemokine position and interaction type. Use the viewer controls to highlight contacting residues.
Download contacts (CSV)| Chemokine residue | CCN | Partner residue | GPCRdb generic | Interaction |
|---|---|---|---|---|
| LYS 1 | NTc.Cm29 | TRP 87 | 2.60x60 | Hydrophobic |
| LYS 1 | NTc.Cm29 | TRP 87 | 2.60x60 | VdWContact |
| LYS 1 | NTc.Cm29 | LEU 106 | 3.29x29 | Hydrophobic |
| LYS 1 | NTc.Cm29 | LEU 106 | 3.29x29 | VdWContact |
| LYS 1 | NTc.Cm29 | ILE 179 | - | VdWContact |
| LYS 1 | NTc.Cm29 | CYS 180 | 45.50x50 | HBDonor |
| LYS 1 | NTc.Cm29 | CYS 180 | 45.50x50 | VdWContact |
| LYS 1 | NTc.Cm29 | GLY 181 | 45.51x51 | VdWContact |
| PRO 2 | NTc.Cm28 | TYR 38 | 1.39x39 | Hydrophobic |
| PRO 2 | NTc.Cm28 | TYR 38 | 1.39x39 | VdWContact |
| PRO 2 | NTc.Cm28 | TRP 87 | 2.60x60 | Hydrophobic |
| PRO 2 | NTc.Cm28 | TRP 87 | 2.60x60 | VdWContact |
| PRO 2 | NTc.Cm28 | GLU 274 | 7.39x38 | VdWContact |
| VAL 3 | NTc.Cm27 | PHE 247 | 6.51x51 | Hydrophobic |
| VAL 3 | NTc.Cm27 | LYS 251 | 6.55x55 | Hydrophobic |
| VAL 3 | NTc.Cm27 | ARG 254 | 6.58x58 | VdWContact |
| VAL 3 | NTc.Cm27 | ILE 270 | 7.35x34 | Hydrophobic |
| VAL 3 | NTc.Cm27 | ILE 270 | 7.35x34 | VdWContact |
| VAL 3 | NTc.Cm27 | GLU 274 | 7.39x38 | HBDonor |
| VAL 3 | NTc.Cm27 | GLU 274 | 7.39x38 | VdWContact |
| SER 4 | NTc.Cm26 | LEU 34 | 1.35x35 | VdWContact |
| LEU 5 | NTc.Cm25 | LEU 34 | 1.35x35 | Hydrophobic |
| LEU 5 | NTc.Cm25 | TYR 38 | 1.39x39 | Hydrophobic |
| LEU 5 | NTc.Cm25 | GLY 91 | 2.64x64 | VdWContact |
| TYR 7 | NTc.Cm23 | HIS 23 | - | HBDonor |
| TYR 7 | NTc.Cm23 | HIS 23 | - | Hydrophobic |
| TYR 7 | NTc.Cm23 | HIS 23 | - | VdWContact |
| TYR 7 | NTc.Cm23 | LEU 27 | 1.28x28 | Hydrophobic |
| TYR 7 | NTc.Cm23 | LEU 27 | 1.28x28 | VdWContact |
| ARG 8 | NTc.Cm22 | PHE 173 | - | VdWContact |
| ARG 8 | NTc.Cm22 | LEU 175 | - | Hydrophobic |
| ARG 8 | NTc.Cm22 | GLY 181 | 45.51x51 | VdWContact |
| ARG 8 | NTc.Cm22 | TYR 182 | 45.52x52 | HBDonor |
| ARG 8 | NTc.Cm22 | TYR 182 | 45.52x52 | VdWContact |
| PRO 10 | NTc.Cm20 | TYR 261 | 7.26x25 | Hydrophobic |
| ARG 12 | NTc.Cm18 | PHE 173 | - | CationPi |
| ARG 12 | NTc.Cm18 | PHE 173 | - | VdWContact |
| ARG 12 | NTc.Cm18 | TYR 182 | 45.52x52 | HBDonor |
| ARG 12 | NTc.Cm18 | TYR 182 | 45.52x52 | VdWContact |
| ARG 12 | NTc.Cm18 | HIS 183 | - | Hydrophobic |
| ARG 12 | NTc.Cm18 | HIS 183 | - | VdWContact |
| ARG 12 | NTc.Cm18 | ASP 184 | 5.31x32 | Cationic |
| ARG 12 | NTc.Cm18 | ASP 184 | 5.31x32 | HBDonor |
| ARG 12 | NTc.Cm18 | ASP 184 | 5.31x32 | Hydrophobic |
| ARG 12 | NTc.Cm18 | ASP 184 | 5.31x32 | VdWContact |
| PHE 13 | NTc.Cm17 | HIS 183 | - | Hydrophobic |
| PHE 13 | NTc.Cm17 | HIS 183 | - | VdWContact |
| PHE 13 | NTc.Cm17 | ASP 184 | 5.31x32 | Hydrophobic |
| ARG 20 | NTc.Cm10 | TYR 10 | - | HBDonor |
| ARG 20 | NTc.Cm10 | TYR 10 | - | Hydrophobic |
| ARG 20 | NTc.Cm10 | TYR 10 | - | VdWContact |
| VAL 23 | NTc.Cm7 | TYR 10 | - | Hydrophobic |
| VAL 23 | NTc.Cm7 | TYR 10 | - | VdWContact |
| HIS 25 | NTc.Cm5 | GLY 11 | - | VdWContact |
| HIS 25 | NTc.Cm5 | SER 13 | - | HBAcceptor |
| HIS 25 | NTc.Cm5 | SER 13 | - | VdWContact |
| LEU 26 | NTc.Cm4 | TYR 10 | - | Hydrophobic |
| LEU 26 | NTc.Cm4 | TYR 10 | - | VdWContact |
| LYS 27 | NTc.Cm3 | PHE 15 | - | VdWContact |
| LYS 27 | NTc.Cm3 | TRP 258 | - | Hydrophobic |
| LYS 27 | NTc.Cm3 | TRP 258 | - | VdWContact |
| LYS 27 | NTc.Cm3 | GLU 259 | 7.24x23 | HBDonor |
| LYS 27 | NTc.Cm3 | GLU 259 | 7.24x23 | VdWContact |
| LYS 27 | NTc.Cm3 | ALA 262 | 7.27x26 | Hydrophobic |
| LYS 27 | NTc.Cm3 | ALA 262 | 7.27x26 | VdWContact |
| ILE 28 | NTc.Cm2 | PHE 12 | - | Hydrophobic |
| ILE 28 | NTc.Cm2 | PHE 12 | - | VdWContact |
| ILE 28 | NTc.Cm2 | PHE 15 | - | HBAcceptor |
| ILE 28 | NTc.Cm2 | PHE 15 | - | VdWContact |
| LEU 29 | NTc.Cm1 | PHE 15 | - | Hydrophobic |
| LEU 29 | NTc.Cm1 | PHE 15 | - | VdWContact |
| LEU 29 | NTc.Cm1 | TRP 258 | - | Hydrophobic |
| LEU 29 | NTc.Cm1 | TRP 258 | - | VdWContact |
| LEU 29 | NTc.Cm1 | ALA 262 | 7.27x26 | Hydrophobic |
| LEU 29 | NTc.Cm1 | ALA 262 | 7.27x26 | VdWContact |
| ASN 30 | CX.1 | GLN 20 | - | HBAcceptor |
| ASN 30 | CX.1 | GLN 20 | - | VdWContact |
| PRO 32 | CX.5 | HIS 23 | - | Hydrophobic |
| PRO 32 | CX.5 | GLN 24 | 1.25x25 | Hydrophobic |
| VAL 39 | cxb1.11 | TRP 258 | - | Hydrophobic |
| VAL 39 | cxb1.11 | TRP 258 | - | VdWContact |
| ARG 41 | cxb1.15 | GLU 259 | 7.24x23 | Cationic |
| ARG 41 | cxb1.15 | GLU 259 | 7.24x23 | HBDonor |
| ARG 41 | cxb1.15 | GLU 259 | 7.24x23 | VdWContact |
| LYS 43 | B1.1 | GLU 8 | - | Cationic |
| LYS 43 | B1.1 | GLU 8 | - | HBDonor |
| LYS 43 | B1.1 | GLU 8 | - | VdWContact |
| GLN 48 | B1.6 | TRP 258 | - | Hydrophobic |
| GLN 48 | B1.6 | TRP 258 | - | VdWContact |
| GLN 48 | B1.6 | GLU 259 | 7.24x23 | HBDonor |
| GLN 48 | B1.6 | GLU 259 | 7.24x23 | VdWContact |
| TYR 61 | B2.4 | TYR 10 | - | Hydrophobic |
| TYR 61 | B2.4 | TYR 10 | - | VdWContact |
| TYR 61 | B2.4 | PHE 12 | - | Hydrophobic |
| TYR 61 | B2.4 | PHE 12 | - | VdWContact |
| LYS 64 | b2b3.2 | HIS 7 | - | HBDonor |
| LYS 64 | b2b3.2 | HIS 7 | - | Hydrophobic |
| LYS 64 | b2b3.2 | HIS 7 | - | VdWContact |
| ALA 65 | b2b3.3 | PHE 12 | - | Hydrophobic |
| ALA 65 | b2b3.3 | PHE 12 | - | VdWContact |
| ARG 69 | B3.1 | ASN 16 | - | VdWContact |
