Interactions for 2K01 (chain A)
Structure details
- PDB ID: 2K01 open_in_new
- Protein: CXCL12_HUMAN
- Organism: Homo sapiens
- UniProt ID: P48061 open_in_new
- Method: Solution nmr
- Resolution: 0.0 Å
- Date: Oct. 28, 2008
- Reference: 10.1126/SCISIGNAL.1160755 open_in_new
- State: dimer
Chemokine diagram
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Interactions found in structure
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| Chemokine Residue | Generic number | Segment | Partner Residue | Partner | Interaction Type |
|---|---|---|---|---|---|
| Pro 2 | 56 | N-term | HIS 225 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Arg 20 | 80 | N-loop | ASN 230 | Stromal cell-derived factor 1 (C) | HBDonor |
| Arg 20 | 80 | N-loop | ASN 230 | Stromal cell-derived factor 1 (C) | VdWContact |
| Val 23 | 83 | B1 | ASN 230 | Stromal cell-derived factor 1 (C) | VdWContact |
| Lys 24 | 84 | B1 | ASN 230 | Stromal cell-derived factor 1 (C) | HBAcceptor |
| Lys 24 | 84 | B1 | ASN 230 | Stromal cell-derived factor 1 (C) | VdWContact |
| His 25 | 85 | B1 | LYS 227 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| His 25 | 85 | B1 | ILE 228 | Stromal cell-derived factor 1 (C) | VdWContact |
| His 25 | 85 | B1 | PRO 202 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| His 25 | 85 | B1 | PRO 202 | Stromal cell-derived factor 1 (C) | VdWContact |
| His 25 | 85 | B1 | LEU 229 | Stromal cell-derived factor 1 (C) | VdWContact |
| Leu 26 | 86 | B1 | LYS 227 | Stromal cell-derived factor 1 (C) | VdWContact |
| Leu 26 | 86 | B1 | ILE 228 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Leu 26 | 86 | B1 | ILE 228 | Stromal cell-derived factor 1 (C) | HBAcceptor |
| Leu 26 | 86 | B1 | ILE 228 | Stromal cell-derived factor 1 (C) | HBDonor |
| Leu 26 | 86 | B1 | ILE 228 | Stromal cell-derived factor 1 (C) | VdWContact |
| Lys 27 | 87 | B1 | LEU 226 | Stromal cell-derived factor 1 (C) | VdWContact |
| Lys 27 | 87 | B1 | HIS 225 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Ile 28 | 88 | B1 | LEU 226 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Ile 28 | 88 | B1 | LEU 226 | Stromal cell-derived factor 1 (C) | HBAcceptor |
| Ile 28 | 88 | B1 | LEU 226 | Stromal cell-derived factor 1 (C) | HBDonor |
| Ile 28 | 88 | B1 | LEU 226 | Stromal cell-derived factor 1 (C) | VdWContact |
| Ile 28 | 88 | B1 | TYR 261 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Ile 28 | 88 | B1 | TYR 261 | Stromal cell-derived factor 1 (C) | VdWContact |
| Ile 28 | 88 | B1 | HIS 225 | Stromal cell-derived factor 1 (C) | VdWContact |
| Asn 30 | 90 | 30s-loop | TYR 261 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Asn 30 | 90 | 30s-loop | TYR 261 | Stromal cell-derived factor 1 (C) | HBAcceptor |
| Asn 30 | 90 | 30s-loop | TYR 261 | Stromal cell-derived factor 1 (C) | HBDonor |
| Asn 30 | 90 | 30s-loop | TYR 261 | Stromal cell-derived factor 1 (C) | VdWContact |
| Asn 30 | 90 | 30s-loop | LYS 224 | Stromal cell-derived factor 1 (C) | HBDonor |
| Asn 30 | 90 | 30s-loop | LYS 224 | Stromal cell-derived factor 1 (C) | VdWContact |
| Ala 35 | 97 | 30s-loop | LYS 268 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Ala 35 | 97 | 30s-loop | LYS 268 | Stromal cell-derived factor 1 (C) | VdWContact |
| Leu 36 | 99 | 30s-loop | CYS 265 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Leu 36 | 99 | 30s-loop | CYS 265 | Stromal cell-derived factor 1 (C) | VdWContact |
| Ile 38 | 101 | B2 | CYS 265 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Pro 53 | 120 | 50s-loop | CYS 265 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Pro 53 | 120 | 50s-loop | CYS 265 | Stromal cell-derived factor 1 (C) | VdWContact |
| Lys 54 | 121 | 50s-loop | LYS 268 | Stromal cell-derived factor 1 (C) | HBDonor |
| Lys 54 | 121 | 50s-loop | LYS 268 | Stromal cell-derived factor 1 (C) | Cationic |
| Lys 54 | 121 | 50s-loop | LYS 268 | Stromal cell-derived factor 1 (C) | VdWContact |
| Gln 59 | 126 | Helix | LEU 266 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Gln 59 | 126 | Helix | LEU 266 | Stromal cell-derived factor 1 (C) | VdWContact |
| Gln 59 | 126 | Helix | ASN 267 | Stromal cell-derived factor 1 (C) | HBAcceptor |
| Gln 59 | 126 | Helix | ASN 267 | Stromal cell-derived factor 1 (C) | VdWContact |
| Tyr 61 | 128 | Helix | ASN 230 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Tyr 61 | 128 | Helix | ASN 230 | Stromal cell-derived factor 1 (C) | VdWContact |
| Tyr 61 | 128 | Helix | ILE 228 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Tyr 61 | 128 | Helix | ILE 228 | Stromal cell-derived factor 1 (C) | HBDonor |
| Tyr 61 | 128 | Helix | ILE 228 | Stromal cell-derived factor 1 (C) | VdWContact |
| Leu 62 | 129 | Helix | LEU 266 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Leu 62 | 129 | Helix | LEU 266 | Stromal cell-derived factor 1 (C) | VdWContact |
| Leu 62 | 129 | Helix | CYS 265 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Leu 62 | 129 | Helix | LEU 262 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Leu 62 | 129 | Helix | LEU 262 | Stromal cell-derived factor 1 (C) | VdWContact |
| Lys 64 | 131 | Helix | CYS 236 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Ala 65 | 132 | Helix | ILE 238 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Ala 65 | 132 | Helix | GLN 259 | Stromal cell-derived factor 1 (C) | VdWContact |
| Ala 65 | 132 | Helix | CYS 236 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Ala 65 | 132 | Helix | CYS 236 | Stromal cell-derived factor 1 (C) | VdWContact |
| Ala 65 | 132 | Helix | PRO 253 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Ala 65 | 132 | Helix | PRO 253 | Stromal cell-derived factor 1 (C) | VdWContact |
| Ala 65 | 132 | Helix | LEU 262 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Leu 66 | 133 | Helix | LEU 266 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Leu 66 | 133 | Helix | GLN 259 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Leu 66 | 133 | Helix | GLN 259 | Stromal cell-derived factor 1 (C) | VdWContact |
| Leu 66 | 133 | Helix | LEU 262 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Leu 66 | 133 | Helix | LEU 262 | Stromal cell-derived factor 1 (C) | VdWContact |
| Asn 67 | 134 | Helix | GLN 259 | Stromal cell-derived factor 1 (C) | VdWContact |
| Lys 68 | 135 | Helix | ALA 235 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Lys 68 | 135 | Helix | ALA 235 | Stromal cell-derived factor 1 (C) | VdWContact |
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