CXCL12_HUMAN

  • Alternate name(s): Stromal cell-derived factor 1
  • Organism: Homo sapiens
  • UniProt ID: P48061 open_in_new


Wild type sequence

Residue N-term   CX   N-loop   B1   30s-loop   B2   40s-loop   B3   50s-loop   Helix   C-term  
  NTc.Cm29 NTc.Cm28 NTc.Cm27 NTc.Cm26 NTc.Cm25 NTc.Cm24 NTc.Cm23 NTc.Cm22 NTc.Cm21 NTc.Cm20 NTc.Cm19 NTc.Cm18 NTc.Cm17 NTc.Cm16 NTc.Cm15 NTc.Cm14 NTc.Cm13 NTc.Cm12 NTc.Cm11 NTc.Cm10 NTc.Cm9 NTc.Cm8 NTc.Cm7 NTc.Cm6 NTc.Cm5 NTc.Cm4 NTc.Cm3 NTc.Cm2 NTc.Cm1   CX.1 CX.4 CX.5   cxb1.1 cxb1.2 cxb1.5 cxb1.6 cxb1.8 cxb1.10 cxb1.11 cxb1.14 cxb1.15 cxb1.16   B1.1 B1.2 B1.3 B1.4 B1.5 B1.6 B1.7   b1b2.4 b1b2.7 b1b2.8 b1b2.9 b1b2.10 b1b2.12 b1b2.14 b1b2.16   B2.1 B2.2 B2.3 B2.4 B2.5 B2.6   b2b3.2 b2b3.3 b2b3.4 b2b3.11 b2b3.12   B3.1 B3.2 B3.3 B3.4   b3h.1 b3h.2 b3h.3 b3h.4   H.1 H.2 H.3 H.4 H.5 H.6 H.7 H.8 H.9 H.10   CT.1 CT.2 CT.3 CT.4 CT.5 CT.6 CT.7  
Wild Type M N A K V V V V L V L V L T A L C L S D G K P V S L S Y R   C P C   R F F E S H V A R A   N V K H L K I   L N T P N C A L   Q I V A R L   K N N N R   Q V C I   D P K L   K W I Q E Y L E K A   L N K R F K M  

Snake Plot

L N T P N C A L 30s-loop K N N N R 40s-loop D P K L 50s-loopC-term M N A K V V V V L V L V L T A L C L S D G K P V S L S Y R C P C R F F E S H V A R A N-term I K L H K V N Q I V A R L I C V Q K W I Q E Y L E K A L N K R F K M
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List of structures

PDB Method Resolution State Publication date Reference
1A15 - A,B X-ray 2.2 Dimer 1998-08-12 10.1073/PNAS.95.12.6941 open_in_new
1QG7 - A,B X-ray 2.0 Dimer 2001-02-28 10.1089/10799900050116390 open_in_new
1SDF - A Nmr None Monomer 1998-01-28 10.1093/EMBOJ/16.23.6996 open_in_new
1VMC - A Nmr None Monomer 2005-03-01 10.1016/J.JMB.2004.11.003 open_in_new
2N55 - A Nmr None Monomer 2016-04-27 10.1126/SCISIGNAL.AAH5756 open_in_new
2NWG - A,B X-ray 2.07 Dimer 2007-02-13 10.1074/JBC.M608796200 open_in_new
2J7Z - A,B X-ray 1.95 Dimer 2006-10-23 10.1002/PROT.21350 open_in_new
2K01 - A,C Nmr None Dimer 2008-10-28 10.1126/SCISIGNAL.1160755 open_in_new
2K03 - A,C Nmr None Dimer 2008-10-28 10.1126/SCISIGNAL.1160755 open_in_new
2K04 - A,C Nmr None Dimer 2008-10-28 10.1126/SCISIGNAL.1160755 open_in_new
3GV3 - A X-ray 1.6 Monomer 2010-01-26 10.1002/PROT.22666 open_in_new
2K05 - A,C Nmr None Dimer 2008-10-28 10.1126/SCISIGNAL.1160755 open_in_new
2KEC - A Nmr None Monomer 2009-09-29 10.1002/PRO.167 open_in_new
2KED - A Nmr None Monomer 2009-09-29 10.1002/PRO.167 open_in_new
2KEE - A Nmr None Monomer 2009-09-29 10.1002/PRO.167 open_in_new
2KOL - A Nmr None Monomer 2010-10-06 -
3HP3 - B,C,E,F,H,I,A,G,J,D X-ray 2.2 Oligomer 2010-01-26 10.1002/PROT.22666 open_in_new
2SDF - A Nmr None Monomer 1998-06-17 10.1093/EMBOJ/16.23.6996 open_in_new
4LMQ - D,F X-ray 2.77 Dimer 2013-08-14 10.1158/1078-0432.CCR-13-0943 open_in_new
4UAI - A,B X-ray 1.9 Dimer 2014-11-12 10.1021/JM501194P open_in_new
7SK4 - B Cryo-em 3.3 Monomer 2022-07-27 10.1126/SCIADV.ABN8063 open_in_new
6SHR - A X-ray 1.75 Monomer 2020-08-26 -
7SK3 - B Cryo-em 3.8 Monomer 2022-07-27 10.1126/SCIADV.ABN8063 open_in_new
7SK5 - B Cryo-em 4.0 Monomer 2022-07-27 10.1126/SCIADV.ABN8063 open_in_new
7SK6 - B Cryo-em 4.0 Monomer 2022-07-27 10.1126/SCIADV.ABN8063 open_in_new
7SK7 - B Cryo-em 3.3 Monomer 2022-07-27 10.1126/SCIADV.ABN8063 open_in_new
7SK8 - B Cryo-em 3.3 Monomer 2022-07-27 10.1126/SCIADV.ABN8063 open_in_new
8K3Z - D Cryo-em 2.81 Monomer 2024-07-17 -
8U4O - J Cryo-em 3.29 Monomer 2024-03-13 10.1101/2024.02.09.579708 open_in_new

Sequence alignment from structures

Position NTc.Cm29 NTc.Cm28 NTc.Cm27 NTc.Cm26 NTc.Cm25 NTc.Cm24 NTc.Cm23 NTc.Cm22 NTc.Cm21 NTc.Cm20 NTc.Cm19 NTc.Cm18 NTc.Cm17 NTc.Cm16 NTc.Cm15 NTc.Cm14 NTc.Cm13 NTc.Cm12 NTc.Cm11 NTc.Cm10 NTc.Cm9 NTc.Cm8 NTc.Cm7 NTc.Cm6 NTc.Cm5 NTc.Cm4 NTc.Cm3 NTc.Cm2 NTc.Cm1 CX.1 CX.4 CX.5 cxb1.1 cxb1.2 cxb1.5 cxb1.6 cxb1.8 cxb1.10 cxb1.11 cxb1.14 cxb1.15 cxb1.16 B1.1 B1.2 B1.3 B1.4 B1.5 B1.6 B1.7 b1b2.4 b1b2.7 b1b2.8 b1b2.9 b1b2.10 b1b2.12 b1b2.14 b1b2.16 B2.1 B2.2 B2.3 B2.4 B2.5 B2.6 b2b3.2 b2b3.3 b2b3.4 b2b3.11 b2b3.12 B3.1 B3.2 B3.3 B3.4 b3h.1 b3h.2 b3h.3 b3h.4 H.1 H.2 H.3 H.4 H.5 H.6 H.7 H.8 H.9 H.10 CT.1 CT.2 CT.3 CT.4 CT.5 CT.6 CT.7
Canonical Sequence M N A K V V V V L V L V L T A L C L S D G K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N K R F K M
1A15 - A,B - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P A C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N - - - - -
1QG7 - A,B - - - - - - - - - - - - - - - - - - - - - - P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N - - - - -
1SDF - A - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N - - - - -
1VMC - A - - - - - - - - - - - - - - - - - - - - - - - - - - - - R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N K - - - -
2N55 - A - - - - - - - - - - - - - - - - - - - G M K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K C K W C Q E Y L E K A L N K - - - -
2NWG - A,B M - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H I A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N - - - - -
2J7Z - A,B - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N K - - - -
2K01 - A,C - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A C Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K C L N K - - - -
2K03 - A,C - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A C Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K C L N K - - - -
2K04 - A,C - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A C Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K C L N K - - - -
3GV3 - A - - - - - - - - - - - - - - - - - - - - - - - - - L S Y R C P C R F F E S H I A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N - - - - -
2K05 - A,C - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A C Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K C L N K - - - -
2KEC - A - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N K - - - -
2KED - A - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N K - - - -
2KEE - A - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N K - - - -
2KOL - A - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K R L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N K - - - -
3HP3 - B,C,E,F,H,I,A,G,J,D - - - - - - - - - - - - - - - - - - - - - - - V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N - - - - -
2SDF - A - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N - - - - -
4LMQ - D,F - - - - - - - - - - - - - - - - - - - - - - - - - - - - R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N K - - - -
4UAI - A,B - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N K - - - -
7SK4 - B - - - - - - - - - - - - - - - - - - - - L R H Q S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N K - - - -
6SHR - A - - - - - - - - - - - - - - - - - - - - - - - - - L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N K - - - -
7SK3 - B - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N K - - - -
7SK5 - B - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E - - - - - - - - -
7SK6 - B - - - - - - - - - - - - - - - - - - - - L R H Q S L S Y R C P C R F F E S - - - - - - - K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A - - - - - - -
7SK7 - B - - - - - - - - - - - - - - - - - - - - - - - - - - - Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N K - - - -
7SK8 - B - - - - - - - - - - - - - - - - - - - - - - - - - - - Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N K - - - -
8K3Z - D - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L - - - - - - - - - -
8U4O - J - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A - - - - - - -