CXCL12_HUMAN

  • Alternate name(s): Stromal cell-derived factor 1, SDF-1, hSDF-1, C-X-C motif chemokine 12, Intercrine reduced in hepatomas, IRH, hIRH, Pre-B cell growth-stimulating factor, PBSF, SDF-1-beta(3-72), SDF-1-alpha(3-67)
  • Organism: Homo sapiens
  • UniProt ID: P48061 open_in_new


Sequence

N-term   CX   N-loop   B1   30s-loop   B2   40s-loop   B3   50s-loop   Helix   C-term  
34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62   63 66 67   68 69 70 71 72 74 75 76 80 81 82   83 84 85 86 87 88 89   90 91 92 94 95 97 99 100   101 102 103 104 105   106 111 112 113 114   115 116 117 118   119 120 121 122   123 124 125 126 127 128 129 130 131 132 133 134 135   136 137 138 139  
M N A K V V V V L V L V L T A L C L S D G K P V S L S Y R   C P C   R F F E S H V A R A N   V K H L K I L   N T P N C A L Q   I V A R L   K N N N R   Q V C I   D P K L   K W I Q E Y L E K A L N K   R F K M  

Snake Plot

N T P N C A L Q 30s-loop K N N N R 40s-loop D P K L 50s-loopN-term M N A K V V V V L V L V L T A L C L S D G K P V S L S Y R C P C R F F E S H V A R A N N-termC-term R F K M C-term L I K L H K V I V A R L I C V Q K W I Q E Y L E K A L N K
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List of structures

PDB Method Resolution State Publication date Reference
1A15 X-ray 2.2 dimer 1998-08-12 10.1073/PNAS.95.12.6941 open_in_new
1QG7 X-ray 2.0 dimer 2001-02-28 10.1089/10799900050116390 open_in_new
1SDF Solution nmr 0.0 monomer 1998-01-28 10.1093/EMBOJ/16.23.6996 open_in_new
1VMC Solution nmr 0.0 monomer 2005-03-01 10.1016/J.JMB.2004.11.003 open_in_new
2J7Z X-ray 1.95 dimer 2006-10-23 10.1002/PROT.21350 open_in_new
2K01 Solution nmr 0.0 dimer 2008-10-28 10.1126/SCISIGNAL.1160755 open_in_new
2K03 Solution nmr 0.0 dimer 2008-10-28 10.1126/SCISIGNAL.1160755 open_in_new
2K04 Solution nmr 0.0 dimer 2008-10-28 10.1126/SCISIGNAL.1160755 open_in_new
2K05 Solution nmr 0.0 dimer 2008-10-28 10.1126/SCISIGNAL.1160755 open_in_new
2KEC Solution nmr 0.0 dimer 2009-09-29 10.1002/PRO.167 open_in_new
2KED Solution nmr 0.0 monomer 2009-09-29 10.1002/PRO.167 open_in_new
2KEE Solution nmr 0.0 monomer 2009-09-29 10.1002/PRO.167 open_in_new
2KOL Solution nmr 0.0 monomer 2010-10-06 -
2N55 Solution nmr 0.0 monomer 2016-04-27 10.1126/SCISIGNAL.AAH5756 open_in_new
2NWG X-ray 2.07 dimer 2007-02-13 10.1074/JBC.M608796200 open_in_new
2SDF Solution nmr 0.0 monomer 1998-06-17 10.1093/EMBOJ/16.23.6996 open_in_new
3GV3 X-ray 1.6 dimer 2010-01-26 10.1002/PROT.22666 open_in_new
3HP3 X-ray 2.2 oligomer 2010-01-26 10.1002/PROT.22666 open_in_new
4LMQ X-ray 2.77 dimer 2013-08-14 10.1158/1078-0432.CCR-13-0943 open_in_new
4UAI X-ray 1.9 dimer 2014-11-12 10.1021/JM501194P open_in_new
6SHR X-ray 1.75 monomer 2020-08-26 -
7SK3 Cryo-em 3.8 monomer 2022-07-27 10.1126/SCIADV.ABN8063 open_in_new
7SK4 Cryo-em 3.3 monomer 2022-07-27 10.1126/SCIADV.ABN8063 open_in_new
7SK5 Cryo-em 4.0 monomer 2022-07-27 10.1126/SCIADV.ABN8063 open_in_new
7SK6 Cryo-em 4.0 monomer 2022-07-27 10.1126/SCIADV.ABN8063 open_in_new
7SK7 Cryo-em 3.3 monomer 2022-07-27 10.1126/SCIADV.ABN8063 open_in_new
7SK8 Cryo-em 3.3 monomer 2022-07-27 10.1126/SCIADV.ABN8063 open_in_new
8U4O Cryo-em 3.29 monomer 2024-03-13 10.1101/2024.02.09.579708 open_in_new

Targets (Guide to Pharmacology)

No targets found