Protein

CXCL12_HUMAN

SUMMARY
Gene
CXCL12_HUMAN
Full name
Stromal cell-derived factor 1
Organism
Homo sapiens
Subfamily
CXCL
Sequence type
Wild-type
UniProt ID
P48061 Open UniProt
IUPHAR ID
4358 Open Guide to Pharmacology
GtoP partners
DIAGRAM
L N T P N C A L 30s-loop K N N N R 40s-loop D P K L 50s-loopC-term M N A K V V V V L V L V L T A L C L S D G K P V S L S Y R C P C R F F E S H V A R A N-term I K L H K V N Q I V A R L I C V Q K W I Q E Y L E K A L N K R F K M
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SEQUENCE

Residues are colour-coded by structural context. Hover to view sequence and CCN numbering.

N-term
M
N
A
K
V
V
V
V
L
V
10
 
L
V
L
T
A
L
C
L
S
D
20
  CX
G
K
P
V
S
L
S
Y
R
C
30
  N-loop
P
C
R
F
F
E
S
H
V
A
40
  B1 30s-loop
R
A
N
V
K
H
L
K
I
L
50
  B2
N
T
P
N
C
A
L
Q
I
V
60
  40s-loop B3
A
R
L
K
N
N
N
R
Q
V
70
  50s-loop Helix
C
I
D
P
K
L
K
W
I
Q
80
  C-term
E
Y
L
E
K
A
L
N
K
R
90
 
F
K
M
93
STRUCTURES

Experimental structures

PDB Method Resolution State Publication date Reference
8K3Z - D Cryo-em 2.81 Monomer 2024-07-17 -
8U4O - J Cryo-em 3.29 Monomer 2024-03-13 10.1101/2024.02.09.579708 open_in_new
7SK8 - B Cryo-em 3.3 Monomer 2022-07-27 10.1126/SCIADV.ABN8063 open_in_new
7SK7 - B Cryo-em 3.3 Monomer 2022-07-27 10.1126/SCIADV.ABN8063 open_in_new
7SK6 - B Cryo-em 4.0 Monomer 2022-07-27 10.1126/SCIADV.ABN8063 open_in_new
7SK5 - B Cryo-em 4.0 Monomer 2022-07-27 10.1126/SCIADV.ABN8063 open_in_new
7SK4 - B Cryo-em 3.3 Monomer 2022-07-27 10.1126/SCIADV.ABN8063 open_in_new
7SK3 - B Cryo-em 3.8 Monomer 2022-07-27 10.1126/SCIADV.ABN8063 open_in_new
6SHR - A X-ray 1.75 Monomer 2020-08-26 -
2N55 - A Nmr None Monomer 2016-04-27 10.1126/SCISIGNAL.AAH5756 open_in_new
4UAI - A,B X-ray 1.9 Dimer 2014-11-12 10.1021/JM501194P open_in_new
4LMQ - D,F X-ray 2.77 Dimer 2013-08-14 10.1158/1078-0432.CCR-13-0943 open_in_new
2KOL - A Nmr None Monomer 2010-10-06 -
3HP3 - B,C,E,F,H,I,A,G,J,D X-ray 2.2 Oligomer 2010-01-26 10.1002/PROT.22666 open_in_new
3GV3 - A X-ray 1.6 Monomer 2010-01-26 10.1002/PROT.22666 open_in_new
2KEE - A Nmr None Monomer 2009-09-29 10.1002/PRO.167 open_in_new
2KED - A Nmr None Monomer 2009-09-29 10.1002/PRO.167 open_in_new
2KEC - A Nmr None Monomer 2009-09-29 10.1002/PRO.167 open_in_new
2K05 - A,C Nmr None Dimer 2008-10-28 10.1126/SCISIGNAL.1160755 open_in_new
2K04 - A,C Nmr None Dimer 2008-10-28 10.1126/SCISIGNAL.1160755 open_in_new
2K03 - A,C Nmr None Dimer 2008-10-28 10.1126/SCISIGNAL.1160755 open_in_new
2K01 - A,C Nmr None Dimer 2008-10-28 10.1126/SCISIGNAL.1160755 open_in_new
2NWG - A,B X-ray 2.07 Dimer 2007-02-13 10.1074/JBC.M608796200 open_in_new
2J7Z - A,B X-ray 1.95 Dimer 2006-10-23 10.1002/PROT.21350 open_in_new
1VMC - A Nmr None Monomer 2005-03-01 10.1016/J.JMB.2004.11.003 open_in_new
1QG7 - A,B X-ray 2.0 Dimer 2001-02-28 10.1089/10799900050116390 open_in_new
1A15 - A,B X-ray 2.2 Dimer 1998-08-12 10.1073/PNAS.95.12.6941 open_in_new
2SDF - A Nmr None Monomer 1998-06-17 10.1093/EMBOJ/16.23.6996 open_in_new
1SDF - A Nmr None Monomer 1998-01-28 10.1093/EMBOJ/16.23.6996 open_in_new

Predicted models and complexes

Type Partner Method State Date View
Complex XCR1 AlphaFold-Multimer - 2025-11-11 Open
Complex CXCR6 AlphaFold-Multimer - 2025-11-11 Open
Complex CXCR5 AlphaFold-Multimer - 2025-11-11 Open
Complex CXCR4 AlphaFold-Multimer - 2025-11-11 Open
Complex CXCR3 AlphaFold-Multimer - 2025-11-11 Open
Complex CXCR2 AlphaFold-Multimer - 2025-11-11 Open
Complex CXCR1 AlphaFold-Multimer - 2025-11-11 Open
Complex CX3CR1 AlphaFold-Multimer - 2025-11-11 Open
Complex CCRL2 AlphaFold-Multimer - 2025-11-11 Open
Complex CCR9 AlphaFold-Multimer - 2025-11-11 Open
Complex CCR8 AlphaFold-Multimer - 2025-11-11 Open
Complex CCR7 AlphaFold-Multimer - 2025-11-11 Open
Complex CCR6 AlphaFold-Multimer - 2025-11-11 Open
Complex CCR5 AlphaFold-Multimer - 2025-11-11 Open
Complex CCR4 AlphaFold-Multimer - 2025-11-10 Open
Complex CCR3 AlphaFold-Multimer - 2025-11-10 Open
Complex CCR2 AlphaFold-Multimer - 2025-11-10 Open
Complex CCR1 AlphaFold-Multimer - 2025-11-10 Open
Complex CCR10 AlphaFold-Multimer - 2025-11-10 Open
Complex ACKR4 AlphaFold-Multimer - 2025-11-10 Open
Complex ACKR3 AlphaFold-Multimer - 2025-11-10 Open
Complex ACKR2 AlphaFold-Multimer - 2025-11-10 Open
Complex ACKR1 AlphaFold-Multimer - 2025-11-10 Open
Model - AlphaFold Monomer v2.0 pipeline (AlphaFold DB v6) - 2025-08-01 Open
SEQUENCE ALIGNMENT

Canonical residues are compared against each available structure at matched CCN positions.

Position NTc.Cm29 NTc.Cm28 NTc.Cm27 NTc.Cm26 NTc.Cm25 NTc.Cm24 NTc.Cm23 NTc.Cm22 NTc.Cm21 NTc.Cm20 NTc.Cm19 NTc.Cm18 NTc.Cm17 NTc.Cm16 NTc.Cm15 NTc.Cm14 NTc.Cm13 NTc.Cm12 NTc.Cm11 NTc.Cm10 NTc.Cm9 NTc.Cm8 NTc.Cm7 NTc.Cm6 NTc.Cm5 NTc.Cm4 NTc.Cm3 NTc.Cm2 NTc.Cm1 CX.1 CX.4 CX.5 cxb1.1 cxb1.2 cxb1.5 cxb1.6 cxb1.8 cxb1.10 cxb1.11 cxb1.14 cxb1.15 cxb1.16 B1.1 B1.2 B1.3 B1.4 B1.5 B1.6 B1.7 b1b2.4 b1b2.7 b1b2.8 b1b2.9 b1b2.10 b1b2.12 b1b2.14 b1b2.16 B2.1 B2.2 B2.3 B2.4 B2.5 B2.6 b2b3.2 b2b3.3 b2b3.4 b2b3.11 b2b3.12 B3.1 B3.2 B3.3 B3.4 b3h.1 b3h.2 b3h.3 b3h.4 H.1 H.2 H.3 H.4 H.5 H.6 H.7 H.8 H.9 H.10 CT.1 CT.2 CT.3 CT.4 CT.5 CT.6 CT.7
Canonical sequence M N A K V V V V L V L V L T A L C L S D G K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N K R F K M
8K3Z - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L - - - - - - - - - -
8U4O - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A - - - - - - -
7SK8 - - - - - - - - - - - - - - - - - - - - - - - - - - - Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N K - - - -
7SK7 - - - - - - - - - - - - - - - - - - - - - - - - - - - Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N K - - - -
7SK6 - - - - - - - - - - - - - - - - - - - - L R H Q S L S Y R C P C R F F E S - - - - - - - K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A - - - - - - -
7SK5 - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E - - - - - - - - -
7SK4 - - - - - - - - - - - - - - - - - - - - L R H Q S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N K - - - -
7SK3 - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N K - - - -
6SHR - - - - - - - - - - - - - - - - - - - - - - - - - L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N K - - - -
2N55 - - - - - - - - - - - - - - - - - - - G M K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K C K W C Q E Y L E K A L N K - - - -
4UAI - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N K - - - -
4LMQ - - - - - - - - - - - - - - - - - - - - - - - - - - - - R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N K - - - -
2KOL - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K R L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N K - - - -
3HP3 - - - - - - - - - - - - - - - - - - - - - - - V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N - - - - -
3GV3 - - - - - - - - - - - - - - - - - - - - - - - - - L S Y R C P C R F F E S H I A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N - - - - -
2KEE - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N K - - - -
2KED - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N K - - - -
2KEC - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N K - - - -
2K05 - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A C Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K C L N K - - - -
2K04 - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A C Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K C L N K - - - -
2K03 - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A C Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K C L N K - - - -
2K01 - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A C Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K C L N K - - - -
2NWG M - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H I A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N - - - - -
2J7Z - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N K - - - -
1VMC - - - - - - - - - - - - - - - - - - - - - - - - - - - - R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N K - - - -
1QG7 - - - - - - - - - - - - - - - - - - - - - - P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N - - - - -
1A15 - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P A C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N - - - - -
2SDF - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N - - - - -
1SDF - - - - - - - - - - - - - - - - - - - - - K P V S L S Y R C P C R F F E S H V A R A N V K H L K I L N T P N C A L Q I V A R L K N N N R Q V C I D P K L K W I Q E Y L E K A L N - - - - -