Interactions for 2K03 (chain C)
Structure details
- PDB ID: 2K03 open_in_new
- Protein: CXCL12_HUMAN
- Organism: Homo sapiens
- UniProt ID: P48061 open_in_new
- Method: Solution nmr
- Resolution: 0.0 Å
- Date: Oct. 28, 2008
- Reference: 10.1126/SCISIGNAL.1160755 open_in_new
- State: dimer
Chemokine diagram
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Interactions found in structure
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| Chemokine Residue | Generic number | Segment | Partner Residue | Partner | Interaction Type |
|---|---|---|---|---|---|
| Lys 201 | 55 | N-term | GLU 314 | C-X-C chemokine receptor type 4 (D) | HBDonor |
| Lys 201 | 55 | N-term | GLU 314 | C-X-C chemokine receptor type 4 (D) | Cationic |
| Lys 201 | 55 | N-term | GLU 314 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Pro 202 | 56 | N-term | GLU 315 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Val 203 | 57 | N-term | GLU 315 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Val 203 | 57 | N-term | GLU 315 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Val 203 | 57 | N-term | THR 313 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Val 203 | 57 | N-term | THR 313 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Tyr 207 | 61 | N-term | GLU 315 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Arg 208 | 62 | N-term | GLU 314 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Arg 208 | 62 | N-term | THR 313 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Arg 208 | 62 | N-term | SER 309 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Arg 208 | 62 | N-term | GLU 315 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Cys 209 | 63 | CX | GLU 315 | C-X-C chemokine receptor type 4 (D) | HBDonor |
| Cys 209 | 63 | CX | GLU 315 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Pro 210 | 66 | CX | GLU 314 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Pro 210 | 66 | CX | GLU 314 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Pro 210 | 66 | CX | TYR 312 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Pro 210 | 66 | CX | TYR 312 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Cys 211 | 67 | CX | GLY 317 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Arg 212 | 68 | N-loop | MET 316 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Arg 212 | 68 | N-loop | MET 316 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Arg 212 | 68 | N-loop | GLY 317 | C-X-C chemokine receptor type 4 (D) | HBDonor |
| Arg 212 | 68 | N-loop | GLY 317 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Phe 213 | 69 | N-loop | SER 323 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Phe 214 | 70 | N-loop | LYS 325 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Phe 214 | 70 | N-loop | LYS 325 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Phe 214 | 70 | N-loop | SER 323 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Glu 215 | 71 | N-loop | SER 323 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Glu 215 | 71 | N-loop | ASP 320 | C-X-C chemokine receptor type 4 (D) | HBAcceptor |
| Glu 215 | 71 | N-loop | ASP 320 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Ser 216 | 72 | N-loop | MET 324 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| His 217 | 74 | N-loop | ASP 322 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| His 217 | 74 | N-loop | ASP 322 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Arg 220 | 80 | N-loop | SER 105 | C-X-C chemokine receptor type 4 (B) | HBDonor |
| Arg 220 | 80 | N-loop | SER 105 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Val 223 | 83 | B1 | TYR 107 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Val 223 | 83 | B1 | TYR 107 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Lys 224 | 84 | B1 | ASN 111 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Lys 224 | 84 | B1 | ASN 111 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Lys 224 | 84 | B1 | ASP 110 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Lys 224 | 84 | B1 | ASP 110 | C-X-C chemokine receptor type 4 (B) | HBDonor |
| Lys 224 | 84 | B1 | ASP 110 | C-X-C chemokine receptor type 4 (B) | Cationic |
| Lys 224 | 84 | B1 | ASP 110 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Lys 224 | 84 | B1 | TYR 107 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| His 225 | 85 | B1 | ILE 28 | Stromal cell-derived factor 1 (A) | VdWContact |
| His 225 | 85 | B1 | ASN 111 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| His 225 | 85 | B1 | LYS 27 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| His 225 | 85 | B1 | LEU 29 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| His 225 | 85 | B1 | LEU 29 | Stromal cell-derived factor 1 (A) | VdWContact |
| Leu 226 | 86 | B1 | ILE 28 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Leu 226 | 86 | B1 | ILE 28 | Stromal cell-derived factor 1 (A) | HBAcceptor |
| Leu 226 | 86 | B1 | ILE 28 | Stromal cell-derived factor 1 (A) | HBDonor |
| Leu 226 | 86 | B1 | ILE 28 | Stromal cell-derived factor 1 (A) | VdWContact |
| Leu 226 | 86 | B1 | LYS 27 | Stromal cell-derived factor 1 (A) | VdWContact |
| Lys 227 | 87 | B1 | LEU 26 | Stromal cell-derived factor 1 (A) | VdWContact |
| Lys 227 | 87 | B1 | HIS 25 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Lys 227 | 87 | B1 | TYR 312 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Lys 227 | 87 | B1 | TYR 312 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Ile 228 | 88 | B1 | ILE 28 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Ile 228 | 88 | B1 | LEU 26 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Ile 228 | 88 | B1 | LEU 26 | Stromal cell-derived factor 1 (A) | HBAcceptor |
| Ile 228 | 88 | B1 | LEU 26 | Stromal cell-derived factor 1 (A) | HBDonor |
| Ile 228 | 88 | B1 | LEU 26 | Stromal cell-derived factor 1 (A) | VdWContact |
| Ile 228 | 88 | B1 | TYR 61 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Ile 228 | 88 | B1 | TYR 61 | Stromal cell-derived factor 1 (A) | VdWContact |
| Ile 228 | 88 | B1 | HIS 25 | Stromal cell-derived factor 1 (A) | VdWContact |
| Leu 229 | 89 | B1 | TYR 307 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Leu 229 | 89 | B1 | HIS 25 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Leu 229 | 89 | B1 | HIS 25 | Stromal cell-derived factor 1 (A) | VdWContact |
| Leu 229 | 89 | B1 | TYR 312 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Leu 229 | 89 | B1 | TYR 312 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Asn 230 | 90 | 30s-loop | ILE 306 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Asn 230 | 90 | 30s-loop | ILE 306 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Asn 230 | 90 | 30s-loop | TYR 307 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Asn 230 | 90 | 30s-loop | TYR 307 | C-X-C chemokine receptor type 4 (D) | HBDonor |
| Asn 230 | 90 | 30s-loop | TYR 307 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Asn 230 | 90 | 30s-loop | TYR 61 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Asn 230 | 90 | 30s-loop | TYR 61 | Stromal cell-derived factor 1 (A) | VdWContact |
| Asn 230 | 90 | 30s-loop | LYS 64 | Stromal cell-derived factor 1 (A) | HBAcceptor |
| Asn 230 | 90 | 30s-loop | LYS 64 | Stromal cell-derived factor 1 (A) | VdWContact |
| Asn 230 | 90 | 30s-loop | CYS 65 | Stromal cell-derived factor 1 (A) | VdWContact |
| Pro 232 | 92 | 30s-loop | ILE 306 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Ala 235 | 97 | 30s-loop | MET 301 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Leu 236 | 99 | 30s-loop | CYS 65 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Leu 236 | 99 | 30s-loop | CYS 65 | Stromal cell-derived factor 1 (A) | VdWContact |
| Val 239 | 102 | B2 | TYR 312 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Val 239 | 102 | B2 | TYR 312 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Lys 243 | 106 | 40s-loop | THR 108 | C-X-C chemokine receptor type 4 (B) | HBDonor |
| Lys 243 | 106 | 40s-loop | THR 108 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Gln 248 | 115 | B3 | TYR 312 | C-X-C chemokine receptor type 4 (D) | HBAcceptor |
| Gln 248 | 115 | B3 | TYR 312 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Asp 252 | 119 | 50s-loop | LYS 325 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Pro 253 | 120 | 50s-loop | CYS 65 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Pro 253 | 120 | 50s-loop | CYS 65 | Stromal cell-derived factor 1 (A) | VdWContact |
| Lys 254 | 121 | 50s-loop | LEU 66 | Stromal cell-derived factor 1 (A) | VdWContact |
| Lys 254 | 121 | 50s-loop | PRO 327 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Lys 254 | 121 | 50s-loop | PRO 327 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Lys 254 | 121 | 50s-loop | GLU 326 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Lys 254 | 121 | 50s-loop | ALA 328 | C-X-C chemokine receptor type 4 (D) | HBAcceptor |
| Lys 254 | 121 | 50s-loop | ALA 328 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Leu 255 | 122 | 50s-loop | ALA 328 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Lys 256 | 123 | Helix | ALA 328 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Lys 256 | 123 | Helix | PHE 329 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Lys 256 | 123 | Helix | PHE 329 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Gln 259 | 126 | Helix | LEU 66 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Gln 259 | 126 | Helix | LEU 66 | Stromal cell-derived factor 1 (A) | HBDonor |
| Gln 259 | 126 | Helix | LEU 66 | Stromal cell-derived factor 1 (A) | VdWContact |
| Gln 259 | 126 | Helix | PHE 329 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Gln 259 | 126 | Helix | PHE 329 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Tyr 261 | 128 | Helix | ILE 28 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Tyr 261 | 128 | Helix | ILE 28 | Stromal cell-derived factor 1 (A) | VdWContact |
| Tyr 261 | 128 | Helix | ASN 30 | Stromal cell-derived factor 1 (A) | VdWContact |
| Tyr 261 | 128 | Helix | TYR 107 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Tyr 261 | 128 | Helix | TYR 107 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Leu 262 | 129 | Helix | LEU 66 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Leu 262 | 129 | Helix | LEU 62 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Leu 262 | 129 | Helix | LEU 62 | Stromal cell-derived factor 1 (A) | VdWContact |
| Leu 262 | 129 | Helix | CYS 65 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Glu 263 | 130 | Helix | LEU 66 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Ala 265 | 132 | Helix | CYS 36 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Ala 265 | 132 | Helix | CYS 36 | Stromal cell-derived factor 1 (A) | VdWContact |
| Ala 265 | 132 | Helix | PRO 53 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Ala 265 | 132 | Helix | PRO 53 | Stromal cell-derived factor 1 (A) | VdWContact |
| Leu 266 | 133 | Helix | LYS 54 | Stromal cell-derived factor 1 (A) | VdWContact |
| Leu 266 | 133 | Helix | GLU 63 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Leu 266 | 133 | Helix | GLN 59 | Stromal cell-derived factor 1 (A) | HBAcceptor |
| Leu 266 | 133 | Helix | GLN 59 | Stromal cell-derived factor 1 (A) | VdWContact |
| Leu 266 | 133 | Helix | LEU 62 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Leu 266 | 133 | Helix | LEU 62 | Stromal cell-derived factor 1 (A) | VdWContact |
| Lys 268 | 135 | Helix | MET 101 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
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