Interactions for 2K04 (chain A)
Structure details
- PDB ID: 2K04 open_in_new
- Protein: CXCL12_HUMAN
- Organism: Homo sapiens
- UniProt ID: P48061 open_in_new
- Method: Solution nmr
- Resolution: 0.0 Å
- Date: Oct. 28, 2008
- Reference: 10.1126/SCISIGNAL.1160755 open_in_new
- State: dimer
Chemokine diagram
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Interactions found in structure
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| Chemokine Residue | Generic number | Segment | Partner Residue | Partner | Interaction Type |
|---|---|---|---|---|---|
| Pro 2 | 56 | N-term | GLU 114 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Pro 2 | 56 | N-term | GLU 114 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Val 3 | 57 | N-term | ASN 111 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Ser 4 | 58 | N-term | ASN 111 | C-X-C chemokine receptor type 4 (B) | HBDonor |
| Ser 4 | 58 | N-term | ASN 111 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Ser 4 | 58 | N-term | TYR 112 | C-X-C chemokine receptor type 4 (B) | HBAcceptor |
| Ser 4 | 58 | N-term | TYR 112 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Pro 10 | 66 | CX | TYR 112 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Pro 10 | 66 | CX | TYR 112 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Pro 10 | 66 | CX | GLY 117 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Arg 12 | 68 | N-loop | GLY 117 | C-X-C chemokine receptor type 4 (B) | HBDonor |
| Arg 12 | 68 | N-loop | GLY 117 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Phe 13 | 69 | N-loop | ASP 120 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Phe 13 | 69 | N-loop | GLY 117 | C-X-C chemokine receptor type 4 (B) | HBDonor |
| Phe 13 | 69 | N-loop | GLY 117 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Phe 13 | 69 | N-loop | SER 118 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Phe 14 | 70 | N-loop | ASP 120 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Glu 15 | 71 | N-loop | SER 118 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Glu 15 | 71 | N-loop | ASP 120 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Glu 15 | 71 | N-loop | GLY 119 | C-X-C chemokine receptor type 4 (B) | HBAcceptor |
| Glu 15 | 71 | N-loop | GLY 119 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Glu 15 | 71 | N-loop | TYR 121 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Glu 15 | 71 | N-loop | TYR 121 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Ser 16 | 72 | N-loop | ASP 122 | C-X-C chemokine receptor type 4 (B) | HBAcceptor |
| Ser 16 | 72 | N-loop | ASP 122 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Ser 16 | 72 | N-loop | SER 123 | C-X-C chemokine receptor type 4 (B) | HBDonor |
| Ser 16 | 72 | N-loop | SER 123 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Ser 16 | 72 | N-loop | TYR 121 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| His 17 | 74 | N-loop | SER 123 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| His 17 | 74 | N-loop | ASP 122 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| His 17 | 74 | N-loop | ASP 122 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Val 18 | 75 | N-loop | TYR 121 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Val 18 | 75 | N-loop | TYR 121 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Ala 19 | 76 | N-loop | TYR 121 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Arg 20 | 80 | N-loop | SER 305 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Arg 20 | 80 | N-loop | ILE 306 | C-X-C chemokine receptor type 4 (D) | HBDonor |
| Arg 20 | 80 | N-loop | ILE 306 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Ala 21 | 81 | N-loop | THR 308 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Val 23 | 83 | B1 | TYR 307 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Val 23 | 83 | B1 | TYR 307 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Lys 24 | 84 | B1 | TYR 307 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Lys 24 | 84 | B1 | SER 309 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Lys 24 | 84 | B1 | ASP 310 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| His 25 | 85 | B1 | TYR 307 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| His 25 | 85 | B1 | TYR 307 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| His 25 | 85 | B1 | LYS 227 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| His 25 | 85 | B1 | ILE 228 | Stromal cell-derived factor 1 (C) | VdWContact |
| His 25 | 85 | B1 | LEU 229 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| His 25 | 85 | B1 | TYR 312 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| His 25 | 85 | B1 | TYR 312 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| His 25 | 85 | B1 | ASP 310 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Leu 26 | 86 | B1 | TYR 307 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Leu 26 | 86 | B1 | TYR 307 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Leu 26 | 86 | B1 | LYS 227 | Stromal cell-derived factor 1 (C) | VdWContact |
| Leu 26 | 86 | B1 | ILE 228 | Stromal cell-derived factor 1 (C) | HBAcceptor |
| Leu 26 | 86 | B1 | ILE 228 | Stromal cell-derived factor 1 (C) | HBDonor |
| Leu 26 | 86 | B1 | ILE 228 | Stromal cell-derived factor 1 (C) | VdWContact |
| Lys 27 | 87 | B1 | TYR 112 | C-X-C chemokine receptor type 4 (B) | HBDonor |
| Lys 27 | 87 | B1 | TYR 112 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Lys 27 | 87 | B1 | LYS 227 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Lys 27 | 87 | B1 | LYS 227 | Stromal cell-derived factor 1 (C) | VdWContact |
| Lys 27 | 87 | B1 | LEU 226 | Stromal cell-derived factor 1 (C) | VdWContact |
| Lys 27 | 87 | B1 | HIS 225 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Lys 27 | 87 | B1 | HIS 225 | Stromal cell-derived factor 1 (C) | VdWContact |
| Ile 28 | 88 | B1 | TYR 261 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Ile 28 | 88 | B1 | TYR 261 | Stromal cell-derived factor 1 (C) | VdWContact |
| Ile 28 | 88 | B1 | ILE 228 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Ile 28 | 88 | B1 | ILE 228 | Stromal cell-derived factor 1 (C) | VdWContact |
| Ile 28 | 88 | B1 | LEU 226 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Ile 28 | 88 | B1 | LEU 226 | Stromal cell-derived factor 1 (C) | HBAcceptor |
| Ile 28 | 88 | B1 | LEU 226 | Stromal cell-derived factor 1 (C) | HBDonor |
| Ile 28 | 88 | B1 | LEU 226 | Stromal cell-derived factor 1 (C) | VdWContact |
| Ile 28 | 88 | B1 | TYR 107 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Ile 28 | 88 | B1 | HIS 225 | Stromal cell-derived factor 1 (C) | VdWContact |
| Leu 29 | 89 | B1 | TYR 112 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Leu 29 | 89 | B1 | TYR 112 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Leu 29 | 89 | B1 | TYR 107 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Leu 29 | 89 | B1 | HIS 225 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Asn 30 | 90 | 30s-loop | TYR 261 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Asn 30 | 90 | 30s-loop | TYR 261 | Stromal cell-derived factor 1 (C) | VdWContact |
| Asn 30 | 90 | 30s-loop | TYR 107 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Asn 30 | 90 | 30s-loop | TYR 107 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Asn 30 | 90 | 30s-loop | LYS 268 | Stromal cell-derived factor 1 (C) | HBAcceptor |
| Asn 30 | 90 | 30s-loop | LYS 268 | Stromal cell-derived factor 1 (C) | VdWContact |
| Asn 30 | 90 | 30s-loop | ILE 106 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Thr 31 | 91 | 30s-loop | TYR 112 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Ala 35 | 97 | 30s-loop | LYS 268 | Stromal cell-derived factor 1 (C) | VdWContact |
| Leu 36 | 99 | 30s-loop | CYS 265 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Leu 36 | 99 | 30s-loop | CYS 265 | Stromal cell-derived factor 1 (C) | VdWContact |
| Leu 36 | 99 | 30s-loop | LYS 268 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Leu 36 | 99 | 30s-loop | LYS 268 | Stromal cell-derived factor 1 (C) | HBDonor |
| Leu 36 | 99 | 30s-loop | LYS 268 | Stromal cell-derived factor 1 (C) | VdWContact |
| Val 39 | 102 | B2 | TYR 112 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Arg 41 | 104 | B2 | GLU 115 | C-X-C chemokine receptor type 4 (B) | Cationic |
| Arg 47 | 114 | 40s-loop | MET 116 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Arg 47 | 114 | 40s-loop | MET 116 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Gln 48 | 115 | B3 | GLU 115 | C-X-C chemokine receptor type 4 (B) | HBDonor |
| Gln 48 | 115 | B3 | GLU 115 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Cys 50 | 117 | B3 | SER 118 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Lys 54 | 121 | 50s-loop | PRO 127 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Lys 54 | 121 | 50s-loop | GLU 126 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Lys 54 | 121 | 50s-loop | GLU 126 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Lys 54 | 121 | 50s-loop | LYS 125 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Lys 56 | 123 | Helix | GLU 132 | C-X-C chemokine receptor type 4 (B) | HBDonor |
| Lys 56 | 123 | Helix | GLU 132 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Gln 59 | 126 | Helix | PRO 127 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Gln 59 | 126 | Helix | LEU 266 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Gln 59 | 126 | Helix | LEU 266 | Stromal cell-derived factor 1 (C) | VdWContact |
| Tyr 61 | 128 | Helix | TYR 307 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Tyr 61 | 128 | Helix | TYR 307 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Tyr 61 | 128 | Helix | ILE 228 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Tyr 61 | 128 | Helix | ILE 228 | Stromal cell-derived factor 1 (C) | VdWContact |
| Leu 62 | 129 | Helix | CYS 265 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Leu 62 | 129 | Helix | LEU 266 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Leu 62 | 129 | Helix | LEU 262 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Glu 63 | 130 | Helix | LEU 266 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Lys 64 | 131 | Helix | ILE 304 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Lys 64 | 131 | Helix | GLU 302 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Lys 64 | 131 | Helix | GLU 302 | C-X-C chemokine receptor type 4 (D) | HBDonor |
| Lys 64 | 131 | Helix | GLU 302 | C-X-C chemokine receptor type 4 (D) | Cationic |
| Lys 64 | 131 | Helix | GLU 302 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Ala 65 | 132 | Helix | CYS 236 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Ala 65 | 132 | Helix | CYS 236 | Stromal cell-derived factor 1 (C) | VdWContact |
| Ala 65 | 132 | Helix | ILE 238 | Stromal cell-derived factor 1 (C) | VdWContact |
| Ala 65 | 132 | Helix | LEU 262 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Leu 66 | 133 | Helix | GLN 259 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Leu 66 | 133 | Helix | GLN 259 | Stromal cell-derived factor 1 (C) | HBAcceptor |
| Leu 66 | 133 | Helix | GLN 259 | Stromal cell-derived factor 1 (C) | VdWContact |
| Leu 66 | 133 | Helix | PHE 329 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Leu 66 | 133 | Helix | GLU 263 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Leu 66 | 133 | Helix | LEU 262 | Stromal cell-derived factor 1 (C) | Hydrophobic |
| Asn 67 | 134 | Helix | MET 301 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Lys 68 | 135 | Helix | ASN 230 | Stromal cell-derived factor 1 (C) | VdWContact |
| Lys 68 | 135 | Helix | MET 301 | C-X-C chemokine receptor type 4 (D) | VdWContact |
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