Interactions for 2K04 (chain C)
Structure details
- PDB ID: 2K04 open_in_new
- Protein: CXCL12_HUMAN
- Organism: Homo sapiens
- UniProt ID: P48061 open_in_new
- Method: Solution nmr
- Resolution: 0.0 Å
- Date: Oct. 28, 2008
- Reference: 10.1126/SCISIGNAL.1160755 open_in_new
- State: dimer
Chemokine diagram
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Interactions found in structure
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| Chemokine Residue | Generic number | Segment | Partner Residue | Partner | Interaction Type |
|---|---|---|---|---|---|
| Val 203 | 57 | N-term | TYR 312 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Val 203 | 57 | N-term | THR 313 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Val 203 | 57 | N-term | THR 313 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Pro 210 | 66 | CX | GLU 314 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Pro 210 | 66 | CX | TYR 312 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Pro 210 | 66 | CX | TYR 312 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Arg 212 | 68 | N-loop | GLY 317 | C-X-C chemokine receptor type 4 (D) | HBDonor |
| Arg 212 | 68 | N-loop | GLY 317 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Phe 213 | 69 | N-loop | SER 318 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Phe 213 | 69 | N-loop | ASP 320 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Phe 213 | 69 | N-loop | GLY 317 | C-X-C chemokine receptor type 4 (D) | HBDonor |
| Phe 213 | 69 | N-loop | GLY 317 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Phe 213 | 69 | N-loop | GLY 319 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Phe 214 | 70 | N-loop | ASP 320 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Glu 215 | 71 | N-loop | SER 318 | C-X-C chemokine receptor type 4 (D) | HBAcceptor |
| Glu 215 | 71 | N-loop | SER 318 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Glu 215 | 71 | N-loop | ASP 320 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Glu 215 | 71 | N-loop | TYR 321 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Glu 215 | 71 | N-loop | TYR 321 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Ser 216 | 72 | N-loop | SER 323 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Ser 216 | 72 | N-loop | ASP 322 | C-X-C chemokine receptor type 4 (D) | HBAcceptor |
| Ser 216 | 72 | N-loop | ASP 322 | C-X-C chemokine receptor type 4 (D) | HBDonor |
| Ser 216 | 72 | N-loop | ASP 322 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Ser 216 | 72 | N-loop | MET 324 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Ser 216 | 72 | N-loop | TYR 321 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| His 217 | 74 | N-loop | SER 323 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| His 217 | 74 | N-loop | ASP 322 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| His 217 | 74 | N-loop | ASP 322 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Val 218 | 75 | N-loop | TYR 321 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Val 218 | 75 | N-loop | TYR 321 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Arg 220 | 80 | N-loop | SER 105 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Arg 220 | 80 | N-loop | ILE 106 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Ala 221 | 81 | N-loop | THR 108 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Val 223 | 83 | B1 | TYR 107 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Val 223 | 83 | B1 | TYR 107 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Lys 224 | 84 | B1 | ASP 110 | C-X-C chemokine receptor type 4 (B) | HBDonor |
| Lys 224 | 84 | B1 | ASP 110 | C-X-C chemokine receptor type 4 (B) | Cationic |
| Lys 224 | 84 | B1 | ASP 110 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Lys 224 | 84 | B1 | TYR 107 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| His 225 | 85 | B1 | TYR 112 | C-X-C chemokine receptor type 4 (B) | PiStacking |
| His 225 | 85 | B1 | ASP 110 | C-X-C chemokine receptor type 4 (B) | HBDonor |
| His 225 | 85 | B1 | ASP 110 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| His 225 | 85 | B1 | TYR 107 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| His 225 | 85 | B1 | TYR 107 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| His 225 | 85 | B1 | LEU 29 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| His 225 | 85 | B1 | ILE 28 | Stromal cell-derived factor 1 (A) | VdWContact |
| His 225 | 85 | B1 | LYS 27 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| His 225 | 85 | B1 | LYS 27 | Stromal cell-derived factor 1 (A) | VdWContact |
| Leu 226 | 86 | B1 | TYR 107 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Leu 226 | 86 | B1 | TYR 107 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Leu 226 | 86 | B1 | ILE 28 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Leu 226 | 86 | B1 | ILE 28 | Stromal cell-derived factor 1 (A) | HBAcceptor |
| Leu 226 | 86 | B1 | ILE 28 | Stromal cell-derived factor 1 (A) | HBDonor |
| Leu 226 | 86 | B1 | ILE 28 | Stromal cell-derived factor 1 (A) | VdWContact |
| Leu 226 | 86 | B1 | LYS 27 | Stromal cell-derived factor 1 (A) | VdWContact |
| Lys 227 | 87 | B1 | HIS 25 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Lys 227 | 87 | B1 | LEU 26 | Stromal cell-derived factor 1 (A) | VdWContact |
| Lys 227 | 87 | B1 | LYS 27 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Lys 227 | 87 | B1 | LYS 27 | Stromal cell-derived factor 1 (A) | VdWContact |
| Ile 228 | 88 | B1 | TYR 307 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Ile 228 | 88 | B1 | HIS 25 | Stromal cell-derived factor 1 (A) | VdWContact |
| Ile 228 | 88 | B1 | ILE 28 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Ile 228 | 88 | B1 | ILE 28 | Stromal cell-derived factor 1 (A) | VdWContact |
| Ile 228 | 88 | B1 | LEU 26 | Stromal cell-derived factor 1 (A) | HBAcceptor |
| Ile 228 | 88 | B1 | LEU 26 | Stromal cell-derived factor 1 (A) | HBDonor |
| Ile 228 | 88 | B1 | LEU 26 | Stromal cell-derived factor 1 (A) | VdWContact |
| Ile 228 | 88 | B1 | TYR 61 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Ile 228 | 88 | B1 | TYR 61 | Stromal cell-derived factor 1 (A) | VdWContact |
| Leu 229 | 89 | B1 | TYR 307 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Leu 229 | 89 | B1 | HIS 25 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Leu 229 | 89 | B1 | TYR 312 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Leu 229 | 89 | B1 | TYR 312 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Leu 229 | 89 | B1 | ASP 310 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Asn 230 | 90 | 30s-loop | LYS 68 | Stromal cell-derived factor 1 (A) | VdWContact |
| Asn 230 | 90 | 30s-loop | ILE 306 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Asn 230 | 90 | 30s-loop | ILE 306 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Thr 231 | 91 | 30s-loop | TYR 312 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Pro 232 | 92 | 30s-loop | ILE 306 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Leu 236 | 99 | 30s-loop | CYS 65 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Leu 236 | 99 | 30s-loop | CYS 65 | Stromal cell-derived factor 1 (A) | VdWContact |
| Ile 238 | 101 | B2 | CYS 65 | Stromal cell-derived factor 1 (A) | VdWContact |
| Arg 241 | 104 | B2 | GLU 315 | C-X-C chemokine receptor type 4 (D) | Cationic |
| Lys 243 | 106 | 40s-loop | SER 109 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Lys 243 | 106 | 40s-loop | THR 108 | C-X-C chemokine receptor type 4 (B) | HBDonor |
| Lys 243 | 106 | 40s-loop | THR 108 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Arg 247 | 114 | 40s-loop | MET 316 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Arg 247 | 114 | 40s-loop | MET 316 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Arg 247 | 114 | 40s-loop | SER 318 | C-X-C chemokine receptor type 4 (D) | HBDonor |
| Arg 247 | 114 | 40s-loop | SER 318 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Gln 248 | 115 | B3 | GLU 315 | C-X-C chemokine receptor type 4 (D) | HBDonor |
| Gln 248 | 115 | B3 | GLU 315 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Lys 254 | 121 | 50s-loop | PRO 327 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Lys 254 | 121 | 50s-loop | GLU 326 | C-X-C chemokine receptor type 4 (D) | HBDonor |
| Lys 254 | 121 | 50s-loop | GLU 326 | C-X-C chemokine receptor type 4 (D) | Cationic |
| Lys 254 | 121 | 50s-loop | GLU 326 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Gln 259 | 126 | Helix | LEU 66 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Gln 259 | 126 | Helix | LEU 66 | Stromal cell-derived factor 1 (A) | HBDonor |
| Gln 259 | 126 | Helix | LEU 66 | Stromal cell-derived factor 1 (A) | VdWContact |
| Gln 259 | 126 | Helix | PRO 327 | C-X-C chemokine receptor type 4 (D) | Hydrophobic |
| Gln 259 | 126 | Helix | PRO 327 | C-X-C chemokine receptor type 4 (D) | VdWContact |
| Tyr 261 | 128 | Helix | TYR 107 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Tyr 261 | 128 | Helix | TYR 107 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Tyr 261 | 128 | Helix | ASN 30 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Tyr 261 | 128 | Helix | ASN 30 | Stromal cell-derived factor 1 (A) | VdWContact |
| Tyr 261 | 128 | Helix | ILE 28 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Tyr 261 | 128 | Helix | ILE 28 | Stromal cell-derived factor 1 (A) | VdWContact |
| Leu 262 | 129 | Helix | LEU 62 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Leu 262 | 129 | Helix | LEU 66 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Leu 262 | 129 | Helix | CYS 65 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Glu 263 | 130 | Helix | LEU 66 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Lys 264 | 131 | Helix | GLU 102 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Lys 264 | 131 | Helix | GLU 102 | C-X-C chemokine receptor type 4 (B) | HBDonor |
| Lys 264 | 131 | Helix | GLU 102 | C-X-C chemokine receptor type 4 (B) | Cationic |
| Lys 264 | 131 | Helix | GLU 102 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Lys 264 | 131 | Helix | MET 101 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Ala 265 | 132 | Helix | LEU 62 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Ala 265 | 132 | Helix | CYS 36 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Ala 265 | 132 | Helix | CYS 36 | Stromal cell-derived factor 1 (A) | VdWContact |
| Leu 266 | 133 | Helix | GLU 63 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Leu 266 | 133 | Helix | LEU 62 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Leu 266 | 133 | Helix | GLN 59 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Leu 266 | 133 | Helix | GLN 59 | Stromal cell-derived factor 1 (A) | VdWContact |
| Leu 266 | 133 | Helix | PHE 129 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Asn 267 | 134 | Helix | PHE 129 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Asn 267 | 134 | Helix | MET 101 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Lys 268 | 135 | Helix | ALA 35 | Stromal cell-derived factor 1 (A) | VdWContact |
| Lys 268 | 135 | Helix | MET 101 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Lys 268 | 135 | Helix | MET 101 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Lys 268 | 135 | Helix | ASN 30 | Stromal cell-derived factor 1 (A) | HBDonor |
| Lys 268 | 135 | Helix | ASN 30 | Stromal cell-derived factor 1 (A) | VdWContact |
| Lys 268 | 135 | Helix | CYS 36 | Stromal cell-derived factor 1 (A) | Hydrophobic |
| Lys 268 | 135 | Helix | CYS 36 | Stromal cell-derived factor 1 (A) | HBAcceptor |
| Lys 268 | 135 | Helix | CYS 36 | Stromal cell-derived factor 1 (A) | VdWContact |
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