Interactions for 2N55 (chain A)
Structure details
- PDB ID: 2N55 open_in_new
- Protein: CXCL12_HUMAN
- Organism: Homo sapiens
- UniProt ID: P48061 open_in_new
- Method: Solution nmr
- Resolution: 0.0 Å
- Date: April 27, 2016
- Reference: 10.1126/SCISIGNAL.AAH5756 open_in_new
- State: monomer
Chemokine diagram
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Interactions found in structure
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| Chemokine Residue | Generic number | Segment | Partner Residue | Partner | Interaction Type |
|---|---|---|---|---|---|
| Leu 5 | 59 | N-term | THR 213 | C-X-C chemokine receptor type 4 (B) | HBDonor |
| Leu 5 | 59 | N-term | THR 213 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Leu 5 | 59 | N-term | ASN 211 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Tyr 7 | 61 | N-term | TYR 212 | C-X-C chemokine receptor type 4 (B) | HBAcceptor |
| Tyr 7 | 61 | N-term | TYR 212 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Tyr 7 | 61 | N-term | ASN 211 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Pro 10 | 66 | CX | TYR 212 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Cys 11 | 67 | CX | SER 218 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Arg 12 | 68 | N-loop | SER 218 | C-X-C chemokine receptor type 4 (B) | HBDonor |
| Arg 12 | 68 | N-loop | SER 218 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Phe 13 | 69 | N-loop | MET 224 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Phe 14 | 70 | N-loop | MET 224 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Phe 14 | 70 | N-loop | MET 224 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Glu 15 | 71 | N-loop | TYR 221 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Glu 15 | 71 | N-loop | TYR 221 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Ser 16 | 72 | N-loop | GLU 226 | C-X-C chemokine receptor type 4 (B) | HBDonor |
| Ser 16 | 72 | N-loop | GLU 226 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Ser 16 | 72 | N-loop | LYS 225 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Ser 16 | 72 | N-loop | MET 224 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| His 17 | 74 | N-loop | LYS 225 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| His 17 | 74 | N-loop | PHE 236 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| His 17 | 74 | N-loop | PHE 236 | C-X-C chemokine receptor type 4 (B) | PiStacking |
| His 17 | 74 | N-loop | PRO 227 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Arg 20 | 80 | N-loop | GLY 199 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Arg 20 | 80 | N-loop | ILE 204 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| His 25 | 85 | B1 | TYR 207 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| His 25 | 85 | B1 | TYR 207 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Leu 26 | 86 | B1 | ILE 204 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Leu 26 | 86 | B1 | ILE 206 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Leu 26 | 86 | B1 | ILE 206 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Lys 27 | 87 | B1 | TYR 212 | C-X-C chemokine receptor type 4 (B) | HBDonor |
| Lys 27 | 87 | B1 | TYR 212 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Lys 27 | 87 | B1 | SER 209 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Lys 27 | 87 | B1 | TYR 207 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Lys 27 | 87 | B1 | TYR 207 | C-X-C chemokine receptor type 4 (B) | HBDonor |
| Lys 27 | 87 | B1 | TYR 207 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Lys 27 | 87 | B1 | GLU 214 | C-X-C chemokine receptor type 4 (B) | HBDonor |
| Lys 27 | 87 | B1 | GLU 214 | C-X-C chemokine receptor type 4 (B) | Cationic |
| Lys 27 | 87 | B1 | GLU 214 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Lys 27 | 87 | B1 | ILE 206 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Ile 28 | 88 | B1 | THR 208 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Ile 28 | 88 | B1 | SER 209 | C-X-C chemokine receptor type 4 (B) | HBAcceptor |
| Ile 28 | 88 | B1 | SER 209 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Ile 28 | 88 | B1 | TYR 207 | C-X-C chemokine receptor type 4 (B) | HBDonor |
| Ile 28 | 88 | B1 | TYR 207 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Ile 28 | 88 | B1 | ILE 206 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Leu 29 | 89 | B1 | TYR 212 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Leu 29 | 89 | B1 | TYR 212 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Leu 29 | 89 | B1 | SER 209 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Asn 30 | 90 | 30s-loop | THR 208 | C-X-C chemokine receptor type 4 (B) | HBDonor |
| Asn 30 | 90 | 30s-loop | THR 208 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Asn 30 | 90 | 30s-loop | SER 209 | C-X-C chemokine receptor type 4 (B) | HBDonor |
| Thr 31 | 91 | 30s-loop | ASP 210 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Val 39 | 102 | B2 | TYR 212 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Arg 41 | 104 | B2 | GLU 214 | C-X-C chemokine receptor type 4 (B) | HBDonor |
| Arg 41 | 104 | B2 | GLU 214 | C-X-C chemokine receptor type 4 (B) | Cationic |
| Arg 41 | 104 | B2 | GLU 214 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Leu 42 | 105 | B2 | TYR 221 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Leu 42 | 105 | B2 | TYR 221 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Arg 47 | 114 | 40s-loop | ASP 220 | C-X-C chemokine receptor type 4 (B) | HBDonor |
| Arg 47 | 114 | 40s-loop | ASP 220 | C-X-C chemokine receptor type 4 (B) | Cationic |
| Arg 47 | 114 | 40s-loop | ASP 220 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Arg 47 | 114 | 40s-loop | TYR 221 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Gln 48 | 115 | B3 | TYR 212 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Gln 48 | 115 | B3 | GLU 215 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Gln 48 | 115 | B3 | GLU 215 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Val 49 | 116 | B3 | TYR 221 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Val 49 | 116 | B3 | TYR 221 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Asp 52 | 119 | 50s-loop | GLU 226 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Asp 52 | 119 | 50s-loop | GLU 226 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Lys 54 | 121 | 50s-loop | GLU 226 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Lys 54 | 121 | 50s-loop | GLU 226 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Leu 55 | 122 | 50s-loop | PRO 227 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Lys 56 | 123 | Helix | GLU 231 | C-X-C chemokine receptor type 4 (B) | Cationic |
| Lys 56 | 123 | Helix | ARG 230 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Lys 56 | 123 | Helix | ARG 230 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Lys 56 | 123 | Helix | PHE 229 | C-X-C chemokine receptor type 4 (B) | HBDonor |
| Lys 56 | 123 | Helix | PHE 229 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Trp 57 | 124 | Helix | ILE 204 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Trp 57 | 124 | Helix | ILE 204 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Tyr 61 | 128 | Helix | ILE 204 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Tyr 61 | 128 | Helix | ILE 204 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Tyr 61 | 128 | Helix | ILE 206 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Tyr 61 | 128 | Helix | ILE 206 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Lys 64 | 131 | Helix | GLU 202 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Lys 64 | 131 | Helix | GLY 203 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Ala 65 | 132 | Helix | ILE 206 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Ala 65 | 132 | Helix | ILE 206 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Lys 68 | 135 | Helix | THR 208 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Lys 68 | 135 | Helix | SER 205 | C-X-C chemokine receptor type 4 (B) | HBAcceptor |
| Lys 68 | 135 | Helix | SER 205 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Lys 68 | 135 | Helix | ILE 206 | C-X-C chemokine receptor type 4 (B) | VdWContact |
| Lys 68 | 135 | Helix | TYR 207 | C-X-C chemokine receptor type 4 (B) | Hydrophobic |
| Lys 68 | 135 | Helix | TYR 207 | C-X-C chemokine receptor type 4 (B) | VdWContact |
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