Interactions for 2NWG (chain A)
Structure details
- PDB ID: 2NWG open_in_new
- Protein: CXCL12_HUMAN
- Organism: Homo sapiens
- UniProt ID: P48061 open_in_new
- Method: X-ray
- Resolution: 2.07 Å
- Date: Feb. 13, 2007
- Reference: 10.1074/JBC.M608796200 open_in_new
- State: dimer
Chemokine diagram
Pick color:
, 'snake_.png', {scale: 3});){kind=link}
, 'snake_.jpg', {scale: 3});){kind=link}
Interactions found in structure
Download list in excel
| Chemokine Residue | Generic number | Segment | Partner Residue | Partner | Interaction Type |
|---|---|---|---|---|---|
| Ala 19 | 76 | N-loop | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | VdWContact |
| Ala 19 | 76 | N-loop | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | VdWContact |
| Arg 20 | 80 | N-loop | ASN 30 | Stromal cell-derived factor 1 (B) | HBDonor |
| Arg 20 | 80 | N-loop | ASN 30 | Stromal cell-derived factor 1 (B) | VdWContact |
| Arg 20 | 80 | N-loop | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | HBAcceptor |
| Arg 20 | 80 | N-loop | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | Anionic |
| Arg 20 | 80 | N-loop | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | VdWContact |
| Arg 20 | 80 | N-loop | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | HBAcceptor |
| Arg 20 | 80 | N-loop | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | Anionic |
| Arg 20 | 80 | N-loop | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | VdWContact |
| Ala 21 | 81 | N-loop | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | HBAcceptor |
| Ala 21 | 81 | N-loop | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | VdWContact |
| Ala 21 | 81 | N-loop | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | HBAcceptor |
| Ala 21 | 81 | N-loop | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | VdWContact |
| Val 23 | 83 | B1 | ASN 30 | Stromal cell-derived factor 1 (B) | HBAcceptor |
| Val 23 | 83 | B1 | ASN 30 | Stromal cell-derived factor 1 (B) | VdWContact |
| Lys 24 | 84 | B1 | ASN 30 | Stromal cell-derived factor 1 (B) | HBAcceptor |
| Lys 24 | 84 | B1 | ASN 30 | Stromal cell-derived factor 1 (B) | VdWContact |
| His 25 | 85 | B1 | LEU 29 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| His 25 | 85 | B1 | ILE 28 | Stromal cell-derived factor 1 (B) | VdWContact |
| His 25 | 85 | B1 | LYS 27 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| His 25 | 85 | B1 | LYS 27 | Stromal cell-derived factor 1 (B) | PiCation |
| Leu 26 | 86 | B1 | ILE 28 | Stromal cell-derived factor 1 (B) | HBAcceptor |
| Leu 26 | 86 | B1 | ILE 28 | Stromal cell-derived factor 1 (B) | HBDonor |
| Leu 26 | 86 | B1 | ILE 28 | Stromal cell-derived factor 1 (B) | VdWContact |
| Leu 26 | 86 | B1 | LYS 27 | Stromal cell-derived factor 1 (B) | VdWContact |
| Lys 27 | 87 | B1 | HIS 25 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Lys 27 | 87 | B1 | HIS 25 | Stromal cell-derived factor 1 (B) | VdWContact |
| Lys 27 | 87 | B1 | LEU 26 | Stromal cell-derived factor 1 (B) | VdWContact |
| Lys 27 | 87 | B1 | LYS 27 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Lys 27 | 87 | B1 | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | HBAcceptor |
| Lys 27 | 87 | B1 | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | Anionic |
| Lys 27 | 87 | B1 | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | VdWContact |
| Lys 27 | 87 | B1 | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | HBAcceptor |
| Lys 27 | 87 | B1 | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | Anionic |
| Lys 27 | 87 | B1 | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | VdWContact |
| Ile 28 | 88 | B1 | ALA 65 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Ile 28 | 88 | B1 | ALA 65 | Stromal cell-derived factor 1 (B) | VdWContact |
| Ile 28 | 88 | B1 | LEU 62 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Ile 28 | 88 | B1 | LEU 62 | Stromal cell-derived factor 1 (B) | VdWContact |
| Ile 28 | 88 | B1 | TYR 61 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Ile 28 | 88 | B1 | TYR 61 | Stromal cell-derived factor 1 (B) | HBAcceptor |
| Ile 28 | 88 | B1 | TYR 61 | Stromal cell-derived factor 1 (B) | VdWContact |
| Ile 28 | 88 | B1 | ILE 28 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Ile 28 | 88 | B1 | LEU 26 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Ile 28 | 88 | B1 | LEU 26 | Stromal cell-derived factor 1 (B) | HBAcceptor |
| Ile 28 | 88 | B1 | LEU 26 | Stromal cell-derived factor 1 (B) | HBDonor |
| Ile 28 | 88 | B1 | LEU 26 | Stromal cell-derived factor 1 (B) | VdWContact |
| Leu 29 | 89 | B1 | HIS 25 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Leu 29 | 89 | B1 | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | Hydrophobic |
| Leu 29 | 89 | B1 | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | Hydrophobic |
| Asn 30 | 90 | 30s-loop | TYR 61 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Asn 30 | 90 | 30s-loop | TYR 61 | Stromal cell-derived factor 1 (B) | VdWContact |
| Asn 30 | 90 | 30s-loop | LYS 24 | Stromal cell-derived factor 1 (B) | HBDonor |
| Asn 30 | 90 | 30s-loop | LYS 24 | Stromal cell-derived factor 1 (B) | VdWContact |
| Asn 30 | 90 | 30s-loop | VAL 23 | Stromal cell-derived factor 1 (B) | HBDonor |
| Asn 30 | 90 | 30s-loop | VAL 23 | Stromal cell-derived factor 1 (B) | VdWContact |
| Gln 37 | 100 | 30s-loop | ALA 65 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Gln 37 | 100 | 30s-loop | ALA 65 | Stromal cell-derived factor 1 (B) | VdWContact |
| Ile 38 | 101 | B2 | ALA 65 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Ile 38 | 101 | B2 | LEU 66 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Arg 41 | 104 | B2 | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | Anionic |
| Arg 41 | 104 | B2 | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | VdWContact |
| Arg 41 | 104 | B2 | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | Anionic |
| Arg 41 | 104 | B2 | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | VdWContact |
| Gln 48 | 115 | B3 | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | VdWContact |
| Gln 48 | 115 | B3 | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | VdWContact |
| Lys 54 | 121 | 50s-loop | ASN 67 | Stromal cell-derived factor 1 (B) | HBDonor |
| Lys 54 | 121 | 50s-loop | ASN 67 | Stromal cell-derived factor 1 (B) | Cationic |
| Lys 54 | 121 | 50s-loop | ASN 67 | Stromal cell-derived factor 1 (B) | VdWContact |
| Ile 58 | 125 | Helix | LEU 66 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Gln 59 | 126 | Helix | LEU 66 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Tyr 61 | 128 | Helix | ASN 30 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Tyr 61 | 128 | Helix | ASN 30 | Stromal cell-derived factor 1 (B) | VdWContact |
| Tyr 61 | 128 | Helix | LEU 29 | Stromal cell-derived factor 1 (B) | VdWContact |
| Tyr 61 | 128 | Helix | ILE 28 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Tyr 61 | 128 | Helix | ILE 28 | Stromal cell-derived factor 1 (B) | HBDonor |
| Tyr 61 | 128 | Helix | ILE 28 | Stromal cell-derived factor 1 (B) | VdWContact |
| Leu 62 | 129 | Helix | LEU 62 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Leu 62 | 129 | Helix | ILE 28 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Leu 62 | 129 | Helix | ILE 28 | Stromal cell-derived factor 1 (B) | VdWContact |
| Leu 62 | 129 | Helix | LEU 66 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Leu 62 | 129 | Helix | LEU 66 | Stromal cell-derived factor 1 (B) | VdWContact |
| Lys 64 | 131 | Helix | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | HBAcceptor |
| Lys 64 | 131 | Helix | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | Anionic |
| Lys 64 | 131 | Helix | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | VdWContact |
| Lys 64 | 131 | Helix | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | HBAcceptor |
| Lys 64 | 131 | Helix | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | Anionic |
| Lys 64 | 131 | Helix | UNL 1 | HEPARIN DISACCHARIDE I-S, (None) | VdWContact |
| Ala 65 | 132 | Helix | ILE 38 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Ala 65 | 132 | Helix | ILE 38 | Stromal cell-derived factor 1 (B) | VdWContact |
| Ala 65 | 132 | Helix | ILE 28 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Ala 65 | 132 | Helix | GLN 37 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Ala 65 | 132 | Helix | GLN 37 | Stromal cell-derived factor 1 (B) | VdWContact |
| Leu 66 | 133 | Helix | ILE 38 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Leu 66 | 133 | Helix | LEU 62 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Leu 66 | 133 | Helix | LYS 54 | Stromal cell-derived factor 1 (B) | HBAcceptor |
| Leu 66 | 133 | Helix | LYS 54 | Stromal cell-derived factor 1 (B) | VdWContact |
| Leu 66 | 133 | Helix | GLN 59 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Leu 66 | 133 | Helix | ILE 58 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Leu 66 | 133 | Helix | ILE 58 | Stromal cell-derived factor 1 (B) | VdWContact |
| Asn 67 | 134 | Helix | LYS 54 | Stromal cell-derived factor 1 (B) | Anionic |
| Asn 67 | 134 | Helix | LYS 54 | Stromal cell-derived factor 1 (B) | VdWContact |
Ligand interaction network
SGN_C_1_UAP_C_2
SGN_D_1_UAP_D_2
Interaction pattern search
Search complexes with similar interaction patterns:
