Interactions for 4LMQ (chain D)
Structure details
- PDB ID: 4LMQ open_in_new
- Protein: CXCL12_HUMAN
- Organism: Homo sapiens
- UniProt ID: P48061 open_in_new
- Method: X-ray
- Resolution: 2.77 Å
- Date: Aug. 14, 2013
- Reference: 10.1158/1078-0432.CCR-13-0943 open_in_new
- State: dimer
Chemokine diagram
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Interactions found in structure
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| Chemokine Residue | Generic number | Segment | Partner Residue | Partner | Interaction Type |
|---|---|---|---|---|---|
| Glu 15 | 71 | N-loop | ASN 99 | hu30D8 Fab heavy chain (H) | Hydrophobic |
| Glu 15 | 71 | N-loop | ASN 99 | hu30D8 Fab heavy chain (H) | HBAcceptor |
| Glu 15 | 71 | N-loop | ASN 99 | hu30D8 Fab heavy chain (H) | VdWContact |
| Ser 16 | 72 | N-loop | TYR 100 | hu30D8 Fab heavy chain (H) | VdWContact |
| His 17 | 74 | N-loop | TYR 31 | hu30D8 Fab light chain (L) | Hydrophobic |
| His 17 | 74 | N-loop | TYR 31 | hu30D8 Fab light chain (L) | PiStacking |
| His 17 | 74 | N-loop | TYR 31 | hu30D8 Fab light chain (L) | VdWContact |
| His 17 | 74 | N-loop | ASN 50 | hu30D8 Fab light chain (L) | HBAcceptor |
| His 17 | 74 | N-loop | ASN 50 | hu30D8 Fab light chain (L) | VdWContact |
| His 17 | 74 | N-loop | TYR 100 | hu30D8 Fab heavy chain (H) | Hydrophobic |
| His 17 | 74 | N-loop | TYR 100 | hu30D8 Fab heavy chain (H) | VdWContact |
| Val 18 | 75 | N-loop | ASN 99 | hu30D8 Fab heavy chain (H) | Hydrophobic |
| Ala 19 | 76 | N-loop | TYR 91 | hu30D8 Fab light chain (L) | Hydrophobic |
| Ala 19 | 76 | N-loop | TYR 91 | hu30D8 Fab light chain (L) | VdWContact |
| Ala 19 | 76 | N-loop | SER 32 | hu30D8 Fab light chain (L) | VdWContact |
| Ala 19 | 76 | N-loop | TYR 100 | hu30D8 Fab heavy chain (H) | HBDonor |
| Ala 19 | 76 | N-loop | TYR 100 | hu30D8 Fab heavy chain (H) | VdWContact |
| Ala 19 | 76 | N-loop | TRP 92 | hu30D8 Fab light chain (L) | Hydrophobic |
| Ala 19 | 76 | N-loop | TRP 92 | hu30D8 Fab light chain (L) | VdWContact |
| Arg 20 | 80 | N-loop | TRP 92 | hu30D8 Fab light chain (L) | Hydrophobic |
| Arg 20 | 80 | N-loop | TRP 92 | hu30D8 Fab light chain (L) | VdWContact |
| Arg 20 | 80 | N-loop | ASN 93 | hu30D8 Fab light chain (L) | VdWContact |
| Ala 21 | 81 | N-loop | PHE 96 | hu30D8 Fab light chain (L) | Hydrophobic |
| Ala 21 | 81 | N-loop | TRP 92 | hu30D8 Fab light chain (L) | HBDonor |
| Ala 21 | 81 | N-loop | TRP 92 | hu30D8 Fab light chain (L) | VdWContact |
| Ala 21 | 81 | N-loop | THR 94 | hu30D8 Fab light chain (L) | Hydrophobic |
| Ala 21 | 81 | N-loop | THR 94 | hu30D8 Fab light chain (L) | VdWContact |
| Ala 21 | 81 | N-loop | ASN 93 | hu30D8 Fab light chain (L) | VdWContact |
| Asn 22 | 82 | N-loop | ASN 99 | hu30D8 Fab heavy chain (H) | HBDonor |
| Asn 22 | 82 | N-loop | ASN 99 | hu30D8 Fab heavy chain (H) | VdWContact |
| Asn 22 | 82 | N-loop | GLY 100 | hu30D8 Fab heavy chain (H) | VdWContact |
| His 25 | 85 | B1 | ILE 28 | Stromal cell-derived factor 1 (F) | VdWContact |
| His 25 | 85 | B1 | LEU 29 | Stromal cell-derived factor 1 (F) | Hydrophobic |
| His 25 | 85 | B1 | LYS 27 | Stromal cell-derived factor 1 (F) | Hydrophobic |
| Leu 26 | 86 | B1 | ILE 28 | Stromal cell-derived factor 1 (F) | Hydrophobic |
| Leu 26 | 86 | B1 | ILE 28 | Stromal cell-derived factor 1 (F) | HBAcceptor |
| Leu 26 | 86 | B1 | ILE 28 | Stromal cell-derived factor 1 (F) | HBDonor |
| Leu 26 | 86 | B1 | ILE 28 | Stromal cell-derived factor 1 (F) | VdWContact |
| Lys 27 | 87 | B1 | HIS 25 | Stromal cell-derived factor 1 (F) | Hydrophobic |
| Lys 27 | 87 | B1 | HIS 25 | Stromal cell-derived factor 1 (F) | CationPi |
| Lys 27 | 87 | B1 | HIS 25 | Stromal cell-derived factor 1 (F) | VdWContact |
| Ile 28 | 88 | B1 | TYR 61 | Stromal cell-derived factor 1 (F) | Hydrophobic |
| Ile 28 | 88 | B1 | ILE 28 | Stromal cell-derived factor 1 (F) | Hydrophobic |
| Ile 28 | 88 | B1 | LEU 26 | Stromal cell-derived factor 1 (F) | HBAcceptor |
| Ile 28 | 88 | B1 | LEU 26 | Stromal cell-derived factor 1 (F) | HBDonor |
| Ile 28 | 88 | B1 | LEU 26 | Stromal cell-derived factor 1 (F) | VdWContact |
| Leu 29 | 89 | B1 | HIS 25 | Stromal cell-derived factor 1 (F) | Hydrophobic |
| Asn 30 | 90 | 30s-loop | LYS 24 | Stromal cell-derived factor 1 (F) | HBDonor |
| Asn 30 | 90 | 30s-loop | LYS 24 | Stromal cell-derived factor 1 (F) | VdWContact |
| Leu 36 | 99 | 30s-loop | TYR 61 | Stromal cell-derived factor 1 (F) | Hydrophobic |
| Leu 36 | 99 | 30s-loop | ALA 65 | Stromal cell-derived factor 1 (F) | Hydrophobic |
| Leu 36 | 99 | 30s-loop | ALA 65 | Stromal cell-derived factor 1 (F) | VdWContact |
| Leu 42 | 105 | B2 | ASN 99 | hu30D8 Fab heavy chain (H) | Hydrophobic |
| Lys 43 | 106 | 40s-loop | TRP 52 | hu30D8 Fab heavy chain (H) | Hydrophobic |
| Lys 43 | 106 | 40s-loop | TRP 52 | hu30D8 Fab heavy chain (H) | VdWContact |
| Lys 43 | 106 | 40s-loop | GLU 58 | hu30D8 Fab heavy chain (H) | Cationic |
| Lys 43 | 106 | 40s-loop | GLU 58 | hu30D8 Fab heavy chain (H) | VdWContact |
| Asn 44 | 111 | 40s-loop | GLY 97 | hu30D8 Fab heavy chain (H) | VdWContact |
| Asn 44 | 111 | 40s-loop | TRP 52 | hu30D8 Fab heavy chain (H) | Hydrophobic |
| Asn 44 | 111 | 40s-loop | TRP 52 | hu30D8 Fab heavy chain (H) | VdWContact |
| Asn 44 | 111 | 40s-loop | LEU 98 | hu30D8 Fab heavy chain (H) | HBDonor |
| Asn 44 | 111 | 40s-loop | LEU 98 | hu30D8 Fab heavy chain (H) | VdWContact |
| Asn 44 | 111 | 40s-loop | SER 33 | hu30D8 Fab heavy chain (H) | HBAcceptor |
| Asn 44 | 111 | 40s-loop | SER 33 | hu30D8 Fab heavy chain (H) | VdWContact |
| Asn 44 | 111 | 40s-loop | ASP 95 | hu30D8 Fab heavy chain (H) | HBDonor |
| Asn 44 | 111 | 40s-loop | ASP 95 | hu30D8 Fab heavy chain (H) | VdWContact |
| Asn 45 | 112 | 40s-loop | GLY 97 | hu30D8 Fab heavy chain (H) | HBDonor |
| Asn 45 | 112 | 40s-loop | GLY 97 | hu30D8 Fab heavy chain (H) | VdWContact |
| Asn 45 | 112 | 40s-loop | ASN 99 | hu30D8 Fab heavy chain (H) | HBDonor |
| Asn 45 | 112 | 40s-loop | ASN 99 | hu30D8 Fab heavy chain (H) | VdWContact |
| Asn 46 | 113 | 40s-loop | SER 54 | hu30D8 Fab heavy chain (H) | HBAcceptor |
| Asn 46 | 113 | 40s-loop | SER 54 | hu30D8 Fab heavy chain (H) | VdWContact |
| Arg 47 | 114 | 40s-loop | ASN 99 | hu30D8 Fab heavy chain (H) | HBDonor |
| Arg 47 | 114 | 40s-loop | ASN 99 | hu30D8 Fab heavy chain (H) | VdWContact |
| Trp 57 | 124 | Helix | TRP 92 | hu30D8 Fab light chain (L) | Hydrophobic |
| Trp 57 | 124 | Helix | TRP 92 | hu30D8 Fab light chain (L) | VdWContact |
| Tyr 61 | 128 | Helix | ILE 28 | Stromal cell-derived factor 1 (F) | Hydrophobic |
| Tyr 61 | 128 | Helix | ILE 28 | Stromal cell-derived factor 1 (F) | HBDonor |
| Tyr 61 | 128 | Helix | ILE 28 | Stromal cell-derived factor 1 (F) | VdWContact |
| Tyr 61 | 128 | Helix | ASN 30 | Stromal cell-derived factor 1 (F) | Hydrophobic |
| Tyr 61 | 128 | Helix | ASN 30 | Stromal cell-derived factor 1 (F) | VdWContact |
| Leu 62 | 129 | Helix | ILE 28 | Stromal cell-derived factor 1 (F) | Hydrophobic |
| Glu 63 | 130 | Helix | LEU 62 | Stromal cell-derived factor 1 (F) | Hydrophobic |
| Glu 63 | 130 | Helix | LEU 62 | Stromal cell-derived factor 1 (F) | VdWContact |
| Ala 65 | 132 | Helix | GLN 37 | Stromal cell-derived factor 1 (F) | Hydrophobic |
| Ala 65 | 132 | Helix | GLN 37 | Stromal cell-derived factor 1 (F) | VdWContact |
| Ala 65 | 132 | Helix | ILE 38 | Stromal cell-derived factor 1 (F) | Hydrophobic |
| Ala 65 | 132 | Helix | ILE 28 | Stromal cell-derived factor 1 (F) | Hydrophobic |
| Leu 66 | 133 | Helix | LEU 62 | Stromal cell-derived factor 1 (F) | Hydrophobic |
| Leu 66 | 133 | Helix | ILE 38 | Stromal cell-derived factor 1 (F) | Hydrophobic |
| Leu 66 | 133 | Helix | ILE 38 | Stromal cell-derived factor 1 (F) | VdWContact |
| Leu 66 | 133 | Helix | ILE 58 | Stromal cell-derived factor 1 (F) | Hydrophobic |
| Leu 66 | 133 | Helix | PRO 53 | Stromal cell-derived factor 1 (F) | Hydrophobic |
| Lys 68 | 135 | Helix | GLN 59 | Stromal cell-derived factor 1 (F) | VdWContact |
| Lys 68 | 135 | Helix | LEU 62 | Stromal cell-derived factor 1 (F) | Hydrophobic |
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