Interactions for 4UAI (chain A)
Structure details
- PDB ID: 4UAI open_in_new
- Protein: CXCL12_HUMAN
- Organism: Homo sapiens
- UniProt ID: P48061 open_in_new
- Method: X-ray
- Resolution: 1.9 Å
- Date: Nov. 12, 2014
- Reference: 10.1021/JM501194P open_in_new
- State: dimer
Chemokine diagram
Pick color:
, 'snake_.png', {scale: 3});){kind=link}
, 'snake_.jpg', {scale: 3});){kind=link}
Interactions found in structure
Download list in excel
| Chemokine Residue | Generic number | Segment | Partner Residue | Partner | Interaction Type |
|---|---|---|---|---|---|
| Glu 15 | 71 | N-loop | UNL 1 | 1-phenyl-3-[4-(1H-tetrazol-5-yl)phenyl]urea (None) | HBDonor |
| Glu 15 | 71 | N-loop | UNL 1 | 1-phenyl-3-[4-(1H-tetrazol-5-yl)phenyl]urea (None) | VdWContact |
| Val 18 | 75 | N-loop | UNL 1 | 1-phenyl-3-[4-(1H-tetrazol-5-yl)phenyl]urea (None) | Hydrophobic |
| Val 18 | 75 | N-loop | UNL 1 | 1-phenyl-3-[4-(1H-tetrazol-5-yl)phenyl]urea (None) | VdWContact |
| Ala 19 | 76 | N-loop | UNL 1 | 1-phenyl-3-[4-(1H-tetrazol-5-yl)phenyl]urea (None) | HBAcceptor |
| Ala 19 | 76 | N-loop | UNL 1 | 1-phenyl-3-[4-(1H-tetrazol-5-yl)phenyl]urea (None) | VdWContact |
| Ala 19 | 76 | N-loop | UNL 1 | 1-phenyl-3-[4-(1H-tetrazol-5-yl)phenyl]urea (None) | VdWContact |
| Arg 20 | 80 | N-loop | UNL 1 | 1-phenyl-3-[4-(1H-tetrazol-5-yl)phenyl]urea (None) | Anionic |
| Arg 20 | 80 | N-loop | UNL 1 | 1-phenyl-3-[4-(1H-tetrazol-5-yl)phenyl]urea (None) | VdWContact |
| Ala 21 | 81 | N-loop | UNL 1 | 1-phenyl-3-[4-(1H-tetrazol-5-yl)phenyl]urea (None) | HBAcceptor |
| Ala 21 | 81 | N-loop | UNL 1 | 1-phenyl-3-[4-(1H-tetrazol-5-yl)phenyl]urea (None) | VdWContact |
| Asn 22 | 82 | N-loop | UNL 1 | 1-phenyl-3-[4-(1H-tetrazol-5-yl)phenyl]urea (None) | Hydrophobic |
| Asn 22 | 82 | N-loop | UNL 1 | 1-phenyl-3-[4-(1H-tetrazol-5-yl)phenyl]urea (None) | HBAcceptor |
| Asn 22 | 82 | N-loop | UNL 1 | 1-phenyl-3-[4-(1H-tetrazol-5-yl)phenyl]urea (None) | VdWContact |
| Val 23 | 83 | B1 | ASN 30 | Stromal cell-derived factor 1 (B) | HBAcceptor |
| Val 23 | 83 | B1 | ASN 30 | Stromal cell-derived factor 1 (B) | VdWContact |
| Lys 24 | 84 | B1 | ASN 30 | Stromal cell-derived factor 1 (B) | HBAcceptor |
| Lys 24 | 84 | B1 | ASN 30 | Stromal cell-derived factor 1 (B) | VdWContact |
| His 25 | 85 | B1 | LYS 27 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| His 25 | 85 | B1 | LEU 29 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Leu 26 | 86 | B1 | ILE 28 | Stromal cell-derived factor 1 (B) | HBAcceptor |
| Leu 26 | 86 | B1 | ILE 28 | Stromal cell-derived factor 1 (B) | HBDonor |
| Leu 26 | 86 | B1 | ILE 28 | Stromal cell-derived factor 1 (B) | VdWContact |
| Leu 26 | 86 | B1 | LYS 27 | Stromal cell-derived factor 1 (B) | VdWContact |
| Lys 27 | 87 | B1 | HIS 25 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Lys 27 | 87 | B1 | LEU 26 | Stromal cell-derived factor 1 (B) | VdWContact |
| Lys 27 | 87 | B1 | LYS 27 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Ile 28 | 88 | B1 | LEU 26 | Stromal cell-derived factor 1 (B) | HBAcceptor |
| Ile 28 | 88 | B1 | LEU 26 | Stromal cell-derived factor 1 (B) | HBDonor |
| Ile 28 | 88 | B1 | LEU 26 | Stromal cell-derived factor 1 (B) | VdWContact |
| Ile 28 | 88 | B1 | ILE 28 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Ile 28 | 88 | B1 | ALA 65 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Ile 28 | 88 | B1 | TYR 61 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Ile 28 | 88 | B1 | TYR 61 | Stromal cell-derived factor 1 (B) | HBAcceptor |
| Ile 28 | 88 | B1 | TYR 61 | Stromal cell-derived factor 1 (B) | VdWContact |
| Ile 28 | 88 | B1 | HIS 25 | Stromal cell-derived factor 1 (B) | VdWContact |
| Ile 28 | 88 | B1 | LEU 62 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Leu 29 | 89 | B1 | HIS 25 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Asn 30 | 90 | 30s-loop | VAL 23 | Stromal cell-derived factor 1 (B) | HBDonor |
| Asn 30 | 90 | 30s-loop | VAL 23 | Stromal cell-derived factor 1 (B) | VdWContact |
| Asn 30 | 90 | 30s-loop | TYR 61 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Asn 30 | 90 | 30s-loop | TYR 61 | Stromal cell-derived factor 1 (B) | VdWContact |
| Asn 30 | 90 | 30s-loop | LYS 24 | Stromal cell-derived factor 1 (B) | HBDonor |
| Asn 30 | 90 | 30s-loop | LYS 24 | Stromal cell-derived factor 1 (B) | VdWContact |
| Ala 35 | 97 | 30s-loop | LYS 68 | Stromal cell-derived factor 1 (B) | VdWContact |
| Gln 37 | 100 | 30s-loop | ALA 65 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Gln 37 | 100 | 30s-loop | ALA 65 | Stromal cell-derived factor 1 (B) | VdWContact |
| Ile 38 | 101 | B2 | ALA 65 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Ile 38 | 101 | B2 | LEU 66 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Leu 42 | 105 | B2 | UNL 1 | 1-phenyl-3-[4-(1H-tetrazol-5-yl)phenyl]urea (None) | Hydrophobic |
| Asn 44 | 111 | 40s-loop | UNL 1 | 1-phenyl-3-[4-(1H-tetrazol-5-yl)phenyl]urea (None) | VdWContact |
| Arg 47 | 114 | 40s-loop | UNL 1 | 1-phenyl-3-[4-(1H-tetrazol-5-yl)phenyl]urea (None) | PiCation |
| Arg 47 | 114 | 40s-loop | UNL 1 | 1-phenyl-3-[4-(1H-tetrazol-5-yl)phenyl]urea (None) | VdWContact |
| Val 49 | 116 | B3 | UNL 1 | 1-phenyl-3-[4-(1H-tetrazol-5-yl)phenyl]urea (None) | Hydrophobic |
| Lys 54 | 121 | 50s-loop | LYS 68 | Stromal cell-derived factor 1 (B) | HBDonor |
| Lys 54 | 121 | 50s-loop | LYS 68 | Stromal cell-derived factor 1 (B) | VdWContact |
| Ile 58 | 125 | Helix | LEU 66 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Gln 59 | 126 | Helix | LEU 66 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Tyr 61 | 128 | Helix | ILE 28 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Tyr 61 | 128 | Helix | ILE 28 | Stromal cell-derived factor 1 (B) | HBDonor |
| Tyr 61 | 128 | Helix | ILE 28 | Stromal cell-derived factor 1 (B) | VdWContact |
| Tyr 61 | 128 | Helix | LEU 29 | Stromal cell-derived factor 1 (B) | VdWContact |
| Tyr 61 | 128 | Helix | ASN 30 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Tyr 61 | 128 | Helix | ASN 30 | Stromal cell-derived factor 1 (B) | VdWContact |
| Leu 62 | 129 | Helix | ILE 28 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Leu 62 | 129 | Helix | ILE 28 | Stromal cell-derived factor 1 (B) | VdWContact |
| Leu 62 | 129 | Helix | LEU 62 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Leu 62 | 129 | Helix | LEU 66 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Ala 65 | 132 | Helix | ILE 28 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Ala 65 | 132 | Helix | GLN 37 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Ala 65 | 132 | Helix | ILE 38 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Leu 66 | 133 | Helix | ILE 58 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Leu 66 | 133 | Helix | ILE 38 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Leu 66 | 133 | Helix | LEU 62 | Stromal cell-derived factor 1 (B) | Hydrophobic |
| Lys 68 | 135 | Helix | LYS 54 | Stromal cell-derived factor 1 (B) | HBAcceptor |
| Lys 68 | 135 | Helix | LYS 54 | Stromal cell-derived factor 1 (B) | VdWContact |
| Lys 68 | 135 | Helix | ALA 35 | Stromal cell-derived factor 1 (B) | VdWContact |
| Lys 68 | 135 | Helix | CYS 34 | Stromal cell-derived factor 1 (B) | HBDonor |
| Lys 68 | 135 | Helix | CYS 34 | Stromal cell-derived factor 1 (B) | VdWContact |
| Lys 68 | 135 | Helix | GLN 37 | Stromal cell-derived factor 1 (B) | HBDonor |
| Lys 68 | 135 | Helix | GLN 37 | Stromal cell-derived factor 1 (B) | VdWContact |
Ligand interaction network
3GG_A_101
Interaction pattern search
Search complexes with similar interaction patterns:
