Interactions for 5CMD (chain A)
Structure details
- PDB ID: 5CMD open_in_new
- Protein: CCL5_HUMAN
- Organism: Homo sapiens
- UniProt ID: P13501 open_in_new
- Method: X-ray
- Resolution: 3.09 Å
- Date: April 13, 2016
- Reference: 10.1073/PNAS.1523981113 open_in_new
- State: oligomer
Chemokine diagram
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Interactions found in structure
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| Chemokine Residue | Generic number | Segment | Partner Residue | Partner | Interaction Type |
|---|---|---|---|---|---|
| Asp 6 | 59 | N-term | GLN 48 | C-C motif chemokine 5 (B) | VdWContact |
| Thr 7 | 60 | N-term | PRO 9 | C-C motif chemokine 5 (B) | Hydrophobic |
| Thr 7 | 60 | N-term | GLN 48 | C-C motif chemokine 5 (B) | Hydrophobic |
| Thr 7 | 60 | N-term | GLN 48 | C-C motif chemokine 5 (B) | HBDonor |
| Thr 7 | 60 | N-term | GLN 48 | C-C motif chemokine 5 (B) | VdWContact |
| Thr 7 | 60 | N-term | VAL 40 | C-C motif chemokine 5 (B) | Hydrophobic |
| Thr 8 | 61 | N-term | PHE 12 | C-C motif chemokine 5 (B) | Hydrophobic |
| Thr 8 | 61 | N-term | PHE 12 | C-C motif chemokine 5 (B) | VdWContact |
| Thr 8 | 61 | N-term | CYS 10 | C-C motif chemokine 5 (B) | HBAcceptor |
| Thr 8 | 61 | N-term | CYS 10 | C-C motif chemokine 5 (B) | HBDonor |
| Thr 8 | 61 | N-term | CYS 10 | C-C motif chemokine 5 (B) | VdWContact |
| Cys 10 | 63 | CX | THR 8 | C-C motif chemokine 5 (B) | HBAcceptor |
| Cys 10 | 63 | CX | THR 8 | C-C motif chemokine 5 (B) | HBDonor |
| Cys 10 | 63 | CX | THR 8 | C-C motif chemokine 5 (B) | VdWContact |
| Cys 11 | 67 | CX | THR 7 | C-C motif chemokine 5 (B) | VdWContact |
| Phe 12 | 68 | N-loop | LYS 33 | C-C motif chemokine 5 (B) | Hydrophobic |
| Ala 13 | 69 | N-loop | LYS 33 | C-C motif chemokine 5 (C) | Hydrophobic |
| Leu 19 | 75 | N-loop | TYR 29 | C-C motif chemokine 5 (C) | Hydrophobic |
| Leu 19 | 75 | N-loop | TYR 29 | C-C motif chemokine 5 (C) | VdWContact |
| His 23 | 82 | N-loop | ASN 63 | C-C motif chemokine 5 (C) | Hydrophobic |
| His 23 | 82 | N-loop | ILE 62 | C-C motif chemokine 5 (C) | Hydrophobic |
| Ser 31 | 90 | 30s-loop | UNL 1 | SULFATE ION (None) | HBAcceptor |
| Ser 31 | 90 | 30s-loop | UNL 1 | SULFATE ION (None) | VdWContact |
| Ser 31 | 90 | 30s-loop | UNL 1 | SULFATE ION (None) | HBAcceptor |
| Ser 31 | 90 | 30s-loop | UNL 1 | SULFATE ION (None) | VdWContact |
| Gly 32 | 91 | 30s-loop | UNL 1 | SULFATE ION (None) | HBAcceptor |
| Gly 32 | 91 | 30s-loop | UNL 1 | SULFATE ION (None) | VdWContact |
| Gly 32 | 91 | 30s-loop | UNL 1 | SULFATE ION (None) | HBAcceptor |
| Gly 32 | 91 | 30s-loop | UNL 1 | SULFATE ION (None) | VdWContact |
| Lys 33 | 94 | 30s-loop | PHE 12 | C-C motif chemokine 5 (B) | Hydrophobic |
| Val 40 | 102 | B2 | THR 7 | C-C motif chemokine 5 (B) | Hydrophobic |
| Lys 45 | 112 | 40s-loop | GLU 66 | C-C motif chemokine 5 (C) | VdWContact |
| Arg 47 | 114 | 40s-loop | TYR 27 | C-C motif chemokine 5 (C) | Hydrophobic |
| Arg 47 | 114 | 40s-loop | TYR 27 | C-C motif chemokine 5 (C) | VdWContact |
| Gln 48 | 115 | B3 | ASP 6 | C-C motif chemokine 5 (B) | Hydrophobic |
| Gln 48 | 115 | B3 | ASP 6 | C-C motif chemokine 5 (B) | VdWContact |
| Val 49 | 116 | B3 | TYR 29 | C-C motif chemokine 5 (C) | Hydrophobic |
| Cys 50 | 117 | B3 | ASP 6 | C-C motif chemokine 5 (B) | VdWContact |
| Lys 56 | 123 | Helix | UNL 1 | SULFATE ION (None) | Anionic |
| Lys 56 | 123 | Helix | UNL 1 | SULFATE ION (None) | VdWContact |
| Lys 56 | 123 | Helix | UNL 1 | SULFATE ION (None) | Anionic |
| Lys 56 | 123 | Helix | UNL 1 | SULFATE ION (None) | VdWContact |
| Arg 59 | 126 | Helix | UNL 1 | SULFATE ION (None) | Anionic |
| Arg 59 | 126 | Helix | UNL 1 | SULFATE ION (None) | VdWContact |
| Arg 59 | 126 | Helix | UNL 1 | SULFATE ION (None) | Anionic |
| Arg 59 | 126 | Helix | UNL 1 | SULFATE ION (None) | VdWContact |
Ligand interaction network
SO4_A_101
SO4_A_102
SO4_A_103
SO4_A_104
SO4_B_101
SO4_B_102
SO4_B_103
SO4_C_101
SO4_C_102
SO4_E_101
SO4_F_101
Interaction pattern search
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