Protein

CCL5_HUMAN

SUMMARY
Gene
CCL5_HUMAN
Full name
C-C motif chemokine 5
Organism
Homo sapiens
Subfamily
CCL
Sequence type
Wild-type
UniProt ID
P13501 Open UniProt
IUPHAR ID
758 Open Guide to Pharmacology
GtoP partners
  • CCR3 (Full agonist)
DIAGRAM
T S G K C S N P 30s-loop R K N R 40s-loop N P E K 50s-loopC-term M K V S A A A L A V I L I A T A L C A P A S A S P Y S S D T T P C C F A Y I A R P L P R A N-term Y F Y E K I H A V V F V T A C V Q K W V R E Y I N S L E M S
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SEQUENCE

Residues are colour-coded by structural context. Hover to view sequence and CCN numbering.

N-term
M
K
V
S
A
A
A
L
A
V
10
 
I
L
I
A
T
A
L
C
A
P
20
 
A
S
A
S
P
Y
S
S
D
T
30
  CX N-loop
T
P
C
C
F
A
Y
I
A
R
40
  B1
P
L
P
R
A
H
I
K
E
Y
50
  30s-loop
F
Y
T
S
G
K
C
S
N
P
60
B2 40s-loop
A
V
V
F
V
T
R
K
N
R
70
B3 50s-loop Helix
Q
V
C
A
N
P
E
K
K
W
80
  C-term
V
R
E
Y
I
N
S
L
E
M
90
 
S
91
STRUCTURES

Experimental structures

PDB Method Resolution State Publication date Reference
7F1R - R Cryo-em 3.0 Monomer 2021-07-14 10.1038/S41467-021-24438-5 open_in_new
7O7F - I Cryo-em 3.15 Monomer 2021-06-30 10.1126/SCIADV.ABG8685 open_in_new
6STK - B, A X-ray 1.52 Dimer 2020-09-02 10.1074/JBC.RA120.013891 open_in_new
6LOG - A X-ray 2.55 Monomer 2020-03-18 10.3390/IJMS21051689 open_in_new
6AEZ - C, A, B X-ray 1.63 Oligomer 2019-08-07 10.1016/J.JMB.2019.12.049 open_in_new
6C6D - M, B, C, E, F, H, I, L, O, A, N, P, R, G, J, S, K, Q, D, T X-ray 5.5 Oligomer 2019-01-23 -
6FGP - B Nmr None Monomer 2018-04-18 10.1111/FEBS.14460 open_in_new
5L2U - B,C,E,F,H,I,A,G,D X-ray 2.28 Oligomer 2017-08-09 -
5UIW - B X-ray 2.2 Monomer 2017-06-28 10.1016/J.IMMUNI.2017.05.002 open_in_new
5DNF - B,C,E,F,H,I,A,G,D X-ray 2.55 Oligomer 2016-04-13 10.1073/PNAS.1523981113 open_in_new
5COY - A,B X-ray 1.44 Dimer 2016-04-13 10.1073/PNAS.1523981113 open_in_new
5CMD - B,C,E,F,A,D X-ray 3.09 Oligomer 2016-04-13 10.1073/PNAS.1523981113 open_in_new
2L9H - A,B,C,D Nmr None Dimer 2011-06-22 10.1016/J.STR.2011.06.001 open_in_new
2VXW - A,B,C,D X-ray 1.7 Oligomer 2008-07-29 10.1002/PROT.22542 open_in_new
1U4R - A,B,C,D X-ray 2.2 Dimer 2004-11-09 10.1016/J.STR.2004.08.014 open_in_new
1U4P - A,B X-ray 1.7 Dimer 2004-11-09 10.1016/J.STR.2004.08.014 open_in_new
1U4M - A,B X-ray 2.0 Dimer 2004-11-09 10.1016/J.STR.2004.08.014 open_in_new
1U4L - A,B X-ray 2.0 Dimer 2004-11-09 10.1016/J.STR.2004.08.014 open_in_new
1EQT - A,B X-ray 1.6 Dimer 2000-04-19 -
1B3A - A,B X-ray 1.6 Dimer 1999-04-23 10.1016/S1074-5521(99)80019-2 open_in_new
1HRJ - A,B Nmr None Dimer 1996-10-14 10.1021/BI00029A005 open_in_new
1RTO - A,B Nmr None Dimer 1995-06-03 10.1021/BI00016A004 open_in_new
1RTN - A,B Nmr None Dimer 1995-06-03 10.1021/BI00016A004 open_in_new

Predicted models and complexes

Type Partner Method State Date View
Complex XCR1 AlphaFold-Multimer - 2025-11-11 Open
Complex CXCR6 AlphaFold-Multimer - 2025-11-11 Open
Complex CXCR5 AlphaFold-Multimer - 2025-11-11 Open
Complex CXCR4 AlphaFold-Multimer - 2025-11-11 Open
Complex CXCR3 AlphaFold-Multimer - 2025-11-11 Open
Complex CXCR2 AlphaFold-Multimer - 2025-11-11 Open
Complex CXCR1 AlphaFold-Multimer - 2025-11-11 Open
Complex CX3CR1 AlphaFold-Multimer - 2025-11-11 Open
Complex CCRL2 AlphaFold-Multimer - 2025-11-11 Open
Complex CCR9 AlphaFold-Multimer - 2025-11-11 Open
Complex CCR8 AlphaFold-Multimer - 2025-11-11 Open
Complex CCR7 AlphaFold-Multimer - 2025-11-11 Open
Complex CCR6 AlphaFold-Multimer - 2025-11-11 Open
Complex CCR5 AlphaFold-Multimer - 2025-11-11 Open
Complex CCR4 AlphaFold-Multimer - 2025-11-10 Open
Complex CCR3 AlphaFold-Multimer - 2025-11-10 Open
Complex CCR2 AlphaFold-Multimer - 2025-11-10 Open
Complex CCR1 AlphaFold-Multimer - 2025-11-10 Open
Complex CCR10 AlphaFold-Multimer - 2025-11-10 Open
Complex ACKR4 AlphaFold-Multimer - 2025-11-10 Open
Complex ACKR3 AlphaFold-Multimer - 2025-11-10 Open
Complex ACKR2 AlphaFold-Multimer - 2025-11-10 Open
Complex ACKR1 AlphaFold-Multimer - 2025-11-10 Open
Model - AlphaFold Monomer v2.0 pipeline (AlphaFold DB v6) - 2025-08-01 Open
SEQUENCE ALIGNMENT

Canonical residues are compared against each available structure at matched CCN positions.

Position NTc.Cm32 NTc.Cm31 NTc.Cm30 NTc.Cm29 NTc.Cm28 NTc.Cm27 NTc.Cm26 NTc.Cm25 NTc.Cm24 NTc.Cm23 NTc.Cm22 NTc.Cm21 NTc.Cm20 NTc.Cm19 NTc.Cm18 NTc.Cm17 NTc.Cm16 NTc.Cm15 NTc.Cm14 NTc.Cm13 NTc.Cm12 NTc.Cm11 NTc.Cm10 NTc.Cm9 NTc.Cm8 NTc.Cm7 NTc.Cm6 NTc.Cm5 NTc.Cm4 NTc.Cm3 NTc.Cm2 NTc.Cm1 CX.1 CX.5 cxb1.1 cxb1.2 cxb1.5 cxb1.6 cxb1.7 cxb1.8 cxb1.10 cxb1.11 cxb1.14 cxb1.15 cxb1.16 B1.1 B1.2 B1.3 B1.4 B1.5 B1.6 B1.7 b1b2.4 b1b2.6 b1b2.9 b1b2.10 b1b2.12 b1b2.13 b1b2.14 b1b2.16 B2.1 B2.2 B2.3 B2.4 B2.5 B2.6 b2b3.2 b2b3.4 b2b3.11 b2b3.12 B3.1 B3.2 B3.3 B3.4 b3h.1 b3h.2 b3h.3 b3h.4 H.1 H.2 H.3 H.4 H.5 H.6 H.7 H.8 H.9 H.10 CT.1 CT.2 CT.3
Canonical sequence M K V S A A A L A V I L I A T A L C A P A S A S P Y S S D T T P C C F A Y I A R P L P R A H I K E Y F Y T S G K C S N P A V V F V T R K N R Q V C A N P E K K W V R E Y I N S L E M S
7F1R - - - - - - - - - - - - - - - - - - - - - - - S P Y S S D T T P C C F A Y - - - - - - - - - - K E Y C Y T S G K C S N P A V V F - - - - - R Q V C A N P E K K W V R E Y I N S L - - -
7O7F G P P G D I V L A - - - - - - - - - - - - - - - - - - - - - - - C C F A Y I A R P L P R A H I K E Y F Y T S G K C S N P A V V F V T R K N R Q V C A N P E K K W V R E Y I N S L E - -
6STK - - - - - - - - - - - - - - - - - - - - - - - - - Y S S D T T P C C F A Y I A R P L P R A H I K E Y F Y T S G K C S N P A V V F V T R K N R Q V C A N P E K K W V R E Y I N S L S M S
6LOG - - - - - - - - - - - - - - - - - - - - - - - - - - - - D T T P C C A A A I A R P L P R A H I K E Y F Y T S G K C S N P A V V F V T R K N R Q V C A N P E K K W V R E Y I N S L E M S
6AEZ - - - - - - - - - - - - - - - - - - - - - - - - P Y S S D T T P C C F A Y I A R P L P R A H I K E Y F Y T S G K C S N P A V V F V T R K N R Q V C A N P E K K W V R E Y I N S L S M S
6C6D - - - - - - - - - - - - - - - - - - - - - - - - - - - S D T T P C C F A Y I A R P L P R A H I K E Y F Y T S G K C S N P A V V F V T R K N R Q V C A N P E K K W V R E Y I N S L E M S
6FGP - - - - - - - - - - - - - - - - - - - - - - - S P Y S S D T T S C C F A Y I A R P L P R A H I K E Y F Y T S G K C S N P A V V F V T R K N R Q V C A N P E K K W V R E Y I N S L S M S
5L2U - - - - - - - - - - - - - - - - - - - - - - - - - - S S D T T P C C F A Y I A R P L P R A H I K E Y F Y T S G K C S N P A V V F V T R K N R Q V C A N P E K K W V R E Y I N S L E M S
5UIW - - - - - - - - - - - - - - - - - - - - - - - G P P L M A L Q S C C F A Y I A R P L P R A H I K E Y F Y T S G K C S N P A V V F V T R K N R Q V C A N P E K K W V R E Y I N S L E M -
5DNF - - - - - - - - - - - - - - - - - - - - - - - - - - S S D T T P C C F A Y I A R P L P R A H I K E Y F Y T S G K C S N P A V V F V T R K N R Q V C A N P E K K W V R E Y I N S L E M S
5COY - - - - - - - - - - - - - - - - - - - - - - - - - - S S D T T P C C F A Y I A R P L P R A H I K E Y F Y T S G K C S N P A V V F V T R K N R Q V C A N P E K K W V R E Y I N S L E M S
5CMD - - - - - - - - - - - - - - - - - - - - - - - - - - S S D T T P C C F A Y I A R P L P R A H I K E Y F Y T S G K C S N P A V V F V T R K N R Q V C A N P E K K W V R E Y I N S L E M S
2L9H - - - - - - - - - - - - - - - - - - - - - - - - P Y S S D T T P C C F A Y I A R P L P R A H I K E Y F Y T S G K C S N P A V V F V T R K N R Q V C A N P E K K W V R E Y I N S L E M S
2VXW - - - - - - - - - - - - - - - - - - - - - - F S P L S S Q S S A C C F A Y I A R P L P R A H I K E Y F Y T S G K C S N P A V V F V T R K N R Q V C A N P E K K W V R E Y I N S L E M S
1U4R - - - - - - - - - - - - - - - - - - - - - - - S P Y S S D T T P C C F A Y I A R P L P R A H I K E Y F Y T S G K C S N P A V V F V T A A N A Q V C A N P E K K W V R E Y I N S L E M S
1U4P - - - - - - - - - - - - - - - - - - - - - - - S P Y S S D T T P C C F A Y I A R P L P R A H I K E Y F Y T S G K C S N P A V V F V T R E N R Q V C A N P E K K W V R E Y I N S L E M -
1U4M - - - - - - - - - - - - - - - - - - - - - - - - P Y S S D T T P C C F A Y I A R P L P R A H I K E Y F Y T S G K C S N P A V V F V T R K N R Q V C A N P E K K W V R E Y I N S L E M S
1U4L - - - - - - - - - - - - - - - - - - - - - - - - P Y S S D T T P C C F A Y I A R P L P R A H I K E Y F Y T S G K C S N P A V V F V T R K N R Q V C A N P E K K W V R E Y I N S L E M S
1EQT - - - - - - - - - - - - - - - - - - - - - - - - G Y S S D T T P C C F A Y I A R P M P R A H I K E Y F Y T S G K C S N P A V V F V T R K N R Q V C A N P E K K W V R E Y I N S L E M S
1B3A - - - - - - - - - - - - - - - - - - - - - - - - P Y S S D T T P C C F A Y I A R P L P R A H I K E Y F Y T S G K C S N P A V V F V T R K N R Q V C A N P E K K W V R E Y I N S L E M S
1HRJ - - - - - - - - - - - - - - - - - - - - - - - S P Y S S D T T P C C F A Y I A R P L P R A H I K E Y F Y T S G K C S N P A V V F V T R K N R Q V C A N P E K K W V R E Y I N S L E M S
1RTO - - - - - - - - - - - - - - - - - - - - - - - S P Y S S D T T P C C F A Y I A R P L P R A H I K E Y F Y T S G K C S N P A V V F V T R K N R Q V C A N P E K K W V R E Y I N S L E M S
1RTN - - - - - - - - - - - - - - - - - - - - - - - S P Y S S D T T P C C F A Y I A R P L P R A H I K E Y F Y T S G K C S N P A V V F V T R K N R Q V C A N P E K K W V R E Y I N S L E M S