Interactions for 6AEZ (chain A)
Structure details
- PDB ID: 6AEZ open_in_new
- Protein: CCL5_HUMAN
- Organism: Homo sapiens
- UniProt ID: P13501 open_in_new
- Method: X-ray
- Resolution: 1.63 Å
- Date: Aug. 7, 2019
- Reference: 10.1016/J.JMB.2019.12.049 open_in_new
- State: trimer
Chemokine diagram
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Interactions found in structure
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| Chemokine Residue | Generic number | Segment | Partner Residue | Partner | Interaction Type |
|---|---|---|---|---|---|
| Phe 13 | 68 | N-loop | ALA 17 | C-C motif chemokine 5 (B) | HBAcceptor |
| Phe 13 | 68 | N-loop | ALA 17 | C-C motif chemokine 5 (B) | VdWContact |
| Ala 14 | 69 | N-loop | ALA 14 | C-C motif chemokine 5 (B) | Hydrophobic |
| Ala 14 | 69 | N-loop | TYR 15 | C-C motif chemokine 5 (B) | VdWContact |
| Tyr 15 | 70 | N-loop | ALA 17 | C-C motif chemokine 5 (B) | Hydrophobic |
| Tyr 15 | 70 | N-loop | ALA 14 | C-C motif chemokine 5 (B) | VdWContact |
| Tyr 15 | 70 | N-loop | TYR 15 | C-C motif chemokine 5 (B) | HBAcceptor |
| Tyr 15 | 70 | N-loop | TYR 15 | C-C motif chemokine 5 (B) | HBDonor |
| Tyr 15 | 70 | N-loop | TYR 15 | C-C motif chemokine 5 (B) | VdWContact |
| Ile 16 | 71 | N-loop | TYR 4 | C-C motif chemokine 5 (C) | Hydrophobic |
| Ala 17 | 72 | N-loop | PHE 13 | C-C motif chemokine 5 (B) | HBDonor |
| Ala 17 | 72 | N-loop | PHE 13 | C-C motif chemokine 5 (B) | VdWContact |
| Ala 17 | 72 | N-loop | TYR 15 | C-C motif chemokine 5 (B) | Hydrophobic |
| Ala 17 | 72 | N-loop | ASN 37 | C-C motif chemokine 5 (B) | Hydrophobic |
| Arg 18 | 73 | N-loop | SER 36 | C-C motif chemokine 5 (B) | VdWContact |
| Arg 18 | 73 | N-loop | ASN 37 | C-C motif chemokine 5 (B) | VdWContact |
| His 24 | 82 | N-loop | UNL 1 | SULFATE ION (None) | VdWContact |
| His 24 | 82 | N-loop | UNL 1 | SULFATE ION (None) | VdWContact |
| Ser 36 | 96 | 30s-loop | ARG 18 | C-C motif chemokine 5 (B) | HBAcceptor |
| Ser 36 | 96 | 30s-loop | ARG 18 | C-C motif chemokine 5 (B) | VdWContact |
| Asn 37 | 97 | 30s-loop | ARG 18 | C-C motif chemokine 5 (B) | VdWContact |
| Asn 37 | 97 | 30s-loop | ALA 17 | C-C motif chemokine 5 (B) | Hydrophobic |
| Thr 44 | 105 | B2 | UNL 1 | SULFATE ION (None) | HBAcceptor |
| Thr 44 | 105 | B2 | UNL 1 | SULFATE ION (None) | VdWContact |
| Thr 44 | 105 | B2 | UNL 1 | SULFATE ION (None) | HBAcceptor |
| Thr 44 | 105 | B2 | UNL 1 | SULFATE ION (None) | VdWContact |
| Arg 45 | 106 | 40s-loop | UNL 1 | SULFATE ION (None) | HBAcceptor |
| Arg 45 | 106 | 40s-loop | UNL 1 | SULFATE ION (None) | Anionic |
| Arg 45 | 106 | 40s-loop | UNL 1 | SULFATE ION (None) | VdWContact |
| Arg 45 | 106 | 40s-loop | UNL 1 | SULFATE ION (None) | HBAcceptor |
| Arg 45 | 106 | 40s-loop | UNL 1 | SULFATE ION (None) | Anionic |
| Arg 45 | 106 | 40s-loop | UNL 1 | SULFATE ION (None) | VdWContact |
| Lys 46 | 112 | 40s-loop | UNL 1 | SULFATE ION (None) | HBAcceptor |
| Lys 46 | 112 | 40s-loop | UNL 1 | SULFATE ION (None) | Anionic |
| Lys 46 | 112 | 40s-loop | UNL 1 | SULFATE ION (None) | VdWContact |
| Lys 46 | 112 | 40s-loop | UNL 1 | SULFATE ION (None) | HBAcceptor |
| Lys 46 | 112 | 40s-loop | UNL 1 | SULFATE ION (None) | Anionic |
| Lys 46 | 112 | 40s-loop | UNL 1 | SULFATE ION (None) | VdWContact |
| Arg 48 | 114 | 40s-loop | TYR 4 | C-C motif chemokine 5 (C) | VdWContact |
| Arg 48 | 114 | 40s-loop | UNL 1 | SULFATE ION (None) | HBAcceptor |
| Arg 48 | 114 | 40s-loop | UNL 1 | SULFATE ION (None) | Anionic |
| Arg 48 | 114 | 40s-loop | UNL 1 | SULFATE ION (None) | VdWContact |
| Arg 48 | 114 | 40s-loop | UNL 1 | SULFATE ION (None) | HBAcceptor |
| Arg 48 | 114 | 40s-loop | UNL 1 | SULFATE ION (None) | Anionic |
| Arg 48 | 114 | 40s-loop | UNL 1 | SULFATE ION (None) | VdWContact |
| Glu 55 | 121 | 50s-loop | LYS 56 | C-C motif chemokine 5 (B) | Anionic |
| Lys 56 | 122 | 50s-loop | GLU 55 | C-C motif chemokine 5 (B) | Cationic |
| Lys 56 | 122 | 50s-loop | UNL 1 | SULFATE ION (None) | HBAcceptor |
| Lys 56 | 122 | 50s-loop | UNL 1 | SULFATE ION (None) | Anionic |
| Lys 56 | 122 | 50s-loop | UNL 1 | SULFATE ION (None) | VdWContact |
| Lys 56 | 122 | 50s-loop | UNL 1 | SULFATE ION (None) | HBAcceptor |
| Lys 56 | 122 | 50s-loop | UNL 1 | SULFATE ION (None) | Anionic |
| Lys 56 | 122 | 50s-loop | UNL 1 | SULFATE ION (None) | VdWContact |
| Lys 57 | 123 | Helix | UNL 1 | SULFATE ION (None) | HBAcceptor |
| Lys 57 | 123 | Helix | UNL 1 | SULFATE ION (None) | VdWContact |
| Lys 57 | 123 | Helix | UNL 1 | SULFATE ION (None) | HBAcceptor |
| Lys 57 | 123 | Helix | UNL 1 | SULFATE ION (None) | VdWContact |
| Arg 60 | 126 | Helix | UNL 1 | SULFATE ION (None) | Anionic |
| Arg 60 | 126 | Helix | UNL 1 | SULFATE ION (None) | Anionic |
Ligand interaction network
SO4_A_101
SO4_A_102
SO4_B_101
SO4_B_102
SO4_B_103
SO4_C_101
Interaction pattern search
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