Interactions for 6LFO (chain D)
Structure details
- PDB ID: 6LFO open_in_new
- Protein: CXCL8_HUMAN
- Organism: Homo sapiens
- UniProt ID: P10145 open_in_new
- Method: Cryo-em
- Resolution: 3.4 Å
- Date: Sept. 2, 2020
- Reference: 10.1038/S41586-020-2492-5 open_in_new
- State: monomer
Chemokine diagram
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Interactions found in structure
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| Chemokine Residue | Generic number | Segment | Partner Residue | Partner | Interaction Type |
|---|---|---|---|---|---|
| Ala 2 | 58 | N-term | LYS 108 | C-X-C chemokine receptor type 2 (R) | Hydrophobic |
| Ala 2 | 58 | N-term | LYS 108 | C-X-C chemokine receptor type 2 (R) | VdWContact |
| Lys 3 | 59 | N-term | TRP 104 | C-X-C chemokine receptor type 2 (R) | Hydrophobic |
| Lys 3 | 59 | N-term | TYR 197 | C-X-C chemokine receptor type 2 (R) | Hydrophobic |
| Lys 3 | 59 | N-term | TYR 197 | C-X-C chemokine receptor type 2 (R) | VdWContact |
| Glu 4 | 60 | N-term | ARG 278 | C-X-C chemokine receptor type 2 (R) | HBAcceptor |
| Glu 4 | 60 | N-term | ARG 278 | C-X-C chemokine receptor type 2 (R) | Anionic |
| Glu 4 | 60 | N-term | ARG 278 | C-X-C chemokine receptor type 2 (R) | VdWContact |
| Glu 4 | 60 | N-term | TYR 197 | C-X-C chemokine receptor type 2 (R) | VdWContact |
| Glu 4 | 60 | N-term | LEU 296 | C-X-C chemokine receptor type 2 (R) | Hydrophobic |
| Glu 4 | 60 | N-term | ARG 289 | C-X-C chemokine receptor type 2 (R) | Anionic |
| Glu 4 | 60 | N-term | ARG 289 | C-X-C chemokine receptor type 2 (R) | VdWContact |
| Leu 5 | 61 | N-term | TYR 197 | C-X-C chemokine receptor type 2 (R) | Hydrophobic |
| Leu 5 | 61 | N-term | TYR 197 | C-X-C chemokine receptor type 2 (R) | VdWContact |
| Leu 5 | 61 | N-term | ARG 289 | C-X-C chemokine receptor type 2 (R) | VdWContact |
| Arg 6 | 62 | N-term | ARG 289 | C-X-C chemokine receptor type 2 (R) | Hydrophobic |
| Arg 6 | 62 | N-term | ARG 289 | C-X-C chemokine receptor type 2 (R) | VdWContact |
| Gln 8 | 66 | CX | PRO 38 | C-X-C chemokine receptor type 2 (R) | Hydrophobic |
| Gln 8 | 66 | CX | PRO 38 | C-X-C chemokine receptor type 2 (R) | VdWContact |
| Lys 11 | 69 | N-loop | ALA 36 | C-X-C chemokine receptor type 2 (R) | Hydrophobic |
| Lys 11 | 69 | N-loop | ALA 36 | C-X-C chemokine receptor type 2 (R) | VdWContact |
| Lys 11 | 69 | N-loop | LEU 34 | C-X-C chemokine receptor type 2 (R) | Hydrophobic |
| Tyr 13 | 71 | N-loop | LEU 34 | C-X-C chemokine receptor type 2 (R) | Hydrophobic |
| Tyr 13 | 71 | N-loop | LEU 34 | C-X-C chemokine receptor type 2 (R) | VdWContact |
| Lys 15 | 73 | N-loop | LEU 29 | C-X-C chemokine receptor type 2 (R) | Hydrophobic |
| Lys 15 | 73 | N-loop | LEU 29 | C-X-C chemokine receptor type 2 (R) | VdWContact |
| His 18 | 76 | N-loop | THR 28 | C-X-C chemokine receptor type 2 (R) | Hydrophobic |
| His 18 | 76 | N-loop | THR 28 | C-X-C chemokine receptor type 2 (R) | VdWContact |
| His 18 | 76 | N-loop | SER 27 | C-X-C chemokine receptor type 2 (R) | VdWContact |
| Phe 21 | 82 | N-loop | PHE 32 | C-X-C chemokine receptor type 2 (R) | Hydrophobic |
| Phe 21 | 82 | N-loop | PHE 32 | C-X-C chemokine receptor type 2 (R) | VdWContact |
| Gly 31 | 92 | 30s-loop | THR 204 | C-X-C chemokine receptor type 2 (R) | HBAcceptor |
| Gly 31 | 92 | 30s-loop | THR 204 | C-X-C chemokine receptor type 2 (R) | VdWContact |
| Pro 32 | 93 | 30s-loop | THR 204 | C-X-C chemokine receptor type 2 (R) | VdWContact |
| Pro 32 | 93 | 30s-loop | VAL 187 | C-X-C chemokine receptor type 2 (R) | Hydrophobic |
| Asp 45 | 112 | 40s-loop | PHE 32 | C-X-C chemokine receptor type 2 (R) | VdWContact |
| Arg 47 | 114 | 40s-loop | ASP 35 | C-X-C chemokine receptor type 2 (R) | HBDonor |
| Arg 47 | 114 | 40s-loop | ASP 35 | C-X-C chemokine receptor type 2 (R) | Cationic |
| Arg 47 | 114 | 40s-loop | ASP 35 | C-X-C chemokine receptor type 2 (R) | VdWContact |
| Arg 47 | 114 | 40s-loop | PHE 32 | C-X-C chemokine receptor type 2 (R) | Hydrophobic |
| Arg 47 | 114 | 40s-loop | PHE 32 | C-X-C chemokine receptor type 2 (R) | VdWContact |
| Glu 48 | 115 | B3 | ALA 37 | C-X-C chemokine receptor type 2 (R) | Hydrophobic |
| Glu 48 | 115 | B3 | ALA 37 | C-X-C chemokine receptor type 2 (R) | VdWContact |
| Leu 49 | 116 | B3 | LEU 34 | C-X-C chemokine receptor type 2 (R) | Hydrophobic |
Interaction pattern search
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