Interactions for 6WZM (chain F)
Structure details
- PDB ID: 6WZM open_in_new
- Protein: CXCL8_HUMAN
- Organism: Homo sapiens
- UniProt ID: P10145 open_in_new
- Method: X-ray
- Resolution: 2.28 Å
- Date: Nov. 25, 2020
- Reference: 10.1080/19420862.2020.1831880 open_in_new
- State: dimer
Chemokine diagram
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Interactions found in structure
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Chemokine Residue | Generic number | Segment | Partner Residue | Partner | Interaction Type |
---|---|---|---|---|---|
Ala 2 | 58 | N-term | LYS 42 | Interleukin-8 (E) | VdWContact |
Leu 5 | 61 | N-term | GLU 93 | LY3041658 Fab light chain (D) | Hydrophobic |
Leu 5 | 61 | N-term | GLU 93 | LY3041658 Fab light chain (D) | VdWContact |
Leu 5 | 61 | N-term | TRP 94 | LY3041658 Fab light chain (D) | HBAcceptor |
Leu 5 | 61 | N-term | TRP 94 | LY3041658 Fab light chain (D) | VdWContact |
Arg 6 | 62 | N-term | TRP 94 | LY3041658 Fab light chain (D) | Hydrophobic |
Arg 6 | 62 | N-term | TYR 110 | LY3041658 Fab heavy chain (C) | Hydrophobic |
Arg 6 | 62 | N-term | TYR 110 | LY3041658 Fab heavy chain (C) | CationPi |
Arg 6 | 62 | N-term | GLU 99 | LY3041658 Fab heavy chain (C) | HBDonor |
Arg 6 | 62 | N-term | GLU 99 | LY3041658 Fab heavy chain (C) | Cationic |
Arg 6 | 62 | N-term | GLU 99 | LY3041658 Fab heavy chain (C) | VdWContact |
Arg 6 | 62 | N-term | ASN 91 | LY3041658 Fab light chain (D) | HBDonor |
Arg 6 | 62 | N-term | ASN 91 | LY3041658 Fab light chain (D) | VdWContact |
Cys 7 | 63 | CX | TRP 94 | LY3041658 Fab light chain (D) | Hydrophobic |
Cys 7 | 63 | CX | TRP 94 | LY3041658 Fab light chain (D) | VdWContact |
Cys 7 | 63 | CX | TRP 33 | LY3041658 Fab heavy chain (C) | Hydrophobic |
Gln 8 | 66 | CX | PRO 106 | LY3041658 Fab heavy chain (C) | Hydrophobic |
Ile 10 | 68 | N-loop | TYR 102 | LY3041658 Fab heavy chain (C) | Hydrophobic |
Ile 10 | 68 | N-loop | TYR 102 | LY3041658 Fab heavy chain (C) | VdWContact |
Ile 10 | 68 | N-loop | SER 52 | LY3041658 Fab heavy chain (C) | HBAcceptor |
Ile 10 | 68 | N-loop | SER 52 | LY3041658 Fab heavy chain (C) | VdWContact |
Ile 10 | 68 | N-loop | TRP 33 | LY3041658 Fab heavy chain (C) | Hydrophobic |
Lys 11 | 69 | N-loop | THR 30 | LY3041658 Fab heavy chain (C) | HBDonor |
Lys 11 | 69 | N-loop | THR 30 | LY3041658 Fab heavy chain (C) | VdWContact |
Lys 11 | 69 | N-loop | SER 31 | LY3041658 Fab heavy chain (C) | VdWContact |
Lys 11 | 69 | N-loop | GLU 28 | LY3041658 Fab heavy chain (C) | Cationic |
Lys 11 | 69 | N-loop | GLU 28 | LY3041658 Fab heavy chain (C) | VdWContact |
Tyr 13 | 71 | N-loop | TYR 104 | LY3041658 Fab heavy chain (C) | Hydrophobic |
Tyr 13 | 71 | N-loop | TYR 104 | LY3041658 Fab heavy chain (C) | PiStacking |
Tyr 13 | 71 | N-loop | TYR 104 | LY3041658 Fab heavy chain (C) | VdWContact |
Lys 23 | 84 | B1 | GLU 29 | Interleukin-8 (E) | HBAcceptor |
Lys 23 | 84 | B1 | GLU 29 | Interleukin-8 (E) | VdWContact |
Glu 24 | 85 | B1 | ARG 26 | Interleukin-8 (E) | Hydrophobic |
Glu 24 | 85 | B1 | ARG 26 | Interleukin-8 (E) | HBAcceptor |
Glu 24 | 85 | B1 | ARG 26 | Interleukin-8 (E) | Anionic |
Glu 24 | 85 | B1 | ARG 26 | Interleukin-8 (E) | VdWContact |
Glu 24 | 85 | B1 | ILE 28 | Interleukin-8 (E) | Hydrophobic |
Glu 24 | 85 | B1 | VAL 27 | Interleukin-8 (E) | VdWContact |
Leu 25 | 86 | B1 | ARG 26 | Interleukin-8 (E) | VdWContact |
Leu 25 | 86 | B1 | VAL 27 | Interleukin-8 (E) | Hydrophobic |
Leu 25 | 86 | B1 | VAL 27 | Interleukin-8 (E) | HBAcceptor |
Leu 25 | 86 | B1 | VAL 27 | Interleukin-8 (E) | HBDonor |
Leu 25 | 86 | B1 | VAL 27 | Interleukin-8 (E) | VdWContact |
Arg 26 | 87 | B1 | ARG 26 | Interleukin-8 (E) | VdWContact |
Arg 26 | 87 | B1 | GLU 24 | Interleukin-8 (E) | Hydrophobic |
Arg 26 | 87 | B1 | GLU 24 | Interleukin-8 (E) | HBDonor |
Arg 26 | 87 | B1 | GLU 24 | Interleukin-8 (E) | Cationic |
Arg 26 | 87 | B1 | GLU 24 | Interleukin-8 (E) | VdWContact |
Arg 26 | 87 | B1 | LEU 25 | Interleukin-8 (E) | VdWContact |
Val 27 | 88 | B1 | GLU 24 | Interleukin-8 (E) | VdWContact |
Val 27 | 88 | B1 | LEU 25 | Interleukin-8 (E) | Hydrophobic |
Val 27 | 88 | B1 | LEU 25 | Interleukin-8 (E) | HBAcceptor |
Val 27 | 88 | B1 | LEU 25 | Interleukin-8 (E) | HBDonor |
Val 27 | 88 | B1 | LEU 25 | Interleukin-8 (E) | VdWContact |
Val 27 | 88 | B1 | PHE 65 | Interleukin-8 (E) | Hydrophobic |
Ile 28 | 89 | B1 | GLU 24 | Interleukin-8 (E) | Hydrophobic |
Glu 29 | 90 | 30s-loop | PHE 65 | Interleukin-8 (E) | Hydrophobic |
Glu 29 | 90 | 30s-loop | LYS 23 | Interleukin-8 (E) | Hydrophobic |
Glu 29 | 90 | 30s-loop | LYS 23 | Interleukin-8 (E) | HBDonor |
Glu 29 | 90 | 30s-loop | LYS 23 | Interleukin-8 (E) | VdWContact |
His 33 | 94 | 30s-loop | TRP 94 | LY3041658 Fab light chain (D) | VdWContact |
Cys 34 | 95 | 30s-loop | ASN 59 | LY3041658 Fab heavy chain (C) | VdWContact |
Ala 35 | 96 | 30s-loop | ALA 58 | LY3041658 Fab heavy chain (C) | VdWContact |
Ala 35 | 96 | 30s-loop | ASN 59 | LY3041658 Fab heavy chain (C) | HBDonor |
Ala 35 | 96 | 30s-loop | ASN 59 | LY3041658 Fab heavy chain (C) | VdWContact |
Asn 36 | 97 | 30s-loop | SER 57 | LY3041658 Fab heavy chain (C) | VdWContact |
Ile 40 | 102 | B2 | PRO 106 | LY3041658 Fab heavy chain (C) | Hydrophobic |
Arg 47 | 114 | 40s-loop | TYR 105 | LY3041658 Fab heavy chain (C) | HBDonor |
Arg 47 | 114 | 40s-loop | TYR 105 | LY3041658 Fab heavy chain (C) | VdWContact |
Glu 48 | 115 | B3 | PRO 106 | LY3041658 Fab heavy chain (C) | Hydrophobic |
Glu 48 | 115 | B3 | PRO 106 | LY3041658 Fab heavy chain (C) | VdWContact |
Glu 48 | 115 | B3 | TYR 105 | LY3041658 Fab heavy chain (C) | VdWContact |
Leu 49 | 116 | B3 | TYR 104 | LY3041658 Fab heavy chain (C) | Hydrophobic |
Leu 49 | 116 | B3 | TYR 105 | LY3041658 Fab heavy chain (C) | Hydrophobic |
Cys 50 | 117 | B3 | TYR 104 | LY3041658 Fab heavy chain (C) | Hydrophobic |
Cys 50 | 117 | B3 | TYR 104 | LY3041658 Fab heavy chain (C) | HBDonor |
Cys 50 | 117 | B3 | TYR 104 | LY3041658 Fab heavy chain (C) | VdWContact |
Glu 63 | 130 | Helix | GLU 63 | Interleukin-8 (E) | VdWContact |
Phe 65 | 132 | Helix | GLU 29 | Interleukin-8 (E) | Hydrophobic |
Phe 65 | 132 | Helix | VAL 27 | Interleukin-8 (E) | Hydrophobic |
Phe 65 | 132 | Helix | VAL 27 | Interleukin-8 (E) | VdWContact |