Interactions for 7SK4 (chain B)
Structure details
- PDB ID: 7SK4 open_in_new
- Protein: CXCL12_HUMAN
- Organism: Homo sapiens
- UniProt ID: P48061 open_in_new
- Method: Cryo-em
- Resolution: 3.3 Å
- Date: July 27, 2022
- Reference: 10.1126/SCIADV.ABN8063 open_in_new
- State: monomer
Chemokine diagram
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Interactions found in structure
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| Chemokine Residue | Generic number | Segment | Partner Residue | Partner | Interaction Type |
|---|---|---|---|---|---|
| Gly 0 | 54 | N-term | LEU 128 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Gly 0 | 54 | N-term | ILE 132 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Gly 0 | 54 | N-term | SER 216 | Atypical chemokine receptor 3 (A) | VdWContact |
| Gly 0 | 54 | N-term | PHE 129 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Lys 1 | 55 | N-term | GLU 213 | Atypical chemokine receptor 3 (A) | Cationic |
| Lys 1 | 55 | N-term | ASP 179 | Atypical chemokine receptor 3 (A) | Cationic |
| Lys 1 | 55 | N-term | ASP 179 | Atypical chemokine receptor 3 (A) | VdWContact |
| Lys 1 | 55 | N-term | HIS 121 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Lys 1 | 55 | N-term | TYR 200 | Atypical chemokine receptor 3 (A) | VdWContact |
| Pro 2 | 56 | N-term | LEU 104 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Pro 2 | 56 | N-term | TRP 100 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Pro 2 | 56 | N-term | TRP 100 | Atypical chemokine receptor 3 (A) | VdWContact |
| Pro 2 | 56 | N-term | GLN 301 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Val 3 | 57 | N-term | LEU 297 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Val 3 | 57 | N-term | GLN 301 | Atypical chemokine receptor 3 (A) | VdWContact |
| Ser 4 | 58 | N-term | SER 103 | Atypical chemokine receptor 3 (A) | HBAcceptor |
| Ser 4 | 58 | N-term | SER 103 | Atypical chemokine receptor 3 (A) | VdWContact |
| Leu 5 | 59 | N-term | LEU 183 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Leu 5 | 59 | N-term | HIS 121 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Leu 5 | 59 | N-term | HIS 121 | Atypical chemokine receptor 3 (A) | VdWContact |
| Leu 5 | 59 | N-term | CYS 196 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Leu 5 | 59 | N-term | CYS 196 | Atypical chemokine receptor 3 (A) | VdWContact |
| Leu 5 | 59 | N-term | TRP 100 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Leu 5 | 59 | N-term | TRP 100 | Atypical chemokine receptor 3 (A) | VdWContact |
| Tyr 7 | 61 | N-term | ARG 197 | Atypical chemokine receptor 3 (A) | PiCation |
| Tyr 7 | 61 | N-term | ARG 197 | Atypical chemokine receptor 3 (A) | VdWContact |
| Tyr 7 | 61 | N-term | TYR 195 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Tyr 7 | 61 | N-term | TYR 195 | Atypical chemokine receptor 3 (A) | PiStacking |
| Tyr 7 | 61 | N-term | TYR 111 | CID25 Fab heavy chain (D) | VdWContact |
| Tyr 7 | 61 | N-term | TRP 106 | CID25 Fab heavy chain (D) | Hydrophobic |
| Arg 8 | 62 | N-term | GLU 290 | Atypical chemokine receptor 3 (A) | Cationic |
| Arg 8 | 62 | N-term | ASP 275 | Atypical chemokine receptor 3 (A) | Cationic |
| Arg 8 | 62 | N-term | ASP 275 | Atypical chemokine receptor 3 (A) | VdWContact |
| Pro 10 | 66 | CX | PHE 285 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Arg 12 | 68 | N-loop | LEU 209 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Arg 12 | 68 | N-loop | ILE 279 | Atypical chemokine receptor 3 (A) | VdWContact |
| Arg 12 | 68 | N-loop | ASP 275 | Atypical chemokine receptor 3 (A) | Cationic |
| Phe 13 | 69 | N-loop | LYS 206 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Phe 13 | 69 | N-loop | ILE 279 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Phe 13 | 69 | N-loop | LEU 280 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Phe 13 | 69 | N-loop | ILE 205 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Phe 14 | 70 | N-loop | TRP 106 | CID25 Fab heavy chain (D) | Hydrophobic |
| Phe 14 | 70 | N-loop | TRP 106 | CID25 Fab heavy chain (D) | VdWContact |
| Arg 20 | 80 | N-loop | ILE 27 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Val 23 | 83 | B1 | ILE 27 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Lys 24 | 84 | B1 | VAL 28 | Atypical chemokine receptor 3 (A) | VdWContact |
| His 25 | 85 | B1 | VAL 28 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Leu 26 | 86 | B1 | VAL 28 | Atypical chemokine receptor 3 (A) | HBDonor |
| Leu 26 | 86 | B1 | VAL 28 | Atypical chemokine receptor 3 (A) | VdWContact |
| Leu 26 | 86 | B1 | ILE 27 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Leu 26 | 86 | B1 | VAL 29 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Lys 27 | 87 | B1 | ASP 30 | Atypical chemokine receptor 3 (A) | Cationic |
| Lys 27 | 87 | B1 | ASP 30 | Atypical chemokine receptor 3 (A) | VdWContact |
| Lys 27 | 87 | B1 | VAL 32 | Atypical chemokine receptor 3 (A) | VdWContact |
| Ile 28 | 88 | B1 | ASP 30 | Atypical chemokine receptor 3 (A) | HBDonor |
| Ile 28 | 88 | B1 | ASP 30 | Atypical chemokine receptor 3 (A) | VdWContact |
| Ile 28 | 88 | B1 | THR 31 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Ile 28 | 88 | B1 | THR 31 | Atypical chemokine receptor 3 (A) | VdWContact |
| Ile 28 | 88 | B1 | VAL 32 | Atypical chemokine receptor 3 (A) | HBAcceptor |
| Ile 28 | 88 | B1 | VAL 32 | Atypical chemokine receptor 3 (A) | VdWContact |
| Leu 29 | 89 | B1 | VAL 32 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Leu 29 | 89 | B1 | VAL 32 | Atypical chemokine receptor 3 (A) | VdWContact |
| Asn 30 | 90 | 30s-loop | TYR 55 | CID25 Fab heavy chain (D) | VdWContact |
| Asn 30 | 90 | 30s-loop | CYS 34 | Atypical chemokine receptor 3 (A) | HBAcceptor |
| Asn 30 | 90 | 30s-loop | CYS 34 | Atypical chemokine receptor 3 (A) | VdWContact |
| Asn 30 | 90 | 30s-loop | VAL 32 | Atypical chemokine receptor 3 (A) | HBDonor |
| Asn 30 | 90 | 30s-loop | VAL 32 | Atypical chemokine receptor 3 (A) | VdWContact |
| Asn 30 | 90 | 30s-loop | TYR 34 | CID25 Fab heavy chain (D) | Hydrophobic |
| Asn 30 | 90 | 30s-loop | TYR 34 | CID25 Fab heavy chain (D) | VdWContact |
| Asn 30 | 90 | 30s-loop | TYR 58 | CID25 Fab heavy chain (D) | HBAcceptor |
| Asn 30 | 90 | 30s-loop | TYR 58 | CID25 Fab heavy chain (D) | VdWContact |
| Thr 31 | 91 | 30s-loop | CYS 34 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Thr 31 | 91 | 30s-loop | CYS 34 | Atypical chemokine receptor 3 (A) | VdWContact |
| Pro 32 | 92 | 30s-loop | TYR 58 | CID25 Fab heavy chain (D) | Hydrophobic |
| Cys 34 | 95 | 30s-loop | TRP 106 | CID25 Fab heavy chain (D) | VdWContact |
| Ala 35 | 97 | 30s-loop | PRO 104 | CID25 Fab heavy chain (D) | VdWContact |
| Leu 36 | 99 | 30s-loop | TRP 105 | CID25 Fab heavy chain (D) | Hydrophobic |
| Leu 36 | 99 | 30s-loop | TRP 106 | CID25 Fab heavy chain (D) | VdWContact |
| Leu 36 | 99 | 30s-loop | PRO 104 | CID25 Fab heavy chain (D) | Hydrophobic |
| Leu 36 | 99 | 30s-loop | PRO 104 | CID25 Fab heavy chain (D) | HBDonor |
| Leu 36 | 99 | 30s-loop | PRO 104 | CID25 Fab heavy chain (D) | VdWContact |
| Gln 37 | 100 | 30s-loop | TRP 106 | CID25 Fab heavy chain (D) | Hydrophobic |
| Ile 38 | 101 | B2 | TRP 105 | CID25 Fab heavy chain (D) | Hydrophobic |
| Val 39 | 102 | B2 | HIS 281 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Arg 47 | 114 | 40s-loop | TYR 282 | Atypical chemokine receptor 3 (A) | VdWContact |
| Arg 47 | 114 | 40s-loop | LEU 280 | Atypical chemokine receptor 3 (A) | HBDonor |
| Arg 47 | 114 | 40s-loop | LEU 280 | Atypical chemokine receptor 3 (A) | VdWContact |
| Gln 48 | 115 | B3 | HIS 281 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Gln 48 | 115 | B3 | HIS 281 | Atypical chemokine receptor 3 (A) | VdWContact |
| Cys 50 | 117 | B3 | HIS 281 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Pro 53 | 120 | 50s-loop | TRP 105 | CID25 Fab heavy chain (D) | Hydrophobic |
| Pro 53 | 120 | 50s-loop | TYR 107 | CID25 Fab heavy chain (D) | Hydrophobic |
| Pro 53 | 120 | 50s-loop | TYR 107 | CID25 Fab heavy chain (D) | VdWContact |
| Lys 54 | 121 | 50s-loop | TYR 107 | CID25 Fab heavy chain (D) | Hydrophobic |
| Lys 54 | 121 | 50s-loop | TYR 107 | CID25 Fab heavy chain (D) | VdWContact |
| Gln 59 | 126 | Helix | TYR 107 | CID25 Fab heavy chain (D) | VdWContact |
| Tyr 61 | 128 | Helix | VAL 29 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Tyr 61 | 128 | Helix | VAL 29 | Atypical chemokine receptor 3 (A) | VdWContact |
| Leu 62 | 129 | Helix | TRP 105 | CID25 Fab heavy chain (D) | Hydrophobic |
| Leu 62 | 129 | Helix | TRP 105 | CID25 Fab heavy chain (D) | VdWContact |
| Glu 63 | 130 | Helix | TRP 105 | CID25 Fab heavy chain (D) | Hydrophobic |
| Glu 63 | 130 | Helix | TRP 105 | CID25 Fab heavy chain (D) | HBAcceptor |
| Glu 63 | 130 | Helix | TRP 105 | CID25 Fab heavy chain (D) | VdWContact |
| Glu 63 | 130 | Helix | TYR 103 | CID25 Fab heavy chain (D) | Hydrophobic |
| Glu 63 | 130 | Helix | TYR 103 | CID25 Fab heavy chain (D) | VdWContact |
| Ala 65 | 132 | Helix | VAL 29 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Leu 66 | 133 | Helix | THR 31 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Leu 66 | 133 | Helix | TYR 103 | CID25 Fab heavy chain (D) | Hydrophobic |
| Leu 66 | 133 | Helix | ASN 31 | CID25 Fab heavy chain (D) | Hydrophobic |
| Leu 66 | 133 | Helix | ASN 31 | CID25 Fab heavy chain (D) | HBAcceptor |
| Leu 66 | 133 | Helix | ASN 31 | CID25 Fab heavy chain (D) | VdWContact |
| Leu 66 | 133 | Helix | TYR 34 | CID25 Fab heavy chain (D) | Hydrophobic |
| Asn 67 | 134 | Helix | PHE 30 | CID25 Fab heavy chain (D) | VdWContact |
| Asn 67 | 134 | Helix | TYR 103 | CID25 Fab heavy chain (D) | VdWContact |
| Asn 67 | 134 | Helix | GLY 29 | CID25 Fab heavy chain (D) | VdWContact |
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