Interactions for 7SK5 (chain B)
Structure details
- PDB ID: 7SK5 open_in_new
- Protein: CXCL12_HUMAN
- Organism: Homo sapiens
- UniProt ID: P48061 open_in_new
- Method: Cryo-em
- Resolution: 4.0 Å
- Date: July 27, 2022
- Reference: 10.1126/SCIADV.ABN8063 open_in_new
- State: monomer
Chemokine diagram
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Interactions found in structure
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| Chemokine Residue | Generic number | Segment | Partner Residue | Partner | Interaction Type |
|---|---|---|---|---|---|
| Lys 1 | 55 | N-term | TYR 268 | Atypical chemokine receptor 3 (A) | HBAcceptor |
| Lys 1 | 55 | N-term | TYR 268 | Atypical chemokine receptor 3 (A) | VdWContact |
| Lys 1 | 55 | N-term | ASP 179 | Atypical chemokine receptor 3 (A) | Cationic |
| Lys 1 | 55 | N-term | ASP 179 | Atypical chemokine receptor 3 (A) | VdWContact |
| Pro 2 | 56 | N-term | GLN 301 | Atypical chemokine receptor 3 (A) | VdWContact |
| Pro 2 | 56 | N-term | PHE 124 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Pro 2 | 56 | N-term | TRP 100 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Val 3 | 57 | N-term | GLN 301 | Atypical chemokine receptor 3 (A) | HBDonor |
| Val 3 | 57 | N-term | GLN 301 | Atypical chemokine receptor 3 (A) | VdWContact |
| Val 3 | 57 | N-term | LEU 297 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Val 3 | 57 | N-term | LEU 297 | Atypical chemokine receptor 3 (A) | VdWContact |
| Val 3 | 57 | N-term | HIS 298 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Val 3 | 57 | N-term | HIS 298 | Atypical chemokine receptor 3 (A) | VdWContact |
| Ser 4 | 58 | N-term | SER 103 | Atypical chemokine receptor 3 (A) | HBDonor |
| Ser 4 | 58 | N-term | SER 103 | Atypical chemokine receptor 3 (A) | VdWContact |
| Leu 5 | 59 | N-term | TRP 100 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Leu 5 | 59 | N-term | TRP 100 | Atypical chemokine receptor 3 (A) | VdWContact |
| Leu 5 | 59 | N-term | TRP 110 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Leu 5 | 59 | N-term | LEU 183 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Leu 5 | 59 | N-term | CYS 117 | Atypical chemokine receptor 3 (A) | VdWContact |
| Leu 5 | 59 | N-term | HIS 121 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Leu 5 | 59 | N-term | CYS 196 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Leu 5 | 59 | N-term | CYS 196 | Atypical chemokine receptor 3 (A) | VdWContact |
| Tyr 7 | 61 | N-term | ARG 197 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Tyr 7 | 61 | N-term | ARG 197 | Atypical chemokine receptor 3 (A) | PiCation |
| Tyr 7 | 61 | N-term | ARG 197 | Atypical chemokine receptor 3 (A) | VdWContact |
| Arg 8 | 62 | N-term | LEU 297 | Atypical chemokine receptor 3 (A) | VdWContact |
| Arg 8 | 62 | N-term | ASP 275 | Atypical chemokine receptor 3 (A) | Cationic |
| Arg 8 | 62 | N-term | ASP 275 | Atypical chemokine receptor 3 (A) | VdWContact |
| Pro 10 | 66 | CX | PHE 285 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Cys 11 | 67 | CX | HIS 281 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Cys 11 | 67 | CX | HIS 281 | Atypical chemokine receptor 3 (A) | VdWContact |
| Arg 12 | 68 | N-loop | ILE 279 | Atypical chemokine receptor 3 (A) | VdWContact |
| Phe 13 | 69 | N-loop | ILE 205 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Phe 13 | 69 | N-loop | LYS 206 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Phe 13 | 69 | N-loop | LYS 206 | Atypical chemokine receptor 3 (A) | VdWContact |
| Phe 13 | 69 | N-loop | ILE 279 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| His 25 | 85 | B1 | VAL 28 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| His 25 | 85 | B1 | VAL 28 | Atypical chemokine receptor 3 (A) | VdWContact |
| Leu 26 | 86 | B1 | VAL 29 | Atypical chemokine receptor 3 (A) | VdWContact |
| Lys 27 | 87 | B1 | ASP 30 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Lys 27 | 87 | B1 | ASP 30 | Atypical chemokine receptor 3 (A) | VdWContact |
| Ile 28 | 88 | B1 | VAL 32 | Atypical chemokine receptor 3 (A) | HBAcceptor |
| Ile 28 | 88 | B1 | VAL 32 | Atypical chemokine receptor 3 (A) | VdWContact |
| Ile 28 | 88 | B1 | ASP 30 | Atypical chemokine receptor 3 (A) | HBDonor |
| Ile 28 | 88 | B1 | ASP 30 | Atypical chemokine receptor 3 (A) | VdWContact |
| Ile 28 | 88 | B1 | VAL 29 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Ile 28 | 88 | B1 | THR 31 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Ile 28 | 88 | B1 | THR 31 | Atypical chemokine receptor 3 (A) | VdWContact |
| Leu 29 | 89 | B1 | VAL 32 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Leu 29 | 89 | B1 | VAL 32 | Atypical chemokine receptor 3 (A) | VdWContact |
| Leu 29 | 89 | B1 | PHE 285 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Asn 30 | 90 | 30s-loop | MET 33 | Atypical chemokine receptor 3 (A) | Hydrophobic |
| Arg 47 | 114 | 40s-loop | TYR 282 | Atypical chemokine receptor 3 (A) | CationPi |
| Arg 47 | 114 | 40s-loop | TYR 282 | Atypical chemokine receptor 3 (A) | VdWContact |
| Gln 48 | 115 | B3 | HIS 281 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Interaction pattern search
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