Interactions for 7SK6 (chain B)
Structure details
- PDB ID: 7SK6 open_in_new
- Protein: CXCL12_HUMAN
- Organism: Homo sapiens
- UniProt ID: P48061 open_in_new
- Method: Cryo-em
- Resolution: 4.0 Å
- Date: July 27, 2022
- Reference: 10.1126/SCIADV.ABN8063 open_in_new
- State: monomer
Chemokine diagram
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Interactions found in structure
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Chemokine Residue | Generic number | Segment | Partner Residue | Partner | Interaction Type |
---|---|---|---|---|---|
Gly 0 | 54 | N-term | LEU 128 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Gly 0 | 54 | N-term | TRP 265 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Gly 0 | 54 | N-term | TYR 268 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Gly 0 | 54 | N-term | TYR 268 | Atypical chemokine receptor 3 (A) | VdWContact |
Lys 1 | 55 | N-term | MET 212 | Atypical chemokine receptor 3 (A) | VdWContact |
Lys 1 | 55 | N-term | LEU 209 | Atypical chemokine receptor 3 (A) | VdWContact |
Lys 1 | 55 | N-term | GLU 213 | Atypical chemokine receptor 3 (A) | Cationic |
Lys 1 | 55 | N-term | ASP 179 | Atypical chemokine receptor 3 (A) | Cationic |
Pro 2 | 56 | N-term | LEU 104 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Pro 2 | 56 | N-term | TRP 100 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Pro 2 | 56 | N-term | TRP 100 | Atypical chemokine receptor 3 (A) | VdWContact |
Val 3 | 57 | N-term | HIS 298 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Val 3 | 57 | N-term | GLN 301 | Atypical chemokine receptor 3 (A) | HBDonor |
Val 3 | 57 | N-term | GLN 301 | Atypical chemokine receptor 3 (A) | VdWContact |
Ser 4 | 58 | N-term | SER 103 | Atypical chemokine receptor 3 (A) | HBAcceptor |
Ser 4 | 58 | N-term | SER 103 | Atypical chemokine receptor 3 (A) | VdWContact |
Ser 4 | 58 | N-term | ASN 108 | Atypical chemokine receptor 3 (A) | HBAcceptor |
Ser 4 | 58 | N-term | ASN 108 | Atypical chemokine receptor 3 (A) | VdWContact |
Leu 5 | 59 | N-term | SER 198 | Atypical chemokine receptor 3 (A) | VdWContact |
Leu 5 | 59 | N-term | LEU 183 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Leu 5 | 59 | N-term | TRP 100 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Leu 5 | 59 | N-term | HIS 121 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Tyr 7 | 61 | N-term | ASN 108 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Tyr 7 | 61 | N-term | ARG 197 | Atypical chemokine receptor 3 (A) | VdWContact |
Tyr 7 | 61 | N-term | TYR 195 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Tyr 7 | 61 | N-term | TYR 195 | Atypical chemokine receptor 3 (A) | PiStacking |
Arg 8 | 62 | N-term | ASP 275 | Atypical chemokine receptor 3 (A) | HBDonor |
Arg 8 | 62 | N-term | ASP 275 | Atypical chemokine receptor 3 (A) | Cationic |
Arg 8 | 62 | N-term | ASP 275 | Atypical chemokine receptor 3 (A) | VdWContact |
Arg 8 | 62 | N-term | PHE 294 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Arg 8 | 62 | N-term | PHE 294 | Atypical chemokine receptor 3 (A) | VdWContact |
Arg 8 | 62 | N-term | GLU 290 | Atypical chemokine receptor 3 (A) | HBDonor |
Arg 8 | 62 | N-term | GLU 290 | Atypical chemokine receptor 3 (A) | Cationic |
Arg 8 | 62 | N-term | GLU 290 | Atypical chemokine receptor 3 (A) | VdWContact |
Cys 9 | 63 | CX | ARG 197 | Atypical chemokine receptor 3 (A) | Anionic |
Cys 11 | 67 | CX | ILE 279 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Arg 12 | 68 | N-loop | ASP 275 | Atypical chemokine receptor 3 (A) | HBDonor |
Arg 12 | 68 | N-loop | ASP 275 | Atypical chemokine receptor 3 (A) | Cationic |
Arg 12 | 68 | N-loop | ASP 275 | Atypical chemokine receptor 3 (A) | VdWContact |
Arg 12 | 68 | N-loop | LEU 209 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Arg 12 | 68 | N-loop | ARG 197 | Atypical chemokine receptor 3 (A) | VdWContact |
Phe 13 | 69 | N-loop | ILE 205 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Phe 13 | 69 | N-loop | LEU 280 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Phe 13 | 69 | N-loop | LEU 209 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Phe 13 | 69 | N-loop | ILE 279 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Phe 13 | 69 | N-loop | ILE 210 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Phe 13 | 69 | N-loop | LYS 206 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Lys 24 | 84 | B1 | ILE 27 | Atypical chemokine receptor 3 (A) | Hydrophobic |
His 25 | 85 | B1 | VAL 28 | Atypical chemokine receptor 3 (A) | Hydrophobic |
His 25 | 85 | B1 | VAL 28 | Atypical chemokine receptor 3 (A) | VdWContact |
His 25 | 85 | B1 | ASP 30 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Leu 26 | 86 | B1 | VAL 29 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Leu 26 | 86 | B1 | ASP 30 | Atypical chemokine receptor 3 (A) | HBAcceptor |
Leu 26 | 86 | B1 | ASP 30 | Atypical chemokine receptor 3 (A) | VdWContact |
Lys 27 | 87 | B1 | HIS 281 | Atypical chemokine receptor 3 (A) | VdWContact |
Lys 27 | 87 | B1 | PHE 285 | Atypical chemokine receptor 3 (A) | VdWContact |
Ile 28 | 88 | B1 | VAL 32 | Atypical chemokine receptor 3 (A) | HBAcceptor |
Ile 28 | 88 | B1 | VAL 32 | Atypical chemokine receptor 3 (A) | VdWContact |
Ile 28 | 88 | B1 | VAL 29 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Ile 28 | 88 | B1 | ASP 30 | Atypical chemokine receptor 3 (A) | HBDonor |
Ile 28 | 88 | B1 | ASP 30 | Atypical chemokine receptor 3 (A) | VdWContact |
Ile 28 | 88 | B1 | THR 31 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Leu 29 | 89 | B1 | VAL 32 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Leu 29 | 89 | B1 | PHE 285 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Leu 29 | 89 | B1 | PHE 285 | Atypical chemokine receptor 3 (A) | VdWContact |
Asn 30 | 90 | 30s-loop | VAL 32 | Atypical chemokine receptor 3 (A) | HBDonor |
Asn 30 | 90 | 30s-loop | VAL 32 | Atypical chemokine receptor 3 (A) | VdWContact |
Asn 30 | 90 | 30s-loop | MET 33 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Asn 30 | 90 | 30s-loop | CYS 34 | Atypical chemokine receptor 3 (A) | HBAcceptor |
Asn 30 | 90 | 30s-loop | CYS 34 | Atypical chemokine receptor 3 (A) | VdWContact |
Thr 31 | 91 | 30s-loop | CYS 34 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Pro 32 | 92 | 30s-loop | ASN 36 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Pro 32 | 92 | 30s-loop | ASN 36 | Atypical chemokine receptor 3 (A) | VdWContact |
Val 39 | 102 | B2 | HIS 281 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Asn 45 | 112 | 40s-loop | TYR 282 | Atypical chemokine receptor 3 (A) | HBDonor |
Asn 45 | 112 | 40s-loop | TYR 282 | Atypical chemokine receptor 3 (A) | VdWContact |
Arg 47 | 114 | 40s-loop | TYR 282 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Arg 47 | 114 | 40s-loop | TYR 282 | Atypical chemokine receptor 3 (A) | VdWContact |
Arg 47 | 114 | 40s-loop | LEU 280 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Arg 47 | 114 | 40s-loop | LEU 280 | Atypical chemokine receptor 3 (A) | VdWContact |
Gln 48 | 115 | B3 | HIS 281 | Atypical chemokine receptor 3 (A) | Hydrophobic |
Gln 48 | 115 | B3 | HIS 281 | Atypical chemokine receptor 3 (A) | VdWContact |
Gln 48 | 115 | B3 | LEU 280 | Atypical chemokine receptor 3 (A) | HBDonor |
Gln 48 | 115 | B3 | LEU 280 | Atypical chemokine receptor 3 (A) | VdWContact |
Val 49 | 116 | B3 | LEU 280 | Atypical chemokine receptor 3 (A) | Hydrophobic |