Interactions for 7XA3 (chain L)
Structure details
- PDB ID: 7XA3 open_in_new
- Protein: CCL2_HUMAN
- Organism: Homo sapiens
- UniProt ID: P13500 open_in_new
- Method: Cryo-em
- Resolution: 2.9 Å
- Date: Aug. 24, 2022
- Reference: 10.1038/S41421-022-00403-4 open_in_new
- State: monomer
Chemokine diagram
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Interactions found in structure
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| Chemokine Residue | Generic number | Segment | Partner Residue | Partner | Interaction Type |
|---|---|---|---|---|---|
| Gln 1 | 53 | N-term | GLY 191 | Isoform B of C-C chemokine receptor type 2 (R) | VdWContact |
| Gln 1 | 53 | N-term | THR 117 | Isoform B of C-C chemokine receptor type 2 (R) | Hydrophobic |
| Gln 1 | 53 | N-term | THR 117 | Isoform B of C-C chemokine receptor type 2 (R) | HBDonor |
| Gln 1 | 53 | N-term | THR 117 | Isoform B of C-C chemokine receptor type 2 (R) | VdWContact |
| Gln 1 | 53 | N-term | CYS 190 | Isoform B of C-C chemokine receptor type 2 (R) | VdWContact |
| Gln 1 | 53 | N-term | TYR 120 | Isoform B of C-C chemokine receptor type 2 (R) | VdWContact |
| Gln 1 | 53 | N-term | TRP 98 | Isoform B of C-C chemokine receptor type 2 (R) | Hydrophobic |
| Gln 1 | 53 | N-term | TRP 98 | Isoform B of C-C chemokine receptor type 2 (R) | VdWContact |
| Gln 1 | 53 | N-term | HIS 121 | Isoform B of C-C chemokine receptor type 2 (R) | VdWContact |
| Gln 1 | 53 | N-term | PRO 192 | Isoform B of C-C chemokine receptor type 2 (R) | VdWContact |
| Pro 2 | 54 | N-term | TYR 120 | Isoform B of C-C chemokine receptor type 2 (R) | Hydrophobic |
| Pro 2 | 54 | N-term | GLU 291 | Isoform B of C-C chemokine receptor type 2 (R) | Hydrophobic |
| Pro 2 | 54 | N-term | TRP 98 | Isoform B of C-C chemokine receptor type 2 (R) | Hydrophobic |
| Asp 3 | 55 | N-term | THR 287 | Isoform B of C-C chemokine receptor type 2 (R) | Hydrophobic |
| Asp 3 | 55 | N-term | THR 287 | Isoform B of C-C chemokine receptor type 2 (R) | VdWContact |
| Ala 4 | 56 | N-term | LEU 45 | Isoform B of C-C chemokine receptor type 2 (R) | Hydrophobic |
| Ala 4 | 56 | N-term | GLN 288 | Isoform B of C-C chemokine receptor type 2 (R) | Hydrophobic |
| Ile 5 | 57 | N-term | TRP 98 | Isoform B of C-C chemokine receptor type 2 (R) | Hydrophobic |
| Asn 6 | 58 | N-term | GLY 191 | Isoform B of C-C chemokine receptor type 2 (R) | VdWContact |
| Asn 6 | 58 | N-term | CYS 190 | Isoform B of C-C chemokine receptor type 2 (R) | HBDonor |
| Asn 6 | 58 | N-term | CYS 190 | Isoform B of C-C chemokine receptor type 2 (R) | VdWContact |
| Ala 7 | 59 | N-term | HIS 33 | Isoform B of C-C chemokine receptor type 2 (R) | Hydrophobic |
| Pro 8 | 60 | N-term | HIS 33 | Isoform B of C-C chemokine receptor type 2 (R) | VdWContact |
| Tyr 13 | 68 | N-loop | THR 280 | Isoform B of C-C chemokine receptor type 2 (R) | Hydrophobic |
| Tyr 13 | 68 | N-loop | THR 280 | Isoform B of C-C chemokine receptor type 2 (R) | VdWContact |
| Tyr 13 | 68 | N-loop | GLN 269 | Isoform B of C-C chemokine receptor type 2 (R) | VdWContact |
| Tyr 13 | 68 | N-loop | SER 275 | Isoform B of C-C chemokine receptor type 2 (R) | VdWContact |
| Tyr 13 | 68 | N-loop | CYS 32 | Isoform B of C-C chemokine receptor type 2 (R) | Hydrophobic |
| Tyr 13 | 68 | N-loop | CYS 32 | Isoform B of C-C chemokine receptor type 2 (R) | VdWContact |
| Arg 29 | 87 | B1 | ASP 185 | Isoform B of C-C chemokine receptor type 2 (R) | Cationic |
| Arg 29 | 87 | B1 | ASP 185 | Isoform B of C-C chemokine receptor type 2 (R) | VdWContact |
| Ser 34 | 92 | 30s-loop | PHE 194 | Isoform B of C-C chemokine receptor type 2 (R) | HBDonor |
| Ser 34 | 92 | 30s-loop | PHE 194 | Isoform B of C-C chemokine receptor type 2 (R) | VdWContact |
| Ser 34 | 92 | 30s-loop | ASN 199 | Isoform B of C-C chemokine receptor type 2 (R) | VdWContact |
| Cys 36 | 95 | 30s-loop | ARG 196 | Isoform B of C-C chemokine receptor type 2 (R) | HBAcceptor |
| Cys 36 | 95 | 30s-loop | ARG 196 | Isoform B of C-C chemokine receptor type 2 (R) | VdWContact |
| Pro 37 | 96 | 30s-loop | ARG 196 | Isoform B of C-C chemokine receptor type 2 (R) | VdWContact |
| Glu 50 | 115 | B3 | ALA 30 | Isoform B of C-C chemokine receptor type 2 (R) | HBAcceptor |
| Glu 50 | 115 | B3 | ALA 30 | Isoform B of C-C chemokine receptor type 2 (R) | VdWContact |
| Glu 50 | 115 | B3 | PRO 31 | Isoform B of C-C chemokine receptor type 2 (R) | Hydrophobic |
| Glu 50 | 115 | B3 | PRO 31 | Isoform B of C-C chemokine receptor type 2 (R) | VdWContact |
| Cys 52 | 117 | B3 | ALA 30 | Isoform B of C-C chemokine receptor type 2 (R) | Hydrophobic |
| Cys 52 | 117 | B3 | ALA 30 | Isoform B of C-C chemokine receptor type 2 (R) | VdWContact |
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