Interactions for 8IC0 (chain F)
Structure details
- PDB ID: 8IC0 open_in_new
- Protein: CXCL8_HUMAN
- Organism: Homo sapiens
- UniProt ID: P10145 open_in_new
- Method: Cryo-em
- Resolution: 3.41 Å
- Date: July 19, 2023
- Reference: 10.1038/S41467-023-39799-2 open_in_new
- State: monomer
Chemokine diagram
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Interactions found in structure
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| Chemokine Residue | Generic number | Segment | Partner Residue | Partner | Interaction Type |
|---|---|---|---|---|---|
| Ser 1 | 57 | N-term | SER 184 | C-X-C chemokine receptor type 1 (A) | VdWContact |
| Ala 2 | 58 | N-term | VAL 186 | C-X-C chemokine receptor type 1 (A) | VdWContact |
| Lys 3 | 59 | N-term | GLU 291 | C-X-C chemokine receptor type 1 (A) | Cationic |
| Glu 4 | 60 | N-term | ARG 269 | C-X-C chemokine receptor type 1 (A) | HBAcceptor |
| Glu 4 | 60 | N-term | ARG 269 | C-X-C chemokine receptor type 1 (A) | Anionic |
| Glu 4 | 60 | N-term | ARG 269 | C-X-C chemokine receptor type 1 (A) | VdWContact |
| Glu 4 | 60 | N-term | ARG 199 | C-X-C chemokine receptor type 1 (A) | Anionic |
| Glu 4 | 60 | N-term | ARG 203 | C-X-C chemokine receptor type 1 (A) | Anionic |
| Glu 4 | 60 | N-term | LEU 287 | C-X-C chemokine receptor type 1 (A) | Hydrophobic |
| Leu 5 | 61 | N-term | TYR 188 | C-X-C chemokine receptor type 1 (A) | Hydrophobic |
| Arg 6 | 62 | N-term | ARG 269 | C-X-C chemokine receptor type 1 (A) | VdWContact |
| Arg 6 | 62 | N-term | ASP 265 | C-X-C chemokine receptor type 1 (A) | HBDonor |
| Arg 6 | 62 | N-term | ASP 265 | C-X-C chemokine receptor type 1 (A) | Cationic |
| Arg 6 | 62 | N-term | ASP 265 | C-X-C chemokine receptor type 1 (A) | VdWContact |
| Arg 6 | 62 | N-term | ARG 280 | C-X-C chemokine receptor type 1 (A) | VdWContact |
| Gln 8 | 66 | CX | PRO 29 | C-X-C chemokine receptor type 1 (A) | Hydrophobic |
| Gln 8 | 66 | CX | PRO 29 | C-X-C chemokine receptor type 1 (A) | VdWContact |
| Cys 9 | 67 | CX | PRO 29 | C-X-C chemokine receptor type 1 (A) | Hydrophobic |
| Ile 10 | 68 | N-loop | GLU 275 | C-X-C chemokine receptor type 1 (A) | Hydrophobic |
| Lys 11 | 69 | N-loop | TYR 27 | C-X-C chemokine receptor type 1 (A) | VdWContact |
| Lys 11 | 69 | N-loop | ASP 26 | C-X-C chemokine receptor type 1 (A) | HBDonor |
| Lys 11 | 69 | N-loop | ASP 26 | C-X-C chemokine receptor type 1 (A) | Cationic |
| Lys 11 | 69 | N-loop | ASP 26 | C-X-C chemokine receptor type 1 (A) | VdWContact |
| Tyr 13 | 71 | N-loop | PRO 22 | C-X-C chemokine receptor type 1 (A) | Hydrophobic |
| Tyr 13 | 71 | N-loop | PRO 22 | C-X-C chemokine receptor type 1 (A) | VdWContact |
| Lys 15 | 73 | N-loop | PRO 21 | C-X-C chemokine receptor type 1 (A) | Cationic |
| Lys 15 | 73 | N-loop | PRO 21 | C-X-C chemokine receptor type 1 (A) | VdWContact |
| Lys 15 | 73 | N-loop | PRO 22 | C-X-C chemokine receptor type 1 (A) | VdWContact |
| Pro 32 | 93 | 30s-loop | THR 195 | C-X-C chemokine receptor type 1 (A) | Hydrophobic |
| Pro 32 | 93 | 30s-loop | THR 195 | C-X-C chemokine receptor type 1 (A) | HBAcceptor |
| Pro 32 | 93 | 30s-loop | THR 195 | C-X-C chemokine receptor type 1 (A) | VdWContact |
| Pro 32 | 93 | 30s-loop | TYR 178 | C-X-C chemokine receptor type 1 (A) | Hydrophobic |
| Pro 32 | 93 | 30s-loop | TYR 178 | C-X-C chemokine receptor type 1 (A) | VdWContact |
| Ile 40 | 102 | B2 | PRO 29 | C-X-C chemokine receptor type 1 (A) | Hydrophobic |
| Arg 47 | 114 | 40s-loop | PRO 22 | C-X-C chemokine receptor type 1 (A) | VdWContact |
| Arg 47 | 114 | 40s-loop | ALA 23 | C-X-C chemokine receptor type 1 (A) | VdWContact |
| Glu 48 | 115 | B3 | SER 28 | C-X-C chemokine receptor type 1 (A) | HBAcceptor |
| Glu 48 | 115 | B3 | SER 28 | C-X-C chemokine receptor type 1 (A) | VdWContact |
| Glu 48 | 115 | B3 | TYR 27 | C-X-C chemokine receptor type 1 (A) | VdWContact |
| Leu 49 | 116 | B3 | TYR 27 | C-X-C chemokine receptor type 1 (A) | Hydrophobic |
| Leu 49 | 116 | B3 | TYR 27 | C-X-C chemokine receptor type 1 (A) | VdWContact |
Interaction pattern search
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