Interactions for 1RHP — Binding Partner: CXCL4
Structure details
- PDB ID: 1RHP open_in_new
- Protein: CXCL4_HUMAN
- Organism: Homo sapiens
- UniProt ID: P02776 open_in_new
- Method: X-ray
- Resolution: 2.4 Å
- Date: Nov. 30, 1994
- Reference: 10.1021/BI00193A025 open_in_new
- State: Tetramer
- Chemokine Chain: C
- Partner Chain: A,B,D
Chemokine diagram
Interactions for this Binding Partner
Download list as CSV
| Chemokine Residue | Generic Number | Segment | Partner Residue | Partner Chain | Interaction Type |
|---|---|---|---|---|---|
| Asp 7 | NTc.Cm3 | N-term | GLN 18 | A | VdWContact |
| Leu 8 | NTc.Cm2 | N-term | GLN 18 | A | Hydrophobic |
| Leu 8 | NTc.Cm2 | N-term | GLN 18 | A | VdWContact |
| Leu 8 | NTc.Cm2 | N-term | ILE 51 | A | Hydrophobic |
| Leu 8 | NTc.Cm2 | N-term | ILE 51 | A | VdWContact |
| Leu 8 | NTc.Cm2 | N-term | THR 16 | A | Hydrophobic |
| Leu 8 | NTc.Cm2 | N-term | THR 16 | A | VdWContact |
| Gln 9 | NTc.Cm1 | N-term | ILE 51 | A | VdWContact |
| Gln 9 | NTc.Cm1 | N-term | LYS 14 | A | Hydrophobic |
| Gln 9 | NTc.Cm1 | N-term | LYS 14 | A | HBDonor |
| Gln 9 | NTc.Cm1 | N-term | LYS 14 | A | VdWContact |
| Leu 11 | CX.4 | CX | LYS 50 | A | Hydrophobic |
| Leu 11 | CX.4 | CX | CYS 52 | A | Hydrophobic |
| Leu 11 | CX.4 | CX | CYS 52 | A | VdWContact |
| Leu 11 | CX.4 | CX | LEU 11 | A | Hydrophobic |
| Leu 11 | CX.4 | CX | LEU 11 | A | VdWContact |
| Val 13 | cxb1.1 | N-loop | VAL 13 | A | Hydrophobic |
| Lys 14 | cxb1.2 | N-loop | VAL 13 | A | Hydrophobic |
| Lys 14 | cxb1.2 | N-loop | GLN 9 | A | VdWContact |
| Thr 16 | cxb1.6 | N-loop | GLN 9 | A | Hydrophobic |
| Thr 16 | cxb1.6 | N-loop | GLN 9 | A | VdWContact |
| Thr 25 | B1.3 | B1 | ILE 30 | D | VdWContact |
| Thr 25 | B1.3 | B1 | LYS 31 | D | HBAcceptor |
| Thr 25 | B1.3 | B1 | LYS 31 | D | VdWContact |
| Ser 26 | B1.4 | B1 | VAL 29 | D | VdWContact |
| Leu 27 | B1.5 | B1 | VAL 29 | D | HBAcceptor |
| Leu 27 | B1.5 | B1 | VAL 29 | D | HBDonor |
| Leu 27 | B1.5 | B1 | VAL 29 | D | VdWContact |
| Leu 27 | B1.5 | B1 | GLU 28 | D | VdWContact |
| Glu 28 | B1.6 | B1 | LYS 50 | A | HBAcceptor |
| Glu 28 | B1.6 | B1 | LYS 50 | A | Anionic |
| Glu 28 | B1.6 | B1 | LYS 50 | A | VdWContact |
| Glu 28 | B1.6 | B1 | SER 26 | D | HBAcceptor |
| Glu 28 | B1.6 | B1 | GLU 28 | D | Hydrophobic |
| Glu 28 | B1.6 | B1 | GLU 28 | D | VdWContact |
| Val 29 | B1.7 | B1 | SER 26 | D | VdWContact |
| Val 29 | B1.7 | B1 | LEU 27 | D | HBAcceptor |
| Val 29 | B1.7 | B1 | LEU 27 | D | HBDonor |
| Val 29 | B1.7 | B1 | LEU 27 | D | VdWContact |
| Val 29 | B1.7 | B1 | LEU 67 | D | Hydrophobic |
| Val 29 | B1.7 | B1 | LEU 68 | D | Hydrophobic |
| Ile 30 | b1b2.4 | 30s-loop | LYS 50 | A | Hydrophobic |
| Ile 30 | b1b2.4 | 30s-loop | THR 25 | D | Hydrophobic |
| Ile 30 | b1b2.4 | 30s-loop | THR 25 | D | VdWContact |
| Ile 30 | b1b2.4 | 30s-loop | ARG 49 | A | VdWContact |
| Lys 31 | b1b2.6 | 30s-loop | THR 25 | D | HBDonor |
| Lys 31 | b1b2.6 | 30s-loop | THR 25 | D | VdWContact |
| Lys 31 | b1b2.6 | 30s-loop | ARG 49 | A | VdWContact |
| Lys 31 | b1b2.6 | 30s-loop | ARG 22 | D | VdWContact |
| Lys 31 | b1b2.6 | 30s-loop | LEU 67 | D | Hydrophobic |
| His 35 | b1b2.10 | 30s-loop | LEU 45 | A | Hydrophobic |
| His 35 | b1b2.10 | 30s-loop | ILE 51 | A | Hydrophobic |
| His 35 | b1b2.10 | 30s-loop | ARG 49 | A | Hydrophobic |
| His 35 | b1b2.10 | 30s-loop | ARG 49 | A | VdWContact |
| Ala 39 | b1b2.16 | 30s-loop | LEU 67 | D | VdWContact |
| Leu 41 | B2.2 | B2 | LEU 68 | D | Hydrophobic |
| Leu 41 | B2.2 | B2 | LEU 68 | D | VdWContact |
| Ile 42 | B2.3 | B2 | LYS 50 | A | Hydrophobic |
| Ile 42 | B2.3 | B2 | LYS 50 | A | VdWContact |
| Lys 46 | b2b3.2 | 40s-loop | LYS 31 | D | VdWContact |
| Asn 47 | b2b3.4 | 40s-loop | THR 25 | B | HBAcceptor |
| Asn 47 | b2b3.4 | 40s-loop | THR 25 | B | VdWContact |
| Arg 49 | b2b3.12 | 40s-loop | ILE 30 | A | Hydrophobic |
| Arg 49 | b2b3.12 | 40s-loop | ILE 30 | A | VdWContact |
| Arg 49 | b2b3.12 | 40s-loop | PRO 34 | A | VdWContact |
| Arg 49 | b2b3.12 | 40s-loop | HIS 35 | A | Hydrophobic |
| Lys 50 | B3.1 | B3 | GLU 28 | A | Cationic |
| Lys 50 | B3.1 | B3 | HIS 35 | A | VdWContact |
| Lys 50 | B3.1 | B3 | LEU 11 | A | Hydrophobic |
| Lys 50 | B3.1 | B3 | LEU 11 | A | VdWContact |
| Lys 50 | B3.1 | B3 | ILE 42 | A | Hydrophobic |
| Lys 50 | B3.1 | B3 | ILE 42 | A | VdWContact |
| Ile 51 | B3.2 | B3 | GLN 9 | A | Hydrophobic |
| Ile 51 | B3.2 | B3 | HIS 35 | A | Hydrophobic |
| Ile 51 | B3.2 | B3 | HIS 35 | A | VdWContact |
| Cys 52 | B3.3 | B3 | GLN 9 | A | VdWContact |
| Cys 52 | B3.3 | B3 | LEU 11 | A | VdWContact |
| Leu 55 | b3h.2 | 50s-loop | LEU 68 | D | Hydrophobic |
| Leu 55 | b3h.2 | 50s-loop | LEU 68 | D | VdWContact |
| Tyr 60 | H.3 | Helix | LEU 68 | D | Hydrophobic |
| Tyr 60 | H.3 | Helix | LEU 68 | D | VdWContact |
| Ile 64 | H.7 | Helix | ILE 64 | D | Hydrophobic |
| Ile 64 | H.7 | Helix | ILE 64 | D | VdWContact |
| Leu 67 | H.10 | Helix | VAL 29 | D | Hydrophobic |
| Leu 67 | H.10 | Helix | LYS 31 | D | Hydrophobic |
| Leu 68 | CT.1 | C-term | TYR 60 | D | Hydrophobic |
| Leu 68 | CT.1 | C-term | TYR 60 | D | VdWContact |
| Leu 68 | CT.1 | C-term | LEU 41 | D | Hydrophobic |
| Leu 68 | CT.1 | C-term | LEU 41 | D | VdWContact |
| Leu 68 | CT.1 | C-term | VAL 29 | D | Hydrophobic |
| Leu 68 | CT.1 | C-term | LEU 55 | D | Hydrophobic |
| Leu 68 | CT.1 | C-term | LEU 55 | D | VdWContact |
| Ser 70 | CT.3 | C-term | LEU 55 | D | VdWContact |
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