Interactions

2K04 | CXCL12_HUMAN — CXCL12

Residue contacts: 51
SUMMARY
Protein
CXCL12_HUMAN View protein entry
Organism
Homo sapiens
UniProt ID
P48061 View on UniProt
PDB ID
2K04 View on PDB
Method
Nmr
Resolution
-
Date
Oct. 28, 2008
Reference
10.1126/SCISIGNAL.1160755 Open DOI
State
Dimer
Chain information
Chemokine chain
C
Partner chain
A
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INTERACTION TABLE
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Chemokine Residue Generic Number Segment Partner Residue Partner Chain Interaction Type
His 225 B1.4 B1 LEU 29 A Hydrophobic
His 225 B1.4 B1 ILE 28 A VdWContact
His 225 B1.4 B1 LYS 27 A Hydrophobic
His 225 B1.4 B1 LYS 27 A VdWContact
Leu 226 B1.5 B1 ILE 28 A Hydrophobic
Leu 226 B1.5 B1 ILE 28 A HBAcceptor
Leu 226 B1.5 B1 ILE 28 A HBDonor
Leu 226 B1.5 B1 ILE 28 A VdWContact
Leu 226 B1.5 B1 LYS 27 A VdWContact
Lys 227 B1.6 B1 LEU 26 A VdWContact
Lys 227 B1.6 B1 LYS 27 A Hydrophobic
Lys 227 B1.6 B1 LYS 27 A VdWContact
Lys 227 B1.6 B1 HIS 25 A Hydrophobic
Ile 228 B1.7 B1 LEU 26 A HBAcceptor
Ile 228 B1.7 B1 LEU 26 A HBDonor
Ile 228 B1.7 B1 LEU 26 A VdWContact
Ile 228 B1.7 B1 ILE 28 A Hydrophobic
Ile 228 B1.7 B1 ILE 28 A VdWContact
Ile 228 B1.7 B1 HIS 25 A VdWContact
Ile 228 B1.7 B1 TYR 61 A Hydrophobic
Ile 228 B1.7 B1 TYR 61 A VdWContact
Leu 229 b1b2.4 30s-loop HIS 25 A Hydrophobic
Asn 230 b1b2.7 30s-loop LYS 68 A HBAcceptor
Asn 230 b1b2.7 30s-loop LYS 68 A VdWContact
Leu 236 b1b2.16 30s-loop CYS 65 A Hydrophobic
Leu 236 b1b2.16 30s-loop CYS 65 A VdWContact
Ile 238 B2.2 B2 CYS 65 A VdWContact
Gln 259 H.4 Helix LEU 66 A Hydrophobic
Gln 259 H.4 Helix LEU 66 A HBDonor
Gln 259 H.4 Helix LEU 66 A VdWContact
Tyr 261 H.6 Helix ASN 30 A Hydrophobic
Tyr 261 H.6 Helix ASN 30 A VdWContact
Tyr 261 H.6 Helix ILE 28 A Hydrophobic
Tyr 261 H.6 Helix ILE 28 A VdWContact
Leu 262 H.7 Helix LEU 66 A Hydrophobic
Leu 262 H.7 Helix LEU 62 A Hydrophobic
Leu 262 H.7 Helix CYS 65 A Hydrophobic
Glu 263 H.8 Helix LEU 66 A Hydrophobic
Ala 265 H.10 Helix LEU 62 A Hydrophobic
Ala 265 H.10 Helix CYS 36 A Hydrophobic
Ala 265 H.10 Helix CYS 36 A VdWContact
Leu 266 CT.1 C-term GLU 63 A Hydrophobic
Leu 266 CT.1 C-term LEU 62 A Hydrophobic
Leu 266 CT.1 C-term GLN 59 A Hydrophobic
Leu 266 CT.1 C-term GLN 59 A VdWContact
Lys 268 CT.3 C-term ASN 30 A HBDonor
Lys 268 CT.3 C-term ASN 30 A VdWContact
Lys 268 CT.3 C-term CYS 36 A Hydrophobic
Lys 268 CT.3 C-term CYS 36 A HBAcceptor
Lys 268 CT.3 C-term CYS 36 A VdWContact
Lys 268 CT.3 C-term ALA 35 A VdWContact
CHEMOKINE DIAGRAM
L N T P N C A C 30s-loop K N N N R 40s-loop D P K L 50s-loopC-term K P V S L S Y R C P C R F F E S H V A R A N-term I K L H K V N Q I V A R L I C V Q K W I Q E Y L E K C L N K
INTERACTION PATTERN SEARCH
0.00 = no similarity, 1.00 = identical