Interactions

2K05 | CXCL12_HUMAN — CXCL12

Residue contacts: 46
SUMMARY
Protein
CXCL12_HUMAN View protein entry
Organism
Homo sapiens
UniProt ID
P48061 View on UniProt
PDB ID
2K05 View on PDB
Method
Nmr
Resolution
-
Date
Oct. 28, 2008
Reference
10.1126/SCISIGNAL.1160755 Open DOI
State
Dimer
Chain information
Chemokine chain
A
Partner chain
C
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INTERACTION TABLE
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Chemokine Residue Generic Number Segment Partner Residue Partner Chain Interaction Type
Lys 24 B1.3 B1 VAL 203 C Hydrophobic
His 25 B1.4 B1 LYS 227 C Hydrophobic
His 25 B1.4 B1 LEU 229 C Hydrophobic
His 25 B1.4 B1 LEU 229 C VdWContact
His 25 B1.4 B1 ILE 228 C VdWContact
Leu 26 B1.5 B1 ILE 228 C HBAcceptor
Leu 26 B1.5 B1 ILE 228 C HBDonor
Leu 26 B1.5 B1 ILE 228 C VdWContact
Leu 26 B1.5 B1 LYS 227 C VdWContact
Lys 27 B1.6 B1 LYS 227 C Hydrophobic
Lys 27 B1.6 B1 LYS 227 C VdWContact
Lys 27 B1.6 B1 HIS 225 C Hydrophobic
Ile 28 B1.7 B1 LEU 226 C Hydrophobic
Ile 28 B1.7 B1 LEU 226 C HBAcceptor
Ile 28 B1.7 B1 LEU 226 C HBDonor
Ile 28 B1.7 B1 LEU 226 C VdWContact
Ile 28 B1.7 B1 ILE 228 C Hydrophobic
Ile 28 B1.7 B1 HIS 225 C VdWContact
Ile 28 B1.7 B1 TYR 261 C Hydrophobic
Ile 28 B1.7 B1 TYR 261 C VdWContact
Leu 29 b1b2.4 30s-loop HIS 225 C Hydrophobic
Leu 29 b1b2.4 30s-loop HIS 225 C VdWContact
Asn 30 b1b2.7 30s-loop TYR 261 C VdWContact
Leu 36 b1b2.16 30s-loop CYS 265 C Hydrophobic
Leu 36 b1b2.16 30s-loop CYS 265 C VdWContact
Pro 53 b3h.2 50s-loop CYS 265 C VdWContact
Gln 59 H.4 Helix LEU 266 C Hydrophobic
Gln 59 H.4 Helix LEU 266 C VdWContact
Tyr 61 H.6 Helix ILE 228 C Hydrophobic
Tyr 61 H.6 Helix ILE 228 C VdWContact
Leu 62 H.7 Helix LEU 262 C Hydrophobic
Leu 62 H.7 Helix LEU 266 C Hydrophobic
Leu 62 H.7 Helix CYS 265 C Hydrophobic
Lys 64 H.9 Helix ASN 230 C VdWContact
Ala 65 H.10 Helix PRO 253 C VdWContact
Ala 65 H.10 Helix CYS 236 C Hydrophobic
Ala 65 H.10 Helix CYS 236 C VdWContact
Ala 65 H.10 Helix LEU 262 C Hydrophobic
Leu 66 CT.1 C-term GLN 259 C Hydrophobic
Leu 66 CT.1 C-term GLN 259 C HBAcceptor
Leu 66 CT.1 C-term GLN 259 C VdWContact
Leu 66 CT.1 C-term LEU 262 C Hydrophobic
Leu 66 CT.1 C-term LEU 262 C VdWContact
Lys 68 CT.3 C-term ALA 235 C Hydrophobic
Lys 68 CT.3 C-term ALA 235 C HBDonor
Lys 68 CT.3 C-term ALA 235 C VdWContact
CHEMOKINE DIAGRAM
L N T P N C A C 30s-loop K N N N R 40s-loop D P K L 50s-loopC-term K P V S L S Y R C P C R F F E S H V A R A N-term I K L H K V N Q I V A R L I C V Q K W I Q E Y L E K C L N K
INTERACTION PATTERN SEARCH
0.00 = no similarity, 1.00 = identical