Interactions for 4LMQ — Binding Partner: CXCL12
Structure details
- PDB ID: 4LMQ open_in_new
- Protein: CXCL12_HUMAN
- Organism: Homo sapiens
- UniProt ID: P48061 open_in_new
- Method: X-ray
- Resolution: 2.77 Å
- Date: Aug. 14, 2013
- Reference: 10.1158/1078-0432.CCR-13-0943 open_in_new
- State: Dimer
- Chemokine Chain: D
- Partner Chain: F
Chemokine diagram
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Interactions for this Binding Partner
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| Chemokine Residue | Generic Number | Segment | Partner Residue | Partner Chain | Interaction Type |
|---|---|---|---|---|---|
| His 25 | 85 | B1 | LEU 29 | F | Hydrophobic |
| His 25 | 85 | B1 | ILE 28 | F | VdWContact |
| His 25 | 85 | B1 | LYS 27 | F | Hydrophobic |
| Leu 26 | 86 | B1 | ILE 28 | F | Hydrophobic |
| Leu 26 | 86 | B1 | ILE 28 | F | HBAcceptor |
| Leu 26 | 86 | B1 | ILE 28 | F | HBDonor |
| Leu 26 | 86 | B1 | ILE 28 | F | VdWContact |
| Lys 27 | 87 | B1 | HIS 25 | F | Hydrophobic |
| Lys 27 | 87 | B1 | HIS 25 | F | CationPi |
| Lys 27 | 87 | B1 | HIS 25 | F | VdWContact |
| Ile 28 | 88 | B1 | ILE 28 | F | Hydrophobic |
| Ile 28 | 88 | B1 | TYR 61 | F | Hydrophobic |
| Ile 28 | 88 | B1 | LEU 26 | F | HBAcceptor |
| Ile 28 | 88 | B1 | LEU 26 | F | HBDonor |
| Ile 28 | 88 | B1 | LEU 26 | F | VdWContact |
| Leu 29 | 89 | B1 | HIS 25 | F | Hydrophobic |
| Asn 30 | 90 | 30s-loop | LYS 24 | F | HBDonor |
| Asn 30 | 90 | 30s-loop | LYS 24 | F | VdWContact |
| Leu 36 | 99 | 30s-loop | ALA 65 | F | Hydrophobic |
| Leu 36 | 99 | 30s-loop | ALA 65 | F | VdWContact |
| Leu 36 | 99 | 30s-loop | TYR 61 | F | Hydrophobic |
| Tyr 61 | 128 | Helix | ILE 28 | F | Hydrophobic |
| Tyr 61 | 128 | Helix | ILE 28 | F | HBDonor |
| Tyr 61 | 128 | Helix | ILE 28 | F | VdWContact |
| Tyr 61 | 128 | Helix | ASN 30 | F | Hydrophobic |
| Tyr 61 | 128 | Helix | ASN 30 | F | VdWContact |
| Leu 62 | 129 | Helix | ILE 28 | F | Hydrophobic |
| Glu 63 | 130 | Helix | LEU 62 | F | Hydrophobic |
| Glu 63 | 130 | Helix | LEU 62 | F | VdWContact |
| Ala 65 | 132 | Helix | GLN 37 | F | Hydrophobic |
| Ala 65 | 132 | Helix | GLN 37 | F | VdWContact |
| Ala 65 | 132 | Helix | ILE 38 | F | Hydrophobic |
| Ala 65 | 132 | Helix | ILE 28 | F | Hydrophobic |
| Leu 66 | 133 | Helix | LEU 62 | F | Hydrophobic |
| Leu 66 | 133 | Helix | ILE 38 | F | Hydrophobic |
| Leu 66 | 133 | Helix | ILE 38 | F | VdWContact |
| Leu 66 | 133 | Helix | PRO 53 | F | Hydrophobic |
| Leu 66 | 133 | Helix | ILE 58 | F | Hydrophobic |
| Lys 68 | 135 | Helix | LEU 62 | F | Hydrophobic |
| Lys 68 | 135 | Helix | GLN 59 | F | VdWContact |
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