Interactions
2N55 | CXCL12_HUMAN — CXCR4 N-terminal peptide
Residue contacts: 95
SUMMARY
- Protein
- CXCL12_HUMAN View protein entry
- Organism
- Homo sapiens
- UniProt ID
- P48061 View on UniProt
- PDB ID
- 2N55 View on PDB
- Method
- Nmr
- Resolution
- -
- Date
- April 27, 2016
- Reference
- 10.1126/SCISIGNAL.AAH5756 Open DOI
- State
- Monomer
Chain information
- Chemokine chain
- A
- Partner chain
- B
3D VIEW
INTERACTION TABLE
Download CSV| Chemokine Residue | Generic Number | Segment | Partner Residue | Partner Chain | Interaction Type |
|---|---|---|---|---|---|
| Leu 5 | NTc.Cm4 | N-term | THR 213 | B | HBDonor |
| Leu 5 | NTc.Cm4 | N-term | THR 213 | B | VdWContact |
| Leu 5 | NTc.Cm4 | N-term | ASN 211 | B | HBAcceptor |
| Leu 5 | NTc.Cm4 | N-term | ASN 211 | B | VdWContact |
| Tyr 7 | NTc.Cm2 | N-term | TYR 212 | B | HBAcceptor |
| Tyr 7 | NTc.Cm2 | N-term | TYR 212 | B | VdWContact |
| Tyr 7 | NTc.Cm2 | N-term | ASN 211 | B | VdWContact |
| Pro 10 | CX.4 | CX | TYR 212 | B | Hydrophobic |
| Cys 11 | CX.5 | CX | SER 218 | B | VdWContact |
| Arg 12 | cxb1.1 | N-loop | SER 218 | B | HBDonor |
| Arg 12 | cxb1.1 | N-loop | SER 218 | B | VdWContact |
| Phe 13 | cxb1.2 | N-loop | MET 224 | B | Hydrophobic |
| Phe 14 | cxb1.5 | N-loop | MET 224 | B | Hydrophobic |
| Phe 14 | cxb1.5 | N-loop | MET 224 | B | VdWContact |
| Glu 15 | cxb1.6 | N-loop | TYR 221 | B | Hydrophobic |
| Glu 15 | cxb1.6 | N-loop | TYR 221 | B | VdWContact |
| Ser 16 | cxb1.8 | N-loop | MET 224 | B | VdWContact |
| Ser 16 | cxb1.8 | N-loop | GLU 226 | B | HBDonor |
| Ser 16 | cxb1.8 | N-loop | GLU 226 | B | VdWContact |
| Ser 16 | cxb1.8 | N-loop | LYS 225 | B | VdWContact |
| His 17 | cxb1.10 | N-loop | PHE 236 | B | Hydrophobic |
| His 17 | cxb1.10 | N-loop | PHE 236 | B | PiStacking |
| His 17 | cxb1.10 | N-loop | PRO 227 | B | VdWContact |
| His 17 | cxb1.10 | N-loop | LYS 225 | B | VdWContact |
| Arg 20 | cxb1.15 | N-loop | ILE 204 | B | VdWContact |
| Arg 20 | cxb1.15 | N-loop | GLY 199 | B | VdWContact |
| His 25 | B1.4 | B1 | TYR 207 | B | Hydrophobic |
| His 25 | B1.4 | B1 | TYR 207 | B | VdWContact |
| Leu 26 | B1.5 | B1 | ILE 206 | B | Hydrophobic |
| Leu 26 | B1.5 | B1 | ILE 206 | B | VdWContact |
| Leu 26 | B1.5 | B1 | ILE 204 | B | Hydrophobic |
| Lys 27 | B1.6 | B1 | TYR 212 | B | HBDonor |
| Lys 27 | B1.6 | B1 | TYR 212 | B | VdWContact |
| Lys 27 | B1.6 | B1 | TYR 207 | B | Hydrophobic |
| Lys 27 | B1.6 | B1 | TYR 207 | B | HBDonor |
| Lys 27 | B1.6 | B1 | TYR 207 | B | VdWContact |
| Lys 27 | B1.6 | B1 | SER 209 | B | VdWContact |
| Lys 27 | B1.6 | B1 | GLU 214 | B | HBDonor |
| Lys 27 | B1.6 | B1 | GLU 214 | B | Cationic |
| Lys 27 | B1.6 | B1 | GLU 214 | B | VdWContact |
| Lys 27 | B1.6 | B1 | ILE 206 | B | VdWContact |
| Ile 28 | B1.7 | B1 | TYR 207 | B | HBDonor |
| Ile 28 | B1.7 | B1 | TYR 207 | B | VdWContact |
| Ile 28 | B1.7 | B1 | SER 209 | B | HBAcceptor |
| Ile 28 | B1.7 | B1 | SER 209 | B | VdWContact |
| Ile 28 | B1.7 | B1 | THR 208 | B | VdWContact |
| Ile 28 | B1.7 | B1 | ILE 206 | B | Hydrophobic |
| Leu 29 | b1b2.4 | 30s-loop | TYR 212 | B | Hydrophobic |
| Leu 29 | b1b2.4 | 30s-loop | TYR 212 | B | VdWContact |
| Leu 29 | b1b2.4 | 30s-loop | SER 209 | B | VdWContact |
| Asn 30 | b1b2.7 | 30s-loop | SER 209 | B | HBDonor |
| Asn 30 | b1b2.7 | 30s-loop | THR 208 | B | HBDonor |
| Asn 30 | b1b2.7 | 30s-loop | THR 208 | B | VdWContact |
| Thr 31 | b1b2.8 | 30s-loop | ASP 210 | B | VdWContact |
| Val 39 | B2.3 | B2 | TYR 212 | B | VdWContact |
| Arg 41 | B2.5 | B2 | GLU 214 | B | HBDonor |
| Arg 41 | B2.5 | B2 | GLU 214 | B | Cationic |
| Arg 41 | B2.5 | B2 | GLU 214 | B | VdWContact |
| Leu 42 | B2.6 | B2 | TYR 221 | B | Hydrophobic |
| Leu 42 | B2.6 | B2 | TYR 221 | B | VdWContact |
| Arg 47 | b2b3.12 | 40s-loop | ASP 220 | B | HBDonor |
| Arg 47 | b2b3.12 | 40s-loop | ASP 220 | B | Cationic |
| Arg 47 | b2b3.12 | 40s-loop | ASP 220 | B | VdWContact |
| Arg 47 | b2b3.12 | 40s-loop | TYR 221 | B | VdWContact |
| Gln 48 | B3.1 | B3 | TYR 212 | B | VdWContact |
| Gln 48 | B3.1 | B3 | GLU 215 | B | Hydrophobic |
| Gln 48 | B3.1 | B3 | GLU 215 | B | VdWContact |
| Val 49 | B3.2 | B3 | TYR 221 | B | Hydrophobic |
| Val 49 | B3.2 | B3 | TYR 221 | B | VdWContact |
| Asp 52 | b3h.1 | 50s-loop | GLU 226 | B | Hydrophobic |
| Asp 52 | b3h.1 | 50s-loop | GLU 226 | B | VdWContact |
| Lys 54 | b3h.3 | 50s-loop | GLU 226 | B | Hydrophobic |
| Lys 54 | b3h.3 | 50s-loop | GLU 226 | B | VdWContact |
| Leu 55 | b3h.4 | 50s-loop | PRO 227 | B | Hydrophobic |
| Lys 56 | H.1 | Helix | ARG 230 | B | Hydrophobic |
| Lys 56 | H.1 | Helix | ARG 230 | B | VdWContact |
| Lys 56 | H.1 | Helix | GLU 231 | B | Cationic |
| Lys 56 | H.1 | Helix | PHE 229 | B | HBDonor |
| Lys 56 | H.1 | Helix | PHE 229 | B | VdWContact |
| Trp 57 | H.2 | Helix | ILE 204 | B | Hydrophobic |
| Trp 57 | H.2 | Helix | ILE 204 | B | VdWContact |
| Tyr 61 | H.6 | Helix | ILE 204 | B | Hydrophobic |
| Tyr 61 | H.6 | Helix | ILE 204 | B | VdWContact |
| Tyr 61 | H.6 | Helix | ILE 206 | B | Hydrophobic |
| Tyr 61 | H.6 | Helix | ILE 206 | B | VdWContact |
| Lys 64 | H.9 | Helix | GLU 202 | B | VdWContact |
| Lys 64 | H.9 | Helix | GLY 203 | B | VdWContact |
| Ala 65 | H.10 | Helix | ILE 206 | B | Hydrophobic |
| Ala 65 | H.10 | Helix | ILE 206 | B | VdWContact |
| Lys 68 | CT.3 | C-term | SER 205 | B | HBAcceptor |
| Lys 68 | CT.3 | C-term | SER 205 | B | VdWContact |
| Lys 68 | CT.3 | C-term | TYR 207 | B | Hydrophobic |
| Lys 68 | CT.3 | C-term | TYR 207 | B | VdWContact |
| Lys 68 | CT.3 | C-term | ILE 206 | B | VdWContact |
| Lys 68 | CT.3 | C-term | THR 208 | B | Hydrophobic |
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